Gene Profiles: Raman SB, et al. (2013) A competitive infection model of hematogenously disseminated candidiasis in mice redefines the role of Candida albicans IRS4 in pathogenesis. Infect Immun 81(5):1430-8

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 Locus Id | Gene Name | Description
 orf19.2131    Ortholog(s) have ubiquitin-protein ligase activity and role in protein ubiquitination, ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway  
 orf19.3997  ADH1   Alcohol dehydrogenase; oxidizes ethanol to acetaldehyde; at yeast cell surface; immunogenic in humans/mice; complements S. cerevisiae adh1 adh2 adh3 mutant; fluconazole, farnesol-induced; flow model biofilm induced; Spider biofilm repressed  
 orf19.5280  MUP1   Putative high affinity methionine permease; alkaline upregulated by Rim101; Spider biofilm induced  
 orf19.2471  GIM5   Putative heterohexameric cochaperone prefoldin complex subunit; macrophage/pseudohyphal-repressed gene and macrophage-induced protein  
 orf19.3065  DAO1   Putative D-amino acid oxidase; transcription is regulated upon yeast-hyphal switch  
 orf19.583    Indoleamine 2,3-dioxygenase (IDO); rate-limiting enzyme of tryptophan catabolism via kynurenine; enzyme inhibition by 1-methyl-D,L-tryptophan increases hyphal growth; expressed in yeast and hyphae; rat catheter and Spider biofilm induced  
 orf19.405  VCX1   Putative H+/Ca2+ antiporter; Spider biofilm repressed  
 orf19.3967  PFK1   Phosphofructokinase alpha subinit; activated by fructose 2,6-bisphosphate, AMP, ATP inhibited; activity reduced on hyphal induction; phagocytosis-repressed; fluconazole, flow model biofilm induced; rat catheter and Spider biofilm repressed  
 orf19.203  STB3   Putative SIN3-binding protein 3 homolog; caspofungin induced; macrophage/pseudohyphal-repressed; rat catheter biofilm induced  
 orf19.3565    Ortholog of C. dubliniensis CD36 : Cd36_19830, C. parapsilosis CDC317 : CPAR2_206470, Candida tenuis NRRL Y-1498 : CANTEDRAFT_113899 and Debaryomyces hansenii CBS767 : DEHA2C05676g  
 orf19.2398    Protein of unknown function; Hap43-repressed; transcript increased in azole-resistant strain overexpressing CDR1 and CDR2; possibly regulated by Tac1; induced by Mnl1 in weak acid stress; flow model biofilm induced; Spider biofilm induced  
 orf19.1945  AUR1   Inositolphosphorylceramide (IPC) synthase; catalyzes the key step in sphingolipid biosynthesis; antifungal drug target; flow model biofilm induced; Spider biofilm induced  
 orf19.538    Ortholog(s) have role in GPI anchor biosynthetic process and glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex localization  
 orf19.5622  GLC3   Putative 1,4-glucan branching enzyme; fluconazole-induced; colony morphology-related gene regulation by Ssn6; stationary phase enriched protein  
 orf19.4654    Protein of unknown function; Spider biofilm induced  
 orf19.736  SRB8   Putative RNA polymerase II mediator complex subunit; early-stage flow model biofilm induced  
 orf19.215    Component of a complex containing the Tor2p kinase; possible a role in regulation of cell growth; Spider biofilm induced  
 orf19.805    Putative protein of unknown function; possibly mitochondrial; Hap43-repressed; Spider biofilm repressed  
 orf19.2020  HGT6   Putative high-affinity MFS glucose transporter; 20 family members; induced in core stress response; fluconazole, oralpharyngeal candidasis induced; flow model biofilm induced; Spider biofilm induced  
 orf19.9013  IPK1    
 orf19.13177     
 orf19.5901  PKC1   Protein kinase C; functional homolog of S. cerevisiae Pkc1p; mutant has abnormal yeast-form cell morphology and increased cell lysis; activated by phosphatidylserine; target of antifungal, cercosporamide; R400P mutant is activated  
 orf19.7710     
 orf19.174    Predicted ORF from Assembly 19; merged with orf19.173 in Assembly 20  
 orf19.1956    Ortholog(s) have role in reciprocal meiotic recombination and mitochondrion localization  
 orf19.211    Predicted homeodomain-like transcription factor; also has a metal-binding Ada DNA repair protein domain; Spider biofilm induced  
 orf19.1467  COX13   Cytochrome c oxidase; flucytosine induced; repressed by nitric oxide  
 orf19.3414  SUR7   Protein required for normal cell wall, plasma membrane, cytoskeletal organization, endocytosis; localizes to eisosome subdomains of plasma membrane; four transmembrane motifs; mutant shows ectopic, chitin-rich cell wall; fluconazole-induced  
 orf19.5288  IFE2   Putative alcohol dehydrogenase; yeast-enriched transcript; Efg1-regulated; induced by prostaglandins, Hog1, fluconazole; rat catheter biofilm induced  
 orf19.3041    Ortholog(s) have ubiquitin protein ligase binding activity  
 orf19.6881  YTH1   Putative mRNA cleavage and polyadenylation specificity factor; transcription is regulated upon yeast-hyphal switch; decreased expression in hyphae compared to yeast-form cells; fluconazole or flucytosine induced  
 orf19.2666    Predicted ORF from Assembly 19; merged with orf19.2665 in Assembly 20  
 orf19.1788    Predicted ORF from Assembly 19; merged with orf19.1290 in Assembly 20  
 orf19.8185  PDX3    
 orf19.5159  DUG3   Putative glutamine amidotransferase (GATase II); role in glutathione catabolism;  
 orf19.1193  GNP1   Similar to asparagine and glutamine permease; fluconazole, caspofungin induced; regulated by Nrg1, Mig1, Tup1, Gcn2, Gcn4, and alkaline regulated by Rim101; repressed during chlamydospore formation; rat catheter, flow model biofilm induced  
 orf19.5079  CDR4   Putative ABC transporter superfamily; fluconazole, Sfu1, Hog1, core stress response induced; caspofungin repressed; fluconazole resistance not affected by mutation or correlated with expression; rat catheter and flow model biofilm induced  
 orf19.4792    Protein with a regulator of G-protein signaling domain; Plc1-regulated; Spider biofilm induced; rat catheter biofilm repressed  
 orf19.7022    Ortholog of C. dubliniensis CD36 : Cd36_70850, Candida tenuis NRRL Y-1498 : cten_CGOB_00183, Debaryomyces hansenii CBS767 : DEHA2F22462g and Pichia stipitis Pignal : PICST_60416  
 orf19.1267    Ortholog of S. cerevisiae : CAJ1, C. glabrata CBS138 : CAGL0L00957g, C. dubliniensis CD36 : Cd36_45380, C. parapsilosis CDC317 : CPAR2_500650 and Candida tenuis NRRL Y-1498 : CANTEDRAFT_132273  
 orf19.4077  MIT1   Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; sphingolipid biosynthesis; fluconazole, caspofungin induced; macrophage-repressed; Spider biofilm induced  
 orf19.4698  PTC8   Predicted type 2C protein phosphatase, ser/thr-specific; required for hyphal growth; transcript induced by stress; flow model biofilm induced; Spider biofilm induced  
 orf19.2609  CET1   mRNA 5'-triphosphatase; large subunit of mRNA capping enzyme; positively regulates Ceg1 activity; functional homolog of S. cerevisiae Cet1; Cet1 and Cgt1 form a 2:1 complex; flow model biofilm induced  
 orf19.2965    Putative guanyl-nucleotide exchange factor; Spider biofilm repressed  
 orf19.745  VAC8   Protein involved in vacuolar inheritance; required for hyphal growth; contains armadillo repeats  
 orf19.1715  IRO1   Putative transcription factor; role in iron utilization, pathogenesis; both IRO1 and adjacent URA3 are mutated in strain CAI4; suppresses S. cerevisiae aft1 mutant low-iron growth defect; hyphal-induced; reports differ about iron regulation  
 orf19.2785  ATP7   Putative subunit of the F1F0-ATPase complex; colony morphology-related gene regulation by Ssn6; farnesol, macrophage-downregulated protein abundance; protein present in exponential and stationary yeast growth phases; Hap43-induced  
 orf19.8937  FCY21    
 orf19.2685  PGA54   GPI-anchored protein; Hog1-repressed; induced in cyr1 or efg1 mutant or in hyphae; colony morphology-related gene regulation by Ssn6; induced in RHE model; mRNA binds She3; regulated in Spider biofilms by Tec1, Egf1, Ntd80, Rob1, Brg1  
 orf19.173    C2H2 transcription factor; induced by Mnl1 under weak acid stress