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These related phenotype terms may also be of interest: protein transport .

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25 Single Mutant Phenotype(s) for protein secretion
Gene Name Organism Experiment type Mutant Information Strain background Phenotype Details References All phenotypes
ARL1/C4_01890C_A C. albicans homozygous diploid, classical genetics Description: null BWP17 protein secretion: abnormal Details: unregulated secretion
Labbaoui H, et al.  (2017) Role of Arf GTPases in fungal morphogenesis and virulence. PLoS Pathog 13(2):e1006205
ARL1 phenotypes
CFL1/C4_05770C_A C. albicans homozygous diploid, classical genetics Description: null BWP17 protein secretion: increased Yu Q, et al.  (2014) A novel role of the ferric reductase Cfl1 in cell wall integrity, mitochondrial function, and invasion to host cells in Candida albicans. FEMS Yeast Res 14(7):1037-47
CFL1 phenotypes
CUP5/C3_04390W_A C. albicans heterozygous diploid, classical genetics Description: repressible
Allele: cup5::dpl200::99/tet-CUP5 		Other C. albicans protein secretion: decreased Condition: repressive conditions, doxycycline or tetracycline
Rane HS, et al.  (2013) Candida albicans VMA3 is necessary for V-ATPase assembly and function and contributes to secretion and filamentation. Eukaryot Cell 12(10):1369-82
CUP5 phenotypes
KEX2/C1_08990C_A C. albicans homozygous diploid, classical genetics Description: null Not recorded protein secretion: decreased Details: decreased secreted aspartyl protease activity
Newport G and Agabian N  (1997) KEX2 influences Candida albicans proteinase secretion and hyphal formation. J Biol Chem 272(46):28954-61
KEX2 phenotypes
MYO5/C4_05100C_A C. albicans homozygous diploid, classical genetics Description: null Not recorded protein secretion: normal Reporter: secreted aspartyl protease
Oberholzer U, et al.  (2004) Functional characterization of myosin I tail regions in Candida albicans. Eukaryot Cell 3(5):1272-86
MYO5 phenotypes
PEP12/C5_02720W_A C. albicans homozygous diploid, classical genetics Description: null
Allele: pep12::dpl200-URA3-dpl200/pep12::ARG4 		BWP17 protein secretion: abnormal Details: mutant shows increased extracellular proteolytic activity and no lipolytic activity
Palanisamy SK, et al.  (2010) Candida albicans PEP12 is required for biofilm integrity and in vivo virulence. Eukaryot Cell 9(2):266-77
PEP12 phenotypes
PEP7/C4_00350W_A C. albicans homozygous diploid, classical genetics Description: null Not recorded protein secretion: decreased Details: decreased secreted aspartyl protease activity
Franke K, et al.  (2006) The vesicle transport protein Vac1p is required for virulence of Candida albicans. Microbiology 152(Pt 10):3111-21
PEP7 phenotypes
PEP7/C4_00350W_A C. albicans heterozygous diploid, classical genetics Description: null Not recorded protein secretion: normal Reporter: secreted aspartyl protease
Franke K, et al.  (2006) The vesicle transport protein Vac1p is required for virulence of Candida albicans. Microbiology 152(Pt 10):3111-21
PEP7 phenotypes
PHO100/C1_07430W_A C. albicans homozygous diploid, classical genetics Description: null Not recorded protein secretion: increased Details: increased secreted acid phosphatase activity
MacCallum DM, et al.  (2009) Property differences among the four major Candida albicans strain clades. Eukaryot Cell 8(3):373-87
PHO100 phenotypes
PTC1/C1_09260C_A C. albicans homozygous diploid, classical genetics Description: null Not recorded protein secretion: decreased Details: decreased extracellular protease activity
Hanaoka N, et al.  (2008) Identification of the putative protein phosphatase gene PTC1 as a virulence-related gene using a silkworm model of Candida albicans infection. Eukaryot Cell 7(10):1640-8
PTC1 phenotypes
SEC14/C5_00480C_A C. albicans heterozygous diploid, classical genetics Description: null Not recorded protein secretion: normal Reporter: exoglucanase and acid phosphatase
Monteoliva L, et al.  (1996) Cloning of Candida albicans SEC14 gene homologue coding for a putative essential function. Yeast 12(11):1097-105
SEC14 phenotypes
SEC4/CR_01750C_A C. albicans heterozygous diploid, classical genetics Description: dominant negative
Allele: sec4-S28N 		CAI-4 protein secretion: decreased Mao Y, et al.  (1999) Overexpression of a dominant-negative allele of SEC4 inhibits growth and protein secretion in Candida albicans. J Bacteriol 181(23):7235-42
SEC4 phenotypes
SEC9/C6_01100W_A C. albicans heterozygous diploid, classical genetics Description: repressible
Allele: tetR-SEC9 		CAI-8 protein secretion: abnormal Condition: repressing conditions (doxycycline)
Bernardo SM, et al.  (2014) Secretion and filamentation are mediated by the Candida albicans t-SNAREs Sso2p and Sec9p. FEMS Yeast Res 14(5):762-75
SEC9 phenotypes
SSO2/C2_09740W_A C. albicans heterozygous diploid, classical genetics Description: repressible
Allele: tetR-SSO2 		CAI-8 protein secretion: abnormal Condition: repressing conditions (doxycycline)
Bernardo SM, et al.  (2014) Secretion and filamentation are mediated by the Candida albicans t-SNAREs Sso2p and Sec9p. FEMS Yeast Res 14(5):762-75
SSO2 phenotypes
STP1/C3_04580C_A C. albicans homozygous diploid, classical genetics Description: null Not recorded protein secretion: decreased Condition: YCB/BSA media
Details: decreased secreted aspartyl protease activity 		Martinez P and Ljungdahl PO  (2005) Divergence of Stp1 and Stp2 transcription factors in Candida albicans places virulence factors required for proper nutrient acquisition under amino acid control. Mol Cell Biol 25(21):9435-46
STP1 phenotypes
VPH1/C4_05240C_A C. albicans homozygous diploid, classical genetics Description: null
Allele: vph1::URA3/vph1::ARG4p 		BWP17 protein secretion: decreased Details: secreted protease and lipase activity
Raines SM, et al.  (2013) Deletion of vacuolar proton-translocating ATPase V(o)a isoforms clarifies the role of vacuolar pH as a determinant of virulence-associated traits in Candida albicans. J Biol Chem 288(9):6190-201
VPH1 phenotypes
VPS11/C4_05910C_A C. albicans homozygous diploid, classical genetics Description: null Not recorded protein secretion: decreased Details: decreased secreted aspartyl protease activity
Palmer GE, et al.  (2003) Candida albicans VPS11 is required for vacuole biogenesis and germ tube formation. Eukaryot Cell 2(3):411-21
VPS11 phenotypes
VPS11/C4_05910C_A C. albicans homozygous diploid, classical genetics Description: null Not recorded protein secretion: decreased Details: decreased secreted lipase activity
Palmer GE, et al.  (2003) Candida albicans VPS11 is required for vacuole biogenesis and germ tube formation. Eukaryot Cell 2(3):411-21
VPS11 phenotypes
VPS15/C6_01190C_A C. albicans homozygous diploid, large-scale survey Description: null BWP17 protein secretion: abnormal Details: Kex2 secreted to the medium
Reporter: KEX2 		Liu Y, et al.  (2014) Role of retrograde trafficking in stress response, host cell interactions, and virulence of Candida albicans. Eukaryot Cell 13(2):279-87
VPS15 phenotypes
VPS4/C5_03090W_A C. albicans homozygous diploid, classical genetics Description: null Not recorded protein secretion: decreased Details: decreased extracellular protease activity
Lee SA, et al.  (2007) A functional analysis of the Candida albicans homolog of Saccharomyces cerevisiae VPS4. FEMS Yeast Res 7(6):973-85
VPS4 phenotypes
VPS4/C5_03090W_A C. albicans homozygous diploid, classical genetics Description: null CAF2-1 protein secretion: decreased Condition: liquid RPMI at 37 deg C
Reporter: Sap4-6p 		Lee SA, et al.  (2009) Candida albicans VPS4 is required for secretion of aspartyl proteases and in vivo virulence. Mycopathologia 167(2):55-63
VPS4 phenotypes
VPS4/C5_03090W_A C. albicans homozygous diploid, classical genetics Description: null CAF2-1 protein secretion: decreased Condition: BSA agar
Details: Sap2p secretion is decreased; BSA degradation is increased
Reporter: Sap2p 		Lee SA, et al.  (2009) Candida albicans VPS4 is required for secretion of aspartyl proteases and in vivo virulence. Mycopathologia 167(2):55-63
VPS4 phenotypes
VPS4/C5_03090W_A C. albicans homozygous diploid, classical genetics Description: null Not recorded protein secretion: decreased Details: decreased secreted lipase activity
Lee SA, et al.  (2009) Candida albicans VPS4 is required for secretion of aspartyl proteases and in vivo virulence. Mycopathologia 167(2):55-63
VPS4 phenotypes
VPS51/C6_02920C_A C. albicans homozygous diploid, large-scale survey Description: null BWP17 protein secretion: abnormal Details: Kex2 secreted to the medium
Reporter: KEX2 		Liu Y, et al.  (2014) Role of retrograde trafficking in stress response, host cell interactions, and virulence of Candida albicans. Eukaryot Cell 13(2):279-87
VPS51 phenotypes
YPT1/C1_03500W_A C. albicans heterozygous diploid, classical genetics Description: dominant negative Not recorded protein secretion: decreased Details: decreased secreted aspartyl protease activity
Lee SA, et al.  (2001) Overexpression of a dominant-negative allele of YPT1 inhibits growth and aspartyl protease secretion in Candida albicans. Microbiology 147(Pt 7):1961-70
YPT1 phenotypes


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