Gene Profiles: Pierce JV, et al. (2013) Normal adaptation of Candida albicans to the murine gastrointestinal tract requires Efg1p-dependent regulation of metabolic and host defense genes. Eukaryot Cell 12(1):37-49

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 Locus Id | Gene Name | Description
 orf19.4318  MIG1   C2H2 transcription factor; repressor; regulates genes for carbon source utilization; Tup1-dependent and independent functions; hyphal, Hap43 and caspofungin repressed; Spider and flow model biofilm induced  
 orf19.3354    Ortholog(s) have structural constituent of ribosome activity and 90S preribosome, cytosolic small ribosomal subunit, extracellular region, nucleolus localization  
 orf19.6540  PFK2   Phosphofructokinase beta subunit; fructose 2,6-bisphosphate, AMP activated; ATP inhibited; phagocytosis, hyphal repressed; fluconazole-induced; stationary-phase enriched; flow model biofilm induced; rat catheter/Spider biofilm repressed  
 orf19.3465  RPL10A   Predicted ribosomal protein; downregulated upon phagocytosis by murine macrophages; Hap43-induced; Spider biofilm repressed  
 orf19.3223  ATP3   F1-ATP synthase complex subunit; caspofungin repressed; flucytosine and macrophage/pseudohyphal-induced; present in exponential and stationary growth phases; Hap43p-induced gene  
 orf19.6109  TUP1   Transcriptional corepressor; represses filamentous growth; regulates switching; role in germ tube induction, farnesol response; in repression pathways with Nrg1, Rfg1; farnesol upregulated in biofilm; rat catheter, Spider biofilm repressed  
 orf19.3374  ECE1   Hypha-specific protein; regulated by Rfg1, Nrg1, Tup1, Cph1, Efg1, Hog1, farnesol, phagocytosis; fluconazole-induced; rat catheter and Spider biofilm induced; flow model biofilm repressed; Bcr1-repressed in RPMI a/a biofilms  
 orf19.1891  APR1   Vacuolar aspartic proteinase; transcript equivalent in yeast-form and mycelial cells but is elevated at lower growth temperatures; upregulated iby human neutrophils; protein enriched in stationary phase; Spider biofilm induced  
 orf19.227  COX7   Putative cytochrome c oxidase; flucytosine induced; repressed by nitric oxide  
 orf19.6472  CYP1   Peptidyl-prolyl cis-trans isomerase; cyclosporin A sensitive activity; soluble in hyphae; biofilm induced, macrophage-induced protein; downregulated upon treatment of biofilm with farnesol; present in exponential and stationary phase cells  
 orf19.2529.1    Protein of unknown function; Spider biofilm repressed  
 orf19.1160    Ortholog(s) have COPII adaptor activity and role in ER to Golgi vesicle-mediated transport, fungal-type cell wall organization, protein glycosylation, protein retention in Golgi apparatus  
 orf19.2770.1  SOD1   Cytosolic copper- and zinc-containing superoxide dismutase; role in protection from oxidative stress; required for full virulence; alkaline induced by Rim101; induced by human blood; rat catheter, flow model and Spider biofilm repressed  
 orf19.1042  POR1   Mitochondrial outer membrane porin; in detergent-resistant membrane fraction (possible lipid raft component); antigenic in human, mouse; Hap43p-induced; flucytosine-, macrophage-, farnesol- induced; fluconazole, caspofungin repressed  
 orf19.778  PIL1   Eisosome component; predicted role in endocytosis; echinocandin-binding protein; localizes to cell surface of hyphae, but not yeast-form cells; Hap43, YNB biofilm induced; rat catheter biofilm repressed  
 orf19.1061  HHT21   Putative histone H3; amphotericin B repressed; regulated by Efg1, farnesol; Hap43-induced; rat catheter and Spider biofilm repressed  
 orf19.68.2    Ortholog of C. dubliniensis CD36 : Cd36_11670, C. parapsilosis CDC317 : CPAR2_201750, Candida tenuis NRRL Y-1498 : CANTEDRAFT_115679 and Debaryomyces hansenii CBS767 : DEHA2E16940g  
 orf19.3110    Possible mannosyltransferase; Spider biofilm induced  
 orf19.6626    Predicted homeodomain-containing protein; possible transcription factor; possibly transcriptionally regulated upon hyphal formation  
 orf19.7386    Ortholog(s) have ribosome binding activity  
 orf19.3309    Ortholog of Candida tropicalis MYA-3404 : CTRG_04422 and Candida albicans WO-1 : CAWG_01254  
 orf19.1668    Protein of unknown function; expression downregulated in an ssr1 null mutant  
 orf19.1264  CFL2   Oxidoreductase; iron utilization; Sfu1/Sef1/Hap43/Nrg1/Tup1/Rim101 regulated; alkaline/low iron/fluphenazine/ciclopirox olamine, flucytosine, fluconazole, Spider/flow model/rat catheter biofilm induced; caspofungin/amphotericin B repressed  
 orf19.1964    Protein of unknown function; repressed by fluphenazine treatment; induced by benomyl treatment and in an RHE model; regulated by Nrg1, Tup1  
 orf19.3935    Ortholog of Candida albicans WO-1 : CAWG_04819  
 orf19.182    Ortholog(s) have rRNA (guanine-N1-)-methyltransferase activity, role in rRNA modification and endoplasmic reticulum, mitochondrion localization  
 orf19.3062    Ortholog(s) have role in chromatin remodeling and ASTRA complex, mitochondrion localization  
 orf19.669  PRM1   Putative membrane protein with a predicted role in membrane fusion during mating; Hap43p-repressed gene; protein induced during the mating process  
 orf19.6907    Ortholog(s) have DNA binding activity and cytoplasm, nuclear chromatin localization  
 orf19.1955    Ortholog(s) have palmitoyltransferase activity, role in protein palmitoylation, protein targeting to membrane and endoplasmic reticulum palmitoyltransferase complex, extrinsic to endoplasmic reticulum membrane localization  
 orf19.7055    Dubious open reading frame  
 orf19.656  DPP1   Putative diacylglycerol pyrophosphate phosphatase of diacylglycerol production for phospholipid biosynthesis; downregulation correlates with clinical development of fluconazole resistance  
 orf19.2541    Ortholog(s) have 3'-5'-exodeoxyribonuclease activity, endonuclease activity, role in apoptotic DNA fragmentation, cellular response to oxidative stress and cytosol, nucleus localization  
 orf19.3321  MRS7   Member of the LETM1-like protein family, mitochondrial membrane protein  
 orf19.5066    Putative pre-60S pre-ribosomal particle subunit; essential gene; S. cerevisiae ortholog RRP17 is essential; Hap43p-induced; rat catheter biofilm induced  
 orf19.1841    Protein of unknown function; Hap43-induced gene  
 orf19.7555    Ortholog of Candida albicans WO-1 : CAWG_02247  
 orf19.1009    Ortholog of Candida albicans WO-1 : CAWG_01857  
 orf19.1956    Ortholog(s) have role in reciprocal meiotic recombination and mitochondrion localization  
 orf19.4304  GAP1   Amino acid permease; antigenic in human/mouse; 10-12 transmembrane regions; regulated by nitrogen source; alkaline, GlcNAc, phagocytosis induced; WT virulence in mice; Spider and flow model biofilm induced  
 orf19.2103    Ortholog of Candida albicans WO-1 : CAWG_03811  
 orf19.6316.4    Protein of unknown function; Hap43-induced; rat catheter and Spider biofilm induced  
 orf19.3407  RAD18   Putative transcription factor with zinc finger DNA-binding motif; Hap43p-repressed gene  
 orf19.1202    Ortholog of C. dubliniensis CD36 : Cd36_60350, C. parapsilosis CDC317 : CPAR2_603550, Candida tenuis NRRL Y-1498 : CANTEDRAFT_114325 and Debaryomyces hansenii CBS767 : DEHA2G04950g  
 orf19.2404    Ortholog(s) have RNA binding, ribonuclease MRP activity, ribonuclease P activity and role in intronic box C/D snoRNA processing, mRNA cleavage, rRNA processing, tRNA processing  
 orf19.206    Putative adhesin-like protein  
 orf19.7100    Putative vacuolar transporter of large neutral amino acids; possibly transcriptionally regulated upon hyphal formation; not the true Avt1 ortholog of S. cerevisiae  
 orf19.701  CFL11   Protein similar to ferric reductase Fre10p; flucytosine repressed; possibly adherence-induced; possibly an essential gene, disruptants not obtained by UAU1 method; rat catheter biofilm repressed  
 orf19.6325.1    Ortholog(s) have mitochondrion localization  
 orf19.5597.1    Has domain(s) with predicted proton-transporting ATP synthase activity, rotational mechanism, proton-transporting ATPase activity, rotational mechanism activity and role in ATP synthesis coupled proton transport