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| Locus Id | | | Gene Name | | | Description |
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| orf19.4491 | | ERG20 | | Putative farnesyl pyrophosphate synthetase involved in isoprenoid and sterol biosynthesis, based on similarity to S. cerevisiae Erg20p; likely to be essential for growth, based on an insertional mutagenesis strategy | |
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| orf19.2186 | | SEH1 | | Ortholog(s) have Seh1-associated complex, cytosol, fungal-type vacuole membrane, nuclear membrane, nuclear pore outer ring localization | |
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| orf19.676 | | | | Microtubule-binding protein of the cortical microtubule; delays exit from mitosis when the spindle is abnormally oriented; Spider biofilm repressed | |
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| orf19.422 | | SPT20 | | Putative transcription factor; downregulated upon adherence to polystyrene; flucytosine repressed | |
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| orf19.4505 | | ADH3 | | Putative NAD-dependent (R,R)-butanediol dehydrogenase; regulated by white-opaque switch; induced by nitric oxide independent of Yhb1; Spider biofilm induced | |
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| orf19.7678 | | ATP16 | | Subunit of the mitochondrial F1F0 ATP synthase; sumoylation target; protein newly produced during adaptation to the serum; Spider biofilm repressed | |
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| orf19.1041 | | | | Ortholog(s) have cyclin-dependent protein serine/threonine kinase activity | |
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| orf19.1843 | | ALG6 | | Putative glucosyltransferase involved in cell wall mannan biosynthesis; transcription is elevated in chk1, nik1, and sln1 homozygous null mutants; repressed by nitric oxide; possibly essential gene, disruptants not obtained by UAU1 method | |
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| orf19.581 | | | | Putative RNA-binding protein; transcript is upregulated in an RHE model of oral candidiasis | |
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| orf19.2054 | | FGR15 | | Putative transcription factor with zinc finger DNA-binding motif; lacks an ortholog in S. cerevisiae; transposon mutation affects filamentous growth; caspofungin induced; mutation causes marginal increase in caspofungin sensitivity | |
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| orf19.2879 | | IFF5 | | Putative GPI-anchored protein; adhesin-like protein; possibly an essential gene, disruptants not obtained by UAU1 method | |
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| orf19.5736 | | ALS5 | | ALS family adhesin; highly variable; expression in S. cerevisiae causes adhesion to human epithelium, endothelium or ECM, endothelial invasiveness by endocytosis and, at high abundance, ECM-induced aggregation; can form amyloid fibrils | |
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| CaalfMt27 | | tP(UGG)6mt | | Mitochondrial proline tRNA, predicted by tRNAscan-SE; UGG anticodon | |
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| orf19.4966 | | AGC1 | | Putative mitochondrial carrier protein; transcript is alkaline upregulated rat catheter biofilm induced | |
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| orf19.2599 | | CRC1 | | Mitochondrial carnitine carrier protein | |
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| orf19.7645 | | | | Biotin protein ligase; catalyzes covalent attachment of biotin to biotin-dependent enzymes including acetyl CoA carboxylase and pyruvate carboxylase | |
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| orf19.2806 | | | | Predicted ORF from Assembly 19; merged with orf19.2805 in Assembly 20 | |
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| orf19.390 | | CDC42 | | Rho-type GTPase; required for budding and maintenance of hyphal growth; GGTase I geranylgeranylated; misexpression blocks hyphal growth, causes avirulence in mouse IV infection; shows actin-dependent localization to hyphal tip | |
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| orf19.6176 | | SEC61 | | ER protein-translocation complex subunit; essential; 10 predicted transmembrane regions; chimeric mutant partially functionally complements S. cerevisiae sec61 defects; Spider biofilm repressed | |
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| orf19.7452 | | | | Ortholog(s) have chromatin binding activity and role in DNA replication initiation, DNA unwinding involved in DNA replication, double-strand break repair via break-induced replication | |
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| orf19.4771 | | | | Protein of unknown function; Spider biofilm induced | |
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| orf19.2012 | | NOT3 | | Transcriptional regulator; not required for buccal epithelial cell adherence or virulence in mouse systemic infection; null mutant colonies exhibit slightly decreased filamentation ratio; required for yeast adherence to silicone substrate | |
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| orf19.7523 | | MKC1 | | MAP kinase; role in biofilm formation, contact-induced invasive filamentation, systemic virulence in mouse, cell wall structure/maintenance, caspofungin response; phosphorylated on surface contact, membrane perturbation, or cell wall stress | |
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| orf19.446 | | | | Protein of unknown function; constitutive expression independent of MTL or white-opaque status; upregulated in a cyr1 mutant | |
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| orf19.2911 | | SEC3 | | Predicted subunit of the exocyst complex, involved in exocytosis; required for hyphal growth after the first septin ring formation; interacts with septins Cdc3p, Cdc10p, and Cdc11p; localizes to a crescent on the surface of the hyphal tip | |
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| orf19.3147 | | | | Ortholog of C. dubliniensis CD36 : Cd36_21050, C. parapsilosis CDC317 : CPAR2_104310, Candida tenuis NRRL Y-1498 : CANTEDRAFT_104515 and Debaryomyces hansenii CBS767 : DEHA2F01650g | |
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| orf19.6827 | | SLU7 | | Protein similar to S. cerevisiae RNA splicing factor, Slu7; induced by alpha pheromone in SpiderM medium | |
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| orf19.3269 | | GSL2 | | Protein similar to beta-1,3-glucan synthase; 16 predicted membrane-spanning regions; transcript regulated by Nrg1; very low gene expression in yeast-form and hyphal cells | |
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| orf19.1665 | | MNT1 | | Alpha-1,2-mannosyl transferase; predicted type II Golgi membrane protein; adds 2nd mannose during cell-wall mannoprotein biosynthesis; required for wild-type virulence and adherence to epithelial cells; Hap43-induced | |
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| orf19.4718 | | TRP5 | | Predicted tryptophan synthase; identified in detergent-resistant membrane fraction (possible lipid raft component); predicted N-terminal acetylation; Gcn4p-regulated; S. cerevisiae ortholog is Gcn4p regulated; upregulated in biofilm; | |
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| orf19.1258 | | | | Adhesin-like protein; regulated by Tsa1, Tsa1B in minimal media at 37 deg; clade-associated gene expression; induced by alpha pheromone in SpiderM medium; Hap43-induced; Spider biofilm repressed | |
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| orf19.7116 | | | | Protein of unknown function; transcript induced in RHE model of oral candidiasis; Spider biofilm repressed | |
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| orf19.908 | | FEN12 | | Putative protein with a predicted role in the elongation of fatty acids; amphotericin B, caspofungin repressed | |
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| orf19.2909 | | ERG26 | | C-3 sterol dehydrogenase, catalyzes the 2nd of 3 steps required to remove 2 C-4 methyl groups from an intermediate in ergosterol biosynthesis; amphotericin B, caspofungin repressed; Spider biofilm repressed | |
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| orf19.6448 | | | | Protein of unknown function; Spider biofilm repressed | |
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| orf19.2221 | | | | Predicted ORF from Assembly 19; merged with orf19.2222 in Assembly 20 | |
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| orf19.147 | | YAK1 | | Predicted serine-threonine protein kinase; involved in hyphal growth regulation and biofilm formation; flow model biofilm induced; induced in core caspofungin response | |
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| orf19.4040 | | ILV3 | | Dihydroxyacid dehydratase; repressed by nitric oxide; macrophage-induced protein; protein in exponential and stationary growth phase; Sef1, Sfu1p, Hap43-regulated; farnesol-repressed; flow model biofilm induced; Spider biofilm repressed | |
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| orf19.2397.3 | | | | Putative aminotransferase; Hap43-repressed; homozygous Tn insertion decreases colony wrinkling in filament-inducing conditions, does not block true hypha formation in liquid media; rat catheter and Spider biofilm induced | |
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| orf19.7648 | | | | Has domain(s) with predicted antiporter activity, drug transmembrane transporter activity, role in drug transmembrane transport and membrane localization | |
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| orf19.2496 | | ATO2 | | Putative fungal-specific transmembrane protein; fluconazole repressed, Hap43-repressed; flow model biofilm induced; Spider biofilm induced | |
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| orf19.4497 | | MED8 | | Ortholog(s) have RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II transcription corepressor activity, TBP-class protein binding, structural molecule activity | |
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| orf19.791 | | RIM11 | | Ortholog of S. cerevisiae Rim11; a protein kinase involved in meiosis and sporulation in S. cerevisiae; mutant is viable | |
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| orf19.7183 | | | | Ortholog(s) have role in protein folding in endoplasmic reticulum and ER membrane protein complex localization | |
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| orf19.2887 | | | | Ortholog in S. cerevisiae is localizedto the bud, mating projection tip, and associates with ribosomes; Spider biofilm induced | |
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| orf19.575 | | HYR3 | | Putative GPI-anchored adhesin-like protein; similar to Hyr1p induced in high iron; clade-specific repeat variation | |
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| orf19.5281 | | | | Predicted essential RNA-binding G protein; ortholog an effector of mating response pathway in S. cerevisiae; mainly associated with nuclear envelope and ER; flow model and Spider biofilm repressed | |
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| orf19.4181 | | SPC2 | | Signal peptidase complex component; role in ER protein translocation; transcript is induced upon filamentous growth | |
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| orf19.151 | | TPO5 | | Putative polyamine transporter; mutation confers hypersensitivity to toxic ergosterol analog; hyphal induced; macrophage induced | |
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| orf19.5962 | | HGT4 | | Glucose and galactose sensor; fermentation, filamentation, virulence roles; 20-member glucose transporter family; extended C terminus; high-glucose repressed; macrophage induced; flow model biofilm repressed; Spider biofilm induced | |
