Gene Profiles: Rohm M, et al. (2013) A family of secreted pathogenesis-related proteins in Candida albicans. Mol Microbiol 87(1):132-51

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 Locus Id | Gene Name | Description
 orf19.2038    Protein of unknown function; Spider biofilm induced  
 orf19.187    Predicted ORF in Assemblies 19, 20 and 21; merged with orf19.188 in Assembly 21  
 orf19.3371  JAB1   Component of the COP9 signalosome (CSN) complex, provides catalytic activity for deneddylation that cleaves the ubiquitin-like protein tag Rub1p off the cullin (Cdc53p) molecule  
 orf19.3649    Ortholog(s) have adenyl-nucleotide exchange factor activity, role in cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process, cytoplasmic translation and cytosolic ribosome, nucleus localization  
 orf19.245  DDC1   Putative DNA damage checkpoint protein; transcript induced during filamentous growth; regulated by Nrg1, Tup1  
 orf19.1588    Putative mitochondrial protein of unknown function; regulated by Sef1p-, Sfu1p-, and Hap43p  
 orf19.3607    Ortholog of C. dubliniensis CD36 : Cd36_22860, C. parapsilosis CDC317 : CPAR2_806540, Candida tenuis NRRL Y-1498 : CANTEDRAFT_108823 and Debaryomyces hansenii CBS767 : DEHA2B13596g  
 orf19.2610    Putative tRNA binding protein; intron-containing gene; Spider biofilm induced  
 orf19.3954  PSD2   Ortholog(s) have phosphatidylserine decarboxylase activity, role in phosphatidylcholine biosynthetic process, phosphatidylethanolamine biosynthetic process and cell division site, cytosol, endosome localization  
 orf19.7512    Has domain(s) with predicted electron carrier activity, heme binding, iron ion binding, oxidoreductase activity, acting on paired donors and with incorporation or reduction of molecular oxygen, more  
 orf19.6592    Predicted membrane transporter, member of the aromatic acid:proton symporter (AAHS) family, major facilitator superfamily (MFS)  
 orf19.3163    Ortholog of C. dubliniensis CD36 : Cd36_51910, C. parapsilosis CDC317 : CPAR2_101650, Candida tenuis NRRL Y-1498 : CANTEDRAFT_94797 and Debaryomyces hansenii CBS767 : DEHA2D06578g  
 orf19.4862    Putative integral membrane protein; S. cerevisiae ortholog Tvp23 localizes to late Golgi vesicles; rat catheter biofilm induced  
 orf19.2062  SOD4   Cu and Zn-containing superoxide dismutase; role in response to host innate immune ROS; regulated on white-opaque switch; ciclopirox olamine induced; caspofungin repressed; SOD1,4,5,6 gene family; yeast-associated; Spider biofilm induced  
 orf19.1200    Protein of unknown function; Spider biofilm induced  
 orf19.5867  WSC1   Putative cell wall component; transcript upregulated in cyr1 mutant (yeast or hyphae); Spider and flow model biofilm induced  
 orf19.395  ENO1   Enolase; glycolysis and gluconeogenesis; major cell-surface antigen; binds host plasmin/plasminogen; immunoprotective; Hap43, phagocytosis induced; farnesol-repressed; flow model biofilm induced; Spider biofilm repressed; may be essential  
 orf19.5840    Ortholog(s) have cytoplasm, mating projection tip localization  
 orf19.7030  SSR1   Beta-glucan associated ser/thr rich cell-wall protein with a role in cell wall structure; GPI anchor; similar mRNA abundance in yeast-form and germ tubes; detected at germ tube plasma membrane; repressed in cells treated with Congo Red  
 orf19.2672  NCP1   NADPH-cytochrome P450 reductase, acts with Erg11p in sterol 14 alpha-demethylation in ergosterol biosynthesis; subject to hypoxic regulation; ketoconazole-induced; caspofungin repressed  
 orf19.6329    Protein of unknown function; opaque-specific transcript; fluconazole-repressed; induced in cyr1 mutant and in oralpharyngeal candidasis; Spider biofilm induced  
 orf19.7316    Putative phytanoyl-CoA dioxygenase family protein; mutation confers hypersensitivity to 5-fluorocytosine (5-FC), 5-fluorouracil (5-FU), and tubercidin (7-deazaadenosine); induced by nitric oxide  
 orf19.2278    Putative 20S proteasome assembly protein; filament induced; induced by alpha pheromone in SpiderM medium  
 orf19.258    Protein of unknown function; Spider biofilm induced  
 orf19.6053  CIS2   Putative role in regulation of biogenesis of the cell wall; upregulated in biofilm; Gcn4p-regulated  
 orf19.3008  COQ4   Protein with a putative role in coenzyme Q biosynthesis; transcriptionally induced by interaction with macrophage; Hap43p-repressed gene  
 orf19.6353    Ortholog of Candida albicans WO-1 : CAWG_00172  
 orf19.3992    BLOC-1 complex subunit involved in endosomal maturation; Predicted ORF from Assembly 19; removed from Assembly 20; subsequently reinstated in Assembly 21 based on comparative genome analysis  
 orf19.2324  UBA4   Putative ubiquitin activating protein; Hap43-repressed; induced by prostaglandins; clade-associated gene expression  
 orf19.2112    snRNP U5 splicing factor component; involved in positioning the 3' splice site during the 2nd catalytic step of splicing; Spider biofilm induced  
 orf19.516    S. cerevisiae ortholog Rft1p has role in glycolipid translocation, protein N-linked glycosylation and localizes to endoplasmic reticulum membrane; regulated by Sef1p-, Sfu1p-, and Hap43p  
 orf19.3399    Ortholog(s) have histone binding activity, role in histone exchange and Swr1 complex, cytoplasm localization  
 orf19.4872    Protein of unknown function; induced by Mnl1 under weak acid stress; Hap43-induced; mutant is viable  
 orf19.7360    Ortholog(s) have enzyme activator activity, role in histone deubiquitination, regulation of transcription from RNA polymerase II promoter and DUBm complex, SAGA complex localization  
 orf19.708    Ortholog(s) have structural constituent of cytoskeleton activity  
 orf19.5502    Ortholog of C. dubliniensis CD36 : Cd36_73420, Debaryomyces hansenii CBS767 : DEHA2A05456g, Pichia stipitis Pignal : PICST_30999 and Candida guilliermondii ATCC 6260 : PGUG_00155  
 orf19.6929    Ortholog(s) have acid phosphatase activity and cytosol, nucleus localization  
 orf19.1823    Predicted membrane protein; transcript repressed by ciclopirox olamine  
 orf19.686    Protein of unknown function; regulated by Nrg1  
 orf19.562  FGR13   Protein encoded in retrotransposon Zorro3 with a potential zinc finger; lacks an ortholog in S. cerevisiae; transposon mutation affects filamentous growth  
 orf19.4376    Protein of unknown function; Spider biofilm induced  
 orf19.6268    Putative cohesin complex subunit; expression downregulated in an ssr1 null mutant  
 orf19.3999    Ortholog(s) have fungal-type vacuole membrane localization  
 orf19.306  USO5   Putative type II myosin heavy chain; transcription is induced upon filamentous growth and in response to alpha pheromone in SpiderM medium  
 orf19.4119  SPO72   Protein described as similar to S. cerevisiae sporulation protein; ortholog of S. cerevisiae Atg2, an autophagic vesicle formation protein; up-regulation associated with azole resistance; Spider biofilm induced  
 orf19.3248    Ortholog of C. dubliniensis CD36 : Cd36_26070, C. parapsilosis CDC317 : CPAR2_803220, Candida tenuis NRRL Y-1498 : CANTEDRAFT_131795 and Debaryomyces hansenii CBS767 : DEHA2E12694g  
 orf19.4861    Protein of unknown function; rat catheter biofilm repressed  
 orf19.1763  IFR1   Predicted oxidoreductase/dehydrogenase; induced by nitric oxide; rat catheter and Spider biofilm induced  
 orf19.4414    Ortholog of C. dubliniensis CD36 : Cd36_45590, C. parapsilosis CDC317 : CPAR2_501450, Candida tenuis NRRL Y-1498 : CANTEDRAFT_105024 and Debaryomyces hansenii CBS767 : DEHA2D12364g  
 orf19.5089  TERT   Telomerase reverse transcriptase; catalytic protein subunit of telomere synthesis; essential for telomerase activity; has telomerase-specific motif T and other conserved reverse transcriptase motifs