CGD Help: Mutant Phenotype
Contents
The Mutant Phenotypes page presents detailed
information about mutant phenotypes for a
particular gene, along with references for each observation. This page
is linked from the Mutant Phenotype tab and section
of the Locus page for that gene, where the data are presented in summary form.
Data are presented in tabular form and they may be downloaded to your computer,
in Excel spreadsheet format, by clicking on any "Download data" link on the page.
Mutant phenotype data
Mutant phenotype data are presented in a table that contains the
following columns: Mutant type, Mutant phenotype, Notes/Phenotype details, and Reference(s).
- Mutant type indicates what kind of a genetic change occured at the locus of interest, for example,
a null mutation, which eradicates function of the gene
product. Currently, CGD uses the following mutant types:
- Activated
- Conditional
- Depletion
- Dominant negative
- Heterozygous null
- Homozygous null
- Homozygous null (inferred)
- Misexpression
- Multiple
- Overexpression
- Point
- Unknown/unspecified
The "homozygous null (inferred)" mutant type is only assigned with a mutant phenotype of "inviable." This assignment indicates that attempts to produce the homozygous null mutant strain failed, and the homozygous null mutation is therefore believed to cause lethality.
- Mutant phenotype is a
description of observable characteristics of a strain carrying a
particular mutation (e.g., slow growth, inviability, reduced
mating efficiency, etc.) Clicking on a phenotype that appears in
the Mutant phenotype column generates a list of all genes that are
known to mutate to that phenotype. We are working towards describing
phenotypes using controlled vocabulary so that mutations conferring the
same phenotype may be sorted and compared.
- Phenotype details contains a free-text description of a phenotype with more descriptive information, experimental conditions, or other qualifiers.
- Reference(s) are published citations that describe the
phenotype. If references are missing, we would
greatly appreciate email from the community alerting us to the
correct references.
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