Gene Profiles: Tebbets B, et al. (2012) Identification and characterization of antifungal compounds using a Saccharomyces cerevisiae reporter bioassay. PLoS One 7(5):e36021

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 Locus Id | Gene Name | Description
 orf19.1151    Predicted ORF from Assembly 19; induced in core stress response; merged with orf19.1152 in Assembly 20  
 orf19.1135  CAS1   Putative transcription factor with Ku70/Ku80 beta-barrel DNA-binding motif; involved in telomerase regulation and telomere protection; mutation causes marginal increase in caspofungin sensitivity  
 orf19.2952  EXG2   GPI-anchored cell wall protein, similar to S. cerevisiae exo-1,3-beta-glucosidase Exg2p; predicted Kex2p substrate; induced during cell wall regeneration; possibly an essential gene, disruptants not obtained by UAU1 method; Hap43p-repressed  
 orf19.1198    Predicted mitochondrial intermembrane space protein of unknown function; possibly an essential gene, disruptants not obtained by UAU1 method  
 orf19.7111.1  SOD3   Cytosolic manganese-containing superoxide dismutase; protects against oxidative stress; repressed by ciclopirox olamine, induced during stationary phase when SOD1 expression is low; Hap43-repressed; Spider and flow model biofilm induced  
 orf19.3900    Ortholog(s) have role in mitochondrial fusion and integral to mitochondrial outer membrane localization  
 orf19.2039  MSF1   Putative phenylalanine-tRNA ligase; protein level decreases in stationary phase cultures; Hap43p-repressed gene  
 orf19.1709    Sterol carrier domain protein; alkaline downregulated; colony morphology-related gene regulation by Ssn6; Spider biofilm induced  
 orf19.1541    Protein with a globin-like domain; repressed by alpha pheromone in SpiderM medium; Spider biofilm induced  
 orf19.3273    Ortholog(s) have actin monomer binding, protein kinase inhibitor activity, ribosome binding activity, role in negative regulation of protein phosphorylation and cytoplasm, nucleus, polysome, ribosome localization  
 orf19.2194    Phosphorylated protein of unknown function  
 orf19.4414    Ortholog of C. dubliniensis CD36 : Cd36_45590, C. parapsilosis CDC317 : CPAR2_501450, Candida tenuis NRRL Y-1498 : CANTEDRAFT_105024 and Debaryomyces hansenii CBS767 : DEHA2D12364g  
 orf19.846    Predicted protein kinase similar to S. cerevisiae Nnk1; implicated in proteasome function in S. cerevisiae; induced by Mnl1 under weak acid stress  
 orf19.203  STB3   Putative SIN3-binding protein 3 homolog; caspofungin induced; macrophage/pseudohyphal-repressed; rat catheter biofilm induced  
 orf19.6888    Zn(II)2Cys6 domain transcription factor; regulated by Mig1 and Tup1; rat catheter and Spider biofilm induced  
 orf19.5159  DUG3   Putative glutamine amidotransferase (GATase II); role in glutathione catabolism;  
 orf19.6487    Ortholog of C. parapsilosis CDC317 : CPAR2_808350, C. dubliniensis CD36 : Cd36_72060, Candida orthopsilosis Co 90-125 : CORT_0C00820 and Candida albicans WO-1 : CAWG_05575  
 orf19.1745    Protein of unknown function; Hap43-repressed gene  
 orf19.5552    Putative transcriptional regulator of ribonucleotide reductase genes; Spider biofilm induced  
 orf19.21    Ortholog(s) have role in ethanol metabolic process and mitochondrial inner membrane localization  
 orf19.91    Protein of unknown function; flow model biofilm induced; Hap43-repressed  
 orf19.4570    Ortholog of C. dubliniensis CD36 : Cd36_42090, Debaryomyces hansenii CBS767 : DEHA2C14872g, Pichia stipitis Pignal : PICST_74821 and Spathaspora passalidarum NRRL Y-27907 : SPAPADRAFT_58607  
 orf19.3159.4    Ortholog of Candida albicans WO-1 : CAWG_04594  
 orf19.395  ENO1   Enolase; glycolysis and gluconeogenesis; major cell-surface antigen; binds host plasmin/plasminogen; immunoprotective; Hap43, phagocytosis induced; farnesol-repressed; flow model biofilm induced; Spider biofilm repressed; may be essential  
 orf19.6834.10  TAR1   Ortholog of S. cerevisiae Tar1p; Transcript Antisense to Ribosomal RNA; encoded within the 25S rRNA gene on the opposite strand; induced by Tbf1  
 orf19.3651  PGK1   Phosphoglycerate kinase; localizes to cell wall and cytoplasm; antigenic in murine/human infection; flow model biofilm, Hog1-, Hap43-, GCN-induced; repressed upon phagocytosis; repressed in Spider biofilms by Bcr1, Ndt80, Rob1, Brg1  
 orf19.1435  TEF1   Translation elongation factor 1-alpha; at cell surface; binds human plasminogen; macrophage/pseudohyphal-induced; induced in RHE model of oral candidiasis, in clinical oral candidiasis isolates; possibly essential; Spider biofilm repressed  
 orf19.1891  APR1   Vacuolar aspartic proteinase; transcript equivalent in yeast-form and mycelial cells but is elevated at lower growth temperatures; upregulated iby human neutrophils; protein enriched in stationary phase; Spider biofilm induced  
 orf19.382  TEF2   Translation elongation factor 1-alpha; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage  
 orf19.6016    Ortholog(s) have GTPase activity, calcium ion binding activity, role in mitochondrion inheritance, phospholipid homeostasis, regulation of mitochondrion organization and ERMES complex, cytosol, nuclear envelope localization  
 orf19.2509    Ortholog of C. parapsilosis CDC317 : CPAR2_401850, C. dubliniensis CD36 : Cd36_80970, Lodderomyces elongisporus NRLL YB-4239 : LELG_04407 and Candida orthopsilosis Co 90-125 : CORT_0E01890  
 orf19.458    Ortholog(s) have protein transmembrane transporter activity and role in chaperone-mediated protein complex assembly, mitochondrial respiratory chain complex III assembly, protein insertion into mitochondrial membrane from inner side  
 orf19.4548  MAK32   Putative protein involved in the structural stability of L-A double-stranded RNA-containing particles; downregulated upon adherence to polystyrene  
 orf19.3043    Ortholog(s) have triglyceride lipase activity, role in triglyceride catabolic process and mitochondrion localization  
 orf19.2077  ZCF9   Putative Zn(II)2Cys6 transcription factor; hypersensitive to toxic ergosterol analog ECC69 and/or ECC1384  
 orf19.317  PNP1   Purine nucleoside phosphorylase; metabolizes inosine and guanosine nucleosides; in the nicotinamide riboside salvage pathway; Spider biofilm repressed  
 orf19.4979  KNS1   Protein kinase involved in negative regulation of PolIII transcription; effector kinase of the TOR signaling pathway, phosphorylates Rpc53p to regulate ribosome and tRNA biosynthesis; Spider and flow model biofilm induced  
 orf19.279    Protein with a predicted D-Tyr-tRNA(Tyr) deacylase domain; Hap43-repressed gene  
 orf19.5423  EST3   Telomerase subunit; required for telomere maintenance in vivo; separable roles in telomerase activity and processivity; not required for catalytic activity in vitro; related to mammalian Tpp1p  
 orf19.6512  EXO70   Predicted subunit of the exocyst complex, involved in exocytosis; localizes to a crescent on the surface of the hyphal tip  
 orf19.2786    Ortholog(s) have AP-2 adaptor complex, cellular bud neck localization  
 orf19.4888    Has domain(s) with predicted nucleic acid binding, nucleotide binding activity  
 orf19.7487    Has domain(s) with predicted RNA binding, RNA-directed DNA polymerase activity and role in RNA-dependent DNA replication  
 orf19.1510  SRD1   Sur7 family protein with PalI-like domains; not required for stress responses; mutant is viable  
 orf19.4196    Dubious open reading frame  
 orf19.645.1  VMA13   Predicted proton-transporting ATPase; predicted role in ATP hydrolysis coupled proton transport; rat catheter biofilm repressed  
 orf19.75    Predicted exocyst component; ortholog of S. cerevisiae Sec5p; merged with orf19.74 in Assembly 21  
 orf19.5031  SSK1   Response regulator of two-component system; role in oxidative stress response, cell wall biosynthesis, virulence, hyphal growth on solid media; expressed in hyphae and yeast; peroxisomal targeting sequence (PTS1); Spider biofilm induced  
 orf19.879    Ortholog(s) have myosin binding activity, role in intracellular mRNA localization, mating type switching and cytoplasm localization  
 orf19.806  VMA7   Putative subunit of the V-ATPase complex, which is involved in control of vacuolar pH; highly similar to S. cerevisiae Vma7p; interacts with phosphatidylinositol 3-kinase Vps34p