Gene Profiles: Flowers SA, et al. (2012) Gain-of-function mutations in UPC2 are a frequent cause of ERG11 upregulation in azole-resistant clinical isolates of Candida albicans. Eukaryot Cell 11(10):1289-99

   Zoom: selected 50 rows.
Fold Change
 < 1/3.0  < 1/2.3  < 1/1.7  < 1/1.3  1:1  > 1.3  > 1.7  > 2.3  > 3.0
 Locus Id | Gene Name | Description
 orf19.4682  HGT17   Putative MFS family glucose transporter; 20 members in C. albicans; 12 probable membrane-spanning segments; induced at low (0.2%, compared to 2%) glucose in rich media; Spider biofilm induced  
 orf19.5862  AFP99   Protein related to arginases; downregulated upon adherence to polystyrene; regulated by Gcn2p and Gcn4p  
 orf19.11618     
 orf19.1341  PRR2   Putative serine/threonine protein kinase; mutation confers resistance to 5-fluorocytosine (5-FC)  
 orf19.3437    Has domain(s) with predicted serine-type endopeptidase activity and role in proteolysis  
 orf19.980    Ortholog(s) have inositol heptakisphosphate kinase activity, inositol hexakisphosphate 1-kinase activity, inositol hexakisphosphate 3-kinase activity, inositol hexakisphosphate 4-kinase activity, inositol hexakisphosphate 6-kinase activity  
 orf19.1341  PRR2   Putative serine/threonine protein kinase; mutation confers resistance to 5-fluorocytosine (5-FC)  
 orf19.3538  FRE9   Ferric reductase; alkaline induced; ciclopirox olamine; Hap43-induced  
 orf19.1406    Ortholog(s) have DNA-directed DNA polymerase activity, role in error-free translesion synthesis, error-prone translesion synthesis and mitochondrion, nuclear chromatin, zeta DNA polymerase complex localization  
 orf19.1462  SMP2   Putative Mg2+-dependent phosphatidate phosphatase; transcript regulated by Nrg1  
 orf19.1941  NUF2   Kinetochore component; amount of Nuf2p and Mtw1p protein detected at each centromere is consistent with a single kinetochore microtubule attachment site  
 orf19.5320  NCE4   Putative RecQ-mediated genome instability protein; Hap43-repressed gene; periodic mRNA expression, peak at cell-cycle G2/M phase; flow model biofilm induced  
 orf19.2888    Ortholog(s) have role in early endosome to Golgi transport, protein complex assembly and Golgi apparatus, TRAPP complex, clathrin-coated vesicle localization  
 orf19.5097  CAT8   Zn(II)2Cys6 transcription factor; similar to S. cerevisiae Cat8 but mutant phenotype suggests different target genes; mutant displays increased filamentous/invasive growth; flucytosine repressed; rat catheter biofilm induced  
 orf19.7585  INO1   Inositol-1-phosphate synthase; antigenic in human; repressed by farnesol in biofilm or by caspofungin; upstream inositol/choline regulatory element; glycosylation predicted; rat catheter, flow model induced; Spider biofilm repressed  
 orf19.5547    Protein of unknown function; Hap43-repressed gene  
 orf19.6589  SSF1   Protein involved in ribosome biogenesis; ortholog of S. cerevisiae Ssf1; Hap43-induced; rat catheter and Spider biofilm induced  
 orf19.6356    Ortholog(s) have role in mRNA splicing, via spliceosome and U4/U6 x U5 tri-snRNP complex localization  
 orf19.2650.1    Mitochondrial ribosomal protein of the small subunit; Spider biofilm repressed  
 orf19.6805    Protein of unknown function; Spider biofilm induced  
 orf19.6920    Protein of unknown function; induced during chlamydospore formation in both C. albicans and C. dubliniensis; Hap43-induced gene; Spider biofilm induced; F-12/CO2 early biofilm induced  
 orf19.6920    Protein of unknown function; induced during chlamydospore formation in both C. albicans and C. dubliniensis; Hap43-induced gene; Spider biofilm induced; F-12/CO2 early biofilm induced  
 orf19.6982    Ortholog(s) have ribosome binding activity and mitochondrion localization  
 orf19.6351    Ortholog of C. dubliniensis CD36 : Cd36_11880, Candida tenuis NRRL Y-1498 : cten_CGOB_00231, Debaryomyces hansenii CBS767 : DEHA2D04928g and Pichia stipitis Pignal : PICST_29234  
 orf19.2006    Ortholog(s) have fungal-type vacuole membrane localization  
 orf19.2006    Ortholog(s) have fungal-type vacuole membrane localization  
 orf19.6460  PEX1   Ortholog(s) have ATPase activity, protein heterodimerization activity, role in fatty acid metabolic process, protein import into peroxisome matrix, receptor recycling and cytosol, peroxisomal membrane localization  
 orf19.1828  BUD16   Putative pyridoxal kinase; a key enzyme in pyridoxal 5'-phosphate synthesis, the active form of vitamin B6; involved in bud-site selection and genome integrity in S. cerevisiae; induced by alpha pheromone in SpiderM medium  
 orf19.2755    Ortholog(s) have role in proteasomal ubiquitin-independent protein catabolic process, proteasome-mediated ubiquitin-dependent protein catabolic process and cytosol, nucleus, proteasome core complex, beta-subunit complex localization  
 orf19.4583    Protein with a mitochondrial carrier protein domain; possibly an essential gene, disruptants not obtained by UAU1 method; Spider biofilm repressed  
 orf19.911    Predicted ORF from Assembly 19; merged with orf19.5776 in Assembly 20  
 orf19.4711    Ortholog of C. dubliniensis CD36 : Cd36_40890, C. parapsilosis CDC317 : CPAR2_401100, Candida tenuis NRRL Y-1498 : CANTEDRAFT_119698 and Debaryomyces hansenii CBS767 : DEHA2G22154g  
 orf19.3121  GST1   Putative glutathione S-transferase; upregulated in the presence of human neutrophils; expression is regulated upon white-opaque switching; increased transcription is observed upon benomyl treatment  
 orf19.4608  PDC12   Putative pyruvate decarboxylase; fungal-specific (no human or murine homolog)  
 orf19.2508  PRM9   Protein described a similar to S. cerevisiae Prm9; not the ortholog though; mutant is viable  
 orf19.2238  LTE1   Protein similar to GDP/GTP exchange factors; repressed by alpha pheromone in SpiderM medium; flow model biofilm repressed  
 orf19.3156    Protein of unknown function; induced by Mnl1 under weak acid stress  
 orf19.6979    Ortholog(s) have role in cellular manganese ion homeostasis, mitochondrion organization and fungal-type vacuole membrane localization  
 orf19.3519  SUA72   Predicted transcription factor; induced during planktonic growth, whereas related SUA71 is downregulated  
 orf19.2839  CIRT4B   Cirt family transposase; transcript repressed in an azole-resistant strain that overexpresses CDR1 and CDR2; Hap43-repressed; flow model biofilm induced  
 orf19.302    Ortholog(s) have Rab guanyl-nucleotide exchange factor activity, role in ER to Golgi vesicle-mediated transport and TRAPP complex, cytosol, nucleus localization  
 orf19.742  ALD6   Putative aldehyde dehydrogenase; stationary phase enriched protein; expression regulated upon white-opaque switch; rat catheter biofilm induced; rat catheter and Spider biofilm induced  
 orf19.7303    Ortholog of C. dubliniensis CD36 : Cd36_34495, Candida tropicalis MYA-3404 : CTRG_05947 and Candida albicans WO-1 : CAWG_02181  
 orf19.1768    Ortholog of C. parapsilosis CDC317 : CPAR2_407480, C. dubliniensis CD36 : Cd36_24170, Candida orthopsilosis Co 90-125 : CORT_0C06830 and Spathaspora passalidarum NRRL Y-27907 : SPAPADRAFT_65786  
 orf19.262  SMC3   Protein similar to S. cerevisiae Smc3p, which is an ATPase involved in sister chromatid cohesion; likely to be essential for growth, based on an insertional mutagenesis strategy  
 orf19.4735    Ornithine cyclodeaminase family protein; Sef1, Sfu1, and Hap43-regulated; ortholog of S. cerevisiae YGL159W and S. pombe SPAP11E10.01; rat catheter biofilm induced  
 orf19.6311    Protein of unknown function; Hap43-induced; rat catheter and Spider biofilm induced  
 orf19.3998    Ortholog(s) have Atg8 ligase activity, protein binding, bridging activity and role in C-terminal protein lipidation, CVT pathway, macroautophagy, mitochondrion degradation, piecemeal microautophagy of nucleus  
 orf19.6790    Ortholog(s) have mRNA binding activity, role in 3'-UTR-mediated mRNA destabilization, mitochondrion organization and cytoplasmic mRNA processing body, cytoplasmic stress granule, cytosol, perinuclear region of cytoplasm localization  
 orf19.6790    Ortholog(s) have mRNA binding activity, role in 3'-UTR-mediated mRNA destabilization, mitochondrion organization and cytoplasmic mRNA processing body, cytoplasmic stress granule, cytosol, perinuclear region of cytoplasm localization