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These related phenotype terms may also be of interest: cell cycle progression .

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9 Single Mutant Phenotype(s) for cell cycle progression through the G2/M phase transition
Gene Name Organism Experiment type Mutant Information Strain background Phenotype Details References All phenotypes
CSE4/C3_00860W_A C. albicans heterozygous diploid, classical genetics Description: repressible
Allele: cse4/PCK1(p)-CSE4 		Other C. albicans cell cycle progression through the G2/M phase transition: arrested Details: arrested cells at G2/M stage with either short or medium-long spindles
Thakur J and Sanyal K  (2011) The essentiality of the fungus-specific Dam1 complex is correlated with a one-kinetochore-one-microtubule interaction present throughout the cell cycle, independent of the nature of a centromere. Eukaryot Cell 10(10):1295-305
CSE4 phenotypes
GLC7/CR_07650W_A C. albicans heterozygous diploid, classical genetics Description: repressible
Allele: glc7/pMET3-GLC7 		BWP17 cell cycle progression through the G2/M phase transition: arrested Condition: repressing conditions, on media containing methionine and cysteine
Hu K, et al.  (2012) Shp1, a regulator of protein phosphatase 1 Glc7, has important roles in cell morphogenesis, cell cycle progression and DNA damage response in Candida albicans. Fungal Genet Biol 49(6):433-42
GLC7 phenotypes
MTW1/C2_09840W_A C. albicans heterozygous diploid, classical genetics Description: repressible
Allele: mtw1::PCK1pr-MTW1(URA3)/mtw1::HIS1
(glucose-repressible PCK1 promoter) 		BWP17 cell cycle progression through the G2/M phase transition: arrested Condition: repressing conditions
Roy B, et al.  (2011) CaMtw1, a member of the evolutionarily conserved Mis12 kinetochore protein family, is required for efficient inner kinetochore assembly in the pathogenic yeast Candida albicans. Mol Microbiol 80(1):14-32
MTW1 phenotypes
RAD54/C1_13660W_A C. albicans homozygous diploid, classical genetics Description: null
Allele: rad54::SAT1-FLP 		SC5314 cell cycle progression through the G2/M phase transition: absent Details: mutant cells arrest in G2 phase of the cell cycle
Hoot SJ, et al.  (2011) The role of Candida albicans homologous recombination factors Rad54 and Rdh54 in DNA damage sensitivity. BMC Microbiol 11:214
RAD54 phenotypes
SHP1/CR_01610C_A C. albicans homozygous diploid, classical genetics Description: null
Allele: shp1::ARG4/shp1::HIS1 		BWP17 cell cycle progression through the G2/M phase transition: delayed Hu K, et al.  (2012) Shp1, a regulator of protein phosphatase 1 Glc7, has important roles in cell morphogenesis, cell cycle progression and DNA damage response in Candida albicans. Fungal Genet Biol 49(6):433-42
SHP1 phenotypes
SLA2/C7_03810W_A C. albicans homozygous diploid, classical genetics Description: null BWP17 cell cycle progression through the G2/M phase transition: delayed Condition: permissive temperature
(30 deg C)
Gale CA, et al.  (2009) SLA2 mutations cause SWE1-mediated cell cycle phenotypes in Candida albicans and Saccharomyces cerevisiae. Microbiology 155(Pt 12):3847-59
SLA2 phenotypes
TUB1/CR_09120C_A C. albicans heterozygous diploid, competitive growth Description: repressible SC5314 cell cycle progression through the G2/M phase transition: arrested Details: cells display a large-budded terminal phenotype
Xu D, et al.  (2007) Genome-wide fitness test and mechanism-of-action studies of inhibitory compounds in Candida albicans. PLoS Pathog 3(6):e92
TUB1 phenotypes
EST2/CAGL0A00869g C. glabrata haploid, classical genetics Description: null CBS138 (ATCC 2001) cell cycle progression through the G2/M phase transition: decreased Kachouri-Lafond R, et al.  (2009) Large telomerase RNA, telomere length heterogeneity and escape from senescence in Candida glabrata. FEBS Lett 583(22):3605-10
EST2 phenotypes
TLC1/CAGL0I04700r C. glabrata haploid, classical genetics Description: null CBS138 (ATCC 2001) cell cycle progression through the G2/M phase transition: decreased Kachouri-Lafond R, et al.  (2009) Large telomerase RNA, telomere length heterogeneity and escape from senescence in Candida glabrata. FEBS Lett 583(22):3605-10
TLC1 phenotypes


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