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| 16 Single Mutant Phenotype(s) for small molecule transport | |||||||||
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| Gene Name | Organism | Experiment type | Mutant Information | Strain background | Phenotype | Chemical | Details | References | All phenotypes |
| ATO5/C3_05620W_A | C. albicans | homozygous diploid, classical genetics | Description: null | SC5314 | small molecule transport: decreased | ammonia | Danhof HA and Lorenz MC (2015) The Candida albicans ATO Gene Family Promotes Neutralization of the Macrophage Phagolysosome. Infect Immun 83(11):4416-26 |
ATO5 phenotypes | |
| CSH3/C4_03390W_A | C. albicans | heterozygous diploid, classical genetics | Description: null | Not recorded | small molecule transport: abnormal | Details: increased adenine transport, slightly decreased lysine, phenylalanine, or proline transport |
Martinez P and Ljungdahl PO (2004) An ER packaging chaperone determines the amino acid uptake capacity and virulence of Candida albicans. Mol Microbiol 51(2):371-84 |
CSH3 phenotypes | |
| CSH3/C4_03390W_A | C. albicans | homozygous diploid, classical genetics | Description: null | Not recorded | small molecule transport: abnormal | Details: abolished lysine or phenylalanine transport; decreased histidine or proline transport; increased adenine transport |
Martinez P and Ljungdahl PO (2004) An ER packaging chaperone determines the amino acid uptake capacity and virulence of Candida albicans. Mol Microbiol 51(2):371-84 |
CSH3 phenotypes | |
| DUR3/C1_04650W_A | C. albicans | homozygous diploid, classical genetics | Description: null | SC5314 | small molecule transport: decreased | urea | Navarathna DH, et al. (2011) Dur3 is the major urea transporter in Candida albicans and is co-regulated with the urea amidolyase Dur1,2. Microbiology 157(Pt 1):270-9 |
DUR3 phenotypes | |
| ERG6/C3_02150C_A | C. albicans | homozygous diploid, classical genetics | Description: null | Not recorded | small molecule transport: abnormal | Details: plasma membrane permeability is altered |
Jensen-Pergakes KL, et al. (1998) Sequencing, disruption, and characterization of the Candida albicans sterol methyltransferase (ERG6) gene: drug susceptibility studies in erg6 mutants. Antimicrob Agents Chemother 42(5):1160-7 |
ERG6 phenotypes | |
| FLC1/C3_00980W_A | C. albicans | homozygous diploid, classical genetics | Description: null | Not recorded | small molecule transport: decreased | heme | Details: decreased heme uptake |
Protchenko O, et al. (2006) A screen for genes of heme uptake identifies the FLC family required for import of FAD into the endoplasmic reticulum. J Biol Chem 281(30):21445-57 |
FLC1 phenotypes |
| FTR1/C1_14130W_A | C. albicans | heterozygous diploid, classical genetics | Description: null | Not recorded | small molecule transport: normal | Details: wild-type growth using diferric transferrin iron source |
Knight SA, et al. (2005) Iron acquisition from transferrin by Candida albicans depends on the reductive pathway. Infect Immun 73(9):5482-92 |
FTR1 phenotypes | |
| ITR1/C2_04940C_A | C. albicans | heterozygous diploid, classical genetics | Description: null | Not recorded | small molecule transport: decreased | myo-inositol | Chen YL, et al. (2008) Candida albicans uses multiple mechanisms to acquire the essential metabolite inositol during infection. Infect Immun 76(6):2793-801 |
ITR1 phenotypes | |
| NGT1/C3_00650W_A | C. albicans | homozygous diploid, classical genetics | Description: null | Not recorded | small molecule transport: decreased | GlcNAc | Alvarez FJ and Konopka JB (2007) Identification of an N-acetylglucosamine transporter that mediates hyphal induction in Candida albicans. Mol Biol Cell 18(3):965-75 |
NGT1 phenotypes | |
| PEP12/C5_02720W_A | C. albicans | homozygous diploid, classical genetics | Description: null Allele: pep12::dpl200-URA3-dpl200/pep12::ARG4 |
BWP17 | small molecule transport: abnormal | Details: mutant vacuoles fail to stain with quinacrine indicating defects in vacuolar acidification |
Palanisamy SK, et al. (2010) Candida albicans PEP12 is required for biofilm integrity and in vivo virulence. Eukaryot Cell 9(2):266-77 |
PEP12 phenotypes | |
| SSY1/C2_04060C_A | C. albicans | homozygous diploid, classical genetics | Description: null | Not recorded | small molecule transport: abnormal | Details: histidine-activated amino acid transport is blocked |
Brega E, et al. (2004) Candida albicans Csy1p is a nutrient sensor important for activation of amino acid uptake and hyphal morphogenesis. Eukaryot Cell 3(1):135-43 |
SSY1 phenotypes | |
| SSY1/C2_04060C_A | C. albicans | heterozygous diploid, classical genetics | Description: null | Not recorded | small molecule transport: normal | Details: histidine-activated amino acid transport |
Brega E, et al. (2004) Candida albicans Csy1p is a nutrient sensor important for activation of amino acid uptake and hyphal morphogenesis. Eukaryot Cell 3(1):135-43 |
SSY1 phenotypes | |
| TOK1/C4_00670W_A | C. albicans | homozygous diploid, classical genetics | Description: null | Not recorded | small molecule transport: decreased | potassium(1+) | Details: decreased K+ efflux |
Miranda M, et al. (2009) Conservation and dispersion of sequence and function in fungal TRK potassium transporters: focus on Candida albicans. FEMS Yeast Res 9(2):278-92 |
TOK1 phenotypes |
| TRK1/CR_07960C_A | C. albicans | heterozygous diploid, classical genetics | Description: null | Not recorded | small molecule transport: decreased | rubidium(1+) | Details: decreased influx of rubidium |
Baev D, et al. (2004) The TRK1 potassium transporter is the critical effector for killing of Candida albicans by the cationic protein, Histatin 5. J Biol Chem 279(53):55060-72 |
TRK1 phenotypes |
| TRK1/CR_07960C_A | C. albicans | heterozygous diploid, classical genetics | Description: null | Not recorded | small molecule transport: decreased | rubidium(1+) | Details: decreased influx of rubidium as an assay for K+ influx |
Miranda M, et al. (2009) Conservation and dispersion of sequence and function in fungal TRK potassium transporters: focus on Candida albicans. FEMS Yeast Res 9(2):278-92 |
TRK1 phenotypes |
| YFH1/C4_04340C_A | C. albicans | homozygous diploid, classical genetics | Description: null | Not recorded | small molecule transport: increased | iron | Details: elevated iron uptake |
Santos R, et al. (2004) Candida albicans lacking the frataxin homologue: a relevant yeast model for studying the role of frataxin. Mol Microbiol 54(2):507-19 |
YFH1 phenotypes |
| Analyze gene list: further analyze the gene list displayed above or download information for this list | ||||
| Further Analysis: | Find common features of genes in list | Sort genes into broad categories | View all GO terms used to describe genes in list | |
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| Download: | Download All Search Results Download data for the entire gene list in a tab-delimited file | Download selected information for entire gene list. Available information types include Sequence, Coordinates, Chromosomal Feature information, GO annotations, Phenotypes, and Ortholog or Best Hit. | ||
Curation of mutant phenotypes is an ongoing project at CGD. Please contact CGD curators to let us know of additional phenotype information that should be incorporated.
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