Gene Profiles: Buschart A, et al. (2012) The fungicide fludioxonil antagonizes fluconazole activity in the human fungal pathogen Candida albicans. J Med Microbiol 61(Pt 12):1696-703

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 Locus Id | Gene Name | Description
 orf19.4839    GET complex subunit; expression downregulated in an ssr1 null mutant  
 orf19.7331  FCY24   Putative transporter; more similar to S. cerevisiae Tpn1, which is a vitamin B6 transporter, than to purine-cytosine permeases; transcription is regulated by Nrg1; Spider biofilm induced  
 orf19.4264    Protein of unknown function; induced during chlamydospore formation in both C. albicans and C. dubliniensis; flow model biofilm induced  
 orf19.2499    Putative peptidyl-prolyl cis-trans isomerase  
 orf19.815  DCK1   Putative guanine nucleotide exchange factor; required for embedded filamentous growth; activates Rac1; has a DOCKER domain; similar to adjacent DCK2 and to S. cerevisiae Ylr422wp; regulated by Nrg1; Spider biofilm induced  
 orf19.2542    Ortholog(s) have nucleus localization  
 orf19.7074    Ortholog(s) have RNA polymerase II transcription factor recruiting transcription factor activity, methylated histone residue binding activity  
 orf19.2758  PGA38   Putative adhesin-like GPI-anchored protein; repressed during cell wall regeneration; possibly an essential gene, disruptants not obtained by UAU1 method; rat catheter and Spider biofilm repressed  
 orf19.7377  ASE1   Putative microtubule-associated protein; member of conserved Mcm1p regulon; periodic mRNA expression, peak at cell-cycle G2/M phase  
 orf19.6494  WHI3   Putative RNA binding protein; induced during infection of murine kidney, compared to growth in vitro; has murine homolog  
 orf19.2968    Protein of unknown function; Spider biofilm induced  
 orf19.351    Ortholog of S. cerevisiae : YPR153W, C. glabrata CBS138 : CAGL0L08382g, C. dubliniensis CD36 : Cd36_83540, C. parapsilosis CDC317 : CPAR2_404520 and Candida tenuis NRRL Y-1498 : CANTEDRAFT_115795  
 orf19.5237  VPH2   Ortholog(s) have role in vacuolar acidification, vacuolar proton-transporting V-type ATPase complex assembly and endoplasmic reticulum membrane localization  
 orf19.240  PAM17   Predicted component of the presequence translocase-associated import motor (PAM complex) involved in protein import into mitochondrial matrix  
 orf19.1401  EAP1   GPI-anchored cell wall adhesin; Efg1-regulated; mutant suppresses cell adhesion, filamentation, invasive growth defects of S. cerevisiae flo8 or flo11 mutant; biofilm induced; required for biofilm formation; Bcr1-repressed in a/a biofilms  
 orf19.2281    Ortholog(s) have mitochondrion localization  
 orf19.606    Protein of unknown function; Hap43-induced; Spider biofilm induced  
 orf19.7486  MRPL6   Putative mitochondrial ribosomal protein  
 orf19.589  VPS21   Late endosomal Rab small monomeric GTPase involved in transport of endocytosed proteins to the vacuole; involved in filamentous growth and virulence; Spider biofilm induced  
 orf19.7680  CTA26   Putative transcription factor/activator; Med2 mediator complex ddomain; transcript is upregulated in an RHE model of oral candidiasis; member of a family of telomere-proximal genes; Efg1, Hap43-repressed  
 orf19.2833  PGA34   Putative GPI-anchored protein; transcript repressed by alpha pheromone in SpiderM medium; induced in oralpharyngeal candidasis; flow model biofilm induced; Spider biofilm induced  
 orf19.1321  HWP1   Hyphal cell wall protein; host transglutaminase substrate; opaque-, a-specific, alpha-factor induced; at MTLa side of conjugation tube; virulence complicated by URA3 effects; Bcr1-repressed in RPMI a/a biofilms; Spider biofilm induced  
 orf19.4818    Protein of unknown function; Spider biofilm induced  
 orf19.5657  SWI1   Protein involved in transcription regulation; ortholog of S. cerevisiae Swi1p, which is a subunit of the SWI/SNF chromatin remodeling complex; interacts with Snf2p; SWI/SNF complex is essential for hyphal growth and virulence  
 orf19.3836    Ortholog(s) have cytoplasm localization  
 orf19.119    Ortholog(s) have protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity  
 orf19.3732  ERG25   Putative C-4 methyl sterol oxidase; C4-demethylation of ergosterol biosynthesis intermediates, based on similarity to S. cerevisiae Erg25; fluconazole-induced; induced in azole-resistant strain; rat catheter and Spider biofilm induced  
 orf19.1591  ERG10   Acetyl-CoA acetyltransferase; role in ergosterol biosynthesis; soluble in hyphae; changes in protein abundance associated with azole resistance; fluconazole or ketoconazole induced; macrophage-downregulated protein; GlcNAc-induced protein  
 orf19.7300    Protein of unknown function; Spider biofilm induced  
 orf19.5043    Ortholog of C. dubliniensis CD36 : Cd36_43610, C. parapsilosis CDC317 : CPAR2_403770, Debaryomyces hansenii CBS767 : DEHA2G16962g and Pichia stipitis Pignal : PICST_30926  
 orf19.5584  PEP3   Peptidase; activity useful for strain identification by multilocus enzyme electrophoresis (MLEE); clade-associated gene expression  
 orf19.1212    Ortholog(s) have FFAT motif binding, phosphatidylinositol binding activity  
 orf19.5144  PGA28   Protein similar to S. cerevisiae Wsc2p, which has roles in stress- and cell-wall-related processes; predicted Kex2p substrate; putative GPI-anchored adhesin-like protein  
 orf19.6265.1  RPS14B   Putative ribosomal protein; repressed upon phagocytosis by murine macrophage; transcript positively regulated by Tbf1; Spider biofilm repressed  
 orf19.6822    Ortholog(s) have NEDD8 ligase activity, ubiquitin binding activity and role in positive regulation of ubiquitin-protein ligase activity, protein neddylation  
 orf19.3335    Plasma membrane protein of unknown function; colony morphology-related gene regulation by Ssn6; repressed by nitric oxide  
 orf19.527    Protein of unknown function; flow model biofilm induced  
 orf19.254    Protein of unknown function; Hog1p-repressed; Spider biofilm induced  
 orf19.4148    Ortholog of C. dubliniensis CD36 : Cd36_50820, C. parapsilosis CDC317 : CPAR2_501670, Candida tenuis NRRL Y-1498 : CANTEDRAFT_115294 and Debaryomyces hansenii CBS767 : DEHA2E13464g  
 orf19.2537    Protein of unknown function; transcript detected on high-resolution tiling arrays  
 orf19.7164    Ortholog(s) have role in ascospore formation, conidiophore development, conidium formation, response to oxidative stress, sporocarp development involved in sexual reproduction, vacuolar protein processing  
 orf19.4440  SEC34   Ortholog(s) have role in CVT pathway, ER to Golgi vesicle-mediated transport, macroautophagy, peroxisome degradation, retrograde transport, vesicle recycling within Golgi and Golgi transport complex, cell division site localization  
 orf19.4072  IFF6   Putative GPI-anchored adhesin-like protein; opaque-specific transcript; macrophage-induced gene; Hap43-repressed gene; Spider biofilm induced  
 orf19.7258  DDI1   Putative DNA damage inducible v-SNARE binding protein; macrophage/pseudohyphal-repressed  
 orf19.2154  HXK1   N-acetylglucosamine (GlcNAc) kinase; involved in GlcNAc utilization; required for wild-type hyphal growth and mouse virulence; GlcNAc-induced transcript; induced by alpha pheromone in SpiderM medium  
 orf19.764    Ortholog(s) have clathrin-coated vesicle, cytoplasm localization  
 orf19.3330.3  POX18   Similar to Pox18, a peroxisomal protein; induced during chlamydospore formation in C. albicans and C. dubliniensis; A21 sequence updated based on new sequence and analysis, the allelic orf19.10841 was reinstated; Spider biofilm induced  
 orf19.5804  HYU1   Putative hydantoin utilization protein A; induced upon adherence to polystyrene; regulated by Gcn2p and Gcn4p  
 orf19.2003  HNM1   Putative choline/ethanolamine transporter; mutation confers hypersensitivity to toxic ergosterol analog; colony morphology-related gene regulation by Ssn6; clade-associated gene expression  
 orf19.1596  FGR28   Protein lacking an ortholog in S. cerevisiae; transposon mutation affects filamentous growth; possibly an essential gene, disruptants not obtained by UAU1 method