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These related phenotype terms may also be of interest: cell cycle progression through the G2/M phase transition , mitotic cell cycle , cell cycle progression through the G1/S phase transition , cell cycle progression in M phase , cell cycle passage through the metaphase-anaphase transition , cell cycle progression in G2 phase , cell cycle progression in telophase ,
| 16 Single Mutant Phenotype(s) for cell cycle progression | ||||||||
|---|---|---|---|---|---|---|---|---|
| Gene Name | Organism | Experiment type | Mutant Information | Strain background | Phenotype | Details | References | All phenotypes |
| ASK1/C4_01150W_A | C. albicans | homozygous diploid, classical genetics | Description: repressible Allele: ask1::HIS1/MET3(p)-ASK1 |
Other C. albicans | cell cycle progression: arrested | Condition: repressing conditions Details: mutant accumulates large budded cells after 4h of growth under nonpermissive conditions, prolonged incubation leads to a transition to an elongated (pseudohyphal-like) bud |
Thakur J and Sanyal K (2011) The essentiality of the fungus-specific Dam1 complex is correlated with a one-kinetochore-one-microtubule interaction present throughout the cell cycle, independent of the nature of a centromere. Eukaryot Cell 10(10):1295-305 |
ASK1 phenotypes |
| CAS4/C3_01530C_A | C. albicans | homozygous diploid, classical genetics | Description: null | Not recorded | cell cycle progression: abnormal | Details: cells are multinucleate |
Song Y, et al. (2008) Role of the RAM network in cell polarity and hyphal morphogenesis in Candida albicans. Mol Biol Cell 19(12):5456-77 |
CAS4 phenotypes |
| CBK1/C1_10380C_A | C. albicans | homozygous diploid, classical genetics | Description: null | Not recorded | cell cycle progression: abnormal | Details: cells are multinucleate |
Song Y, et al. (2008) Role of the RAM network in cell polarity and hyphal morphogenesis in Candida albicans. Mol Biol Cell 19(12):5456-77 |
CBK1 phenotypes |
| CDC5/C1_00950C_A | C. albicans | heterozygous diploid, classical genetics | Description: repressible | CAI-4 | cell cycle progression: abnormal | Bachewich C, et al. (2003) Depletion of a polo-like kinase in Candida albicans activates cyclase-dependent hyphal-like growth. Mol Biol Cell 14(5):2163-80 |
CDC5 phenotypes | |
| DAD2/C2_05210W_A | C. albicans | homozygous diploid, classical genetics | Description: repressible Allele: dad2::HIS1/PCK1(p)-DAD2 |
Other C. albicans | cell cycle progression: arrested | Condition: repressing conditions Details: mutant accumulates large budded cells after 4h of growth under nonpermissive conditions, prolonged incubation leads to a transition to an elongated (pseudohyphal-like) bud |
Thakur J and Sanyal K (2011) The essentiality of the fungus-specific Dam1 complex is correlated with a one-kinetochore-one-microtubule interaction present throughout the cell cycle, independent of the nature of a centromere. Eukaryot Cell 10(10):1295-305 |
DAD2 phenotypes |
| DAM1/C1_09730W_A | C. albicans | homozygous diploid, classical genetics | Description: repressible Allele: dam1::HIS1/MET3(p)-DAM1 |
Other C. albicans | cell cycle progression: arrested | Condition: repressing condition Details: mutant accumulates large budded cells after 4h of growth under nonpermissive conditions, prolonged incubation leads to a transition to an elongated (pseudohyphal-like) bud |
Thakur J and Sanyal K (2011) The essentiality of the fungus-specific Dam1 complex is correlated with a one-kinetochore-one-microtubule interaction present throughout the cell cycle, independent of the nature of a centromere. Eukaryot Cell 10(10):1295-305 |
DAM1 phenotypes |
| DBF2/C2_06670C_A | C. albicans | heterozygous diploid, classical genetics | Description: repressible | Not recorded | cell cycle progression: arrested | Details: cell cycle arrest after DNA replication |
Gonzalez-Novo A, et al. (2009) Dbf2 is essential for cytokinesis and correct mitotic spindle formation in Candida albicans. Mol Microbiol 72(6):1364-78 |
DBF2 phenotypes |
| HYM1/C2_04240C_A | C. albicans | homozygous diploid, classical genetics | Description: null | Not recorded | cell cycle progression: abnormal | Details: cells are multinucleate |
Song Y, et al. (2008) Role of the RAM network in cell polarity and hyphal morphogenesis in Candida albicans. Mol Biol Cell 19(12):5456-77 |
HYM1 phenotypes |
| KAR3/C2_09370C_A | C. albicans | homozygous diploid, classical genetics | Description: null | Not recorded | cell cycle progression: abnormal | Details: delayed progression through anaphase |
Sherwood RK and Bennett RJ (2008) Microtubule motor protein Kar3 is required for normal mitotic division and morphogenesis in Candida albicans. Eukaryot Cell 7(9):1460-74 |
KAR3 phenotypes |
| KIC1/C2_04760W_A | C. albicans | homozygous diploid, classical genetics | Description: null | Not recorded | cell cycle progression: abnormal | Details: cells are multinucleate |
Song Y, et al. (2008) Role of the RAM network in cell polarity and hyphal morphogenesis in Candida albicans. Mol Biol Cell 19(12):5456-77 |
KIC1 phenotypes |
| KIP1/CR_06540W_A | C. albicans | homozygous diploid, classical genetics | Description: null | Not recorded | cell cycle progression: abnormal | Details: transient cell cycle arrest |
Chua PR, et al. (2007) Effective killing of the human pathogen Candida albicans by a specific inhibitor of non-essential mitotic kinesin Kip1p. Mol Microbiol 65(2):347-62 |
KIP1 phenotypes |
| MOB2/C1_00620W_A | C. albicans | homozygous diploid, classical genetics | Description: null | Not recorded | cell cycle progression: abnormal | Details: cells are multinucleate |
Song Y, et al. (2008) Role of the RAM network in cell polarity and hyphal morphogenesis in Candida albicans. Mol Biol Cell 19(12):5456-77 |
MOB2 phenotypes |
| SOG2/C1_07190W_A | C. albicans | homozygous diploid, classical genetics | Description: null | Not recorded | cell cycle progression: abnormal | Details: cells are multinucleate |
Song Y, et al. (2008) Role of the RAM network in cell polarity and hyphal morphogenesis in Candida albicans. Mol Biol Cell 19(12):5456-77 |
SOG2 phenotypes |
| SPA2/C1_12620W_A | C. albicans | homozygous diploid, classical genetics | Description: null | Not recorded | cell cycle progression: abnormal | Details: cells are multinucleate |
Zheng XD, et al. (2003) CaSPA2 is important for polarity establishment and maintenance in Candida albicans. Mol Microbiol 49(5):1391-405 |
SPA2 phenotypes |
| SPC19/C1_03980W_A | C. albicans | homozygous diploid, classical genetics | Description: repressible Allele: spc19::HIS1/MET3(p)-SPC19 |
Other C. albicans | cell cycle progression: arrested | Condition: repressing conditions Details: mutant accumulates large budded cells after 4h of growth under nonpermissive conditions, prolonged incubation leads to a transition to an elongated (pseudohyphal-like) bud |
Thakur J and Sanyal K (2011) The essentiality of the fungus-specific Dam1 complex is correlated with a one-kinetochore-one-microtubule interaction present throughout the cell cycle, independent of the nature of a centromere. Eukaryot Cell 10(10):1295-305 |
SPC19 phenotypes |
| STE2/CR_06610W_A | C. albicans | homozygous diploid, classical genetics | Description: null | P37005 | cell cycle progression: increased | Details: IC3 and C-369 mutants lost the ability to undergo cell cycle arrest whereas C417 and C-392 mutants showed diminished arrest |
Lin CH, et al. (2011) Defining pheromone-receptor signaling in Candida albicans and related asexual Candida species. Mol Biol Cell 22(24):4918-30 |
STE2 phenotypes |
| Analyze gene list: further analyze the gene list displayed above or download information for this list | ||||
| Further Analysis: | Find common features of genes in list | Sort genes into broad categories | View all GO terms used to describe genes in list | |
|---|---|---|---|---|
| Download: | Download All Search Results Download data for the entire gene list in a tab-delimited file | Download selected information for entire gene list. Available information types include Sequence, Coordinates, Chromosomal Feature information, GO annotations, Phenotypes, and Ortholog or Best Hit. | ||
Curation of mutant phenotypes is an ongoing project at CGD. Please contact CGD curators to let us know of additional phenotype information that should be incorporated.
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