GWEIGHT irs4 null mutant versus CAI-12 wild-type Replicate1 irs4 null mutant versus CAI-12 wild-type Replicate2 irs4 null mutant versus CAI-12 wild-type Replicate3
EWEIGHT 1 1 1
0 "|| orf19.2131 || || || Ortholog(s) have ubiquitin-protein ligase activity and role in protein ubiquitination, ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway ||" 1 0.20 0.14
1 "|| orf19.3997 || ADH1 || || Alcohol dehydrogenase; oxidizes ethanol to acetaldehyde; at yeast cell surface; immunogenic in humans/mice; complements S. cerevisiae adh1 adh2 adh3 mutant; fluconazole, farnesol-induced; flow model biofilm induced; Spider biofilm repressed ||" 1 0.32 -0.89 0.22
2 || orf19.5280 || MUP1 || || Putative high affinity methionine permease; alkaline upregulated by Rim101; Spider biofilm induced || 1 0.06 -0.19 0.06
3 || orf19.2471 || GIM5 || || Putative heterohexameric cochaperone prefoldin complex subunit; macrophage/pseudohyphal-repressed gene and macrophage-induced protein || 1 0.06 0.06
4 || orf19.3065 || DAO1 || || Putative D-amino acid oxidase; transcription is regulated upon yeast-hyphal switch || 1 0.04 -0.13 0.04
5 "|| orf19.583 || || || Indoleamine 2,3-dioxygenase (IDO); rate-limiting enzyme of tryptophan catabolism via kynurenine; enzyme inhibition by 1-methyl-D,L-tryptophan increases hyphal growth; expressed in yeast and hyphae; rat catheter and Spider biofilm induced ||" 1 0.13 -0.35 0.15
6 || orf19.405 || VCX1 || || Putative H+/Ca2+ antiporter; Spider biofilm repressed || 1 0.20 0.20
7 "|| orf19.3967 || PFK1 || || Phosphofructokinase alpha subinit; activated by fructose 2,6-bisphosphate, AMP, ATP inhibited; activity reduced on hyphal induction; phagocytosis-repressed; fluconazole, flow model biofilm induced; rat catheter and Spider biofilm repressed ||" 1 0.28 -0.52 0.29
8 || orf19.203 || STB3 || || Putative SIN3-binding protein 3 homolog; caspofungin induced; macrophage/pseudohyphal-repressed; rat catheter biofilm induced || 1 0.04 -0.40 0.42
9 "|| orf19.3565 || || || Ortholog of C. dubliniensis CD36 : Cd36_19830, C. parapsilosis CDC317 : CPAR2_206470, Candida tenuis NRRL Y-1498 : CANTEDRAFT_113899 and Debaryomyces hansenii CBS767 : DEHA2C05676g ||" 1 0.01 0.08
10 || orf19.2398 || || || Protein of unknown function; Hap43-repressed; transcript increased in azole-resistant strain overexpressing CDR1 and CDR2; possibly regulated by Tac1; induced by Mnl1 in weak acid stress; flow model biofilm induced; Spider biofilm induced || 1 0.00 -0.63 0.32
11 || orf19.1945 || AUR1 || || Inositolphosphorylceramide (IPC) synthase; catalyzes the key step in sphingolipid biosynthesis; antifungal drug target; flow model biofilm induced; Spider biofilm induced || 1 0.08 -0.53 0.21
12 || orf19.538 || || || Ortholog(s) have role in GPI anchor biosynthetic process and glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex localization || 1 0.05 0.13
13 "|| orf19.5622 || GLC3 || || Putative 1,4-glucan branching enzyme; fluconazole-induced; colony morphology-related gene regulation by Ssn6; stationary phase enriched protein ||" 1 0.07 -0.39 0.18
14 || orf19.4654 || || || Protein of unknown function; Spider biofilm induced || 1 0.04 -0.23 0.10
15 || orf19.736 || SRB8 || || Putative RNA polymerase II mediator complex subunit; early-stage flow model biofilm induced || 1 0.03 -0.12 0.06
16 || orf19.215 || || || Component of a complex containing the Tor2p kinase; possible a role in regulation of cell growth; Spider biofilm induced || 1 0.09 -0.42 0.23
17 || orf19.805 || || || Putative protein of unknown function; possibly mitochondrial; Hap43-repressed; Spider biofilm repressed || 1 0.06 0.08
18 "|| orf19.2020 || HGT6 || || Putative high-affinity MFS glucose transporter; 20 family members; induced in core stress response; fluconazole, oralpharyngeal candidasis induced; flow model biofilm induced; Spider biofilm induced ||" 1 0.18 -1.02 0.24
19 || orf19.9013 || IPK1 || || || 1 0.07 -0.51 0.13
20 || orf19.13177 || || || || 1 -0.03 -0.54 0.12
21 "|| orf19.5901 || PKC1 || || Protein kinase C; functional homolog of S. cerevisiae Pkc1p; mutant has abnormal yeast-form cell morphology and increased cell lysis; activated by phosphatidylserine; target of antifungal, cercosporamide; R400P mutant is activated ||" 1 -0.04 -0.72 0.15
22 || orf19.7710 || || || || 1 -0.01 -0.22 0.04
23 || orf19.174 || || || Predicted ORF from Assembly 19; merged with orf19.173 in Assembly 20 || 1 -0.01 -0.50 0.09
24 || orf19.1956 || || || Ortholog(s) have role in reciprocal meiotic recombination and mitochondrion localization || 1 -0.02 0.18
25 || orf19.211 || || || Predicted homeodomain-like transcription factor; also has a metal-binding Ada DNA repair protein domain; Spider biofilm induced || 1 -0.01 -0.59 0.16
26 || orf19.1467 || COX13 || || Cytochrome c oxidase; flucytosine induced; repressed by nitric oxide || 1 -0.03 -0.52 0.18
27 "|| orf19.3414 || SUR7 || || Protein required for normal cell wall, plasma membrane, cytoskeletal organization, endocytosis; localizes to eisosome subdomains of plasma membrane; four transmembrane motifs; mutant shows ectopic, chitin-rich cell wall; fluconazole-induced ||" 1 -0.01 -0.41 0.15
28 "|| orf19.5288 || IFE2 || || Putative alcohol dehydrogenase; yeast-enriched transcript; Efg1-regulated; induced by prostaglandins, Hog1, fluconazole; rat catheter biofilm induced ||" 1 -0.22 -0.92 0.05
29 || orf19.3041 || || || Ortholog(s) have ubiquitin protein ligase binding activity || 1 -0.10 -0.59 0.05
30 || orf19.6881 || YTH1 || || Putative mRNA cleavage and polyadenylation specificity factor; transcription is regulated upon yeast-hyphal switch; decreased expression in hyphae compared to yeast-form cells; fluconazole or flucytosine induced || 1 -0.09 -0.52 0.04
31 || orf19.2666 || || || Predicted ORF from Assembly 19; merged with orf19.2665 in Assembly 20 || 1 -0.12 -0.67 0.05
32 || orf19.1788 || || || Predicted ORF from Assembly 19; merged with orf19.1290 in Assembly 20 || 1 -0.07 -0.42 0.03
33 || orf19.8185 || PDX3 || || || 1 -0.10 -0.75 0.04
34 || orf19.5159 || DUG3 || || Putative glutamine amidotransferase (GATase II); role in glutathione catabolism; || 1 -0.07 -0.60 0.11
35 "|| orf19.1193 || GNP1 || || Similar to asparagine and glutamine permease; fluconazole, caspofungin induced; regulated by Nrg1, Mig1, Tup1, Gcn2, Gcn4, and alkaline regulated by Rim101; repressed during chlamydospore formation; rat catheter, flow model biofilm induced ||" 1 -0.07 -0.40 0.09
36 "|| orf19.5079 || CDR4 || || Putative ABC transporter superfamily; fluconazole, Sfu1, Hog1, core stress response induced; caspofungin repressed; fluconazole resistance not affected by mutation or correlated with expression; rat catheter and flow model biofilm induced ||" 1 -0.19 -1.08 0.20
37 || orf19.4792 || || || Protein with a regulator of G-protein signaling domain; Plc1-regulated; Spider biofilm induced; rat catheter biofilm repressed || 1 -0.02 -0.69 0.08
38 "|| orf19.7022 || || || Ortholog of C. dubliniensis CD36 : Cd36_70850, Candida tenuis NRRL Y-1498 : cten_CGOB_00183, Debaryomyces hansenii CBS767 : DEHA2F22462g and Pichia stipitis Pignal : PICST_60416 ||" 1 -0.01 -0.52 0.06
39 "|| orf19.1267 || || || Ortholog of S. cerevisiae : CAJ1, C. glabrata CBS138 : CAGL0L00957g, C. dubliniensis CD36 : Cd36_45380, C. parapsilosis CDC317 : CPAR2_500650 and Candida tenuis NRRL Y-1498 : CANTEDRAFT_132273 ||" 1 -0.01 -0.25 0.01
40 "|| orf19.4077 || MIT1 || || Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; sphingolipid biosynthesis; fluconazole, caspofungin induced; macrophage-repressed; Spider biofilm induced ||" 1 -0.08 -0.68 -0.04
41 "|| orf19.4698 || PTC8 || || Predicted type 2C protein phosphatase, ser/thr-specific; required for hyphal growth; transcript induced by stress; flow model biofilm induced; Spider biofilm induced ||" 1 -0.08 -0.62 -0.04
42 || orf19.2609 || CET1 || || mRNA 5'-triphosphatase; large subunit of mRNA capping enzyme; positively regulates Ceg1 activity; functional homolog of S. cerevisiae Cet1; Cet1 and Cgt1 form a 2:1 complex; flow model biofilm induced || 1 -0.03 -0.28 -0.06
43 || orf19.2965 || || || Putative guanyl-nucleotide exchange factor; Spider biofilm repressed || 1 -0.02 -0.20 -0.06
44 || orf19.745 || VAC8 || || Protein involved in vacuolar inheritance; required for hyphal growth; contains armadillo repeats || 1 -0.01 -0.18 -0.06
45 "|| orf19.1715 || IRO1 || || Putative transcription factor; role in iron utilization, pathogenesis; both IRO1 and adjacent URA3 are mutated in strain CAI4; suppresses S. cerevisiae aft1 mutant low-iron growth defect; hyphal-induced; reports differ about iron regulation ||" 1 -0.01 -0.52 -0.14
46 "|| orf19.2785 || ATP7 || || Putative subunit of the F1F0-ATPase complex; colony morphology-related gene regulation by Ssn6; farnesol, macrophage-downregulated protein abundance; protein present in exponential and stationary yeast growth phases; Hap43-induced ||" 1 -0.00 -0.25 -0.04
47 || orf19.8937 || FCY21 || || || 1 0.02 -0.45 -0.04
48 "|| orf19.2685 || PGA54 || || GPI-anchored protein; Hog1-repressed; induced in cyr1 or efg1 mutant or in hyphae; colony morphology-related gene regulation by Ssn6; induced in RHE model; mRNA binds She3; regulated in Spider biofilms by Tec1, Egf1, Ntd80, Rob1, Brg1 ||" 1 0.05 -0.48 -0.07
49 || orf19.173 || || || C2H2 transcription factor; induced by Mnl1 under weak acid stress || 1 0.03 -0.21 -0.05
50 "|| orf19.2877 || PDC11 || || Pyruvate decarboxylase; antigenic; on hyphal not yeast cell surface; Hap43, Gcn4, Efg1, Efh1, Hsf1 regulated; fluconazole, farnesol induced; amino acid starvation repressed; flow model biofilm induced; Spider biofilm repressed ||" 1 0.11 -0.63 -0.01
51 "|| orf19.4618 || FBA1 || || Fructose-bisphosphate aldolase; glycolytic enzyme; antigenic in murine/human infection; regulated by yeast-hypha switch; induced by Efg1, Gcn4, Hog1, fluconazole; phagocytosis-repressed; flow model biofilm induced; Spider biofilm repressed ||" 1 0.08 -0.39 -0.01
52 || orf19.2774 || LAB5 || || Ortholog(s) have role in protein lipoylation and mitochondrion localization || 1 0.06 -0.29 0.01
53 "|| orf19.3401 || CTA1 || || Protein similar to S. cerevisiae Mos10p, which affects S. cerevisiae filamentous growth; activates transcription in 1-hybrid assay in S. cerevisiae; protein levels increase under weak acid stress; nonessential ||" 1 0.06 -0.38 0.03
54 || orf19.7788 || || || || 1 0.11 -0.31 0.02
55 || orf19.11824 || || || || 1 0.24 -0.25 -0.09
56 "|| orf19.1010 || MNT3 || || Mannosyltransferase; transcription elevated in cyr1, chk1, nik1, and sln1 homozygous null mutants; fungal-specific (no human or murine homolog) ||" 1 0.08 -0.03
57 "|| orf19.6843 || || || Ortholog(s) have role in CENP-A containing nucleosome assembly at centromere, chromatin silencing at centromere, mitotic sister chromatid segregation and nucleoplasm localization ||" 1 0.07 -0.11 -0.03
58 || orf19.1709 || || || Sterol carrier domain protein; alkaline downregulated; colony morphology-related gene regulation by Ssn6; Spider biofilm induced || 1 0.17 -0.34 -0.14
59 || orf19.1711 || END3 || || Regulated by Gcn4p; induced in response to amino acid starvation (3-aminotriazole treatment) || 1 0.09 -0.21 -0.06
60 "|| orf19.5383 || PMA1 || || Plasma membrane H(+)-ATPase; highly expressed, comprises 20-40% of total plasma membrane protein; levels increase at stationary phase transition; fluconazole induced; caspofungin repressed; upregulated in RHE model; Spider biofilm repressed ||" 1 0.10 -0.28 -0.09
61 || orf19.1562 || || || Protein of unknown function; flow model biofilm induced; Spider biofilm induced; repressed by alpha pheromone in SpiderM medium || 1 0.09 -0.33 -0.08
62 "|| orf19.5117 || OLE1 || || Fatty acid desaturase, essential protein involved in oleic acid synthesis; required for aerobic hyphal growth and chlamydospore formation; subject to hypoxic regulation; fluconazole-induced; caspofungin repressed; Hap43p-induced ||" 1 0.19 -0.53 -0.08
63 || orf19.11038 || || || || 1 0.08 -0.39 -0.13
64 || orf19.1836 || APN2 || || Putative class II abasic (AP) endonuclease; flucytosine induced || 1 0.01 -0.11 -0.05
65 || orf19.3815 || || || Has domain(s) with predicted ubiquitin thiolesterase activity and role in ubiquitin-dependent protein catabolic process || 1 0.07 -0.36 -0.20
66 "|| orf19.6540 || PFK2 || || Phosphofructokinase beta subunit; fructose 2,6-bisphosphate, AMP activated; ATP inhibited; phagocytosis, hyphal repressed; fluconazole-induced; stationary-phase enriched; flow model biofilm induced; rat catheter/Spider biofilm repressed ||" 1 0.21 -0.68 -0.37
67 "|| orf19.5682 || || || Ortholog(s) have protein binding, bridging, protein transporter activity and role in chromosome condensation, protein import into nucleus, protein targeting to membrane, regulation of mitotic cell cycle ||" 1 0.00 -0.21 -0.12
68 || orf19.2559 || CDC4 || || F-box subunit of SCF(CDC4) ubiquitin ligase; functional homolog of S. cerevisiae Cdc4; mutation/depletion causes hyperfilamentation; Sol1 is a substrate of SCF-Cdc4; Spider biofilm induced || 1 -0.01 -0.31 -0.17
69 || orf19.3710 || YHB5 || || Flavohemoglobin-related protein; not required for normal NO resistance; predicted globin/FAD-binding/NAD(P)-binding domains but lacks some conserved residues of flavohemoglobins; filament induced; rat catheter and Spider biofilm induced || 1 -0.13 -0.28 -0.07
70 "|| orf19.5636 || RBT5 || || GPI-linked cell wall protein; hemoglobin utilization; Rfg1, Rim101, Tbf1, Fe regulated; Sfu1, Hog1, Tup1, serum, alkaline pH, antifungal drugs, geldamycin repressed; Hap43 induced; required for RPMI biofilms; Spider biofilm induced ||" 1 -0.26 -0.61 -0.19
71 || orf19.1211 || || || Predicted ORF from Assembly 19; removed from Assembly 20 || 1 -0.22 -0.63 -0.26
72 || orf19.3663 || PHO91 || || Putative low-affinity phosphate transporter; fungal-specific (no human or murine homolog) || 1 -0.24 -0.59 -0.25
73 "|| orf19.5982 || RPL18 || || Predicted ribosomal protein; Plc1p-regulated, Tbf1-activated; repressed upon phagocytosis by murine macrophage; Hap43p-induced; Spider biofilm repressed ||" 1 -0.21 -0.51 -0.20
74 || orf19.986 || GLY1 || || L-threonine aldolase; complements glycine auxotrophy of S. cerevisiae shm1 shm2 gly1-1 triple mutant; macrophage/pseudohyphal-induced; the GLY1 locus has an RFLP and is triploid in strain SGY269; flow model biofilm induced || 1 -0.18 -0.36 -0.15
75 || orf19.2643 || RPO26 || || Putative RNA polymerase subunit; heterozygous null mutant exhibits resistance to parnafungin in the C. albicans fitness test || 1 -0.08 -0.16 -0.07
76 "|| orf19.3898 || || || Ortholog(s) have SNAP receptor activity, role in endocytosis, vesicle fusion and Golgi apparatus, SNARE complex, endoplasmic reticulum, endosome, trans-Golgi network localization ||" 1 -0.10 -0.20 -0.09
77 "|| orf19.2832 || INN1 || || Protein with similarity to S. cerevisiae Inn1p, which is an essential protein of the contractile actomyosin ring required for ingression of the plasma membrane into the bud neck during cytokinesis; contains a C2 membrane targeting domain ||" 1 -0.35 -0.56 -0.25
78 "|| orf19.5760 || IHD1 || || GPI-anchored protein; alkaline, hypha-induced; regulated by Nrg1, Rfg1, Tup1 and Tsa1, Tsa1B in minimal media at 37; oralpharyngeal candidasis induced ; Spider biofilm induced; regulated in Spider biofilms by Tec1, Efg1, Ndt80, Rob1, Brg1 ||" 1 -0.27 -0.47 -0.17
79 "|| orf19.3616 || ERG9 || || Putative farnesyl-diphosphate farnesyl transferase (squalene synthase); sterol biosynthesis pathway; likely essential for growth; regulated by fluconazole, lovastatin; amphotericin B, caspofungin repressed; Spider biofilm repressed ||" 1 -0.13 -0.41 -0.23
80 || orf19.2864.1 || RPL28 || || Putative ribosomal protein; Plc1-regulated; downregulated upon phagocytosis by murine macrophage; Spider biofilm repressed || 1 -0.08 -0.39 -0.22
81 || orf19.6873 || RPS8A || || Small 40S ribosomal subunit protein; induced by ciclopirox olamine; repressed upon phagocytosis by murine macrophage; 5'-UTR intron; Hap43-induced; Spider biofilm repressed || 1 -0.13 -0.59 -0.26
82 "|| orf19.6343 || FEN1 || || Putative fatty acid elongase; predicted role in sphingolipid biosynthesis; possibly an essential gene, disruptants not obtained by UAU1 method; Spider and flow model biofilm induced ||" 1 -0.14 -0.56 -0.22
83 "|| orf19.6321 || PGA48 || || Putative GPI-anchored adhesin-like protein; similar to S. cerevisiae Spi1p, which is induced at stationary phase; transcript induced in high iron; flow model biofilm induced; Spider biofilm repressed ||" 1 -0.17 -0.64 -0.27
84 || orf19.3116 || EXM2 || || Putative U1 snRNP complex compotent; decreased transcription is observed upon fluphenazine treatment || 1 -0.18 -0.77 -0.26
85 || orf19.8233 || TRK1 || || || 1 -0.12 -0.52 -0.18
86 || orf19.13071 || || || || 1 -0.22 -0.75 -0.27
87 || orf19.4028 || || || Putative cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting; flow model biofilm induced || 1 -0.27 -0.30
88 || orf19.4043 || || || Protein with a predicted pleckstrin homology domain; induced by alpha pheromone in SpiderM medium || 1 -0.08 -0.67 -0.09
89 || orf19.3330 || CRL1 || || Predicted GTPase of RHO family; CAAX motif geranylgeranylated; expression in S. cerevisiae causes dominant-negative inhibition of pheromone response || 1 -0.01 -0.04
90 "|| orf19.3886 || || || Ortholog of C. dubliniensis CD36 : Cd36_31820, C. parapsilosis CDC317 : CPAR2_205050, Debaryomyces hansenii CBS767 : DEHA2G10736g and Pichia stipitis Pignal : PICST_32993 ||" 1 -0.85 -0.68
91 "|| orf19.5064 || MRPL3 || || Ribosomal protein of the large subunit, mitochondrial; repressed in core stress response; protein present in exponential and stationary growth phase yeast cultures ||" 1 -0.50 -0.03
92 || orf19.7321 || || || Ortholog(s) have role in re-entry into mitotic cell cycle after pheromone arrest and endoplasmic reticulum localization || 1 -0.37 -0.53 -0.02
93 || orf19.1317 || OSH3 || || Protein required for wild-type filamentation; has oxysterol binding protein domain and pleckstrin homology motif; overproducton suppresses cph1 homozygous null filamnetation defect; similar to S. cerevisiae Osh3p || 1 -0.17 -0.01
94 || orf19.3000 || ORC1 || || Putative origin recognition complex large subunit; essential for viability; similar to S. cerevisiae Orc1p origin recognition complex subunit || 1 -0.33 -0.52 -0.00
95 || orf19.5823 || SGT2 || || Putative small tetratricopeptide repeat (TPR)-containing protein; protein abundance is affected by URA3 expression in the CAI-4 strain background; Mig1-regulated || 1 -0.27 -0.39 -0.02
96 "|| orf19.4110 || || || Ortholog of C. dubliniensis CD36 : Cd36_20490, C. parapsilosis CDC317 : CPAR2_104180, Candida tenuis NRRL Y-1498 : CANTEDRAFT_116074 and Debaryomyces hansenii CBS767 : DEHA2F05148g ||" 1 -0.12 -0.17 0.00
97 "|| orf19.3839 || SAP10 || || Secreted aspartyl protease; roles in adhesion, virulence (RHE model), cell surface integrity; distinct specificity from Sap9; at cell membrane and wall; GPI-anchored; induced in low iron; Tbf1-activated; Spider biofilm induced ||" 1 -0.80 -1.05 -0.01
98 "|| orf19.5131 || || || Ortholog of S. cerevisiae Gid7, a GID complex protein; involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; Hap43-repressed gene ||" 1 -0.25 -0.01
99 "|| orf19.6668 || || || Ortholog(s) have ubiquitin-protein ligase activator activity and role in ER-associated ubiquitin-dependent protein catabolic process, establishment of protein localization to endoplasmic reticulum membrane ||" 1 -0.69 -0.65 -0.03
100 || orf19.989 || || || Mitochondrial ribosomal protein of the small subunit; Spider biofilm repressed || 1 -0.31 0.04
101 || orf19.10072 || || || || 1 -0.05 -0.25 0.01
102 || orf19.4048 || DES1 || || Putative delta-4 sphingolipid desaturase; planktonic growth-induced gene || 1 -0.03 -0.14 0.00
103 || orf19.2703 || || || Specificity factor required for ubiquitination and sorting of specific cargo proteins at the multivesicular body; ortholog of S. cerevisiae Ear1; transcript regulated by iron; Ssr1-represssed; Spider biofilm induced || 1 -0.18 0.02
104 || orf19.606 || || || Protein of unknown function; Hap43-induced; Spider biofilm induced || 1 -0.60 -0.67 0.06
105 "|| orf19.6322 || ARD || || D-arabitol dehydrogenase, NAD-dependent (ArDH); enzyme of D-arabitol and D-arabinose catabolism; D-arabitol is a marker for active infection in humans; rat catheter and Spider biofilm induced ||" 1 -0.48 -0.54 0.04
106 || orf19.1655 || PXP2 || || Putative acyl-CoA oxidase; enzyme of fatty acid beta-oxidation; induced during macrophage infection; opaque specific transcript; putative peroxisome targeting signal; Spider biofilm induced || 1 -0.50 0.04
107 || orf19.3822 || SCS7 || || Putative ceramide hydroxylase; regulated by Nrg1; induced in high iron; fluconazole-induced; Hap43-repressed; Spider biofilm induced || 1 -1.02 -1.25 0.07
108 || orf19.7329 || || || Ortholog(s) have ubiquitin-protein ligase activity || 1 -0.44 -0.60 0.03
109 || orf19.13435 || || || || 1 -0.30 0.02
110 "|| orf19.4000 || GRF10 || || Putative homeodomain transcription factor; null mutant is an adenine auxotroph; Spider biofilm induced; promoter bound by Bcr1, Tec1, Efg1, Ndt80 and Brg1 ||" 1 -0.77 -0.68 0.02
111 || orf19.4014 || || || Planktonic growth-induced gene || 1 -0.08 0.00
112 "|| orf19.5031 || SSK1 || || Response regulator of two-component system; role in oxidative stress response, cell wall biosynthesis, virulence, hyphal growth on solid media; expressed in hyphae and yeast; peroxisomal targeting sequence (PTS1); Spider biofilm induced ||" 1 -0.54 -0.83 0.04
113 || orf19.5854 || SBP1 || || Similar to RNA binding proteins; downregulated upon adherence to polystyrene; stationary-phase enriched protein || 1 -0.50 -0.67 -0.14
114 || orf19.9755 || || || || 1 -0.10 -0.03
115 || orf19.4771 || || || Protein of unknown function; Spider biofilm induced || 1 -0.64 -1.00 -0.20
116 "|| orf19.4492 || || || Ortholog(s) have role in nuclear division, rRNA processing and mitotic spindle pole body, nuclear periphery, nucleolus, preribosome, large subunit precursor localization ||" 1 -0.21 -0.07
117 "|| CaalfMp05 || ATP9 || || Subunit 9 of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis ||" 1 -0.37 -0.80 -0.12
118 "|| orf19.2501 || FLC1 || || Protein involved in heme uptake; putative FAD transporter, similar to S. cerevisiae Flc1; regulated by iron; macrophage-induced; mutant defective in filamentous growth; Spider biofilm induced ||" 1 -0.23 -0.47 -0.08
119 || orf19.1535 || || || Protein of unknown function; Hap43-induced gene || 1 -0.09 -0.03
120 "|| orf19.5515 || || || Ortholog(s) have ribosome binding activity, role in mitochondrial respiratory chain complex III assembly, positive regulation of mitochondrial translation and integral to mitochondrial membrane, mitochondrial ribosome localization ||" 1 -0.15 -0.24 -0.06
121 || orf19.1936 || SNF1 || || Essential protein; functional homolog of S. cerevisiae Snf1p regulator of sugar metabolism; constitutively expressed; Thr208 phosphorylation may have regulatory role; up-regulation associated with azole resistance; has polyhistidine tract || 1 -0.38 -0.68 -0.08
122 || orf19.2853 || || || Protein of unknown function; rat catheter biofilm induced || 1 -0.77 -0.16
123 || orf19.9778 || || || || 1 -0.11 -0.02
124 || orf19.5390 || || || Ortholog of Candida albicans WO-1 : CAWG_02403 || 1 -0.22 -0.05
125 || orf19.7612 || CTM1 || || Putative cytochrome c lysine methyltransferase; regulated by Gcn2 and Gcn4; transcript induced by Mnl1 under weak acid stress; early-stage flow model biofilm induced || 1 -0.78 -1.09 -0.16
126 || orf19.3532 || MRPL10 || || Putative mitochondrial large subunit ribosomal protein; colony morphology-related gene regulation by Ssn6 || 1 -0.30 -0.44 -0.07
127 || orf19.3530 || CKA2 || || Catalytic alpha-subunit of protein kinase CK2; interaction with calcineurin pathway affects fluconazole sensitivity; synthetically lethal with CKA1; attenuated virulence in a mouse oropharyngeal candidiasis but not in a systemic mouse model || 1 -0.37 -0.09
128 || orf19.12526 || GCS1 || || || 1 -0.23 -0.05
129 "|| orf19.1738 || UGP1 || || UTP-glucose-1-phosphaturidyl transferase; localizes to yeast, not hyphal cell surface; Hog1-repressed; stationary phase enriched; induced in oralpharyngeal candidasis; rat catheter biofilm repressed; Bcr1-repressed in RPMI a/a biofilms ||" 1 -0.36 -0.74 -0.07
130 || orf19.11797 || DAP2 || || || 1 -0.47 -0.11
131 || orf19.5174 || TAF19 || || Putative TFIID subunit; mutation confers hypersensitivity to amphotericin B; rat catheter biofilm induced || 1 -0.71 -0.01
132 "|| orf19.387 || GCR3 || || Functional homolog of S. cerevisiae Gcr3, which acts in regulation of glycolytic genes; no intron predicted, in contrast to intron in S. cerevisiae GCR3 gene ||" 1 -0.35 -0.05
133 "|| orf19.4326 || || || Ortholog(s) have role in mRNA cis splicing, via spliceosome, maturation of 5S rRNA and U4/U6 x U5 tri-snRNP complex localization ||" 1 -0.32 -0.04
134 "|| orf19.5920 || || || Ortholog of C. dubliniensis CD36 : Cd36_84570, C. parapsilosis CDC317 : CPAR2_404420, Candida tenuis NRRL Y-1498 : CANTEDRAFT_115339 and Debaryomyces hansenii CBS767 : DEHA2G13618g ||" 1 -0.30 -0.04
135 "|| orf19.2402 || SSU72 || || Ortholog(s) have CTD phosphatase activity, protein tyrosine phosphatase activity ||" 1 -0.05 -0.20 -0.00
136 || orf19.11827 || || || || 1 -0.17 -0.02
137 || orf19.13289 || WSC1 || || || 1 -0.67 -1.01 -0.02
138 || orf19.4156 || || || Predicted ORF from Assembly 19; merged with orf19.4711 in Assembly 20 || 1 -0.30 -0.01
139 || orf19.1971 || TRY3 || || RING-finger transcription factor; regulator of yeast form adherence; required for yeast cell adherence to silicone substrate; Spider biofilm induced || 1 -0.29 -0.61 -0.00
140 || orf19.7392 || DED1 || || Predicted ATP-dependent RNA helicase; RNA strand annealing activity; Spider biofilm induced || 1 -0.42 -0.82 -0.01
141 || orf19.469 || HST7 || || MAP kinase kinase involved in mating and hyphal growth signal transduction pathways; phosphorylates Cek1p; wild-type virulence in mouse systemic infection; functional homolog of S. cerevisiae Ste7p; mutants are hypersensitive to caspofungin || 1 -0.27 -0.52 0.00
142 || orf19.2119 || NDT80 || || Ortholog of Ndt80; meiosis-specific transcription factor; activator of CDR1 induction by antifungal drugs; required for wild-type drug resistance and for Spider biofilm formation; transcript induced by antifungal drug treatment || 1 -0.20 -0.43 -0.04
143 || orf19.1307 || || || Predicted membrane protein; rat catheter biofilm induced || 1 -0.21 -0.04
144 || orf19.11045 || || || || 1 -0.49 -0.09
145 || orf19.4263 || || || Has domain(s) with predicted nucleotide binding activity || 1 -0.40 -0.41 -0.07
146 || orf19.1792 || || || Ortholog(s) have ubiquitin-protein ligase activity || 1 -0.22 -0.04
147 || orf19.2534 || PIN4 || || Protein with similarity to S. cerevisiae Pin4p; transposon mutation affects filamentous growth || 1 -0.21 -0.04
148 || orf19.6639 || || || Ortholog of S. cerevisiae Mdm36; mitochondrial distribution and morphology protein; Hap43-repressed gene || 1 -0.31 -0.50 -0.05
149 || orf19.7229 || IML2 || || Protein of unknown function; early-stage flow model biofilm induced; Hap43-repressed; Spider biofilm repressed || 1 -0.56 -0.88 -0.19
150 "|| orf19.3547 || || || Ortholog(s) have mRNA 3'-UTR binding, translation repressor activity, nucleic acid binding activity, role in negative regulation of translation, ribosomal large subunit biogenesis and large ribosomal subunit, nucleolus localization ||" 1 -0.60 -0.19
151 || orf19.8864 || || || || 1 -0.34 -0.73 -0.11
152 || orf19.6779 || PRO2 || || Putative gamma-glutamyl phosphate reductase with a predicted role in proline biosynthesis; regulated by Gcn2p and Gcn4p || 1 -0.10 -0.18 -0.03
153 "|| orf19.5032 || SIM1 || || Adhesin-like protein; involved in cell wall maintenance, redundant with Sun41; possibly secreted; macrophage-repressed; repressed by Rim101, Cyr1, Ras1; Spider biofilm induced ||" 1 -0.53 -0.94 -0.20
154 "|| orf19.3517 || || || Ortholog(s) have Dsc E3 ubiquitin ligase complex, endoplasmic reticulum, fungal-type vacuole lumen localization ||" 1 -0.23 -0.10
155 "|| orf19.4867 || SWE1 || || Putative protein kinase with a role in control of growth and morphogenesis, required for full virulence; mutant cells are small, rounded, and sometimes binucleate; not required for filamentous growth; mutant is hypersensitive to caspofungin ||" 1 -0.08 -0.04
156 "|| orf19.5007 || ACT1 || || Actin; gene has intron; transcript regulated by growth phase, starvation; at polarized growth site in budding and hyphal cells; required for wild-type Cdc42 localization; unprocessed N terminus; Hap43-induced; Spider biofilm repressed ||" 1 -0.61 -0.54 -0.26
157 || orf19.1734 || || || Putative ATPase and nucleosome spacing factor; heterozygous null mutant displays sensitivity to virgineone || 1 -0.12 -0.09
158 "|| orf19.3419 || MAE1 || || Malic enzyme, mitochondrial; transcription regulated by Mig1, Tup1; colony morphology-related gene regulation by Ssn6; Hap43-repressed; Spider biofilm repressed ||" 1 -0.84 -1.66 -0.61
159 "|| orf19.3720 || || || Ortholog(s) have endo-1,4-beta-xylanase activity and SCF ubiquitin ligase complex, cytoplasm localization ||" 1 -0.33 -0.23
160 || orf19.5537 || WSC2 || || Putative cell wall integrity and stress response protein; mRNA binds She3; Spider biofilm induced || 1 -0.23 -0.69 -0.17
161 "|| orf19.1338 || || || Protein of unknown function; possible COPI-coated vesicle, Golgi apparatus, ribosome localization; rat catheter biofilm repressed ||" 1 -0.13 -0.09
162 || orf19.255 || ZCF1 || || Zn(II)2Cys6 transcription factor; transcript regulated during hypha formation; 5'-UTR intron; mutants show decreased colonization of mouse kidneys; flow model biofilm induced; Spider biofilm induced || 1 -0.55 -1.50 -0.27
163 || orf19.7810 || || || || 1 -0.15 -0.06
164 "|| CaalfMp10 || NAD3 || || Subunit 3 of NADH:ubiquinone oxidoreductase (NADH:ubiquinone dehydrogenase), a multisubunit enzyme complex (complex I) of the mitochondrial inner membrane that catalyzes the first step in mitochondrial respiration ||" 1 -0.58 -0.92 -0.21
165 "|| orf19.4666 || || || Protein of unknown function; hyphal-induced expression, regulated by Cyr1, Ras1, Efg1; Spider biofilm induced ||" 1 -0.30 -1.06 -0.05
166 || orf19.5932 || || || Protein of unknown function; Spider biofilm induced || 1 -0.13 -0.01
167 || orf19.10842 || ABC1 || || || 1 -0.39 -0.81 -0.04
168 || orf19.9345 || MP65 || || || 1 -0.45 -0.85 0.05
169 || orf19.13650 || || || || 1 -0.06 0.01
170 || orf19.12243 || || || || 1 -0.24 -0.64 0.03
171 "|| orf19.95 || || || Ortholog of S. cerevisiae : PRM5, C. dubliniensis CD36 : Cd36_60980, C. parapsilosis CDC317 : CPAR2_603060, Candida tenuis NRRL Y-1498 : CANTEDRAFT_113703 and Debaryomyces hansenii CBS767 : DEHA2F10032g ||" 1 -0.18 -0.39 0.01
172 || orf19.3104 || YDC1 || || Alkaline dihydroceramidase; involved in sphingolipid metabolism; Mob2-dependent hyphal regulation; transcript is regulated by Nrg1 and Mig1; Hap43-repressed || 1 -0.14 0.00
173 "|| orf19.7368 || || || Ortholog(s) have mRNA binding, poly(U) RNA binding activity and role in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, regulation of mRNA stability, stress granule assembly ||" 1 -0.56 -0.15 -0.12
174 || orf19.323 || || || Putative haloacid dehalogenase; localized to plasma membrane || 1 -0.03 -0.01
175 || orf19.4363 || SGD1 || || Predicted small ribosomal subunit biogenesis protein; repressed in core stress response; transcript increases in populations of cells exposed to fluconazole over multiple generations; Spider biofilm induced || 1 -0.45 -0.26 -0.09
176 || orf19.13454 || CMP1 || || || 1 -0.65 -0.42 -0.10
177 "|| orf19.125 || EBP1 || || NADPH oxidoreductase; interacts with phenolic substrates (17beta-estradiol); possible role in estrogen response; induced by oxidative, weak acid stress, NO, benomyl, GlcNAc; Cap1, Mnl1 induced; Hap43-repressed; rat catheter biofilm induced ||" 1 -1.19 -0.77 -0.15
178 "|| orf19.3374 || ECE1 || || Hypha-specific protein; regulated by Rfg1, Nrg1, Tup1, Cph1, Efg1, Hog1, farnesol, phagocytosis; fluconazole-induced; rat catheter and Spider biofilm induced; flow model biofilm repressed; Bcr1-repressed in RPMI a/a biofilms ||" 1 -1.59 -0.96 -0.17
179 || orf19.4271 || || || Predicted ORF from Assembly 19; removed from Assembly 20; subsequently reinstated in Assembly 21 based on comparative genome analysis || 1 -0.21 -0.13 -0.02
180 || orf19.11206 || || || || 1 -0.63 -0.40 -0.06
181 "|| orf19.1816 || ALS3 || || Cell wall adhesin; epithelial adhesion, endothelial invasion; alleles vary in adhesiveness; immunoprotective in mice; binds SspB adhesin of S. gordonii in mixed biofilm; induced in/required for Spider biofilm; flow model biofilm repressed ||" 1 -2.31 -1.25 -0.22
182 || orf19.2815 || || || Predicted ORF from Assembly 19; merged with orf19.163 in Assembly 20 || 1 -0.77 -0.40 -0.02
183 "|| orf19.6318 || || || Ortholog(s) have endoplasmic reticulum, mitochondrion localization ||" 1 -0.41 0.00
184 "|| orf19.3603 || MFG1 || || Regulator of filamentous growth; required for biofilm formation, virulence; interacts with Flo8 and Mss11 ||" 1 -0.22 -0.17 0.00
185 || orf19.75 || || || Predicted exocyst component; ortholog of S. cerevisiae Sec5p; merged with orf19.74 in Assembly 21 || 1 -0.51 -0.49 -0.20
186 || orf19.6511 || LIG1 || || tRNA ligase; functional homolog of S. cerevisiae Trl1 || 1 -0.60 -0.23
187 || orf19.815 || DCK1 || || Putative guanine nucleotide exchange factor; required for embedded filamentous growth; activates Rac1; has a DOCKER domain; similar to adjacent DCK2 and to S. cerevisiae Ylr422wp; regulated by Nrg1; Spider biofilm induced || 1 -0.41 -0.37 -0.16
188 || orf19.374 || || || Ortholog(s) have role in protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway || 1 -0.32 -0.28 -0.12
189 || orf19.5547 || || || Protein of unknown function; Hap43-repressed gene || 1 -0.25 -0.18 -0.07
190 "|| orf19.5714 || SAP1 || || Secreted aspartyl proteinase; acts in utilization of protein as nitrogen source; assessment of virulence role complicated by URA3 effects; regulated by growth phase, alpha-pheromone; produced by opaque cells ||" 1 -0.63 -0.16
191 "|| orf19.1047 || ERB1 || || Protein with a predicted role in ribosomal large subunit biogenesis; mutation confers hypersensitivity to 5-fluorocytosine (5-FC), 5-fluorouracil (5-FU), and tubercidin (7-deazaadenosine); hyphal, macrophage repressed ||" 1 -0.38 -0.10
192 || orf19.13191 || SNF4 || || || 1 -0.38 -0.10
193 || orf19.10235 || || || || 1 -0.57 -0.40 -0.14
194 "|| orf19.1666 || || || Ortholog of Dig2, a MAP kinase-responsive inhibitor of Ste12; regulates mating-specific genes and invasive growth in S. cerevisiae; induced by alpha pheromone in SpiderM medium ||" 1 -1.19 -0.77 -0.35
195 || orf19.6906 || ASC1 || || 40S ribosomal subunit similar to G-beta subunits; glucose or N starvation induced filamentation; required for virulence in mice; snoRNA snR24 encoded in ASC1 intron; repressed in stationary phase; GlcNAc-induced; Spider biofilm repressed || 1 -0.51 -0.36 -0.23
196 "|| orf19.764 || || || Ortholog(s) have clathrin-coated vesicle, cytoplasm localization ||" 1 -0.43 -0.22
197 || orf19.8298 || HAP43 || || || 1 -0.74 -0.39 -0.38
198 "|| orf19.5445 || GLO3 || || Putative ARF GTPase activator; role in COPI coating of Golgi vesicle, ER to Golgi vesicle-mediated transport, retrograde Golgi to ER vesicle-mediated transport; Spider biofilm repressed ||" 1 -0.68 -0.51 -0.15
199 || orf19.13450 || ROT1 || || || 1 -0.44 -0.10
200 || orf19.5964 || ARF2 || || Putative ADP-ribosylation factor; mutation confers hypersensitivity to Brefeldin A; Spider biofilm repressed || 1 -0.62 -0.50 -0.13
201 || orf19.1332 || SNG4 || || Putative membrane transporter; Hap43-induced; inducd by Mnl1p under weak acid stress; shows Mob2-dependent hyphal regulation || 1 -0.32 -0.06
202 "|| orf19.3753 || SEF1 || || Zn2-Cys6 transcription factor; regulates iron uptake; negatively regulated by Sfu1p, positively regulated by Tbf1; promotes virulence in mice; mutants display decreased colonization of mouse kidneys; Spider biofilm induced ||" 1 -0.59 -0.31 -0.11
203 "|| orf19.7020 || || || Protein similar to S. cerevisiae Kex1p, which is a pheromone-processing peptidase; possible Kex2p substrate ||" 1 -0.32 -0.06
204 "|| orf19.2392 || || || Ortholog of C. dubliniensis CD36 : Cd36_28460, Debaryomyces hansenii CBS767 : DEHA2B00704g, Pichia stipitis Pignal : PICST_43964 and Spathaspora passalidarum NRRL Y-27907 : spas_CGOB_00057 ||" 1 -0.15 -0.27 -0.03
205 "|| orf19.5167 || IFM1 || || Putative mitochondrial translation initiation factor; transcript regulated by Nrg1, Mig1, and Tup1 ||" 1 -0.52 -0.09
206 "|| orf19.5334 || || || Ortholog od S. cerevisiae Tis11, a mRNA-binding protein; transcription regulated by yeast-hyphal switch; flow model biofilm induced; Spider biofilm repressed ||" 1 -1.00 -0.85 -0.18
207 || orf19.968 || PGA14 || || Putative GPI-anchored protein; induced during cell wall regeneration; regulated by Ssn6p || 1 -0.32 -0.31 -0.06
208 "|| orf19.3799 || || || Ortholog(s) have role in endoplasmic reticulum tubular network maintenance, nuclear pore complex assembly and Golgi apparatus, cortical endoplasmic reticulum, integral to endoplasmic reticulum membrane, mitochondrion localization ||" 1 -0.37 -0.35 -0.06
209 || orf19.5325 || KIN3 || || Protein similar to S. cerevisiae Kin3p; induced under Cdc5p depletion; shows Mob2p-dependent hyphal regulation; mutants are hypersensitive to caspofungin || 1 -0.66 -0.10
210 || orf19.3844 || MRP8 || || Mitochondrial ribosomal protein; ortholog of S. cerevisiae Mrp8; transcript induced in hyphal form; mutant is viable; flow model and rat catheter biofilm repressed || 1 -0.58 -0.61 -0.09
211 || orf19.4818 || || || Protein of unknown function; Spider biofilm induced || 1 -0.66 -0.09
212 || orf19.2605 || PRK1 || || Putative protein serine/threonine kinase; mutants sensitive to growth on hydrogen peroxide medium || 1 -0.66 -0.58 -0.09
213 "|| orf19.1321 || HWP1 || || Hyphal cell wall protein; host transglutaminase substrate; opaque-, a-specific, alpha-factor induced; at MTLa side of conjugation tube; virulence complicated by URA3 effects; Bcr1-repressed in RPMI a/a biofilms; Spider biofilm induced ||" 1 -2.36 -2.09 -0.19
214 "|| orf19.1760 || RAS1 || || RAS signal transduction GTPase; regulates cAMP and MAP kinase pathways; role in hyphal induction, virulence, apoptosis, heat-shock sensitivity; nonessential; plasma membrane-localized; complements viability of S. cerevisiae ras1 ras2 mutant ||" 1 -0.65 -0.60 -0.06
215 || orf19.10860 || || || || 1 -0.68 -0.63 -0.07
216 "|| orf19.6705 || || || Putative guanyl nucleotide exchange factor with Sec7 domain; required for normal filamentous growth; regulated by yeast-hyphal switch; filament induced; regulated by Nrg1, Tup1, Mob2, Hap43; mRNA binds She3; Spider biofilm induced ||" 1 -0.57 -0.59 -0.05
217 || orf19.3540 || MAK5 || || Putative nucleolar DEAD-box RNA helicase; oxidative stress-repressed via Cap1; repressed by prostaglandins || 1 -0.22 -0.02
218 || orf19.10367 || || || || 1 -1.43 -0.86 -0.11
219 || orf19.7997 || || || || 1 -0.36 -0.02
220 || orf19.2857 || || || Ortholog(s) have ATP-dependent DNA helicase activity || 1 -0.28 -0.22 -0.02
221 || orf19.4234 || || || Protein of unknown function; Hap43-induced gene; Ctr86 ortholog in S. cerveisiae is essential; Spider biofilm induced || 1 -0.19 -0.01
222 || orf19.1490 || MSB2 || || Mucin family adhesin-like protein; cell wall damage sensor; required for Cek1 phosphorylation by cell wall stress; Rim101-repressed; activation releases extracellular domain into medium; Spider biofilm induced || 1 -0.79 -0.56 -0.07
223 || orf19.1191 || || || Ortholog(s) have ubiquitin-protein ligase activity and role in ER-associated ubiquitin-dependent protein catabolic process || 1 -0.47 -0.34 -0.05
224 || orf19.2688 || NAN1 || || Putative U3 snoRNP protein; Hap43p-induced gene; physically interacts with TAP-tagged Nop1p || 1 -0.67 -0.50 -0.08
225 "|| orf19.4874 || MNN23 || || Alpha-1,2-mannosyltransferase; mutants hypersensitive to toxic ergosterol analog, amphotericin B, calcofluor white, growth at 42 degrees and have decreased cell wall mannan; flow model biofilm induced ||" 1 -0.32 -0.25 -0.04
226 "|| orf19.1321 || HWP1 || || Hyphal cell wall protein; host transglutaminase substrate; opaque-, a-specific, alpha-factor induced; at MTLa side of conjugation tube; virulence complicated by URA3 effects; Bcr1-repressed in RPMI a/a biofilms; Spider biofilm induced ||" 1 -2.47 -1.97 -0.36
227 "|| orf19.5771 || PBP2 || || Putative RNA binding protein; transcript regulated by Nrg1, Mig1, and Tup1 ||" 1 -0.53 -0.49 -0.06
228 || orf19.2564 || || || Putative nucleolar protein; implicated in ribosome biogenesis; rat catheter biofilm repressed || 1 -0.35 -0.04
229 "|| orf19.6469 || || || Predicted ORF in retrotransposon Tca11 with similarity to the Gag-Pol region of retrotransposons, which encodes nucleocapsid-like protein, reverse transcriptase, protease, and integrase ||" 1 -0.46 -0.51 -0.04
230 "|| orf19.1671 || UTR2 || || Putative GPI anchored cell wall glycosidase; role in adhesion, hyphal growth on Spider (not serum) medium; chitin-binding, glycosyl hydrolase domains; induced during cell wall regeneration; mRNA in yeast-form cells; Spider biofilm induced ||" 1 -0.70 -0.73 -0.07
231 "|| orf19.642 || || || Ortholog of C. dubliniensis CD36 : Cd36_30470, C. parapsilosis CDC317 : CPAR2_203380, Candida tenuis NRRL Y-1498 : CANTEDRAFT_117493 and Debaryomyces hansenii CBS767 : DEHA2G19228g ||" 1 -0.33 -0.36 -0.02
232 "|| CaalfMp03 || NAD1 || || Subunit 6 of NADH:ubiquinone oxidoreductase (NADH:ubiquinone dehydrogenase), a multisubunit enzyme complex (complex I) of the mitochondrial inner membrane that catalyzes the first step in mitochondrial respiration ||" 1 -1.17 -1.25 -0.07
233 "|| orf19.2892 || || || Ortholog of C. dubliniensis CD36 : Cd36_45910, C. parapsilosis CDC317 : CPAR2_501110, Candida tenuis NRRL Y-1498 : CANTEDRAFT_119393 and Debaryomyces hansenii CBS767 : DEHA2E08976g ||" 1 -0.79 -0.82 -0.03
234 || orf19.6448 || || || Protein of unknown function; Spider biofilm repressed || 1 -0.58 -0.69 -0.02
235 "|| orf19.4688 || DAG7 || || Secretory protein; a-specific, alpha-factor induced; mutation confers hypersensitivity to toxic ergosterol analog; fluconazole-induced; induced during chlamydospore formation in C. albicans and C. dubliniensis ||" 1 -0.55 -0.67 -0.05
236 || orf19.6736 || || || Protein required for mitochondrial ribosome small subunit biogenesis; role in maturation of SSU-rRNA; Spider biofilm induced || 1 -0.38 -0.43 -0.00
237 "|| orf19.4645 || BEM1 || || Protein required for wild-type budding, hyphal growth, and virulence in a mouse systemic infection; suppresses pseudohyphal and filamentous growth defects of various S. cerevisiae mutants and heat sensitivity of S. cerevisiae cdc24-4 mutant ||" 1 -0.46 -0.57 -0.06
238 "|| CaalfMp01 || COX2 || || Subunit II of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; one of three mitochondrially-encoded subunits ||" 1 -0.82 -0.96 -0.22
239 "|| orf19.5635 || PGA7 || || GPI-linked hyphal surface antigen; induced by ciclopirox olamine, ketoconazole, Rim101 at pH 8; Hap43, fluconazole; flow model biofilm induced; Spider biofilm induced; required for RPMI biofilm; Bcr1-induced in a/a biofilm ||" 1 -0.51 -0.52 -0.16
240 "|| orf19.7356 || || || Ortholog of C. parapsilosis CDC317 : CPAR2_807080, C. dubliniensis CD36 : Cd36_85690, Candida orthopsilosis Co 90-125 : CORT_0C02090 and Candida albicans WO-1 : CAWG_02885 ||" 1 -0.73 -0.22
241 || orf19.7015 || RPP0 || || Putative ribosomal protein; antigenic in mouse; repressed upon phagocytosis by murine macrophage; induced by Tbf1; overlaps orf19.7014; Spider biofilm repressed || 1 -0.17 -0.49 -0.05
242 "|| orf19.5919 || MEA1 || || Protein similar to A. nidulans MesA, which is involved in localization of actin cables; Hap43p-induced gene ||" 1 -0.16 -0.07
243 "|| orf19.5968 || RDI1 || || Putative rho GDP dissociation inhibitor; transposon mutation affects filamentous growth; farnesol, filament-induced; regulated by Nrg1, Tup1; protein levels low in stationary phase yeast ||" 1 -0.51 -0.43 -0.21
244 "|| orf19.5210 || || || Putative Xbp1 transcriptional repressor; binds to cyclin gene promoters in S. cerevisiae; Hap43-repressed; possibly essential, disruptants not obtained by UAU1 method ||" 1 -0.52 -0.22
245 || orf19.1856 || || || Ortholog(s) have histone deacetylase activity || 1 -0.20 -0.08
246 || orf19.316 || SEC13 || || Putative protein transport factor; antigenic during murine systemic infection; macrophage-downregulated protein; protein level decreases in stationary phase cultures; Spider biofilm repressed || 1 -0.65 -0.27
247 "|| orf19.1926 || SEF2 || || Zn(II)2Cys6 transcription factor, required for normal resistance to copper; repressed by Sfu1 in high-iron conditions; regulated by Sef1, Sfu1, and Hap43; rat catheter and Spider biofilm induced ||" 1 -0.19 -0.08
248 || orf19.7381 || AHR1 || || Zn(II)2Cys6 transcription factor; involved in regulation of adhesion genes; involved in white-opaque switch; forms complex with Mcm1; mutant is sensetive to 5-fluorocytosine and lithium chloride; Spider biofilm induced || 1 -0.35 -0.38 -0.15
249 || orf19.3737 || || || Protein with a Vps9 vacuolar protein sorting protein domain; Hap43-repressed; repressed by ciclopirox olamine; Spider biofilm induced || 1 -0.54 -0.57 -0.20
250 || orf19.1093 || FLO8 || || Transcription factor; required for hyphal formation and CO2 induced white-opaque switching; regulates hyphal gene expression; required for virulence in mouse systemic infection; binds Efg1p; binds Mss11p via LisH motif; has LUFS domain || 1 -0.41 -0.49 -0.15
251 "|| orf19.4889 || || || Predicted MFS family membrane transporter, member of the drug:proton antiporter (12 spanner) (DHA1) family; Spider biofilm induced ||" 1 -0.29 -0.11
252 || orf19.8921 || || || || 1 -0.49 -0.64 -0.19
253 || orf19.2185 || NSA1 || || Putative 66S pre-ribosomal particles conmponent; Hap43-induced; repressed by prostaglandins || 1 -0.27 -0.27 0.03
254 "|| orf19.4835 || || || Ortholog(s) have role in endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA and LSU-rRNA), more ||" 1 -0.58 0.06
255 "|| orf19.7114 || CSA1 || || Surface antigen on elongating hyphae and buds; strain variation in repeat number; ciclopirox, filament induced, alkaline induced by Rim101; Efg1-, Cph1, Hap43-regulated; required for WT RPMI biofilm formation; Bcr1-induced in a/a biofilms ||" 1 -0.29 -0.31 0.04
256 "|| orf19.5959 || NOP14 || || Putative nucleolar protein; Hap43-induced; mutation confers resistance to 5-fluorocytosine (5-FC), 5-fluorouracil (5-FU), and tubercidin (7-deazaadenosine); heterozygous mutant is resistant to parnafungin; Spider biofilm induced ||" 1 -0.68 0.09
257 "|| orf19.4269 || || || Has domain(s) with predicted ATP binding, protein kinase activity and role in protein phosphorylation ||" 1 -0.44 -0.29 0.06
258 || orf19.7238 || NPL3 || || Putative RNA-binding protein; required for normal flow model biofilm growth; nuclear export is facilitated by Hmt1p; transcript upregulated in RHE model of oralcandidiasis; Spider biofilm repressed || 1 -0.55 -0.33 0.04
259 "|| orf19.6621 || MHP1 || || Protein similar to S. cerevisiae Mhp1p, which is involved in microtubule stabilization; transposon mutation affects filamentous growth; possibly transcriptionally regulated upon hyphal formation; possibly an essential gene (by UAU1 method) ||" 1 -0.63 0.05
260 || orf19.9215 || || || || 1 -0.32 -0.19 0.02
261 || orf19.1361 || TIM23 || || Protein involved in mitochondrial matrix protein import || 1 -0.49 -0.24 0.05
262 || orf19.1461 || || || S. pombe ortholog SPCC576.01c is a predicted sulfonate dioxygenase; possibly transcriptionally regulated upon hyphal formation; Spider biofilm induced || 1 -1.61 -0.98 0.36
263 "|| orf19.7326 || || || Ortholog(s) have protein-lysine N-methyltransferase activity, role in peptidyl-lysine dimethylation and cytoplasm, nucleus localization ||" 1 -0.41 -0.23 0.09
264 || orf19.2260 || || || Putative transcription factor with zinc finger DNA-binding motif || 1 -0.41 0.09
265 || orf19.7386 || || || Ortholog(s) have ribosome binding activity || 1 -0.34 0.08
266 || orf19.11375 || || || || 1 -0.61 -0.34 0.13
267 "|| orf19.7668 || MAL2 || || Alpha-glucosidase; hydrolyzes sucrose for sucrose utilization; transcript regulated by Suc1, induced by maltose, repressed by glucose; Tn mutation affects filamentous growth; upregulated in RHE model; rat catheter and Spider biofilm induced ||" 1 -0.81 -0.47 0.19
268 "|| orf19.6886 || || || Ortholog(s) have rRNA binding activity, role in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), ribosomal large subunit export from nucleus and nucleolus localization ||" 1 -0.65 -0.43 0.15
269 "|| orf19.6039 || || || Ortholog(s) have SNAP receptor activity and role in ER to Golgi vesicle-mediated transport, Golgi organization, intra-Golgi vesicle-mediated transport, vesicle fusion with Golgi apparatus ||" 1 -0.49 -0.34 0.10
270 || orf19.7116 || || || Protein of unknown function; transcript induced in RHE model of oral candidiasis; Spider biofilm repressed || 1 -0.44 -0.30 0.11
271 || orf19.4766 || ARG81 || || Zn(II)2Cys6 transcription factor; required for utilization of ornithine as a nitrogen source and for wild-type resistance to caffeine; required for yeast cell adherence to silicone substrate || 1 -0.47 -0.30 0.15
272 "|| orf19.7566 || || || Predicted amino acid transport domain; transcript upregulated in clinical strains from HIV+ patients with oral candidiasis; alkaline upregulated by Rim101; rat catheter, Spider and flow model biofilm induced ||" 1 -0.44 -0.28 0.15
273 || orf19.2391 || || || Putative protein of unknown function; Hap43p-repressed gene; S. cerevisiae ortholog YKR023W localizes to mitochondria || 1 -0.23 0.08
274 || orf19.5989 || || || Putative cleavage factor I subunit; required for the cleavage and polyadenylation of pre-mRNA 3' ends; Spider biofilm repressed || 1 -0.46 -0.24 0.16
275 || orf19.9891 || ALS10 || || || 1 -2.20 -1.19 0.00
276 "|| orf19.5442 || || || Ortholog of C. dubliniensis CD36 : Cd36_80240, C. parapsilosis CDC317 : CPAR2_504040, Candida tenuis NRRL Y-1498 : CANTEDRAFT_130872 and Debaryomyces hansenii CBS767 : DEHA2C06006g ||" 1 -0.53 -0.00
277 "|| orf19.4565 || BGL2 || || Cell wall 1,3-beta-glucosyltransferase; mutant has cell-wall and growth defects, but wild-type 1,3- or 1,6-beta-glucan content; antigenic; virulence role in mouse systemic infection; rat catheter biofilm induced ||" 1 -0.79 -0.81 0.00
278 || orf19.6871 || || || Protein of unknown function; Hap43-induced; flow model biofilm repressed || 1 -0.79 -0.75 0.05
279 || orf19.1333 || SNG3 || || Putative membrane transporter; Hap43p-induced gene; mutation confers hypersensitivity to toxic ergosterol analog; shows colony morphology-related gene regulation by Ssn6p || 1 -0.49 -0.50 0.04
280 || orf19.6754 || || || Protein of unknown function; Spider biofilm induced || 1 -0.86 -0.91 0.08
281 || orf19.2690 || || || Putative mitochondrial GTPase; required for mitochondrial morphology and genome maintenance; Spider biofilm induced || 1 -0.57 -0.44 0.05
282 || orf19.603 || IMP4 || || Putative SSU processome component; Hap43-induced; repressed by prostaglandins; Spider biofilm induced || 1 -0.58 -0.45 0.03
283 "|| orf19.5835 || || || Ortholog(s) have role in rRNA processing, ribosomal small subunit assembly and CURI complex, UTP-C complex, cytosol localization ||" 1 -0.56 -0.46 0.03
284 || orf19.5864 || URK1 || || Protein similar to uridine kinase; repressed by ciclopirox olamine; Spider biofilm induced || 1 -0.52 0.02
285 "|| orf19.5991 || || || Ortholog(s) have role in maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ||" 1 -0.69 0.03
286 || orf19.11040 || || || || 1 -0.79 -0.54 0.04
287 || orf19.1553 || ENT3 || || Putative epsin; induced during the mating process; transcript is upregulated in an RHE model of oral candidiasis || 1 -0.76 -0.53 0.06
288 "|| orf19.6689 || ARG4 || || Argininosuccinate lyase, catalyzes the final step in the arginine biosynthesis pathway; alkaline downregulated; flow model biofilm induced; Spider biofilm induced ||" 1 -0.75 -0.35 0.13
289 || orf19.8637 || WAR1 || || || 1 -0.54 0.09
290 || orf19.5299 || ECM1 || || Putative pre-ribosomal factor; decreased mRNA abundance observed in cyr1 homozygous mutant hyphae; induced by heavy metal (cadmium) stress; Hog1p regulated || 1 -0.36 0.06
291 || orf19.7675 || || || Mitochondrial ribosomal protein of the large subunit; Spider biofilm repressed || 1 -0.25 0.04
292 || orf19.11212 || || || || 1 -0.70 -0.54 0.13
293 "|| orf19.640 || || || Integral membrane protein of the ER; role in the synthesis of beta-1,6-glucan in the cell wall; S. cerevisiae ortholog required for cell viability; Spider biofilm induced ||" 1 -0.20 -0.16 0.04
294 || orf19.7590 || || || Putative NADH-ubiquinone oxidoreductase; identified in detergent-resistant membrane fraction (possible lipid raft component); predicted N-terminal acetylation; repressed by nitric oxide || 1 -0.39 -0.32 0.04
295 "|| orf19.7369 || TRM12 || || Ortholog(s) have S-adenosylmethionine-dependent methyltransferase activity, transferase activity, transferring alkyl or aryl (other than methyl) groups activity and role in tRNA methylation, wybutosine biosynthetic process ||" 1 -0.72 0.10
296 || orf19.575 || HYR3 || || Putative GPI-anchored adhesin-like protein; similar to Hyr1p induced in high iron; clade-specific repeat variation || 1 -0.20 -0.39 0.03
297 "|| orf19.6480 || || || Ortholog(s) have role in UDP-glucose transport and COPI-coated vesicle, Golgi apparatus localization ||" 1 -0.18 -0.33 0.05
298 || orf19.6885 || SPO7 || || Putative regulatory subunit of Nem1-Spo7 phosphatase holoenzyme that regulates nuclear growth by controling phospholipid biosynthesis; induced by alpha pheromone in SpiderM medium || 1 -0.52 0.14
299 || orf19.2727 || GRX3 || || Putative glutaredoxin; flucytosine induced; regulated by Gcn4p; repressed in response to amino acid starvation (3-aminotriazole treatment) || 1 -0.38 -0.37 0.11
300 "|| orf19.4435 || || || Ortholog(s) have structural constituent of cytoskeleton activity, role in microtubule nucleation and spindle pole body localization ||" 1 -0.58 -0.61 0.19
301 "|| orf19.1542 || HEX3 || || Protein similar to S. cerevisiae Hex3p, which is involved in DNA damage response; transposon mutation affects filamentous growth ||" 1 -0.62 -0.61 0.10
302 || orf19.3609 || UTP15 || || Small subunit (SSU) processome component; mutation confers resistance to 5-fluorocytosine (5-FC); physically interacts with TAP-tagged Nop1p || 1 -0.36 -0.35 0.06
303 || orf19.1422 || FZO1 || || Mitochondrial biogenesis protein; rat catheter and Spider biofilm induced || 1 -0.66 -0.63 0.14
304 "|| orf19.3681 || || || Ortholog(s) have Ran guanyl-nucleotide exchange factor activity, protein transporter activity ||" 1 -0.34 -0.37 0.08
305 || orf19.4757 || NAR1 || || Putative cytosolic iron-sulfur (FeS) protein assembly machinery protein; induced by nitric oxide; oxidative stress-induced via Cap1p || 1 -0.80 0.18
306 || orf19.7504 || || || Ortholog of S. cerevisiae Rts3; a component of the protein phosphatase type 2A complex; Plc1-regulated; induced in core caspofungin response; Spider biofilm induced || 1 -0.72 -0.81 0.16
307 || orf19.8412 || CAK1 || || || 1 -0.56 -0.59 0.12
308 || orf19.7625 || PGA1 || || Putative GPI-anchored protein; induced during cell wall regeneration; required for normal adhesion to host cells and for adherence during Sabouraud biofilm formation; Spider biofilm induced || 1 -0.73 0.15
309 "|| orf19.7107 || || || Ortholog(s) have role in ribosomal large subunit biogenesis and cytoplasm, nucleus, ribosome localization ||" 1 -0.56 -0.52 0.13
310 "|| orf19.4035 || PGA4 || || GPI-anchored cell surface protein; beta-1,3-glucanosyltransferase with similarity to the A. fumigatus GEL family; transcript induced in RHE model of oral candidiasis; fluconazol-induced ||" 1 -1.15 -1.02 0.21
311 "|| orf19.4292 || || || Ortholog(s) have SNAP receptor activity, role in Golgi to vacuole transport, vacuole inheritance and Golgi apparatus, endosome localization ||" 1 -0.46 -0.41 0.16
312 "|| orf19.6846 || PHO85 || || Functional homolog of S. cerevisiae Pho85p, a cyclin-dependent kinase that regulates transcription of PHO genes involved in phosphate metabolism; necessary for geldanamycin-induced filamentation; gene has intron ||" 1 -0.62 -0.53 0.20
313 || orf19.1225 || PEX22 || || Putative peroxin || 1 -0.37 0.11
314 || orf19.6707 || || || Predicted vacuolar protein with a calcineurin-like phosphoesterase domain; repressed by alpha pheromone in SpiderM medium || 1 -0.59 -0.42 0.18
315 "|| orf19.2867 || || || Ortholog(s) have phosphatidylinositol-3-phosphate binding, protein transporter activity and role in ascospore formation, intracellular protein transport, protein retention in Golgi apparatus, retrograde transport, endosome to Golgi ||" 1 -0.55 -0.36 0.16
316 || orf19.947 || MRP17 || || Predicted mitochondrial ribosomal protein || 1 -0.36 0.10
317 "|| orf19.7285 || || || Ortholog(s) have role in mRNA cleavage, mRNA polyadenylation, snoRNA 3'-end processing, termination of RNA polymerase II transcription, exosome-dependent, termination of RNA polymerase II transcription, poly(A)-coupled ||" 1 -0.55 -0.42 0.16
318 || orf19.1418 || SEC15 || || Predicted exocyst subunit; cellular bud tip-associated protein; ortholog of S. cerevisiae SEC15 || 1 -0.50 -0.37 0.12
319 "|| orf19.4421 || || || Processing alpha glucosidase I, involved in N-linked protein glycosylation and assembly of cell wall beta 1,6 glucan; merged with orf19.4719 in Assembly 20 ||" 1 -0.49 -0.24
320 || orf19.6577 || FLU1 || || Multidrug efflux pump of the plasma membrane; MDR family member of the MFS (major facilitator superfamily) of transporters; involved in histatin 5 efflux; fungal-specific (no human/murine homolog) || 1 -0.10 0.07
321 || orf19.4623 || || || Protein of unknown function; Spider biofilm repressed || 1 -0.52 -0.25 0.30
322 || orf19.5420 || || || Ortholog(s) have role in fatty acid metabolic process || 1 -0.66 -0.33 0.35
323 "|| orf19.4556 || || || Putative GPI-anchored protein, member of the ALS gene family; ketoconazole induced; caspofungin repressed; merged with orf19.4555 in Assembly 20 ||" 1 -0.20 -0.10 0.10
324 "|| orf19.6355 || || || Ortholog(s) have role in ribosome biogenesis and cytosol, nucleolus localization ||" 1 -0.28 -0.17 0.15
325 "|| orf19.871 || || || Ortholog(s) have protein transporter activity, role in Golgi to plasma membrane transport, intracellular protein transport and vesicle coat localization ||" 1 -0.34 -0.20 0.19
326 || orf19.5339 || || || Ortholog of S. cerevisiae Spg5; required for proteasome assembly during quiescence; transcript detected on high-resolution tiling arrays; Spider biofilm induced || 1 -0.48 -0.30 0.31
327 || orf19.10670 || || || || 1 -0.44 -0.27 0.29
328 "|| orf19.1575 || PRS1 || || Phosphoribosylpyrophosphate synthetase; enzyme of purine, pyrimidine, histidine, and tryptophan biosynthesis; essential; flucytosine induced; macrophage/pseudohyphal-induced ||" 1 -0.45 -0.37 0.36
329 || orf19.4150 || || || Putative glutaredoxin; induced by nitric oxide; Spider biofilm induced || 1 -0.69 -0.50 0.53
330 "|| orf19.4628 || || || Putative cleavage and polyadenylation factor; heterozygous null mutant exhibits hypersensitivity to parnafungin and cordycepin in the C. albicans fitness test; possibly an essential gene, disruptants not obtained by UAU1 method ||" 1 -0.51 -0.37 0.35
331 || orf19.1809 || || || Predicted 3-hydroxyacyl-CoA epimerase; merged with orf19.1288 in Assembly 20 || 1 -0.55 -0.37 0.33
332 || orf19.1248 || || || Putative RNA polymerase II subunit B44; heterozygous null mutant exhibits resistance to parnafungin in the C. albicans fitness test; Spider biofilm repressed || 1 -0.29 -0.19 0.16
333 "|| orf19.4677 || || || Putative protein of unknown function, transcript is upregulated in clinical isolates from HIV+ patients with oral candidiasis; Spider biofilm induced ||" 1 -0.23 -0.16 0.13
334 "|| orf19.7036 || || || Ortholog(s) have phosphatase activator activity, role in actin filament organization, endocytosis, mitochondrion degradation, regulation of growth, response to heat, response to salt stress and cytosol, nucleus localization ||" 1 -0.30 -0.16
335 "|| orf19.6402 || CYS3 || || Cystathionine gamma-lyase; induced by alkaline, amphotericin B, cadmium stress, oxidative stress via Cap1; possibly adherence-induced; Hog1 regulated; reduced levels in stationary phase yeast cells; Spider and flow model biofilm induced ||" 1 -0.17 0.13
336 || orf19.9556 || REG1 || || || 1 -0.63 -0.53 0.42
337 "|| orf19.6503 || || || Ortholog(s) have structural constituent of ribosome activity, role in mitochondrial translation and mitochondrial large ribosomal subunit localization ||" 1 -0.41 -0.46 0.34
338 "|| orf19.2101 || || || Ortholog(s) have protein anchor activity, role in protein insertion into ER membrane, retrograde vesicle-mediated transport, Golgi to ER and GET complex, mitochondrion localization ||" 1 -0.35 -0.40 0.27
339 "|| orf19.418 || KOG1 || || Putative TORC1 subunit; heterozygous null mutant displays sensitivity to rapamycin; likely to be essential for growth, based on an insertional mutagenesis strategy ||" 1 -0.24 0.18
340 || orf19.1107 || || || Protein of unknown function; Spider biofilm induced || 1 -0.49 -0.38 0.37
341 "|| orf19.3505 || || || Ortholog(s) have role in TOR signaling cascade, actin filament bundle assembly, eisosome assembly, endosomal transport, establishment or maintenance of actin cytoskeleton polarity, regulation of cell growth ||" 1 -0.30 -0.24 0.22
342 || orf19.236 || RPL9B || || Ribosomal protein L9; repressed upon phagocytosis by murine macrophages; repressed by nitric oxide; protein levels decrease in stationary phase; Hap43-induced; Spider biofilm repressed || 1 -0.23 0.17
343 || orf19.484 || MRPL40 || || Putative mitochondrial ribosomal protein; Spider biofilm repressed || 1 -0.32 -0.30 0.24
344 || orf19.1364 || || || Ortholog of S. pombe Stm1 G-protein coupled receptor; PQ-loop domains; constitutive expression independent of MTL or white-opaque status; Hap43-repressed || 1 -0.29 0.22
345 "|| orf19.6459 || DPP3 || || Protein similar to S. cerevisiae pyrophosphate phosphatase Dpp1; required for farnesol biosynthesis; repressed by 17-beta-estradiol, ethynyl estradiol; Spider biofilm induced ||" 1 -0.20 -0.23 0.15
346 || orf19.5905 || || || Protein of unknown function; Hap43-induced; F-12/CO2 early biofilm induced || 1 -0.18 0.14
347 || orf19.5440 || RPT2 || || Putative ATPase of the 19S regulatory particle of the 26S proteasome; oxidative stress-induced via Cap1; Spider biofilm repressed || 1 -0.59 -0.39 0.46
348 || orf19.3227 || FTH2 || || Putative iron transporter; similar to S. cerevisiae Fth1p || 1 -0.44 -0.25 0.30
349 || orf19.3205 || MPRL36 || || Mitochondrial ribosomal protein of the large subunit; rat catheter biofilm induced || 1 -0.14 0.09
350 "|| orf19.3392 || DOG1 || || Putative 2-deoxyglucose-6-phosphatase; haloacid dehalogenase hydrolase/phosphatase superfamily; similar to S. cerevisiae Dog1, Dog2, Hor1, Rhr2; regulated by Nrg1, Tup1; Spider biofilm repressed ||" 1 -0.44 -0.40 0.30
351 "|| orf19.4997 || KIS2 || || Scaffold protein of Snf1p complex; similar to S. cerevisiae Gal83p and Sip2p; interacts with Snf4p; interaction with Snf1p complex is regulated by carbon source, decreased on ethanol; N-terminal myristoylation; Hog1p-downregulated ||" 1 -0.70 -0.69 0.46
352 || orf19.1710 || ALI1 || || Putative NADH-ubiquinone oxidoreductase; in detergent-resistant membrane fraction (possible lipid raft component); predicted N-terminal acetylation; nitric oxide-repressed; plasma membrane-localized; protein decreases in stationary phase || 1 -0.26 -0.27 0.17
353 "|| orf19.2180 || || || Ortholog(s) have calcium ion binding, zinc ion binding activity, role in axial cellular bud site selection, bipolar cellular bud site selection, regulation of COPII vesicle coating and cellular bud neck, cytosol, nucleus localization ||" 1 -0.62 -0.57 0.40
354 || orf19.6183 || TIM8 || || Predicted mitochondrial intermembrane space protein with role in protein import into mitochondrial inner membrane and cytosol || 1 -0.35 0.22
355 "|| orf19.291 || || || Ortholog(s) have role in cellular response to DNA damage stimulus, protein sumoylation, response to UV-B, response to UV-C and nuclear envelope localization ||" 1 -0.33 0.21
356 || orf19.4528 || || || Ortholog(s) have role in vacuolar protein processing and endoplasmic reticulum localization || 1 -0.47 0.29
357 || orf19.1652 || POX1-3 || || Predicted acyl-CoA oxidase; farnesol regulated; stationary phase enriched protein; Spider biofilm induced || 1 -0.43 -0.34 0.27
358 || orf19.4031 || || || Ortholog(s) have cytoplasm localization || 1 -0.55 -0.57 0.28
359 || orf19.7076 || GBP2 || || Putative single-strand telomeric DNA-binding protein; protein level decreases in stationary phase cultures; Spider biofilm repressed || 1 -0.44 -0.45 0.24
360 || orf19.5357 || AKL1 || || Putative serine/threonine protein kinase; induced during the mating process || 1 -0.55 -0.47 0.29
361 || orf19.2151 || NAG6 || || Protein required for wild-type mouse virulence and wild-type cycloheximide resistance; putative GTP-binding motif; similar to S. cerevisiae Yor165Wp; in gene cluster that encodes enzymes of GlcNAc catabolism; no human or murine homolog || 1 -0.87 -0.76 0.47
362 "|| orf19.4721 || || || Ortholog(s) have RNA binding activity, role in cytoplasmic translation, mRNA processing and mitochondrion localization ||" 1 -0.38 -0.35 0.21
363 || orf19.8154 || || || || 1 -0.46 -0.35 0.25
364 || orf19.9089 || || || || 1 -0.22 0.12
365 "|| orf19.1669 || AFG3 || || Similar to S. cerevisiae Afg3p, a subunit of the mitochondrial inner membrane m-AAA protease; likely to be essential for growth, based on an insertional mutagenesis strategy ||" 1 -0.10 -0.13 0.05
366 "|| orf19.5612 || BMT4 || || Beta-mannosyltransferase; for elongation of beta-mannose chains on the acid-labile fraction of cell wall phosphopeptidomannan; 9-gene family member; regulated by Tsa1, Tsa1B; flow model biofilm induced; rat catheter biofilm repressed ||" 1 -0.14 -0.16 0.07
367 || orf19.4121 || || || Predicted thioesterase/thiol ester dehydrase-isomerase; Spider biofilm induced || 1 -0.44 0.20
368 || orf19.5503 || || || Putative protein of unknown function; transcript is upregulated in clinical isolates from HIV+ patients with oral candidiasis; Spider biofilm induced || 1 -0.70 -0.43 0.32
369 "|| orf19.4670 || CAS5 || || Transcription factor; cell wall damage response; required for adherence, response/resistance to caspofungin; repressed in core stress response; mutants have reduced CFU in mice, hyphal defect in C. elegans infection; Spider biofilm induced ||" 1 -0.49 -0.34 0.23
370 "|| orf19.7216 || YPT52 || || Rab-family GTPase involved in vacuolar trafficking, colocolizes with Vps1p and Ypt53p in late endosome ||" 1 -0.53 -0.39 0.27
371 "|| orf19.7038 || || || Ortholog(s) have phosphatidylinositol-3-phosphate binding activity, role in protein targeting to vacuole and cytoplasm, nucleus localization ||" 1 -0.36 -0.26 0.19
372 "|| orf19.6250 || || || Ortholog(s) have eukaryotic initiation factor 4G binding, mRNA binding activity ||" 1 -0.27 -0.19 0.14
373 || orf19.6902 || DBP7 || || Putative ATP-dependent DEAD-box RNA helicase; Hap43-induced; rat catheter biofilm induced || 1 -0.57 -0.44 0.26
374 || orf19.11168 || || || || 1 -0.45 -0.34 0.20
375 || orf19.1494 || RAD23 || || S. cerevisiae Rad23 ortholog; binds damaged DNA; Spider biofilm repressed || 1 -0.71 -0.50 0.28
376 || orf19.4524 || ZCF24 || || Predicted Zn(II)2Cys6 transcription factor; caspofungin induced; Hap43-repressed || 1 -0.40 -0.33 0.15
377 || orf19.12451 || || || || 1 -0.66 -0.56 0.29
378 || orf19.480 || || || Protein of unknown function; rat catheter and Spider biofilm induced || 1 -0.64 -0.57 0.31
379 "|| orf19.4540 || UBC8 || || Predicted ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase; induced by alpha pheromone in SpiderM medium ||" 1 -0.27 -0.48 0.28
380 || orf19.13015 || || || || 1 -0.37 -0.66 0.37
381 "|| orf19.6376 || PTC5 || || Mitochondrial protein phosphatase of the Type 2C-related family (serine/threonine-specific), involved in drug response and cadmium tolerance ||" 1 -0.34 -0.63 0.34
382 || orf19.7006 || || || Ortholog(s) have role in reciprocal meiotic recombination || 1 -0.32 -0.64 0.34
383 "|| orf19.1201 || || || Ortholog(s) have serine-tRNA ligase activity, role in invasive growth in response to glucose limitation, mitochondrial seryl-tRNA aminoacylation, pseudohyphal growth, spore germination and mitochondrion localization ||" 1 -0.21 -0.41 0.20
384 || orf19.5782 || || || Ortholog(s) have mitochondrion localization || 1 -0.67 -1.16 0.59
385 || orf19.7284 || ASR2 || || Adenylyl cyclase and stress responsive protein; induced in cyr1 or ras1 mutant; stationary phase enriched protein; Spider biofilm induced || 1 -0.62 -1.08 0.54
386 || orf19.2039 || MSF1 || || Putative phenylalanine-tRNA ligase; protein level decreases in stationary phase cultures; Hap43p-repressed gene || 1 -0.53 0.47
387 || orf19.7235 || || || Putative protein of unknown function; mutation confers hypersensitivity to amphotericin B || 1 -0.39 0.35
388 || orf19.11762 || || || || 1 -0.25 -0.53 0.21
389 || orf19.7652 || CKA1 || || Putative alpha subunit (catalytic subunit) of protein kinase CK2; Cka1p and Cka2p have a common target with respect to fluconazole resistance; synthetically lethal with CKA2; flucytosine induced || 1 -0.51 0.41
390 || orf19.2073 || || || Protein with a multidrug and toxin extrusion protein domain; induced by Mnl1 under weak acid stress || 1 -0.47 0.38
391 "|| orf19.6877 || PNG2 || || Putative peptide:N-glycanase; gene has variable numbers of 12-bp repeats; induced by caspofungin, ciclopirox olamine, ketoconazole or hypoxia; gene of core caspofungin response; Hap43-induced; Spider biofilm induced ||" 1 -0.52 -0.95 0.42
392 || orf19.2665 || MSN5 || || Predicted karyopherin involved in nuclear import and export of proteins; flow model biofilm induced; Spider biofilm induced || 1 -0.43 -0.78 0.32
393 || orf19.9716 || PHM7 || || || 1 -0.17 -0.28 0.14
394 || orf19.10960 || || || || 1 -0.21 0.17
395 "|| orf19.7626 || EIF4E || || Translation initiation factor eIF4E; genes encoding ribosomal subunits, translation factors, tRNA synthetases downregulated by phagocytosis by macrophage; alternatively spliced intron in 5' UTR; protein levels decrease in stationary phase ||" 1 -0.14 -0.20 0.11
396 || orf19.682 || || || Predicted ORF from Assembly 19; ketoconazole-induced; fluconazole-downregulated; induced in a cyr1 homozygous null mutant; shows colony morphology-related gene regulation by Ssn6p; merged with orf19.2296 in Assembly 20 || 1 -0.81 -1.06 0.58
397 || orf19.5571 || || || Protein not essential for viability; merged with orf19.5569 in Assembly 20 || 1 -0.22 -0.31 0.16
398 || orf19.7089 || PMR1 || || Putative secretory pathway P-type Ca2+/Mn2+-ATPase; required for protein glycosylation and cell wall maintenance; required for hyphal tip oscillation in semisolid substrate; putative ortholog of S. cerevisiae PMR1 || 1 -0.60 -0.86 0.45
399 || orf19.11427 || || || || 1 -0.59 -0.81 0.42
400 "|| orf19.7357 || || || Ortholog(s) have role in coenzyme A biosynthetic process and cytosol, nucleus localization ||" 1 -0.58 0.41
401 || orf19.52 || || || Ortholog(s) have role in cellular iron ion homeostasis and mitochondrion localization || 1 -0.16 0.11
402 "|| orf19.5492 || || || Ortholog(s) have mRNA binding, pre-mRNA 5'-splice site binding activity, role in mRNA 5'-splice site recognition and U1 snRNP, U2-type prespliceosome, commitment complex localization ||" 1 -0.31 0.21
403 || orf19.3412 || ATG15 || || Putative lipase; fungal-specific (no human or murine homolog); Hap43p-repressed gene || 1 -0.43 -0.36 0.30
404 || orf19.1634 || || || Has domain(s) with predicted fatty-acyl-CoA binding activity || 1 -0.36 0.25
405 || orf19.863 || || || Ortholog(s) have structural constituent of ribosome activity and mitochondrial large ribosomal subunit localization || 1 -0.06 0.04
406 "|| orf19.3628 || RSP5 || || Putative NEDD4 family E3 ubiquitin ligase; induced during infection of murine kidney, compared to growth in vitro; has murine homolog; possibly an essential gene, disruptants not obtained by UAU1 method ||" 1 -0.51 -0.58 0.33
407 || orf19.121 || ARC18 || || Putative ARP2/3 complex subunit; mutation confers hypersensitivity to cytochalasin D || 1 -0.25 0.18
408 "|| orf19.756 || SAP7 || || Pepstatin A-insensitive secreted aspartyl protease; self-processing; expressed in human oral infection; Ssn6p-regulated; role in murine intravenous infection; induced during, but not required for, murine vaginal infection; N-glycosylated ||" 1 -0.40 0.17
409 "|| orf19.150 || TIM17 || || Predicted component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex), involved in protein import into mitochondria ||" 1 -0.36 -0.56 0.23
410 "|| orf19.439 || || || Ortholog(s) have recombinase activity, single-stranded DNA binding activity ||" 1 -0.06 0.03
411 "|| orf19.6512 || EXO70 || || Predicted subunit of the exocyst complex, involved in exocytosis; localizes to a crescent on the surface of the hyphal tip ||" 1 -0.14 -0.16 0.08
412 "|| orf19.504 || || || Ortholog(s) have ATP-dependent 3'-5' DNA helicase activity, role in nucleosome mobilization and Ino80 complex, cytosol localization ||" 1 -0.26 0.15
413 || orf19.5001 || CUP2 || || Putative copper-binding transcription factor; required for normal resistance to copper; activates transcription of metallothionein genes; Hap43-repressed; Spider biofilm induced || 1 -0.69 -0.70 0.42
414 "|| orf19.980 || || || Ortholog(s) have inositol heptakisphosphate kinase activity, inositol hexakisphosphate 1-kinase activity, inositol hexakisphosphate 3-kinase activity, inositol hexakisphosphate 4-kinase activity, inositol hexakisphosphate 6-kinase activity ||" 1 -0.53 0.32
415 "|| orf19.5628 || || || Mitochondrial dicarboxylate transporter; possibly an essential gene, disruptants not obtained by UAU1 method ||" 1 -0.17 -0.57 0.11
416 || orf19.4056 || BRG1 || || Transcription factor; recruits Hda1 to hypha-specific promoters; Tn mutation affects filamentation; Hap43-repressed; Spider and flow model biofilm induced; required for Spider biofilm formation; Bcr1-repressed in RPMI a/a biofilms || 1 -0.20 -0.49 0.06
417 || orf19.6872 || || || Putative protein of unknown function; Hap43p-repressed gene || 1 -0.43 0.13
418 "|| orf19.4625 || TOA2 || || Putative TFIIA small subunit; protein abundance decreased in CAI4 strain compared to the SC5314 strain, abundance not affected by reintegration of URA3 in CAI4; flucytosine induced; possibly an essential gene (UAU1 method) ||" 1 -0.38 -0.52 0.12
419 || orf19.6882 || OSM1 || || Putative flavoprotein subunit of fumarate reductase; soluble protein in hyphae; caspofungin repressed; stationary phase enriched protein; flow model biofilm induced; Spider biofilm repressed || 1 -1.29 -1.85 0.40
420 "|| orf19.7053 || GAC1 || || Putative regulatory subunit of ser/thr phosphoprotein phosphatase 1; fluconazole-induced; caspofungin repressed; transcript induced by Mnl1 under weak acid stress; regulated by Nrg1, Tup1; Spider and flow model biofilm induced ||" 1 -0.47 -0.68 0.14
421 || orf19.9320 || SPT23 || || || 1 -0.30 -0.52 0.12
422 || orf19.8644 || POR1 || || || 1 -0.25 -0.38 0.09
423 || orf19.11019 || || || || 1 -0.50 -0.76 0.21
424 || orf19.5110 || OPY2 || || Predicted transmembrane protein; role in cell wall biogenesis; required for Cek1 phosphorylation; Spider biofilm induced || 1 -1.00 -1.29 0.24
425 || orf19.5352 || || || Protein with a predicted magnesium transporter domain; mutants are viable || 1 -0.40 0.09
426 || orf19.8776 || || || || 1 -0.82 -0.76 0.18
427 || orf19.9070 || RAD7 || || || 1 -0.28 0.05
428 "|| orf19.7388 || PBS2 || || MAPK kinase (MAPKK); role in osmotic and oxidative stress responses, oxidative stress adaptation; required for stress regulation of Hog1p localization and activity; functional homolog of S. cerevisiae Pbs2p ||" 1 -0.53 -0.56 0.09
429 || orf19.3845 || FGR3 || || Protein lacking an ortholog in S. cerevisiae; transposon mutation affects filamentous growth || 1 -0.42 0.08
430 || orf19.2363 || || || Ortholog(s) have thiosulfate sulfurtransferase activity and mitochondrion localization || 1 -0.33 -0.52 0.07
431 "|| orf19.7001 || YCK2 || || Plasma membrane protein similar to S. cerevisiae casein kinase I, Yck2p; null mutant has defect in damaging oral epithelial cells and in hyphal branching; transcription is activated in weak acid stress or on contact with host cells ||" 1 -0.70 -0.83 0.19
432 "|| orf19.1632 || || || Ortholog(s) have cytosol, nucleus localization ||" 1 -0.20 -0.25 0.05
433 || orf19.4084 || KIS1 || || Snf1p complex scaffold protein; similar to S. cerevisiae Gal83p and Sip2p with regions of similarity to Sip1p (ASC and KIS domain); interacts with Snf4p; mutants are hypersensitive to caspofungin and hydrogen peroxide; Hap43p-repressed gene || 1 -0.59 -0.70 0.13
434 || orf19.7591 || || || Putative NADH-ubiquinone oxidoreductase; identified in detergent-resistant membrane fraction (possible lipid raft component); predicted N-terminal acetylation; repressed by nitric oxide; merged with orf19.7590 in Assembly 20 || 1 -0.36 -0.40 0.09
435 || orf19.4699 || || || Putative phospholipase of patatin family; similar to S. cerevisiae Tgl3p; predicted Kex2p substrate || 1 -0.29 -0.34 0.07
436 "|| orf19.6712 || || || Ortholog(s) have COPI-coated vesicle, Golgi apparatus localization ||" 1 -0.38 0.09
437 "|| orf19.6274 || PBR1 || || Protein of unknown function; required for cohesion, adhesion, and RPMI biofilm formation; induced by alpha pheromone in white cells; fluconazole-induced; Spider biofilm induced ||" 1 -0.15 -0.31 0.04
438 || orf19.7300 || || || Protein of unknown function; Spider biofilm induced || 1 -0.40 0.09
439 "|| orf19.1658 || || || Ortholog(s) have cell cortex, cellular bud neck, cellular bud tip, mating projection tip localization ||" 1 -0.31 -0.41 0.07
440 || orf19.7812 || || || || 1 -0.24 0.04
441 || orf19.7263 || || || Putative X-Pro aminopeptidase; Spider biofilm repressed || 1 -0.42 -0.40 0.06
442 || orf19.6040 || SNF7 || || ESCRT III complex protein; role in proteolytic activation of Rim101 and Rim8 processing/activation; separable roles in RIM101 pathway and in transport from MVB to vacuole; involved in echinocandin and azole sensitivity || 1 -0.34 -0.42 0.22
443 "|| orf19.3455 || || || Putative mitochondrial inner membrane magnesium transporter; possibly an essential gene, disruptants not obtained by UAU1 method ||" 1 -0.55 -0.63 0.30
444 || orf19.4799 || CEF1 || || Putative mRNA splicing factor; ortholog is essential in S. cerevisiae; Spider biofilm induced || 1 -0.49 -0.58 0.25
445 "|| orf19.6044 || MOB2 || || Mob1/phocein domain protein of RAM signaling network; cell wall integrity; role in cell separation, cortical actin polarization; required for hyphal growth; phosphorylated by Cdc28 on hyphal induction; activates Cbk1; mRNA binds She3 ||" 1 -0.60 -0.66 0.22
446 || orf19.4526 || HSP30 || || Putative heat shock protein; fluconazole repressed; amphotericin B induced; Spider biofilm induced; rat catheter biofilm induced || 1 -1.18 -1.20 0.48
447 "|| orf19.3052 || YPT1 || || Functional homolog of S. cerevisiae Ypt1p, which is an essential small Ras-type GTPase involved in protein secretion at ER-to-Golgi; dominant-negative mutation causes SAP secretion defect and accumulation of intracellular secretory vesicles ||" 1 -0.39 -0.42 0.16
448 || orf19.12698 || RBD1 || || || 1 -0.58 0.24
449 || orf19.1416 || COX11 || || Cytochrome oxidase assembly protein; transcript regulated by Nrg1; protein repressed during the mating process; Hap43-repressed gene; rat catheter biofilm induced || 1 -1.07 -0.96 0.45
450 "|| orf19.7161 || SUI3 || || Putative translation initiation factor; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage ||" 1 -0.34 -0.33 0.13
451 "|| orf19.5425 || || || Ortholog(s) have 3'-tRNA processing endoribonuclease activity, role in tRNA 3'-trailer cleavage, endonucleolytic and mitochondrion, nucleus localization ||" 1 -0.45 0.18
452 "|| orf19.1849 || || || Ortholog(s) have U3 snoRNA binding, rRNA binding activity, role in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and nucleolus, small-subunit processome localization ||" 1 -0.31 0.12
453 || orf19.1989 || DCW1 || || Protein with predicted GPI modification; dfg5 dcw1 double mutant is inviable; not required for wild-type hyphal growth; upregulated in cyr1 mutant (yeast or hyphal form); Hap43-induced || 1 -0.28 0.11
454 || orf19.7049 || CYB5 || || Cytochrome b(5); ortholog of S. cerevisiae Cyb5; induced in high iron; fluconazole-induced; shows colony morphology-related gene regulation by Ssn6; mutants are viable || 1 -0.16 -0.27 0.06
455 "|| orf19.3695 || || || Ortholog(s) have diacylglycerol cholinephosphotransferase activity, ethanolaminephosphotransferase activity, role in phosphatidylcholine biosynthetic process, phosphatidylethanolamine biosynthetic process and Golgi apparatus localization ||" 1 -0.30 -0.47 0.12
456 || orf19.6853 || || || Protein of unknown function; Spider biofilm repressed || 1 -0.44 0.17
457 || orf19.5995 || MCA1 || || Putative cysteine protease with similarity to S. cerevisiae Mca1p; has a role in apoptotic cell death upon H2O2 treatment; fungal-specific (no human or murine homolog); farnesol-induced || 1 -0.45 0.17
458 "|| orf19.1942 || SGE1 || || Putative multidrug resistance factor; induced in low iron; regulated by Sef1, Sfu1, and Hap43 ||" 1 -0.58 -0.69 0.22
459 || orf19.6259 || || || Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in the nucleus and cytoplasm; Spider biofilm induced || 1 -0.42 -0.53 0.15
460 || orf19.5416 || ESA1 || || Subunit of the NuA4 histone acetyltransferase complex; member of MYST family; Spider biofilm induced || 1 -0.44 -0.60 0.17
461 || orf19.6196 || || || Component of the SWI/SNF and RSC chromatin remodeling complexes; suggested role in chromosome maintenance; Spider biofilm induced || 1 -0.30 -0.41 0.12
462 "|| orf19.97 || CAN1 || || Basic amino acid permease; complements lysine transport mutation; 10 predicted transmembrane regions, 3 predicted N-glycosylation sites; phagocytosis by macrophages induces transcript; rat catheter, Spider and flow model biofilm induced ||" 1 -0.79 -1.04 0.34
463 "|| orf19.4585 || TFG1 || || Protein similar to S. cerevisiae Tfg1p, which is part of transcription factor TFIIF; transposon mutation affects filamentous growth; possibly an essential gene, disruptants not obtained by UAU1 method ||" 1 -0.55 -0.78 0.26
464 "|| orf19.2465 || POL32 || || Putative subunit of DNA polymerase delta, involved in chromosomal DNA replication; cell-cycle regulated periodic mRNA expression ||" 1 -0.72 0.33
465 "|| orf19.5238 || || || Ortholog(s) have cytosol, nucleus localization ||" 1 -0.85 -1.04 0.41
466 || orf19.3841 || || || Putative protein serine/threonine kinase; predicted role in vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; Spider biofilm induced || 1 -0.98 -1.27 0.48
467 || orf19.9988 || || || || 1 -0.48 0.23
468 || orf19.7154 || UTP18 || || Putative U3 snoRNA-associated protein; Hap43-induced; repressed in core stress response; physically interacts with TAP-tagged Nop1 || 1 -0.61 -0.70 0.29
469 || orf19.3022 || || || Ortholog(s) have structural constituent of ribosome activity and mitochondrial small ribosomal subunit localization || 1 -0.60 -0.57 0.36
470 || orf19.4480 || || || Predicted ORF from Assembly 19; merged with orf19.4479 in Assembly 20 || 1 -0.23 0.14
471 || orf19.7148 || TPO2 || || Putative polyamine transport protein; fungal-specific (no human or murine homolog) || 1 -0.44 -0.59 0.25
472 || orf19.7051 || || || Maf-like protein; rat catheter biofilm induced || 1 -0.40 -0.59 0.22
473 || orf19.1175 || || || Predicted ORF from Assembly 19; merged with orf19.6319 in Assembly 20 || 1 -0.38 0.20
474 || orf19.9755 || || || || 1 -0.90 -0.93 0.49
475 || orf19.6759 || || || Protein of unknown function || 1 -0.14 0.07
476 || orf19.4828 || || || WD repeat domain protein; Hap43-repressed gene; flow model biofilm induced || 1 -0.76 -0.57 0.40
477 || orf19.7084 || DFI1 || || Cell-surface associated glycoprotein; promotes activation of Cek1 in a matrix-dependent manner; N-glycosylated; Spider biofilm induced || 1 -0.54 -0.57 0.27
478 || orf19.6896 || || || Predicted ORF overlapping the Major Repeat Sequence on chromosome 7; member of a family encoded by FGR6-related genes in the RB2 repeat sequence || 1 -0.17 0.08
479 || orf19.6681 || || || Protein of unknown function; Spider biofilm induced || 1 -0.31 0.16
480 || orf19.8923 || || || || 1 -0.16 0.08
481 || orf19.4759 || COX5 || || Cytochrome oxidase subunit V; putative upstream CCAAT box regulatory element; macrophage/pseudohyphal-induced; repressed by nitric oxide; intron in 5'-UTR; Hap43p-dependent repression in low iron medium || 1 -0.34 -0.42 0.17
482 "|| orf19.3972 || || || Ortholog(s) have role in ER to Golgi vesicle-mediated transport, Golgi to endosome transport and ER to Golgi transport vesicle, Golgi membrane, endoplasmic reticulum localization ||" 1 -0.48 0.25
483 || orf19.3828 || || || Ortholog of Candida albicans WO-1 : CAWG_03357 || 1 -0.61 -0.89 0.32
484 "|| orf19.4622 || || || Ortholog(s) have role in telomere maintenance, transcription-coupled nucleotide-excision repair, ubiquitin-dependent protein catabolic process and nucleus localization ||" 1 -0.29 -0.48 0.14
485 || orf19.6643 || MCT1 || || Putative malonyl-CoA acyl carrier protein acyltransferase || 1 -0.50 -0.83 0.28
486 || orf19.4534 || || || Putative UBX-domain (ubiquitin-regulatory domain) protein; macrophage-downregulated gene || 1 -0.38 -0.66 0.21
487 "|| orf19.6529 || CDC34 || || Putative ubiquitin-protein ligase; transcript regulated by Nrg1 and Tup1, and by Gcn2 and Gcn4; rat catheter biofilm induced ||" 1 -0.53 -0.95 0.31
488 || orf19.7283 || || || Protein of unknown function; rat catheter and Spider biofilm induced || 1 -1.14 -2.03 0.69
489 "|| orf19.6461 || || || Ortholog(s) have unfolded protein binding activity, role in aerobic respiration, mitochondrial respiratory chain complex IV assembly, protein processing and mitochondrial inner membrane localization ||" 1 -0.11 0.06
490 || orf19.336 || YAH1 || || Protein similar to oxidoreductases; induced in high iron; Hap43-repressed || 1 -0.48 -0.58 0.28
491 || orf19.897 || VPS20 || || ESCRT III complex protein; role in multivesicular body (MVB) trafficking; required for processing of Rim8; Bcr1-repressed in RPMI a/a biofilms || 1 -0.81 -1.28 0.54
492 || orf19.7552 || || || Putative U3-containing small subunit processome complex protein; Hap43-induced gene; repressed in core stress response; Spider biofilm induced || 1 -0.30 0.20
493 "|| orf19.7021 || GPH1 || || Putative glycogen phosphorylase; role in glycogen metabolism; regulated by Ssk1, Mig1, Tup1, Hap43; fluconazole-induced; localizes to cell surface of hyphae, not yeast; stationary phase enriched protein; Spider biofilm induced ||" 1 -0.42 -0.93 0.24
494 || orf19.11659 || MUC1 || || || 1 -0.23 0.14
495 || orf19.7393 || || || Predicted NAD+/NADH kinase; possible role in cellular iron ion homeostasis; Spider biofilm induced || 1 -0.70 0.41
496 || orf19.3220 || || || Putative rRNA processing protein; Spider biofilm induced || 1 -0.03 0.02
497 "|| orf19.6135 || || || Ortholog of C. dubliniensis CD36 : Cd36_32970, C. parapsilosis CDC317 : CPAR2_701710, Candida tenuis NRRL Y-1498 : CANTEDRAFT_106599 and Debaryomyces hansenii CBS767 : DEHA2E04488g ||" 1 -0.31 0.18
498 || orf19.6939 || || || Predicted ORF from Assembly 19; removed from Assembly 20; restored based on comparative genome analysis || 1 -0.32 0.19
499 || orf19.6769 || || || Ortholog(s) have cytoplasm localization || 1 -0.35 -0.72 0.20
500 || orf19.1471 || COX4 || || Putative cytochrome c oxidase subunit IV; Mig1-regulated; macrophage/pseudohyphal-induced gene; macrophage-induced protein; repressed by nitric oxide; 5'-UTR intron; Hap43-repressed || 1 -0.46 -0.91 0.24
501 || orf19.5848 || || || RING-type zinc finger protein; upregulated during oral infection; mutants have reduced ability to damage oral epithelial cells; Spider and flow model biofilm induced || 1 -0.34 0.18
502 "|| orf19.7023 || || || Ortholog of S. cerevisiae Ioc4, a protein that influences gene expression through chromatin remodeling; oxidative stress-induced via Cap1 ||" 1 -0.38 -0.83 0.19
503 || orf19.1150 || || || GATA-like transcription factor; oral infection induced; mutant has reduced capacity to damage oral epithelial cells; regulated by Gcn2 and Gcn4; Spider biofilm induced || 1 -0.30 0.16
504 || orf19.7027 || || || Protein of unknown function; Spider biofilm induced || 1 -0.54 -0.89 0.28
505 || orf19.4539 || || || Protein with a Rho GDP-dissociation inhibitor domain; Hap43-repressed gene; Spider biofilm induced || 1 -0.21 -0.41 0.14
506 || orf19.2644 || QCR2 || || Ubiquinol-cytochrome-c reductase; antigenic; induced by interaction with macrophage; repressed by nitric oxide; in detergent-resistant membrane fraction (possible lipid raft component); levels decrease in stationary phase; Hap43p-repressed || 1 -0.06 -0.15 0.05
507 "|| orf19.3395 || || || Predicted MFS membrane transporter, member of the drug:proton antiporter (12 spanner) (DHA1) family; induced by nitric oxide, oxidative stress, alpha pheromone; fungal-specific; Hap43-repressed; Spider biofilm induced ||" 1 -0.11 0.09
508 "|| orf19.6770 || || || protein with ENTH Epsin domain, N-terminal; Spider biofilm repressed ||" 1 -0.46 -0.75 0.33
509 || orf19.5773 || || || Putative dipeptidyl-peptidase III; protein detected by mass spec in exponential and stationary phase cultures; Hog1p-induced; clade-associated gene expression || 1 -0.50 -0.86 0.40
510 "|| orf19.4175 || TOK1 || || Outwardly rectifying, noisily gated potassium channel; modulates sensitivity to human salivary histatin (Hst5); very similar to S. cerevisiae Tok1p; Bcr1-repressed in RPMI a/a biofilms ||" 1 -0.26 0.21
511 || orf19.6937 || PTR22 || || Oligopeptide transporter involved in uptake of di-/tripeptides; regulated by Stp2 and Stp3; transcript induced upon phagocytosis by macrophage; repressed by Rim101 at pH 8; flow model biofilm induced || 1 -0.40 -0.92 0.30
512 || orf19.9553 || || || || 1 -0.21 -0.52 0.19
513 "|| orf19.2972 || PDE2 || || High affinity cyclic nucleotide phosphodiesterase; moderates signaling by cAMP; required for virulence, switching, cell wall, hyphal, not pseudohyphal growth; expressed shortly after hyphal induction; rat catheter and Spider biofilm induced ||" 1 -0.40 -0.97 0.36
514 || orf19.6180 || || || Protein similar to Pichia anomala YDL054c and S. cerevisiae Ydl054cp; transmembrane regions predicted; Hap43p-repressed gene || 1 -0.22 0.18
515 "|| orf19.2608 || ADH5 || || Putative alcohol dehydrogenase; regulated by white-opaque switch; fluconazole-induced; antigenic in murine infection; regulated by Nrg1, Tup1; Hap43, macrophage repressed, flow model biofilm induced; Spider biofilm induced ||" 1 -0.37 -0.80 0.31
516 "|| orf19.2708 || || || Ortholog(s) have guanyl-nucleotide exchange factor activity, role in mature ribosome assembly and cytosol, nucleolus, polysome, preribosome, large subunit precursor localization ||" 1 -0.26 0.21
517 || orf19.6640 || TPS1 || || Trehalose-6-phosphate synthase; role in hyphal growth and virulence in mouse systemic infection; induced in presence of human neutrophils; macrophage/pseudohyphal-repressed after 16h; stationary phase enriched protein; Hap43-repressed || 1 -0.56 -1.04 0.45
518 "|| orf19.1756 || GPD1 || || Glycerol-3-phosphate dehydrogenase; glycerol biosynthesis; regulated by Efg1; regulated by Tsa1, Tsa1B under H2O2 stress conditions; Sflow model and Spider biofilm induced ||" 1 -0.16 -0.54 0.07
519 "|| orf19.941 || SEC14 || || Essential protein; functional homolog of S. cerevisiae Sec14p, a Golgi phosphatidylinositol/phosphatidylcholine transfer protein that regulates choline-phosphate cytidyltransferase and thereby affects secretion; biofilm-regulated ||" 1 -0.13 -0.50 0.08
520 "|| orf19.3400 || COQ3 || || Protein with a predicted role in coenzyme Q biosynthesis; transcriptionally induced by interaction with macrophages; possibly an essential gene, disruptants not obtained by UAU1 method ||" 1 -0.23 0.12
521 "|| orf19.4657 || || || Ortholog(s) have phosphoprotein phosphatase activity, role in negative regulation of phospholipid biosynthetic process, nuclear envelope organization and Nem1-Spo7 phosphatase complex, integral to membrane, mitochondrion localization ||" 1 -0.27 -0.78 0.14
522 || orf19.3826 || || || Predicted transmembrane protein with a role in cell wall polymer composition; Plc1-regulated; Spider biofilm induced || 1 -0.61 -0.78 0.21
523 || orf19.539 || LAP3 || || Putative aminopeptidase; positively regulated by Sfu1; clade-associated gene expression; virulence-group-correlated expression; induced by alpha pheromone in SpiderM medium; Hap43-induced; Spider and flow model biofilm induced || 1 -0.54 0.19
524 "|| orf19.4194 || || || Putative TFIIH complex subunit; possibly an essential gene, disruptants not obtained by UAU1 method ||" 1 -0.42 0.15
525 || orf19.721 || || || Ortholog(s) have polynucleotide 5'-hydroxyl-kinase activity || 1 -0.20 0.07
526 "|| orf19.7598 || || || Ortholog(s) have histone acetyltransferase activity, role in histone acetylation and Ada2/Gcn5/Ada3 transcription activator complex localization ||" 1 -0.30 0.11
527 || orf19.5431 || || || Protein of unknown function; Hap43-repressed; Spider biofilm induced || 1 -0.67 -1.27 0.27
528 || orf19.14177 || || || || 1 -0.44 -1.11 0.16
529 || orf19.7459 || || || Putative mitochondrial protein with a predicted role in respiratory growth; fluconazole-induced; ketoconazole-repressed; mutants display a strong defect in flow model biofilm formation; Spider biofilm induced || 1 -0.35 -0.71 0.09
530 || orf19.4862.2 || PET100 || || Chaperone that facilitates the assembly of cytochrome c oxidase; plasma membrane protein || 1 -0.19 -0.40 0.06
531 "|| orf19.3515 || || || Putative 3-hydroxyanthranilic acid dioxygenase, involved in NAD biosynthesis; Hap43p-repressed gene ||" 1 -0.11 0.03
532 || orf19.6045 || || || Putative phosphatidylserine decarboxylase; involved in phosphatidylethanolamine; Spider biofilm repressed || 1 -0.47 -0.62 0.13
533 || orf19.1604 || || || Predicted Gal4-like DNA-binding transcription factor; Spider biofilm induced || 1 -0.38 -0.52 0.07
534 "|| orf19.3802 || PMT6 || || Protein mannosyltransferase; required for virulence in mice, adhesion to endothelium; role in hyphal growth signaling, hygromycin B sensitivity; no major role in cellular PMT activity; Hap4-repressed; Bcr1-repressed in RPMI a/a biofilms ||" 1 -0.15 0.03
535 || orf19.7024 || || || Ortholog of Candida albicans WO-1 : CAWG_05448 || 1 -0.35 -0.78 0.07
536 || orf19.4664 || NAT4 || || Putative histone acetyltransferase; involved in regulation of white-opaque switch; early-stage flow model biofilm induced; Spider biofilm induced || 1 -1.48 -1.80
537 "|| orf19.5906 || ADE2 || || Phosphoribosylaminoimadazole carboxylase; role in adenine biosynthesis; required for normal growth and virulence in immunosuppressed mouse infection; not induced in GCN response, in contrast to S. cerevisiae ADE2; stationary phase-enriched ||" 1 -0.02 0.18
538 "|| orf19.3888 || PGI1 || || Glucose-6-phosphate isomerase; enzyme of glycolysis; antigenic; Efg1-regulated; induced upon adherence to polystyrene; repressed by phagocytosis, human neutrophils; flow model biofilm induced; rat catheter and Spider biofilm repressed ||" 1 -0.04 -0.41 0.70
539 || orf19.7266 || || || Ortholog of Candida albicans WO-1 : CAWG_00007 || 1 -0.01 0.21
540 || orf19.3712 || || || Protein of unknown function; induced by Mnl1 under weak acid stress; flow model biofilm induced; Spider biofilm induced || 1 -0.02 -0.32 0.29
541 "|| orf19.4543 || UGA2 || || Predicted succinate semialdehyde dehydrogenase; predicted role in glutamate catabolism; transcription regulated by Mig1, Tup1, Gcn4; mutants are viable ||" 1 -0.04 0.39
542 || orf19.10861 || || || || 1 -0.04 -0.41 0.44
543 "|| orf19.4836 || URA1 || || Dihydroorotate dehydrogenase; de novo pyrimidine biosynthesis; regulated by yeast-hypha switch, Nrg1/Mig1/Tup1; flow model biofilm induced; rat catheter and Spider biofilm repressed ||" 1 -0.02 0.25
544 || orf19.2726 || || || Putative plasma membrane protein; Plc1-regulated; Spider biofilm induced || 1 -0.03 -0.29 0.28
545 || orf19.6607 || || || Ortholog(s) have role in mitochondrial respiratory chain complex I assembly and mitochondrial membrane localization || 1 -0.07 -0.40 0.40
546 || orf19.5308 || || || Protein of unknown function; induced by Rgt1 || 1 -0.08 -0.41 0.41
547 || orf19.6538 || VMA11 || || Predicted ortholog of S. cerevisiae Tfp3/Vma11; c' subunit of the V0 subcomplex of the vacuolar ATPase; required for hemoglobin-iron utilization; Spider biofilm repressed || 1 -0.12 0.60
548 || orf19.2048 || || || Proten of unknown function; transcript positively regulated by Sfu1; Hap43 repressed; Spider biofilm induced || 1 -0.28 -1.06 1.14
549 || orf19.7228 || || || Possible Golgi membrane protein; transcript positively regulated by Tbf1; mRNA binds She3 || 1 -0.15 -0.49 0.55
550 || orf19.339 || NDE1 || || Putative NADH dehydrogenase; may act alternatively to complex I in respiration; caspofungin repressed; rat catheter biofilm induced; Spider biofilm repressed || 1 -0.04 -0.44 0.32
551 || orf19.8852 || || || || 1 -0.01 0.08
552 || orf19.6745 || TPI1 || || Triose-phosphate isomerase; antigenic in mouse/human; mutation affects filamentation; macrophage-repressed; protein in exponential and stationary growth phase yeast; possibly essential; flow model biofilm induced; Spider biofilm repressed || 1 -0.05 -0.41 0.55
553 || orf19.1648 || RAD50 || || Putative DNA double-strand break repair factor; involved in response to oxidative stress and drug resistance; flow model biofilm repressed || 1 -0.03 0.25
554 || orf19.3004 || || || Ortholog(s) have fungal-type vacuole localization || 1 -0.02 -0.27 0.18
555 || orf19.3290 || || || Plasma membrane-localized protein; repressed by nitric oxide; Hap43p-repressed gene || 1 -0.02 -0.16 0.10
556 "|| orf19.3038 || TPS2 || || Trehalose-6-phosphate (Tre6P) phosphatase; mutant heat sensitive, accumulates Tre6P, decreased mouse virulence; possible drug target; 2 conserved phospohydrolase motifs; no mammalian homolog; Hap43-repressed; flow model biofilm induced ||" 1 -0.07 -0.79 0.50
557 "|| orf19.7152 || || || Protein similar to Aspergillus CYSK O-acetylserine sulfhydrylase, suggesting that C. albicans uses an O-acetyl-serine (OAS) pathway of sulfur assimilation; upregulated in biofilm; protein level decreases in stationary phase cultures ||" 1 -0.27 -0.84 0.52
558 || orf19.6688 || || || Protein of unknown function; expression decreases by benomyl treatment or in an azole-resistant strain overexpressing MDR1; Spider biofilm induced || 1 -0.15 -0.49 0.32
559 || orf19.729 || || || Adaptor protein required for specific mRNA transport; protein similar but not orthologous to S. cerevisiae She3; transposon mutation affects filamentous growth || 1 -0.20 0.42
560 || orf19.1944 || GPR1 || || Plasma membrane G-protein-coupled receptor of the cAMP-PKA pathway; required for WT hyphal growth; reports differ on role in cAMP-mediated glucose signaling; Gpr1 C terminus binds Gpa2; regulates HWP1 and ECE1; flow model biofilm induced || 1 -0.08 -0.46 0.18
561 || orf19.8419 || STE4 || || || 1 -0.12 -0.65 0.28
562 || orf19.428 || || || Putative serine/threonine kinase; induced during planktonic growth; rat catheter biofilm repressed || 1 -0.18 0.42
563 || orf19.7150 || NRG1 || || Transcription factor/repressor; regulates chlamydospore formation/hyphal gene induction/virulence and rescue/stress response genes; effects both Tup1 dependent and independent regulation; flow model biofilm induced; Spider biofilm repressed || 1 -0.25 -0.66 0.55
564 || orf19.4362 || || || Ortholog(s) have role in protein targeting to mitochondrion and mitochondrial outer membrane localization || 1 -0.06 0.14
565 "|| orf19.178 || || || Ortholog of C. dubliniensis CD36 : Cd36_32460, C. parapsilosis CDC317 : CPAR2_205480, Candida tenuis NRRL Y-1498 : CANTEDRAFT_115156 and Debaryomyces hansenii CBS767 : DEHA2E22154g ||" 1 -0.11 0.21
566 || orf19.7370 || || || Possible G-protein coupled receptor; vacuolar membrane transporter for cationic amino acids; PQ-loop motif; rat catheter and Spider biofilm induced || 1 -0.14 -0.46 0.26
567 || orf19.5123 || || || Predicted ORF from Assembly 19; merged with orf19.5124 in Assembly 20 || 1 -0.06 -0.32 0.18
568 || orf19.12241 || DAK2 || || || 1 -0.01 -0.05 0.03
569 || orf19.10359 || PGM2 || || || 1 -0.13 -0.64 0.40
570 || orf19.1151 || || || Predicted ORF from Assembly 19; induced in core stress response; merged with orf19.1152 in Assembly 20 || 1 -0.17 -0.75 0.46
571 "|| orf19.1957 || CYC3 || || Mitochondrial cytochrome c heme lyase; antigenic cell-wall protein; filament induced; induced on polystyrene adherence, interaction with macrophage; N-glycosylation, 2 heme-binding motifs; rat catheter, Spider biofilm induced ||" 1 -0.04 -0.17 0.11
572 || orf19.5417 || DOT5 || || Putative nuclear thiol peroxidase; alkaline downregulated; sumoylation target; Spider and flow model biofilm induced || 1 -0.13 -0.56 0.37
573 || orf19.287 || || || Putative NADH-ubiquinone oxidoreductase subunit; Hap43p-repressed gene; repressed by nitric oxide; identified in detergent-resistant membrane fraction (possible lipid raft component) || 1 -0.07 -0.32 0.22
574 "|| orf19.5348 || TPS3 || || Predicted trehalose-phosphate synthase regulatory subunit; regulated by Efg1; regulated by Tsa1, Tsa1B under H2O2 stress conditions; flow model biofilm induced (reports differ) ||" 1 -0.25 -0.67 0.69
575 "|| orf19.5585 || SAP5 || || Secreted aspartyl proteinase; sap4,5,6 triple null defective in utilization of protein as N source; virulence role effected by URA3; expressed during infection; mRNA localized to hyphal tip via She3; rat catheter and Spider biofilm induced ||" 1 -0.15 0.43
576 "|| orf19.7185 || || || Ortholog of C. dubliniensis CD36 : Cd36_73630, C. parapsilosis CDC317 : CPAR2_805330, Candida tenuis NRRL Y-1498 : CANTEDRAFT_119330 and Debaryomyces hansenii CBS767 : DEHA2G16544g ||" 1 -0.14 0.41
577 "|| orf19.4899 || GCA1 || || Extracellular/plasma membrane-associated glucoamylase; expressed in rat oral infection; regulated by carbohydrates, pH, galactose; promotes biofilm matrix formation; flow model biofilm induced; Bcr1 repressed in RPMI a/a biofilms ||" 1 -0.11 0.31
578 || orf19.1544 || || || Putative cis-golgi localized protein involved in ER to Golgi transport; Spider biofilm repressed || 1 -0.07 0.19
579 "|| orf19.1623 || CAP1 || || AP-1 bZIP transcription factor; apoptotic, oxidative stress response/resistance, multidrug resistance; nuclear in oxidative stress; complements S. cerevisiae yap1 mutant; oralpharyngeal candidasis-, human neutrophil, Spider biofilm induced ||" 1 -0.06 -0.33 0.16
580 "|| orf19.2050 || || || Ortholog(s) have sterol esterase activity, role in cellular lipid metabolic process, sterol metabolic process and fungal-type vacuole, integral to membrane, lipid particle localization ||" 1 -0.09 -0.61 0.34
581 || orf19.4953 || || || Putative ATPase; predicted role in ER-associated protein catabolism; induced during chlamydospore formation in both C. albicans and C. dubliniensis; rat catheter biofilm repressed || 1 -0.13 0.51
582 "|| orf19.4849 || || || Protein required for localizing proteasomes to the nucleus; involved in ubiquitin-mediated protein degradation; possibly an essential gene, disruptants not obtained by UAU1 method; Spider biofilm induced ||" 1 -0.07 0.28
583 || orf19.2655 || BUB3 || || Protein similar to S. cerevisiae Bub3; a kinetochore checkpoint component; induced by hydroxyurea treatment; flow model biofilm induced; Spider biofilm induced || 1 -0.06 -0.43 0.28
584 || orf19.7708 || || || || 1 -0.05 -0.33 0.23
585 || orf19.951 || || || Protein of unknown function; transcript repressed upon yeast-hyphal switch; fluconazole-induced; Hap43-repressed; flow model biofilm induced || 1 -0.09 -0.43 0.37
586 "|| orf19.2211 || || || Ortholog of C. dubliniensis CD36 : Cd36_21990, C. parapsilosis CDC317 : CPAR2_103660, Debaryomyces hansenii CBS767 : DEHA2F19756g and Pichia stipitis Pignal : PICST_61375 ||" 1 -0.12 0.41
587 || orf19.8778 || CPH2 || || || 1 -0.01 -0.25 0.03
588 || orf19.1704 || FOX3 || || Putative peroxisomal 3-oxoacyl CoA thiolase; transcript regulated by white-opaque switch; Spider biofilm induced || 1 -0.06 -0.35 0.16
589 || orf19.6720 || || || P-Loop domain-containing protein of unknown function; transposon mutation affects filamentous growth; Spider biofilm induced || 1 -0.34 -1.28 0.69
590 || orf19.943 || FET33 || || Putative multicopper ferro-O2-oxidoreductase; repressed in core caspofungin response; fails to complement S. cerevisiae fet3 iron-related phenotypes; rat catheter and Spider biofilm induced || 1 -0.09 0.18
591 || orf19.5118 || SDS24 || || Protein similar to S. cerevisiae Sds24 involved in cell separation during budding; transcript regulated by Mig1 and Tup1; fluconazole-induced; flow model biofilm induced || 1 -0.11 -0.66 0.20
592 || orf19.3042 || || || Protein of unknown function; Hap43-induced; rat catheter biofilm induced || 1 -0.13 -0.76 0.30
593 "|| orf19.6527 || || || Pheromone-regulated protein (Prm10) of S. cerevisiae; colony morphology-related gene regulation by Ssn6; induced by Mnl1 under weak acid stress; possibly essential gene, disruptants not obtained by UAU1 method; Spider biofilm induced ||" 1 -0.13 -0.57 0.21
594 || orf19.6645 || HMO1 || || HMG-box transcription factor; binds upstream of hexose and ergosterol metabolism and cell cycle genes; activates pseudohyphal growth when expressed in S. cerevisiae; repressed in hyphae; Spider biofilm repressed || 1 -0.16 -0.59 0.17
595 "|| orf19.399 || || || Putative serine/threonine protein kinase; possibly an essential gene, disruptants not obtained by UAU1 method ||" 1 -0.12 -0.35 0.13
596 || orf19.6146 || CLG1 || || Putative cyclin-like protein; transcription is regulated upon yeast-hyphal switch || 1 -0.32 -0.92 0.36
597 || orf19.4372 || || || Predicted transmembrane transporter; rat catheter and Spider biofilm induced || 1 -0.15 -0.42 0.17
598 "|| orf19.3401 || CTA1 || || Protein similar to S. cerevisiae Mos10p, which affects S. cerevisiae filamentous growth; activates transcription in 1-hybrid assay in S. cerevisiae; protein levels increase under weak acid stress; nonessential ||" 1 -0.18 -0.52 0.22
599 "|| orf19.299 || ECM14 || || Ortholog(s) have endoplasmic reticulum, fungal-type vacuole localization ||" 1 -0.16 0.40
600 "|| orf19.7032 || || || Ortholog of C. dubliniensis CD36 : Cd36_70790, C. parapsilosis CDC317 : CPAR2_301530, Candida tenuis NRRL Y-1498 : CANTEDRAFT_94947 and Debaryomyces hansenii CBS767 : DEHA2A05258g ||" 1 -0.39 -0.47
601 "|| orf19.3059 || SUA71 || || Transcription factor TFIIB; required for transcription initiation and start site selection by RNA polymerase II; downregulated during planktonic growth, whereas related SUA72 is induced; induced by Tbf1; rat catheter, Spider biofilm induced ||" 1 -0.10 -0.16 0.14
602 "|| orf19.7181 || || || Ortholog of C. dubliniensis CD36 : Cd36_73670, C. parapsilosis CDC317 : CPAR2_702370, Candida tenuis NRRL Y-1498 : CANTEDRAFT_119320 and Debaryomyces hansenii CBS767 : DEHA2G16632g ||" 1 -0.25 -0.34 0.27
603 "|| orf19.891 || || || Putative AMP deaminase; possibly an essential gene, disruptants not obtained by UAU1 method ||" 1 -0.29 -0.41 0.33
604 "|| orf19.677 || CHO1 || || Putative phosphatidylserine synthase; ortholog of S. cerevisiae CHO1; transposon mutation affects filamentous growth; regulated by Nrg1, Tup1 ||" 1 -0.50 -0.72 0.62
605 || orf19.6941 || || || Putative diacylglycerol acyltransferase; catalyzes the terminal step of triacylglycerol formation; flow model biofilm induced; Spider biofilm induced || 1 -0.21 -0.29 0.25
606 || orf19.3768 || || || Predicted ORF from Assembly 19; merged with orf19.736 in Assembly 20 || 1 -0.25 0.31
607 "|| orf19.3040 || EHT1 || || Putative acyl-coenzymeA:ethanol O-acyltransferase; regulated by Sef1, Sfu1, and Hap43; induced by alpha pheromone in SpiderM medium; Spider biofilm induced; promoter bound by Ndt80 ||" 1 -0.47 -0.56 0.54
608 || orf19.7177 || KAP120 || || Putative karyopherin; mutation confers hypersensitivity to cytochalasin D || 1 -0.46 -0.59 0.53
609 "|| orf19.7179 || || || Ortholog(s) have role in intracellular sequestering of iron ion, iron-sulfur cluster assembly, protein maturation and mitochondrial matrix localization ||" 1 -0.41 -0.52 0.59
610 || orf19.3308 || STB5 || || Putative transcription factor with zinc cluster DNA-binding motif; has similarity to S. cerevisiae Stb5p; Hap43p-repressed gene || 1 -0.44 -0.52 0.60
611 "|| orf19.2915 || || || Ortholog(s) have ATPase activity, GTPase activity, adenosine-diphosphatase activity, cytidine diphosphatase activity, guanosine-diphosphatase activity, nucleoside-triphosphate diphosphatase activity, uridine-diphosphatase activity ||" 1 -0.19 0.26
612 || orf19.7106 || VPS70 || || Ortholog(s) have role in protein targeting to vacuole and endoplasmic reticulum localization || 1 -0.45 -0.44 0.60
613 || orf19.3294 || MBF1 || || Putative transcriptional coactivator; caspofungin repressed || 1 -0.27 -0.34 0.27
614 || orf19.7091 || || || Protein of unknown function; induced by nitric oxide; Spider biofilm repressed || 1 -0.31 0.32
615 || orf19.3656 || COX15 || || Cytochrome oxidase assembly protein; transcript regulated by Nrg1 and Tup1; alkaline repressed; Hap43-repressed; early-stage flow model biofilm induced; Spider biofilm repressed || 1 -0.37 -0.42 0.37
616 "|| orf19.4119 || SPO72 || || Protein described as similar to S. cerevisiae sporulation protein; ortholog of S. cerevisiae Atg2, an autophagic vesicle formation protein; up-regulation associated with azole resistance; Spider biofilm induced ||" 1 -0.26 -0.30 0.24
617 || orf19.7123 || || || Protein of unknown function; Spider biofilm repressed || 1 -0.35 -0.46 0.34
618 || orf19.3297 || || || Ortholog(s) have structural constituent of ribosome activity and mitochondrial small ribosomal subunit localization || 1 -0.36 -0.46 0.33
619 "|| orf19.5016 || || || Ortholog(s) have role in cellular response to UV and cytosol, nucleus localization ||" 1 -0.22 -0.28 0.20
620 || orf19.1453 || SPT5 || || Protein similar to S. cerevisiae Spt5p transcription elongation factor; transposon mutation affects filamentous growth || 1 -0.62 -0.79 0.55
621 "|| orf19.1940 || || || Ortholog(s) have role in cellular response to cadmium ion, detoxification of cadmium ion, ubiquinone biosynthetic process and mitochondrial inner membrane localization ||" 1 -0.61 -0.79 0.51
622 "|| orf19.7239 || MDG1 || || Ortholog(s) have role in pheromone-dependent signal transduction involved in conjugation with cellular fusion and cytoplasm, membrane raft, nucleus, plasma membrane localization ||" 1 -0.36 -0.57 0.35
623 "|| orf19.4456 || GAP4 || || Putative amino acid permease; hyphal induced; regulated by Hap43, Gcn2 and Gcn4; colony morphology-related gene regulation by Ssnp; detected at plasma membrane of yeast and germ tube by mass spec; Spider biofilm induced ||" 1 -0.33 -0.49 0.30
624 || orf19.1477 || || || Protein of unknown function; possible ER protein; Hap43p-repressed; Spider biofilm induced || 1 -0.62 -0.87 0.57
625 || orf19.6794 || FESUR1 || || Putative ubiquinone reductase; transcriptionally induced by interaction with macrophage; alkaline downregulated; repressed by nitric oxide; clade-associated gene expression; Hap43p-repressed gene || 1 -0.37 -0.52 0.36
626 || orf19.7529 || EPL1 || || Subunit of the NuA4 histone acetyltransferase complex || 1 -0.47 -0.63 0.43
627 "|| orf19.4943 || PSA2 || || Mannose-1-phosphate guanyltransferase; Hap43, macrophage-repressed; stationary phase enriched protein; Spider biofilm induced; rat catheter biofilm repressed ||" 1 -0.79 -0.87 0.81
628 || orf19.446 || || || Protein of unknown function; constitutive expression independent of MTL or white-opaque status; upregulated in a cyr1 mutant || 1 -0.33 0.34
629 "|| orf19.190 || || || Ortholog(s) have role in endoplasmic reticulum organization, histone exchange and Swr1 complex, mitochondrion localization ||" 1 -0.26 0.26
630 || orf19.5010 || DIM1 || || Putative 18S rRNA dimethylase; predicted role in rRNA modification and processing; Hap43-induced; likely to be essential for growth based on insertional mutagenesis strategy; F-12/CO2 early biofilm induced || 1 -0.29 -0.31 0.30
631 "|| orf19.5618 || || || Ortholog(s) have SNARE binding, unfolded protein binding activity ||" 1 -0.55 -0.58 0.60
632 "|| orf19.5661 || PTC7 || || Protein phosphatase, type 2C; has S/T phosphatase activity, Mn2+/Mg2+ dependent; predicted membrane-spanning segment and mitochondrion-targeting signal ||" 1 -0.21 0.24
633 "|| orf19.2095 || || || Ortholog(s) have role in negative regulation of transcription from RNA polymerase II promoter in response to iron and cytosol, nucleus localization ||" 1 -0.15 -0.59 0.17
634 || orf19.5360 || RPC11 || || Putative RNA polymerase III subunit C11; repressed in core caspofungin response; Spider biofilm induced || 1 -0.20 0.22
635 "|| orf19.1960 || CLN3 || || G1 cyclin; depletion abolishes budding and causes hyphal growth defects; farnesol regulated, functional in S. cerevisiae; possibly essential (UAU1 method); other biofilm induced; Spider biofilm induced ||" 1 -0.75 0.84
636 || orf19.7136 || SPT6 || || Putative transcription elongation factor; transposon mutation affects filamentous growth; transcript induced in an RHE model of oral candidiasis and in clinical isolates from oral candidiasis || 1 -0.17 -0.29 0.19
637 "|| orf19.6509 || || || Ortholog(s) have role in cellular response to zinc ion and cytosol, nucleus localization ||" 1 -0.47 0.54
638 || orf19.2612 || || || C2H2 zinc finger transcription factor; expression reduced in ssr1 null mutant; flow model biofilm induced || 1 -0.15 0.17
639 "|| orf19.2111 || || || Ortholog(s) have core RNA polymerase II binding transcription factor activity and role in transcription elongation from RNA polymerase II promoter, transcriptional start site selection at RNA polymerase II promoter ||" 1 -0.28 -0.56 0.32
640 || orf19.576 || CTF8 || || Putative kinetochore protein with a predicted role in sister chromatid cohesion; repressed during the mating process; flow model biofilm induced || 1 -0.31 -0.65 0.37
641 || orf19.10615 || || || || 1 -0.29 -0.63 0.37
642 "|| orf19.3329 || || || Ortholog(s) have sphingosine-1-phosphate phosphatase activity, role in calcium-mediated signaling and endoplasmic reticulum localization ||" 1 -0.33 0.42
643 || orf19.6915 || MRE11 || || Putative DNA double-strand break repair factor; involved in response to oxidative stress and drug resistance || 1 -0.31 0.39
644 || orf19.846 || || || Predicted protein kinase similar to S. cerevisiae Nnk1; implicated in proteasome function in S. cerevisiae; induced by Mnl1 under weak acid stress || 1 -0.19 -0.23 0.25
645 "|| orf19.4653 || || || Protein similar to GPI-linked cell-wall proteins; induced in low iron; Spider biofilm induced; regulated in Spider biofilms by Bcr1, Tec1, Ndt80, Brg1 ||" 1 -0.02 0.03
646 "|| orf19.3613 || || || Ortholog(s) have RNA polymerase II core binding, RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity, TFIIF-class binding transcription factor activity, chromatin binding activity ||" 1 -0.16 0.22
647 || orf19.147 || YAK1 || || Predicted serine-threonine protein kinase; involved in hyphal growth regulation and biofilm formation; flow model biofilm induced; induced in core caspofungin response || 1 -0.24 -0.47 0.33
648 "|| orf19.6514 || CUP9 || || Transcription factor; upregulated in clinical strains from HIV patients with oral candidiasis; yeast-hypha switch repressed; ketoconazole-induced; Plc1-regulated; colony morphology-related Ssn6 regulation; Spider, flow model biofilm induced ||" 1 -0.24 -0.53 0.32
649 || orf19.5552 || || || Putative transcriptional regulator of ribonucleotide reductase genes; Spider biofilm induced || 1 -0.33 -0.78 0.47
650 || orf19.240 || PAM17 || || Predicted component of the presequence translocase-associated import motor (PAM complex) involved in protein import into mitochondrial matrix || 1 -0.24 0.36
651 || orf19.3363 || VTC4 || || Putative polyphosphate synthetase; decreased expression in hyphae compared to yeast-form cells; fungal-specific (no human or murine homolog); virulence-group-correlated expression || 1 -0.22 -0.57 0.33
652 || orf19.13265 || || || || 1 -0.18 -0.43 0.21
653 || orf19.4668 || || || Protein with a glycoside hydrolase domain; mutants are viable || 1 -0.21 0.27
654 || orf19.2094 || PDR6 || || Putative pleiotropic drug resistance regulatory protein 6; transcript regulated by Nrg1; induced by alpha pheromone in SpiderM medium || 1 -0.18 0.23
655 "|| orf19.6358 || || || Ortholog(s) have protein homodimerization activity, ubiquitin-protein ligase activity and role in free ubiquitin chain polymerization, postreplication repair, protein K63-linked ubiquitination ||" 1 -0.35 -0.65 0.45
656 || orf19.6531 || NUC2 || || Putative NADH-ubiquinone oxidoreductase; identified in detergent-resistant membrane fraction (possible lipid raft component); alkaline repressed; Hap43-repressed; Spider biofilm repressed || 1 -0.22 -0.41 0.32
657 "|| orf19.7648 || || || Has domain(s) with predicted antiporter activity, drug transmembrane transporter activity, role in drug transmembrane transport and membrane localization ||" 1 -0.18 0.25
658 "|| orf19.7561 || DEF1 || || RNA polymerase II regulator; role in filamentation, epithelial cell escape, dissemination in RHE model; induced by fluconazole, high cell density; Efg1/hyphal regulated; role in adhesion, hyphal growth on solid media; Spider biofilm induced ||" 1 -0.40 -0.89 0.58
659 || orf19.4753 || PFK26 || || Putative 6-phosphofructo-2-kinase; protein repressed during the mating process || 1 -0.10 -0.28 0.22
660 || orf19.956 || || || Ortholog(s) have role in fermentation and mitochondrion localization || 1 -0.14 -0.43 0.30
661 || orf19.5974 || ATG9 || || Protein similar to S. cerevisiae Atg9; required for early step in autophagy; required for cytoplasm to vacuole trafficking of Lap41; Spider biofilm induced || 1 -0.16 -0.43 0.32
662 "|| orf19.4983 || || || Ortholog of C. dubliniensis CD36 : Cd36_12520, C. parapsilosis CDC317 : CPAR2_201720, Candida tenuis NRRL Y-1498 : CANTEDRAFT_108003 and Debaryomyces hansenii CBS767 : DEHA2D05214g ||" 1 -0.19 0.36
663 || orf19.2791 || BBC1 || || Putative SH3-domain-containing protein || 1 -0.23 -0.57 0.45
664 "|| orf19.3798 || || || Ortholog(s) have tRNA (guanine-N7-)-methyltransferase activity, role in tRNA methylation and nucleolus, tRNA methyltransferase complex localization ||" 1 -0.03 0.06
665 || orf19.4016 || || || Putative ubiquinol-cytochrome-c reductase; amphotericin B induced; repressed by nitric oxide; protein level decreases in stationary phase cultures; Hap43-repressed; Spider biofilm repressed || 1 -0.19 -0.40 0.35
666 || orf19.7092 || || || Putative NAD dependent epimerase/dehydratase family protein; Spider biofilm repressed || 1 -0.38 0.70
667 "|| orf19.1570 || ERG7 || || 2,3-epoxysqualene-lanosterol cyclase (lanosterol synthase), conversion of 2,3-oxidosqualene to lanosterol in sterol biosynthesis; fluconazole-induced; possibly essential, disruptants not obtained by UAU1 method; rat catheter biofilm induced ||" 1 -0.20 0.36
668 || orf19.3310 || || || Protein of unknown function; Hap43-repressed; rat catheter and Spider biofilm induced || 1 -0.33 -0.69 0.62
669 "|| orf19.6913 || GCN2 || || Translation initiation factor 2-alpha (eIF2alpha) kinase; has nonessential role in amino acid starvation response, in contrast to S. cerevisiae homolog; similar to S. cerevisiae Gcn2p ||" 1 -0.15 0.25
670 || orf19.916 || || || Putative protein involved in apoptosis; Spider biofilm induced || 1 -0.30 -0.49 0.49
671 || orf19.5161 || || || Ortholog(s) have structural constituent of ribosome activity and mitochondrial large ribosomal subunit localization || 1 -0.18 0.27
672 || orf19.5942 || || || Zinc finger protein orthologous to S. cerevisiae Itt1; repressed by adherence to polystyrene; Spider biofilm induced || 1 -0.42 0.64
673 || orf19.6811 || ISA2 || || Protein required for maturation of mitochondrial [4Fe-4S] proteins; role in biotin biosynthetic process; rat catheter and Spider biofilm induced || 1 -0.37 -0.62 0.55
674 || orf19.6035 || || || Protein of unknown function; repressed by nitric oxide || 1 -0.23 0.34
675 || orf19.4593 || RGA2 || || Putative GTPase-activating protein (GAP) for Rho-type GTPase Cdc42; involved in cell signaling pathways controlling cell polarity; induced by low-level peroxide stress; flow model biofilm induced || 1 -0.34 -0.41 0.51
676 "|| orf19.499 || || || Ortholog(s) have S-adenosylmethionine-dependent methyltransferase activity, role in translational readthrough and mitochondrion localization ||" 1 -0.12 0.18
677 || orf19.7183 || || || Ortholog(s) have role in protein folding in endoplasmic reticulum and ER membrane protein complex localization || 1 -0.31 -0.55 0.45
678 || orf19.590 || || || Putative thiamine biosynthesis enzyme; decreased expression in an ssr1 null mutant; protein present in exponential and stationary growth phase yeast cultures || 1 -0.16 -0.31 0.30
679 "|| orf19.1621 || GPA2 || || G-protein alpha subunit; regulates filamentous growth, copper resistance; involved in cAMP-mediated glucose signaling; reports differ on role in cAMP-PKA pathway, MAP kinase cascade; Gpr1 C terminus binds Gpa2; regulates HWP1 and ECE1 ||" 1 -0.14 0.29
680 || orf19.4432 || KSP1 || || Putative serine/threonine protein kinase; mRNA binds She3 and is localized to hyphal tips; mutation confers hypersensitivity to amphotericin B || 1 -0.29 -0.50 0.61
681 || orf19.1279 || CDS1 || || Protein similar to S. cerevisiae Cds1p; transposon mutation affects filamentous growth || 1 -0.56 0.55
682 || orf19.3132 || || || Predicted endoplasmic reticulum zinc transporter; induced by nitric oxide || 1 -0.84 0.10
683 || orf19.10422 || || || || 1 -0.18 0.04 0.15
684 "|| orf19.6344 || RBK1 || || Ortholog(s) have cytosol, nucleus localization ||" 1 -0.42 0.08 0.27
685 "|| orf19.6064 || || || Ortholog(s) have phosphatidylinositol binding, ubiquitin binding activity ||" 1 -0.20 0.01 0.13
686 "|| orf19.3482 || || || Ortholog(s) have NAD+ diphosphatase activity, role in NADH metabolic process and cytosol, nucleus, peroxisome localization ||" 1 -0.39 0.01 0.22
687 || orf19.7488 || || || Component of the SSU processome; predicted role in pre-18S rRNA processing; Spider biofilm induced || 1 -0.36 0.17
688 || orf19.1563 || ECM3 || || Ortholog(s) have endoplasmic reticulum localization || 1 -0.25 0.04 0.12
689 || orf19.13562 || || || || 1 -0.56 0.15 0.27
690 || orf19.7618 || || || Putative nucleolar protein with a predicted role in pre-18S rRNA processing; Plc1p-regulated; Spider biofilm induced || 1 -0.70 0.26
691 "|| orf19.5846 || || || Putative TFIIH and nucleotide excision repair factor 3 complex subunit; possibly an essential gene, disruptants not obtained by UAU1 method ||" 1 -0.29 0.11
692 || orf19.11208 || || || || 1 -0.53 0.09 0.19
693 "|| orf19.809 || || || Ortholog(s) have role in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and nucleolus, preribosome localization ||" 1 -0.26 0.01 0.11
694 "|| orf19.5941 || || || Ortholog(s) have role in ER to Golgi vesicle-mediated transport and ER to Golgi transport vesicle, integral to Golgi membrane, integral to endoplasmic reticulum membrane localization ||" 1 -0.46 0.03 0.18
695 || orf19.7054 || || || Dubious open reading frame || 1 -0.49 -0.00 0.18
696 || orf19.6535 || || || Predicted ORF from Assembly 19; merged with orf19.6534.2 in Assembly 20 || 1 -0.31 -0.02 0.13
697 || orf19.6524 || TOM40 || || Protein involved in mitochondrial protein import; Spider biofilm repressed || 1 -0.12 -0.00 0.06
698 || orf19.9218 || || || || 1 -0.36 -0.01 0.19
699 "|| orf19.5197 || APE2 || || Neutral arginine, alanine, leucine specific metallo-aminopeptidase; purified from cell wall/intracellular fractions; protein repressed during mating; Hog1, farnesol-induced; may be essential (UAU1 method); rat catheter biofilm repressed ||" 1 -0.31 -0.02 0.16
700 "|| orf19.4855 || BUD31 || || Bud31 ortholog; not subject to mating-type regulation, in contrast to S. cerevisiae Bud31 which has a role in specifying the bud site; Spider biofilm induced ||" 1 -0.24 0.15
701 || orf19.4896 || RPA34 || || Putative RNA polymerase I subunit; rat catheter biofilm induced || 1 -0.67 -0.08
702 || orf19.3430 || || || Plasma membrane-associated protein; physically interacts with TAP-tagged Nop1p || 1 -0.40 -0.08 0.13
703 || orf19.7072 || PEL1 || || Predicted enzyme of mitochondrial phospholipid biosynthesis; rat catheter and flow model biofilm induced || 1 -0.47 0.16
704 "|| orf19.111 || CAN2 || || Basic amino acid permease; arginine metabolism; regulated by Nrg1/Tup1; caspofungin, flucytosine induced; colony morphology-related regulation by Ssn6; Hap43-repressed; rat catheter and Spider biofilm induced; promoter bound by Efg1 ||" 1 -0.42 -0.06 0.14
705 || orf19.12265 || FTH1 || || || 1 -0.24 0.08
706 "|| orf19.4599 || PHO89 || || Putative phosphate permease; transcript regulated upon white-opaque switch; alkaline induced by Rim101; possibly adherence-induced; F-12/CO2 model, rat catheter and Spider biofilm induced ||" 1 -0.17 -0.05 0.05
707 || orf19.684 || || || Putative transcription factor with zinc finger DNA-binding motif; heterozygous null mutant exhibits hypersensitivity to parnafungin and cordycepin in the C. albicans fitness test || 1 -0.49 0.13
708 "|| orf19.6803 || HUT1 || || Ortholog(s) have UDP-galactose transmembrane transporter activity, role in UDP-galactose transmembrane transport, UDP-glucose transport, regulation of protein folding in endoplasmic reticulum and endoplasmic reticulum localization ||" 1 -0.42 -0.00 0.10
709 || orf19.7222 || PAM16 || || Putative maltase; regulated by Gcn4; repressed by amino acid starvation (3-AT); rat catheter biofilm induced || 1 -0.57 -0.02 0.15
710 || orf19.1200 || || || Protein of unknown function; Spider biofilm induced || 1 -0.19 0.05
711 || orf19.7115 || SAC7 || || Putative GTPase activating protein (GAP) for Rho1; repressed upon adherence to polystyrene; macrophage/pseudohyphal-repressed; transcript is upregulated in RHE model of oral candidiasis and in clinical oral candidiasis || 1 -0.51 -0.01 0.14
712 "|| orf19.6649 || BRF1 || || Component of the general transcription factor for RNA polymerase III (TFIIIB); possibly an essential gene, disruptants not obtained by UAU1 method ||" 1 -0.31 -0.03 0.08
713 || orf19.1664 || || || Protein of unknown function; expression downregulated in an ssr1 null mutant || 1 -0.26 0.08
714 || orf19.1091 || NOP8 || || Ortholog of S. cereviiae Nop8; has a role in ribosomal large subunit biogenesis; rat catheter and Spider biofilm induced || 1 -0.48 -0.03 0.16
715 "|| orf19.7378 || || || Ortholog(s) have phosphopantothenoylcysteine decarboxylase activity, protein phosphatase inhibitor activity and role in regulation of mitotic cell cycle, response to salt stress ||" 1 -0.36 0.01 0.02
716 || orf19.7531 || || || Protein of unknown function; stationary phase enriched protein; induced upon yeast-hypha transition; benomyl or caspofungin induced; Hap43-repressed; Spider biofilm induced || 1 -0.54 -0.01 0.01
717 || orf19.2393 || || || Putative transcription factor with zinc finger DNA-binding motif || 1 -0.14 0.00
718 || orf19.6831 || PRP5 || || Putative pre-mRNA processing RNA-helicase; induced upon adherence to polystyrene; rat catheter and Spider biofilm induced || 1 -0.43 0.03
719 "|| orf19.1426 || || || Ortholog of S. cerevisiae Skg6; localizes to the cell cortex, cell bud neck, cell bud tip, incipient cellular bud site, and is membrane-bound; Spider biofilm induced ||" 1 -0.90 0.07
720 "|| orf19.7367 || UBP1 || || Ortholog(s) have ubiquitin-specific protease activity, role in protein deubiquitination and endoplasmic reticulum localization ||" 1 -0.48 -0.02 0.04
721 "|| orf19.1626 || || || Deoxyhypusine synthase; catalyzes formation of deoxyhypusine, the first step in hypusine biosynthesis; Spider biofilm repressed ||" 1 -0.41 0.04
722 || orf19.1281 || || || Putative splicing factor required for the first step of pre-mRNA splicing; Spider biofilm induced || 1 -0.59 -0.09 0.06
723 "|| orf19.696 || STE2 || || Receptor for alpha factor mating pheromone, MFalpha; required for a-type cells to respond to alpha factor, for opaque a-form mating and white a-form response; possible Kex2p substrate; a-specific, alpha-factor induced, A1p-Alpha2p repressed ||" 1 -0.16 -0.03 0.02
724 || orf19.939 || NAM7 || || Putative role in nonsense-mediated mRNA decay; similar to S. cerevisiae Nam7p; gene induced by ciclopirox olamine treatment || 1 -0.41 -0.07 0.04
725 || orf19.5436 || UTP8 || || Essential nucleolar protein; involved in tRNA export from the nucleus and ribosomal small subunit biogenesis; physically interacts with TAP-tagged Nop1; Spider biofilm induced || 1 -0.74 0.06
726 || orf19.5418 || || || Ortholog(s) have role in ER to Golgi vesicle-mediated transport and endoplasmic reticulum localization || 1 -0.81 -0.07 0.07
727 || orf19.2208 || || || Ortholog(s) have role in response to salt stress and cytoplasm localization || 1 -0.41 -0.04 0.05
728 "|| orf19.2099 || HIR1 || || Component of the HIR complex, a nucleosome assembly factor involved in chromatin formation; involved in regulation of white-opaque switching frequency ||" 1 -0.30 0.04
729 "|| orf19.434 || PRD1 || || Putative proteinase; transcript regulated by Nrg1, Mig1, and Tup1; Hogp-induced; stationary phase enriched protein; Hap43-repressed; rat catheter biofilm repressed ||" 1 -0.41 -0.05 0.04
730 || orf19.4450 || ZCF23 || || Predicted Zn(II)2Cys6 transcription factor; ortholog of S. cerevisiae Gsm1; flow model biofilm induced || 1 -0.63 -0.05
731 || orf19.3653 || FAT1 || || Predicted enzyme of sphingolipid biosynthesis; upregulated in biofilm || 1 -0.32 0.05
732 || orf19.3345 || SIZ1 || || Possible SUMO/Smt3 ligase; Rim101-repressed || 1 -0.23 0.11 -0.02
733 "|| orf19.549 || || || Ortholog(s) have structural constituent of ribosome activity and mitochondrial inner membrane, mitochondrial large ribosomal subunit localization ||" 1 -0.28 0.11 0.02
734 "|| orf19.7221 || SET3 || || NAD-dependent histone deacetylase; mutations affect filamentous growth; genetic evidence suggests Set3/Hos2 function as a complex to regulate white-opaque switching, morphogenesis, and virulence; flow model biofilm induced ||" 1 -0.36 0.16 0.06
735 || orf19.2701 || || || Protein of unknown function; Ras1 and Cyr1 repressed; rat catheter and Spider biofilm induced || 1 -0.80 0.14
736 || orf19.6236 || NOP6 || || Putative ortholog of S. cerevisiae Nop6; role in ribosomal small subunit biogenesis; Spider biofilm induced || 1 -0.29 0.08 0.05
737 || orf19.6990 || || || Putative peptidyl-prolyl cis-trans isomerase; predicted endoplasmic reticulum (ER) localization || 1 -0.76 0.17 0.08
738 || orf19.44 || || || Predicted ORF from Assembly 19; removed from Assembly 20 || 1 -0.55 0.09 0.04
739 || orf19.4495 || NDH51 || || Nicotinamide adenine dinucleotide dehydrogenase complex I subunit of the mitochondrial electron transport chain; required for wild-type filamentous growth; alkaline repressed; Hap43-repressed; Spider biofilm repressed || 1 -0.18 0.03 0.03
740 || orf19.414 || RSM22 || || Predicted mitochondrial small ribosomal subunit; rat catheter and Spider biofilm induced || 1 -0.36 0.06
741 "|| orf19.2518 || || || Ortholog(s) have ATPase activator activity, soluble NSF attachment protein activity ||" 1 -0.34 0.04 0.04
742 || orf19.585 || || || Ortholog(s) have structural constituent of ribosome activity and mitochondrial large ribosomal subunit localization || 1 -0.41 0.04
743 "|| orf19.7599 || UTP5 || || Putative U3 snoRNA-associated protein; Hap43p-induced gene; mutation confers resistance to 5-fluorocytosine (5-FC), 5-fluorouracil (5-FU), and tubercidin (7-deazaadenosine); physically interacts with TAP-tagged Nop1p ||" 1 -0.55 0.02 0.08
744 "|| orf19.2167 || || || Ortholog(s) have role in ribosomal large subunit biogenesis, ribosomal small subunit biogenesis and cytosolic large ribosomal subunit, nucleolus localization ||" 1 -0.47 0.05 -0.04
745 || orf19.2504 || BMS1 || || Putative GTPase; Hap43-induced gene; mutation confers resistance to 5-fluorocytosine (5-FC); flucytosine induced; repressed by prostaglandins; Spider biofilm induced || 1 -0.37 0.07 -0.01
746 || orf19.1142 || AVT4 || || Putative vacuolar transporter of large neutral amino acids; induced by alpha pheromone in SpiderM medium || 1 -0.48 -0.01
747 || orf19.3328 || || || Putative transcription factor; S. cerevisiae ortholog Hot1 is required for the transient induction of glycerol biosynthetic genes GPD1 and GPP2 in response to high osmolarity; filament induced || 1 -0.43 -0.01
748 || orf19.2684 || || || Protein of unknown function; flow model biofilm repressed || 1 -0.40 0.07 -0.02
749 || orf19.12110 || PWP1 || || || 1 -0.39 0.09 -0.04
750 "|| orf19.979 || FAS1 || || Beta subunit of fatty-acid synthase; multifunctional enzyme; Hap43, fluconazole-induced; amphotericin B, caspofungin repressed; macrophage/pseudohyphal-induced; flow model and Spider biofilm repressed ||" 1 -0.82 0.09
751 "|| orf19.5081 || FUN12 || || Functional homolog of S. cerevisiae Fun12 translation initiation factor eIF5B; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage ||" 1 -0.26 -0.06
752 || orf19.7236 || TIF35 || || Putative translation initiation factor; repressed upon phagocytosis by murine macrophage; Spider biofilm repressed || 1 -0.64 -0.23 0.06
753 || orf19.13978 || || || || 1 -0.53 0.05
754 || orf19.3856 || CDC28 || || Cyclin-dependent protein kinase; interacts with regulatory subunit Cyb1; determination of cell morphology during the cell cycle; phosphorylated mostly by Swe1 and phosphorylation is regulated by Hsl1; 5'-UTR intron; Spider biofilm repressed || 1 -0.50 -0.21 0.04
755 "|| orf19.7336 || || || Predicted membrane transporter; member of the drug:proton antiporter (14 spanner) (DHA2) family, major facilitator superfamily (MFS); Spider biofilm induced ||" 1 -0.52 -0.22 0.08
756 "|| orf19.4553 || || || Ortholog of C. dubliniensis CD36 : Cd36_64990, C. parapsilosis CDC317 : CPAR2_600170, Candida tenuis NRRL Y-1498 : CANTEDRAFT_121753 and Debaryomyces hansenii CBS767 : DEHA2E19712g ||" 1 -0.21 -0.09 0.03
757 "|| orf19.4430 || || || Ortholog(s) have ubiquitin binding activity, role in proteasome-mediated ubiquitin-dependent protein catabolic process and cytoplasm, nucleus localization ||" 1 -0.37 0.05
758 "|| orf19.7141 || UFE1 || || Protein interacting with Sec20p, possibly involved in retrograde transport between the Golgi and the endoplasmic reticulum; functional homolog of S. cerevisiae Ufe1p, which is an ER t-SNARE that mediates the retrograde traffic ||" 1 -0.41 0.06
759 "|| orf19.4659 || || || Ortholog(s) have RNA binding activity, role in mRNA splicing, via spliceosome and U2 snRNP, U2-type prespliceosome localization ||" 1 -0.71 -0.18 0.10
760 "|| orf19.3260 || || || Ortholog(s) have phosphopantothenoylcysteine decarboxylase activity, role in coenzyme A biosynthetic process, response to salt stress and phosphopantothenoylcysteine decarboxylase complex localization ||" 1 -0.57 -0.11 0.15
761 || orf19.760 || || || Ortholog(s) have role in ribosome biogenesis and mitochondrion localization || 1 -0.24 0.06
762 || orf19.7379 || FAA2 || || Putative acyl CoA synthetase; expression regulated upon white-opaque switch; rat catheter biofilm induced; Spider biofilm induced || 1 -0.57 -0.18 0.13
763 || orf19.698 || || || Integral ER membrane protein; predicted role in maintenance of ER zinc homeostasis; Spider biofilm induced || 1 -0.32 -0.09 0.07
764 "|| orf19.5965 || || || Ortholog(s) have ubiquitin-ubiquitin ligase activity, role in ER-associated ubiquitin-dependent protein catabolic process, protein ubiquitination, response to stress and cytoplasm, nucleus localization ||" 1 -0.36 -0.11 0.06
765 || orf19.905 || AVT7 || || Ortholog of S. cerevisiae Avt7 transporter; repressed upon adherence to polystyrene; constitutive expression independent of MTL or white-opaque status; Spider biofilm induced || 1 -0.59 -0.23 0.14
766 || orf19.5689 || || || Epsilon-COP subunit of the coatomer; regulates retrograde Golgi-to-ER protein traffic; Spider biofilm repressed || 1 -0.27 -0.11 0.07
767 "|| orf19.7255 || RPC10 || || Putative RNA polymerase subunit ABC10-alpha of RNA polymerase complexes I, II, and III; flucytosine induced; Spider biofilm induced ||" 1 -0.29 -0.14 0.07
768 || orf19.7030 || SSR1 || || Beta-glucan associated ser/thr rich cell-wall protein with a role in cell wall structure; GPI anchor; similar mRNA abundance in yeast-form and germ tubes; detected at germ tube plasma membrane; repressed in cells treated with Congo Red || 1 -0.57 -0.29 0.16
769 || orf19.5758 || SAL6 || || Putative protein phosphatase of the Type 1 family; serine/threonine-specific; similar to S. cerevisiae Ppq1; mutant has virulence defect; Spider biofilm induced || 1 -0.38 -0.20 0.11
770 "|| orf19.3117 || CSA2 || || Extracellular-associated protein; repressed by Rim101 at pH 8; regulated by Tsa1, Tsa1B in minimal media at 37 deg; induced by ketoconazole, nitric oxide, Hap43; required for normal RPMI biofilm formation; Bcr1 induced in RPMI ||" 1 -0.43 -0.23 0.18
771 "|| orf19.4522 || || || Ortholog(s) have role in response to drug and cytosol, nucleus localization ||" 1 -0.45 0.17
772 "|| orf19.27 || || || Ortholog of C. dubliniensis CD36 : Cd36_20860, C. parapsilosis CDC317 : CPAR2_104250, Candida tenuis NRRL Y-1498 : CANTEDRAFT_115100 and Debaryomyces hansenii CBS767 : DEHA2E10450g ||" 1 -0.28 0.10
773 || orf19.7258 || DDI1 || || Putative DNA damage inducible v-SNARE binding protein; macrophage/pseudohyphal-repressed || 1 -0.66 -0.27 0.24
774 || orf19.4100 || || || Predicted ORF from Assembly 19; merged with orf19.564 in Assembly 20 || 1 -0.94 -0.18 0.42
775 || orf19.4166 || ZCF21 || || Predicted Zn(II)2Cys6 transcription factor; mutants display increased colonization of mouse kidneys; Spider biofilm induced || 1 -0.50 0.22
776 "|| orf19.6747 || || || Ortholog(s) have acid phosphatase activity, role in dephosphorylation, intracellular sterol transport and cytoplasm, nucleus localization ||" 1 -0.45 -0.14 0.20
777 "|| orf19.2256 || || || Ortholog(s) have cytosol, nucleus localization ||" 1 -0.57 0.26
778 || orf19.874 || || || Predicted mitochondrial i-AAA protease supercomplex; degrades misfolded mitochondrial proteins; Hap43-repressed gene || 1 -0.39 -0.12 0.18
779 || orf19.5114 || || || Sorting nexin; role in maintaining late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; Spider biofilm induced || 1 -0.40 -0.11 0.14
780 || orf19.1801 || CBR1 || || Putative cytochrome B5 reductase; plasma membrane-localized || 1 -0.25 -0.08 0.08
781 || orf19.7565 || GNP3 || || Putative high-affinity glutamine permease; fungal-specific (no human or murine homolog) || 1 -0.50 -0.15 0.16
782 "|| orf19.3833 || || || Putative DNA-binding transcription factor; decreased transcription is observed upon fluphenazine treatment; possibly an essential gene, disruptants not obtained by UAU1 method; Hap43p-induced gene ||" 1 -0.36 -0.14 0.12
783 "|| orf19.3474 || IPL1 || || Putative Aurora kinase; Hap43-induced; induced during planktonic growth; possibly an essential gene, disruptants not obtained by UAU1 method ||" 1 -0.70 0.28
784 "|| orf19.7387 || ELP3 || || Predicted histone acetyltransferase; role in regulation of transcription, tRNA wobble uridine modification; Spider biofilm induced ||" 1 -0.51 -0.24 0.20
785 || orf19.7424 || NSA2 || || Putative protein constituent of 66S pre-ribosomal particles; Hap43-induced; repressed by prostaglandins || 1 -0.44 -0.20 0.16
786 || orf19.4204 || || || Ortholog(s) have structural constituent of ribosome activity and mitochondrial small ribosomal subunit localization || 1 -0.21 -0.09 0.08
787 || orf19.5459 || || || mRNA polyadenylation regulating protein; Hap43-repressed; transcript is upregulated in RHE model of oral candidiasis and in clinical isolates from HIV+ patients with oral candidiasis; Spider biofilm repressed || 1 -0.62 0.25
788 "|| orf19.2333 || || || Ortholog(s) have role in retrograde transport, endosome to Golgi and cytosol, late endosome, nucleus localization ||" 1 -0.54 0.22
789 "|| orf19.3182 || GIS2 || || Translational activator for mRNAs with internal ribosome entry sites; induced in high iron; repressed by yeast-hypha switch; null exhibits sensitivity to sorbitol, 5-fluorocytosine, and cold temperatures; Spider biofilm repressed ||" 1 -0.32 -0.23 0.13
790 || orf19.6710 || UTP9 || || Small-subunit processome protein; Ssr1-induced; repressed by prostaglandins; physically interacts with TAP-tagged Nop1 || 1 -0.60 -0.11 0.02
791 || orf19.6041 || RPO41 || || Putative mitochondrial RNA polymerase; repressed in core stress response; Spider biofilm induced || 1 -0.40 -0.09 0.00
792 || orf19.7569 || SIK1 || || Putative U3 snoRNP protein; Hap43p-induced gene; physically interacts with TAP-tagged Nop1p || 1 -0.50 -0.10 -0.01
793 || orf19.14145 || || || || 1 -0.27 -0.01
794 || orf19.10232 || SAS10 || || || 1 -0.15 -0.04 -0.00
795 "|| orf19.3250 || || || Ortholog(s) have RNA binding activity, role in mRNA cis splicing, via spliceosome and U1 snRNP, U2-type prespliceosome localization ||" 1 -0.32 -0.11 -0.03
796 "|| orf19.5801 || RNR21 || || Ribonucleoside-diphosphate reductase; regulated by tyrosol and cell density; ciclopirox olamine, fluconazole or flucytosine induced; regulated by Sef1, Sfu1, and Hap43 ||" 1 -0.30 -0.02
797 "|| orf19.4096 || TAZ1 || || Putative lyso-phosphatidylcholine acyltransferase, required for normal phospholipid content of mitochondrial membranes; rat catheter biofilm induced ||" 1 -0.48 -0.17
798 "|| orf19.390 || CDC42 || || Rho-type GTPase; required for budding and maintenance of hyphal growth; GGTase I geranylgeranylated; misexpression blocks hyphal growth, causes avirulence in mouse IV infection; shows actin-dependent localization to hyphal tip ||" 1 -0.77 -0.04
799 || orf19.4805 || || || Putative membrane protein; induced by alpha pheromone in SpiderM medium; Hap4-induced gene; Spider biofilm induced || 1 -0.69 -0.15
800 "|| orf19.417 || MTM1 || || Ortholog(s) have metallochaperone activity, role in manganese ion transport and mitochondrion localization ||" 1 -0.38 -0.05
801 || orf19.6817 || FCR1 || || Transcription factor; repressor of fluconazole/ketoconazole/brefeldin A resistance; Tn mutation enhances filamentation; partially rescues S. cerevisiae pdr1 pdr3 fluconazole sensitivity; rat catheter biofilm induced/Spider biofilm repressed || 1 -0.53 -0.16 -0.07
802 || orf19.7029 || || || Putative guanine deaminase; mutation confers hypersensitivity to toxic ergosterol analog; Spider biofilm induced || 1 -0.29 -0.06 -0.03
803 "|| orf19.5741 || ALS1 || || Cell-surface adhesin; adhesion, virulence, immunoprotective roles; band at hyphal base; Rfg1, Ssk1, Spider biofilm induced; flow model biofilm repressed; CAI-4 strain background effects; promoter bound Bcr1, Tec1, Efg1, Ndt80, and Brg1 ||" 1 -0.59 -0.12 -0.06
804 "|| orf19.3887 || || || Ortholog(s) have cytoplasm, nucleus localization ||" 1 -0.14 -0.02
805 || orf19.726 || PPZ1 || || Protein phosphatase Z; type 1 family serine/threonine specific protein phosphatase involved in cation homeostasis and cell wall integrity || 1 -0.48 -0.07 -0.06
806 || orf19.10653 || || || || 1 -0.31 -0.06 -0.05
807 "|| orf19.3751 || || || Putative serine/threonine protein kinase; possibly an essential gene, disruptants not obtained by UAU1 method ||" 1 -0.91 -0.37 -0.15
808 "|| orf19.2444 || CHS7 || || Protein required for wild-type chitin synthase III activity; similar to (but not functional homolog of) S. cerevisiae Chs7p, which effects ER export of Chs3p; induced cyr1 mutant hyphae and ras1 yeast-form cells; Spider biofilm induced ||" 1 -0.72 -0.24 -0.11
809 "|| orf19.4563 || || || Protein of unknown function; repressed by prostaglandins; Hap43-induced, Spider biofilm induced ||" 1 -0.82 -0.30 -0.05
810 "|| orf19.6992 || || || Predicted MFS membrane transporter, member of the drug:proton antiporter (12 spanner) (DHA1) family; Spider biofilm induced ||" 1 -0.44 -0.02
811 "|| orf19.3831 || || || Ortholog(s) have telomerase inhibitor activity, role in box C/D snoRNA 3'-end processing, negative regulation of telomere maintenance via telomerase and nucleolus, nucleoplasm localization ||" 1 -0.35 -0.18 -0.02
812 "|| orf19.6099 || CCT8 || || Chaperonin-containing T-complex subunit; role in hyphal morphogenesis, particularly starvation-induced; essential; expression in S. cerevisiae inhibits Ras2-mediated pathways; CCT8 and TRP1 overlap; Spider biofilm repressed ||" 1 -0.13 -0.08 -0.03
813 || orf19.7327 || PHO88 || || Protein with a role in phosphate transport; biofilm-regulated expression; amphotericin B repressed || 1 -0.56 -0.14
814 || orf19.5947 || SEC7 || || Putative guanine nucleotide exchange factor (GEF); mutation confers hypersensitivity to Brefeldin A; caspofungin repressed || 1 -0.32 -0.12 -0.10
815 || orf19.1712 || GEA2 || || Putative ARF GTP/GDP exchange factor; induced in low iron; flow model biofilm repressed || 1 -0.82 -0.23
816 || orf19.5106 || DIP2 || || Putative small ribonucleoprotein complex; Tn mutation affects filamentous growth; physically interacts with TAP-tagged Nop1; heterozygous null mutant exhibits resistance to parnafungin; Hap43-induced gene; Spider biofilm induced || 1 -0.66 -0.28 -0.18
817 || orf19.3355 || ISN1 || || Putative inosine 5'-monophosphate 5'-nucleotidase; fungal-specific (no human or murine homolog) || 1 -0.38 -0.17 -0.13
818 || orf19.3564 || RPC40 || || Putative RNA polymerase; protein level decreases in stationary phase cultures; Hap43p-induced gene || 1 -0.52 -0.24 -0.14
819 "|| orf19.3959 || SSD1 || || Protein with role in resistance to host antimicrobial peptides; virulence role in murine infection; functional homolog of S. cerevisiae Ssd1p, which suppresses various mutant phenotypes; constitutively expressed and not cell-cycle regulated ||" 1 -0.42 -0.20 -0.12
820 || orf19.8907 || RBT1 || || || 1 -1.34 -0.51 -0.39
821 "|| orf19.1687 || || || Ortholog of S. cerevisiae Prp43, an RNA helicase in the DEAH-box family that functions in both RNA polymerase I and polymerase II transcript metabolism; Hap43-induced gene ||" 1 -0.59 -0.17
822 "|| orf19.6403 || || || Ortholog(s) have adenyl-nucleotide exchange factor activity, role in SRP-dependent cotranslational protein targeting to membrane, translocation and endoplasmic reticulum localization ||" 1 -0.39 -0.22 -0.13
823 || orf19.5068 || IRE1 || || Putative protein kinase; role in cell wall regulation; mutant is hypersensitive to caspofungin; Spider biofilm induced || 1 -0.14 -0.12 0.13
824 "|| orf19.6987 || DNM1 || || Putative dynamin-related GTPase; transcript upregulated inbRHE model of oral candidiasis; transcript regulated by Nrg1, Mig1, and Tup1 ||" 1 -0.49 0.46
825 "|| orf19.1754 || || || Putative calmodulin-dependent protein kinase; possibly an essential gene, disruptants not obtained by UAU1 method ||" 1 -0.30 -0.12 0.28
826 || orf19.1162 || || || Protein of unknown function; transcript upregulated by benomyl treatment || 1 -0.20 -0.08 0.17
827 || orf19.10676 || || || || 1 -0.35 0.29
828 || orf19.563 || RRP15 || || Putative nucleolar protein; constituent of pre-60S ribosomal particles; Hap43-induced; repressed by prostaglandins || 1 -0.25 -0.08 0.20
829 "|| orf19.1531 || || || Ortholog(s) have RNA binding, protein heterodimerization activity, role in mRNA cleavage, mRNA polyadenylation and cytosol, mRNA cleavage factor complex, mitochondrion localization ||" 1 -0.28 -0.07 0.22
830 || orf19.4987 || NUP49 || || Nuclear pore protein || 1 -0.57 -0.14 0.46
831 || orf19.8303 || YHM1 || || || 1 -0.29 0.26
832 "|| orf19.474 || || || Ortholog(s) have role in mRNA export from nucleus, nuclear envelope organization, protein export from nucleus and endoplasmic reticulum, nuclear envelope localization ||" 1 -0.20 0.17
833 "|| orf19.337 || VTI1 || || Ortholog(s) have SNAP receptor activity and role in Golgi to vacuole transport, intra-Golgi vesicle-mediated transport, vacuole fusion, non-autophagic, vesicle fusion ||" 1 -0.58 0.50
834 "|| orf19.3342 || || || Ortholog(s) have role in protein deubiquitination and cytoplasm, nucleus localization ||" 1 -0.27 0.24
835 || orf19.4591 || CAT2 || || Major carnitine acetyl transferase; intracellular acetyl-CoA transport; localized in peroxisomes and mitochondria; induced in macrophages; Hog1-repressed; stationary phase enriched; farnesol-upregulated in biofilm; Spider biofilm induced || 1 -0.39 -0.08 0.34
836 "|| orf19.4445 || || || Protein of unknown function; Plc1p-regulated; expression induced early upon infection of reconstituted human epithelium (RHE), while expression of the C. dubliniensis ortholog is not; mutant is viable; Spider biofilm induced ||" 1 -0.57 -0.17 0.53
837 "|| orf19.1528 || || || Putative mitochondrial RNA polymerase specificity factor; possibly an essential gene, disruptants not obtained by UAU1 method ||" 1 -0.29 -0.10 0.28
838 "|| orf19.6424 || || || Ortholog(s) have SUMO ligase activity and role in cellular response to DNA damage stimulus, hyphal growth, mitotic spindle elongation, protein sumoylation, regulation of mitotic cell cycle ||" 1 -0.30 -0.09 0.30
839 "|| orf19.5455 || || || Ortholog(s) have mRNA binding, small GTPase regulator activity ||" 1 -0.47 -0.14 0.35
840 || orf19.2557 || SEC65 || || Component of the protein-targeting Signal Recognition Particle (SRP); similar to mammalian Srp19; functional homolog of S. cerevisiae Sec65; Tbf1-induced || 1 -0.13 -0.05 0.09
841 "|| orf19.1588 || || || Putative mitochondrial protein of unknown function; regulated by Sef1p-, Sfu1p-, and Hap43p ||" 1 -0.35 0.25
842 || orf19.5141 || || || Ortholog of Candida albicans WO-1 : CAWG_05647 || 1 -0.13 0.09
843 || orf19.13133 || || || || 1 -0.37 0.27
844 "|| orf19.4538 || || || Ortholog(s) have mRNA binding, protein heterodimerization activity, role in mRNA cleavage, mRNA polyadenylation and U2 snRNP, mRNA cleavage factor complex localization ||" 1 -0.47 0.34
845 || orf19.2275 || || || Putative mitochondrial ribosomal protein; predicted role in aerobic respiration; Spider biofilm repressed || 1 -0.12 -0.11 0.09
846 "|| orf19.1907 || EMC9 || || Ortholog of S. cerevisiae Nnf2; possible role in chromosome segregation; mutants are viable, induced during the mating process ||" 1 -0.19 0.12
847 || orf19.7095 || || || Ortholog(s) have endoplasmic reticulum localization || 1 -0.29 -0.09 0.19
848 || orf19.104 || || || Protein of unknown function; induced by alpha pheromone in SpiderM medium || 1 -0.30 0.20
849 || orf19.3867 || RPL7 || || Ribosomal protein L7; repressed upon phagocytosis by murine macrophages; Hap43-induced; rat catheter and Spider biofilm induced || 1 -0.12 -0.06 0.08
850 "|| orf19.2809 || CTN3 || || Peroxisomal carnitine acetyl transferase; no obvious metabolic, hyphal, virulence defects in Ura+ strain; induced by macrophage engulfment, hyphal growth, starvation, nonfermentable carbon sources; rat catheter, Spider biofilm induced ||" 1 -0.37 -0.17 0.25
851 "|| orf19.969 || || || Ortholog(s) have ribose phosphate diphosphokinase activity, role in 5-phosphoribose 1-diphosphate biosynthetic process, cytokinesis, fungal-type cell wall organization and cytosol, nucleus localization ||" 1 -0.42 -0.22 0.30
852 "|| orf19.4448 || SOG2 || || Leucine-rich-repeat domain protein of RAM cell wall integrity signaling network; role in cell separation, azole sensitivity; required for hyphal growth; lacks orthologs in higher eukaryotes ||" 1 -0.67 -0.37 0.51
853 || orf19.4842 || || || Protein of unknown function; Spider biofilm induced || 1 -0.51 -0.29 0.39
854 || orf19.7477 || YRB1 || || Functional homolog of S. cerevisiae Yrb1p; regulates Gsp1 GTPase activity and thereby affects nucleocytoplasmic transport and cytoskeletal dynamics; transcript is not regulated by white-opaque switch or by dimorphic transition || 1 -0.29 -0.18 0.22
855 "|| orf19.4297 || CKB2 || || Regulatory subunit of protein kinase CK2 (casein kinase II), beta' subunit; null mutants are hypersensitive to caspofungin ||" 1 -0.32 -0.21 0.27
856 || orf19.5030 || DOS2 || || Protein of unknown function; induced during planktonic growth || 1 -0.29 -0.19 0.26
857 "|| orf19.5732 || NOG2 || || Putative nucleolar GTPase; repressed by prostaglandins; Hap43-induced, rat catheter and Spider biofilm induced ||" 1 -0.45 -0.26 0.39
858 || orf19.3058 || COQ6 || || Ortholog(s) have role in ubiquinone biosynthetic process and mitochondrial inner membrane localization || 1 -0.47 -0.19 0.42
859 "|| orf19.871 || || || Ortholog(s) have protein transporter activity, role in Golgi to plasma membrane transport, intracellular protein transport and vesicle coat localization ||" 1 -0.28 0.25
860 "|| orf19.3064 || MRPL27 || || Putative 60S ribosomal protein L27, mitochondrial precursor ||" 1 -0.37 -0.17 0.31
861 || orf19.1682 || || || Membrane protein; Hap43p-repressed gene; repressed by nitric oxide || 1 -0.34 -0.17 0.28
862 "|| orf19.6739 || || || Ortholog(s) have phosphopentomutase activity, role in deoxyribose phosphate catabolic process and cytosol, nucleus localization ||" 1 -0.60 0.52
863 "|| orf19.7109 || || || Ortholog(s) have role in meiosis and cytosol, nucleus localization ||" 1 -0.28 0.24
864 || orf19.8830 || || || || 1 -0.35 -0.22 0.30
865 || orf19.2901 || NUP60 || || Ortholog of S. cerevisiae Nup60p; a subunit of the nuclear pore complex; mutants are viable || 1 -0.30 0.26
866 || orf19.7103 || || || Predicted exonuclease; Spider biofilm induced || 1 -0.48 0.41
867 "|| orf19.1832 || FCY23 || || Putative transporter; Gcn4p-regulated; more similar to S. cerevisiae Tpn1p, which is a vitamin B6 transporter, than to purine-cytosine permeases ||" 1 -0.28 -0.22
868 || orf19.742 || ALD6 || || Putative aldehyde dehydrogenase; stationary phase enriched protein; expression regulated upon white-opaque switch; rat catheter biofilm induced; rat catheter and Spider biofilm induced || 1 -0.59 0.37
869 "|| orf19.5702 || || || Ortholog(s) have cell division site, spindle localization ||" 1 -0.19 -0.09 0.14
870 "|| orf19.7295 || || || Ortholog(s) have protein phosphatase 1 binding activity, role in actin filament organization, cortical actin cytoskeleton organization, endocytosis, protein secretion and actin cortical patch, nucleus localization ||" 1 -0.13 0.10
871 "|| orf19.7500 || PXA1 || || Putative peroxisomal, half-size adrenoleukodystrophy protein (ALD or ALDp) subfamily ABC family transporter ||" 1 -0.35 -0.11 0.27
872 "|| orf19.7119 || RAD3 || || Ortholog of S. cerevisiae Rad3; 5' to 3' DNA helicase, nucleotide excision repair and transcription, subunit of RNA polII initiation factor TFIIH and Nucleotide Excision Repair Factor 3 (NEF3) ||" 1 -0.38 -0.05 0.29
873 "|| orf19.7391 || OCH1 || || Alpha-1,6-mannosyltransferase; initiates N-glycan outer chain branch addition; similar to S. cerevisiae Och1p; required for wild-type virulence in mouse intravenous infection; fungal-specific (no human or murine homolog) ||" 1 -0.64 0.47
874 "|| orf19.1403 || || || Ortholog(s) have ATP:ADP antiporter activity, calcium ion binding activity, role in ADP transport, ATP transport, mitochondrial transport and mitochondrion localization ||" 1 -0.12 -0.02 0.09
875 "|| orf19.7469 || ARG1 || || Argininosuccinate synthase; arginine synthesis; Gcn4, Rim101 regulated; induced by amino acid starvation (3-AT), benomyl treatment; stationary phase enriched protein; repressed in alkalinizing medium; rat catheter, Spider biofilm induced ||" 1 -0.72 0.55
876 "|| orf19.7331 || FCY24 || || Putative transporter; more similar to S. cerevisiae Tpn1, which is a vitamin B6 transporter, than to purine-cytosine permeases; transcription is regulated by Nrg1; Spider biofilm induced ||" 1 -0.05 0.38
877 "|| orf19.1228 || HAP2 || || CCAAT-binding transcription factor; regulates low-iron induction of FRP1; in these conditions CBF comprises Hap43 and probably Hap2 and Hap3; possibly essential, disruptants not obtained by UAU1 method; Cap1-dependent induction in low iron ||" 1 -0.35 -0.04 0.21
878 || orf19.991 || DJP1 || || Similar to bacterial DnaJ; reported to have a role in peroxisome biogenesis; induced in low iron and upon adherence to polystyrene || 1 -0.61 0.25
879 "|| orf19.1972 || || || Ortholog(s) have S-adenosylmethionine-dependent methyltransferase activity, role in histone lysine methylation and cytoplasm, nuclear chromatin localization ||" 1 -0.28 -0.10
880 || orf19.5824 || || || Protein of unknown function; rat catheter and Spider biofilm induced || 1 -0.44 -0.11 0.25
881 || orf19.4658 || || || RING finger and CHY zinc finger domain-containing protein; mutant are viable || 1 -0.41 -0.10 0.25
882 "|| orf19.7096 || || || Ortholog(s) have fungal-type vacuole membrane, mitochondrion localization ||" 1 -0.47 -0.08 0.25
883 || orf19.9108 || || || || 1 -0.53 -0.08 0.35
884 || orf19.5251 || ZCF30 || || Predicted Zn(II)2Cys6 transcription factor; mutants are viable; repressed by fluphenazine; Spider biofilm induced || 1 -0.39 0.26
885 || orf19.11979 || || || || 1 -0.25 -0.05 0.16
886 || orf19.8604 || || || || 1 -0.64 0.42
887 || orf19.3795 || AGP3 || || Putative serine transporter; possible role in assimilation of sulfur; F-12/CO2 early biofilm induced || 1 -0.15 -0.08 0.10
888 || orf19.4018 || || || Ortholog(s) have structural constituent of ribosome activity and mitochondrial small ribosomal subunit localization || 1 -0.38 0.01 0.31
889 || orf19.6926 || CSC25 || || Guanyl-nucleotide exchange factor; activator of Ras/adenylyl cyclase pathway; functional homolog of S. cerevisiae Cdc25p; commonly called Cdc25; transposon mutation affects filamentous growth || 1 -0.27 0.01 0.23
890 "|| orf19.6252 || || || Ortholog(s) have RNA polymerase II transcription factor binding transcription factor activity, core RNA polymerase II binding transcription factor activity ||" 1 -0.28 0.24
891 "|| orf19.6422 || SSY5 || || Ortholog(s) have serine-type endopeptidase activity, role in protein processing, response to amino acid and extrinsic to plasma membrane localization ||" 1 -0.21 0.00 0.18
892 "|| orf19.4780 || || || Predicted MFS family membrane transporter, member of the drug:proton antiporter (12 spanner) (DHA1) family; Spider biofilm induced ||" 1 -0.44 0.37
893 || orf19.5368 || || || Ortholog of Vms1; component of a Cdc48-complex involved in protein quality control in S. cerevisiae; Spider biofilm repressed || 1 -0.19 0.01 0.16
894 || orf19.7097 || || || Putative cytoplasmic RNA-binding protein; heterozygous null mutant exhibits hypersensitivity to parnafungin and cordycepin in C. albicans fitness test; Spider biofilm repressed || 1 -0.35 0.00 0.34
895 "|| orf19.5962 || HGT4 || || Glucose and galactose sensor; fermentation, filamentation, virulence roles; 20-member glucose transporter family; extended C terminus; high-glucose repressed; macrophage induced; flow model biofilm repressed; Spider biofilm induced ||" 1 -0.31 0.03 0.32
896 || orf19.9554 || HNM1 || || || 1 -0.20 0.02 0.21
897 || orf19.10724 || MID1 || || || 1 -0.69 0.72
898 "|| orf19.864 || || || Ortholog(s) have role in nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay and cytosol, polysome localization ||" 1 -0.32 0.02 0.34
899 || orf19.2737 || || || Carbohydrate kinase domain-containing protein; Spider biofilm induced || 1 -0.47 -0.05 0.47
900 "|| orf19.2057 || || || Ortholog(s) have ATP binding, ATPase activity, metallopeptidase activity, role in protein complex assembly, proteolysis, signal peptide processing and m-AAA complex, mitochondrial inner boundary membrane localization ||" 1 -0.31 -0.05 0.35
901 || orf19.3123 || RPT5 || || 26S proteasome regulatory subunit; transcript regulated by Nrg1 and Mig1; regulated by Gcn2 and Gcn4; protein level decreases in stationary phase || 1 -0.29 -0.06 0.36
902 "|| orf19.1994 || || || Ortholog(s) have phosphatidylinositol-3-phosphate binding activity, role in retrograde transport, endosome to Golgi and endosome localization ||" 1 -0.36 -0.04 0.44
903 "|| orf19.5005 || OSM2 || || Putative mitochondrial fumarate reductase; regulated by Ssn6p, Gcn2p, and Gcn4p; Hog1p-downregulated; stationary phase enriched protein; Hap43p-repressed gene ||" 1 -0.28 -0.02
904 || orf19.13589 || MEF2 || || || 1 -0.19 0.29
905 || orf19.7069 || || || Putative AdoMet-dependent proline methyltransferase; Hap43-induced; required for normal flow model biofilm growth; Spider biofilm repressed || 1 -0.40 -0.02 0.56
906 || orf19.620 || || || Predicted ORF from Assembly 19; removed from Assembly 20 || 1 -0.23 -0.01 0.30
907 "|| orf19.7118 || || || Ortholog(s) have adenylate kinase activity, nucleoside triphosphate adenylate kinase activity, role in nucleotide metabolic process and mitochondrial inner membrane localization ||" 1 -0.37 -0.02 0.61
908 || orf19.10993 || || || || 1 -0.08 -0.00 0.13
909 || orf19.577 || || || Predicted protein tyrosine phosphatase; rat catheter biofilm induced || 1 -0.19 -0.04 0.28
910 || orf19.5278 || || || Protein of unknown function; Spider biofilm induced || 1 -0.23 -0.10 0.26
911 || orf19.9682 || TSM1 || || || 1 -0.27 -0.11 0.28
912 || orf19.7438 || UBA1 || || Ubiquitin-activating enzyme; protein level decreases in stationary phase cultures || 1 -0.30 -0.11 0.34
913 "|| orf19.1567 || || || Ortholog(s) have Rab guanyl-nucleotide exchange factor activity, phosphatidylinositol binding activity ||" 1 -0.25 0.33
914 "|| orf19.6307 || || || Ortholog of C. dubliniensis CD36 : Cd36_30250, Candida tenuis NRRL Y-1498 : CANTEDRAFT_98619, Debaryomyces hansenii CBS767 : DEHA2G22594g and Pichia stipitis Pignal : PICST_50168 ||" 1 -0.41 -0.14 0.56
915 "|| orf19.749 || || || Protein likely to be essential for growth, based on an insertional mutagenesis strategy; merged with orf19.48 in Assembly 20 ||" 1 -0.22 -0.14 0.32
916 "|| orf19.5095 || || || Putative oxysterol-binding protein; caspofungin induced; possibly an essential gene, disruptants not obtained by UAU1 method ||" 1 -0.25 -0.15 0.35
917 || orf19.9664 || || || || 1 -0.35 -0.23 0.49
918 "|| orf19.7323 || CBP1 || || Corticosteroid binding protein; transcription induced at late log-phase or upon adherence to polystyrene; not induced by corticosterone; contains a possible NAD/FAD binding region; regulated by Nrg1, Tup1; Spider biofilm induced ||" 1 -0.58 -0.33 0.77
919 || orf19.6934 || || || Ortholog(s) have role in protein insertion into mitochondrial membrane from inner side and integral to mitochondrial inner membrane localization || 1 -0.34 -0.19 0.45
920 || orf19.954 || || || Putative DnaJ-like chaperone; Hap43-repressed gene || 1 -0.25 0.33
921 || orf19.4416 || VPS13 || || Putative vacuolar protein sorting-associated protein; gene used for multilocus sequence typing || 1 -0.21 -0.13 0.26
922 "|| orf19.5640 || PEX5 || || Pex5p family protein; required for PTS1-mediated peroxisomal protein import, fatty acid beta-oxidation; similar to S. cerevisiae Pas10p peroxisomal targeting receptor; macrophage/pseudohyphal-repressed; Hap43p-repressed ||" 1 -0.37 -0.18 0.38
923 "|| orf19.6061 || || || Ortholog(s) have role in N-acylethanolamine metabolic process, N-acylphosphatidylethanolamine metabolic process and integral to mitochondrial inner membrane localization ||" 1 -0.41 -0.23 0.45
924 || orf19.4841 || SHY1 || || Cytochrome c oxidase biosynthesis protein; transcript regulated by Nrg1 and Mig1 || 1 -0.27 0.31
925 "|| orf19.6993 || GAP2 || || General amino acid permease; ketoconazole, flucytosine repressed; Ssy1-dependent histidine induction; regulated by Nrg1, Tup1; colony morphology-related gene regulation by Ssn6; Spider and flow model biofilm induced ||" 1 -1.20 -0.42 1.40
926 "|| orf19.4595 || || || Ortholog of C. dubliniensis CD36 : Cd36_41860, C. parapsilosis CDC317 : CPAR2_400440, Candida tenuis NRRL Y-1498 : CANTEDRAFT_103033 and Debaryomyces hansenii CBS767 : DEHA2B03234g ||" 1 -0.37 0.43
927 "|| orf19.7433 || || || Ortholog(s) have nucleocytoplasmic transporter activity, structural constituent of nuclear pore activity ||" 1 -0.53 0.62
928 "|| orf19.7131 || || || Butyrobetaine dioxygenase, the fourth enzyme of the carnitine biosynthesis pathway ||" 1 -0.39 -0.31 0.46
929 || orf19.5087 || BUD6 || || Protein required for Spitzenkorper formation in hyphal cells (wild-type localization of Mlc1p to the Spitzenkorper); localizes to polarisome || 1 -0.15 -0.15 0.31
930 "|| orf19.7198 || || || CCR4-NOT complex component; involved in controlling mRNA initiation, elongation and degradation; rat catheter biofilm induced ||" 1 -0.23 0.43
931 "|| orf19.3226 || || || Ortholog(s) have role in intracellular sterol transport and extracellular region, fungal-type vacuole lumen localization ||" 1 -0.33 0.62
932 || orf19.7104 || || || Adhesin-like cell wall protein; similar to mucins and to a Litomosoides microfilarial sheath protein; N-terminal secretion signal; rat catheter and Spider biofilm repressed || 1 -0.19 -0.23 0.35
933 "|| orf19.7380 || || || Has domain(s) with predicted nucleic acid binding, nucleotide binding activity ||" 1 -0.32 0.57
934 || orf19.6973 || || || ATP-dependent LON protease family member; Hap43-repressed gene; regulated by Gcn2 and Gcn4; Spider biofilm induced || 1 -0.42 -0.27 0.74
935 || orf19.8054 || TRP99 || || || 1 -0.37 0.64
936 "|| orf19.4798 || || || Ortholog(s) have role in establishment of protein localization to plasma membrane and mitochondrion, plasma membrane localization ||" 1 -0.10 0.17
937 || orf19.1866 || VMA10 || || Subunit G of the V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase); involved in vacuolar acidification; rat catheter biofilm repressed || 1 -0.26 -0.17 0.44
938 "|| orf19.5255 || PXA2 || || Putative peroxisomal, half-size adrenoleukodystrophy protein (ALD or ALDp) subfamily ABC transporter; Gcn4p-regulated ||" 1 -0.21 -0.15 0.41
939 || orf19.4024 || RIB5 || || Putative riboflavin synthase; fungal-specific (no human or murine homolog); farnesol-downregulated; protein present in exponential and stationary growth phase yeast cultures || 1 -0.29 -0.23 0.63
940 || orf19.7187 || MAM33 || || Putative mitochondrial acidic matrix protein; regulated by Ssn6p; protein present in exponential and stationary growth phase yeast cultures || 1 -0.42 -0.26 0.89
941 || orf19.5450 || ETR1 || || Putative 2-enoyl thioester reductase; protein present in exponential and stationary growth phase yeast cultures; rat catheter biofilm repressed || 1 -0.41 -0.24 0.79
942 "|| orf19.6457 || || || Ortholog of S. cerevisiae : YBL086C, C. glabrata CBS138 : CAGL0C01815g, C. dubliniensis CD36 : Cd36_72270, C. parapsilosis CDC317 : CPAR2_702850 and Candida tenuis NRRL Y-1498 : CANTEDRAFT_107537 ||" 1 -0.29 0.55
943 || orf19.6781 || ZFU2 || || Zn(II)2Cys6 transcription factor; regulator of yeast form adherence; mutants display increased colonization of mouse kidneys; required for yeast cell adherence to silicone substrate; Spider biofilm induced || 1 -0.42 0.80
944 || orf19.9560 || || || || 1 -0.50 -0.19 0.96
945 "|| orf19.3136 || || || Ortholog(s) have transcription coactivator activity, role in DNA repair, cellular carbohydrate metabolic process and cytoplasm localization ||" 1 -0.22 -0.09 0.37
946 || orf19.3542 || LEM3 || || Putative membrane protein; mutation increases resistance to miltefosine; early-stage flow model biofilm induced || 1 -0.10 0.16
947 || orf19.2520 || || || Ortholog(s) have structural constituent of ribosome activity and mitochondrial small ribosomal subunit localization || 1 -0.07 -0.05 0.11
948 || orf19.6263 || || || Predicted MFS membrane transporter; member of the monocarboxylate porter (MCP) family; Spider biofilm induced || 1 -0.12 0.20
949 "|| orf19.5019 || || || Ortholog of C. dubliniensis CD36 : Cd36_12800, C. parapsilosis CDC317 : CPAR2_203460, Candida tenuis NRRL Y-1498 : CANTEDRAFT_94106 and Debaryomyces hansenii CBS767 : DEHA2C13948g ||" 1 -0.23 0.38
950 || orf19.5250 || || || Has domain(s) with predicted cofactor binding activity || 1 -0.26 -0.08 0.42
951 || orf19.7317 || UGA33 || || Zinc-finger transcription factor; similar to S. cerevisiae Uga3 which regulates gamma-aminobutyrate metabolism gene expression; required for yeast cell adherence to silicone substrate; rat catheter biofilm induced || 1 -0.30 -0.13 0.51
952 || orf19.1880 || HEM15 || || Putative ferrochelatase involved in heme biosynthesis; transcript not regulated by iron levels and not affected by a yfh1 null mutation; Spider biofilm repressed || 1 -0.25 -0.11 0.41
953 || orf19.1891 || APR1 || || Vacuolar aspartic proteinase; transcript equivalent in yeast-form and mycelial cells but is elevated at lower growth temperatures; upregulated iby human neutrophils; protein enriched in stationary phase; Spider biofilm induced || 1 -0.27 -0.20 0.69
954 "|| orf19.6074 || HBR1 || || Essential protein involved in regulation of MTL gene expression; hemoglobin-regulated inhibitor of white-opaque switching, may affect survival in host; activator of MTLalpha1 and MTLalpha2; transcript activated by hemoglobin ||" 1 -0.13 -0.13 0.21
955 "|| orf19.6136 || || || Ortholog of S. cerevisiae Mrpl4, a mitochondrial ribosomal protein of the large subunit; repressed by nitric oxide ||" 1 -0.14 -0.15 0.24
956 "|| orf19.6445 || ECI1 || || Protein similar to S. cerevisiae Eci1p, which is involved in fatty acid oxidation; transposon mutation affects filamentous growth; expression is regulated upon white-opaque switching ||" 1 -0.31 -0.43 0.52
957 || orf19.6637 || || || Predicted glycosyl hydrolase; hypoxia induced; flow model biofilm induced || 1 -0.37 0.63
958 "|| orf19.5175 || || || Ortholog(s) have ubiquitin-protein ligase activity, role in ER-associated ubiquitin-dependent protein catabolic process and Doa10p ubiquitin ligase complex, integral to endoplasmic reticulum membrane, nuclear inner membrane localization ||" 1 -0.11 -0.14 0.19
959 "|| orf19.7547 || || || Ortholog(s) have phosphatidylinositol-3-phosphate binding, ubiquitin-protein ligase activity, role in protein ubiquitination and cytosol, fungal-type vacuole membrane, late endosome, nucleus localization ||" 1 -0.28 0.48
960 "|| orf19.3689 || || || Putative protein similar to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase; expression downregulated in an ssr1 null mutant ||" 1 -0.08 -0.19 0.13
961 "|| orf19.1057 || || || Ortholog of C. dubliniensis CD36 : Cd36_03980, C. parapsilosis CDC317 : CPAR2_107050, Candida tenuis NRRL Y-1498 : CANTEDRAFT_113999 and Debaryomyces hansenii CBS767 : DEHA2D12518g ||" 1 -0.09 0.17
962 || orf19.6048 || || || Protein of unknown function; Spider biofilm induced || 1 -0.37 -0.30 0.70
963 "|| orf19.4428 || || || Ortholog of C. dubliniensis CD36 : Cd36_06910, C. parapsilosis CDC317 : CPAR2_208560, Candida tenuis NRRL Y-1498 : CANTEDRAFT_95854 and Debaryomyces hansenii CBS767 : DEHA2F25982g ||" 1 -0.10 0.20
964 || orf19.1891 || APR1 || || Vacuolar aspartic proteinase; transcript equivalent in yeast-form and mycelial cells but is elevated at lower growth temperatures; upregulated iby human neutrophils; protein enriched in stationary phase; Spider biofilm induced || 1 -0.42 -0.29 0.88
965 || orf19.6874 || || || Putative helix-loop-helix (HLH) transcription factor with a role in filamentous growth || 1 -0.47 -0.33
966 || orf19.672 || || || Ortholog(s) have U5 snRNP localization || 1 -0.07 0.11
967 || orf19.8472 || SAP98 || || || 1 -0.21 0.33
968 "|| orf19.2047 || || || Putative protein of unknown function; Hap43p-repressed gene; mutation confers hypersensitivity to toxic ergosterol analog, and to amphotericin B ||" 1 -0.31 0.49
969 || orf19.794 || SSN3 || || Putative cyclin-dependent protein kinase; mutants are sensitive to growth on H2O2 medium || 1 -0.21 0.33
970 "|| orf19.5976 || || || Protein of unknown function; ortholog of S. cerevisiae Urn1; downregulated by fluphenazine treatment, in azole-resistant strains that overexpress CDR1 and CDR2 or MDR1 ||" 1 -0.22 -0.19 0.34
971 || orf19.6867 || || || Protein with a predicted cytochrome b5-like heme/steroid binding domain; repressed by alpha pheromone in SpiderM medium || 1 -0.42 -0.42 0.63
972 || orf19.3045 || || || Predicted aldehyde dehydrogenase domain; virulence-group-correlated expression || 1 -0.18 -0.15 0.22
973 || orf19.1625 || || || Putative ubiquinone oxidoreductase; repressed by nitric oxide; Hap43p-repressed || 1 -0.31 -0.27 0.40
974 || orf19.992 || LKH1 || || Putative leukotriene A(4) hydrolase; repressed during the mating process; Hog1p-induced || 1 -0.31 -0.28 0.40
975 || orf19.5247 || || || Ortholog(s) have cytoplasm localization || 1 -0.42 -0.33 0.57
976 "|| orf19.2682 || || || Ortholog(s) have TBP-class protein binding, TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly activity ||" 1 -0.29 -0.23 0.42
977 || orf19.7366 || || || Ortholog(s) have S-adenosylmethionine-dependent methyltransferase activity and nucleolus localization || 1 -0.27 0.40
978 || orf19.3054 || RPN3 || || Putative non-ATPase regulatory subunit of the 26S proteasome lid; amphotericin B repressed; oxidative stress-induced via Cap1p || 1 -0.40 -0.23 0.60
979 "|| orf19.5985 || || || Ortholog(s) have tubulin binding activity, role in response to cold, tubulin complex assembly and nucleus, polysome, prefoldin complex localization ||" 1 -0.23 0.34
980 || orf19.7468 || || || Putative transcriptional activator; expression upregulated during growth in the mouse cecum; Spider biofilm induced || 1 -0.20 0.30
981 || orf19.7520 || POT1 || || Putative peroxisomal 3-oxoacyl CoA thiolase; transcript regulated by Nrg1 and Mig1; farnesol regulated; Hap43-repressed || 1 -0.59 -0.53 0.85
982 || orf19.2983 || CDC73 || || Putative transcription elongation factor; cdc73 kap114 double transposon mutation affects filamentous growth; Spider biofilm repressed || 1 -0.04 -0.05 0.06
983 || orf19.7203 || MRP7 || || Mitochondrial ribosomal protein of the large subunit; rat catheter biofilm induced || 1 -0.28 -0.28 0.37
984 || orf19.7210 || || || Protein of unknown function; Spider biofilm induced || 1 -0.42 -0.45 0.59
985 || orf19.7140 || || || Putative catechol o-methyltransferase; stationary phase enriched protein; transcription upregulated in clinical isolates from HIV+ patients with oral candidiasis; Spider biofilm repressed || 1 -0.42 -0.44 0.60
986 "|| orf19.1210 || || || Ortholog(s) have L-arginine transmembrane transporter activity, L-aspartate transmembrane transporter activity and L-glutamate transmembrane transporter activity, more ||" 1 -0.46 0.63
987 "|| orf19.2242 || PRB1 || || Endoprotease B; regulated by heat, carbon source (GlcNAc-induced), nitrogen, macrophage response, human neutrophils; similar to (does not replace) S. cerevisiae vacuolar B protease Prb1p; flow model biofilm induced; Spider biofilm induced ||" 1 -0.26 -0.36 0.36
988 || orf19.5876 || || || Protein of unknown function; Cyr1-repressed; induced by alpha pheromone in SpiderM medium; rat catheter and Spider biofilm induced || 1 -0.37 -0.37 0.46
989 || orf19.7592 || FAA4 || || Predicted acyl CoA synthase || 1 -0.21 -0.19 0.21
990 || orf19.7050 || NOP15 || || Nucleolar ribosome biogenesis factor; hyphal-induced expression; Hap43-induced; rat catheter biofilm induced || 1 -0.33 -0.28 0.30
991 "|| orf19.6373 || DCP2 || || Ortholog(s) have m7G(5')pppN diphosphatase activity, mRNA binding activity and role in deadenylation-dependent decapping of nuclear-transcribed mRNA, deadenylation-independent decapping of nuclear-transcribed mRNA, stress granule assembly ||" 1 -0.47 -0.44 0.46
992 || orf19.5027 || LCB2 || || Putative serine palmitoyltransferase component; mutation confers hypersensitivity to aureobasidin A || 1 -0.31 -0.30 0.31
993 || orf19.6706 || GYP7 || || Protein similar to S. cerevisiae Gyp7p (GTPase-activating protein for Ypt1p); caspofungin-induced || 1 -0.39 -0.40 0.43
994 || orf19.6481 || YPS7 || || Putative aspartic-type endopeptidase with limited ability to degrade alpha pheromone; mutants show increased sensitivity to alpha pheromone || 1 -0.27 -0.29 0.30
995 "|| orf19.5901 || PKC1 || || Protein kinase C; functional homolog of S. cerevisiae Pkc1p; mutant has abnormal yeast-form cell morphology and increased cell lysis; activated by phosphatidylserine; target of antifungal, cercosporamide; R400P mutant is activated ||" 1 -0.31 0.34
996 || orf19.3029 || || || Predicted 3-hydroxyisobutyryl-CoA hydrolase; mitochondrially localized; Spider biofilm induced || 1 -0.41 -0.39 0.45
997 "|| orf19.1236 || GVP36 || || BAR domain protein; ocalizes to early and late Golgi vesicles; predicted role in adaptation to varying nutrient concentrations, fluid-phase endocytosis, actin cytoskeleton polarization and vacuole biogenesis; rat catheter biofilm repressed ||" 1 -0.45 0.49
998 || orf19.4768 || || || Protein of unknown function; Spider biofilm induced || 1 -0.33 -0.28 0.36
999 || orf19.14178 || MKK2 || || || 1 -0.18 0.20
1000 || orf19.392 || || || Ortholog(s) have role in mitochondrial respiratory chain complex III assembly and integral to mitochondrial membrane localization || 1 -0.47 -0.41 0.52
1001 "|| orf19.7360 || || || Ortholog(s) have enzyme activator activity, role in histone deubiquitination, regulation of transcription from RNA polymerase II promoter and DUBm complex, SAGA complex localization ||" 1 -0.44 -0.37 0.48
1002 "|| orf19.7676 || XYL2 || || D-xylulose reductase; immunogenic in mice; soluble protein in hyphae; induced by caspofungin, fluconazole, Hog1 and during cell wall regeneration; Mnl1-induced in weak acid stress; stationary phase enriched; flow model biofilm induced ||" 1 -1.09 -0.93 1.13
1003 || orf19.7325 || SCO1 || || Putative copper transporter; Hap43p-repressed gene || 1 -0.43 -0.33 0.42
1004 "|| orf19.7034 || || || Putative eIF4E-associated protein;, accelerates mRNA degradation by promoting decapping; Spider biofilm repressed ||" 1 -0.18 -0.13 0.16
1005 || orf19.7196 || || || Putative vacuolar protease; upregulated in the presence of human neutrophils; Spider biofilm induced || 1 -0.68 -0.48 0.62
1006 || orf19.1999 || || || Protein of unknown function; transcript detected on high-resolution tiling arrays || 1 -0.71 -0.46 0.75
1007 || orf19.3835 || || || Putative DNA-binding transcription factor; merged with orf19.3833 in Assembly 20 || 1 -0.37 -0.22 0.39
1008 || orf19.4947 || || || Mitochondrial membrane protein of unknown function; Spider biofilm induced || 1 -0.18 -0.12 0.18
1009 || orf19.7581 || || || Protein with a predicted role in assembly of U2 snRNP into the spliceosome; Spider biofilm induced || 1 -0.50 0.52
1010 "|| orf19.4851 || TFA1 || || Protein with polyglutamate motifs and abundant Ser/Thr residues; described as a subunit of TFIIE, which is a basal transcription initiation factor of RNA Polymerase II; possibly an essential gene, disruptants not obtained by UAU1 method ||" 1 -0.07 0.07
1011 || orf19.7319 || SUC1 || || Zinc-finger transcription factor; regulates alpha-glucosidase exression; complements S. cerevisiae suc2 for sucrose utilization and mal13 maltase defect; required for yeast cell adherence to silicone substrate; rat catheter biofilm induced || 1 -0.56 0.58
1012 || orf19.1377 || IPK2 || || Putative inositol polyphosphate multikinase; moderately induced at 42 deg || 1 -0.12 -0.22 0.13
1013 || orf19.5975 || TRY4 || || C2H2 transcription factor; fluconazole-repressed; induced in ssr1 mutant; required for yeast cell adherence to silicone substrate; Spider biofilm induced || 1 0.02 -0.28 0.38
1014 || orf19.1905 || || || Predicted ORF from Assembly 19; merged with orf19.2290 in Assembly 20 || 1 0.01 0.18
1015 "|| orf19.1166 || CTA3 || || Protein similar to S. cerevisiae Ede1p, which is involved in endocytosis; activates transcription in 1-hybrid assay in S. cerevisiae ||" 1 0.01 -0.11 0.12
1016 "|| orf19.6763 || SLK19 || || Alkaline-induced protein of plasma membrane; affects cell aggregation, cell wall; similar to S. cerevisiae Slk19p (a kinetochore protein with roles in mitosis, meiosis); required for wild-type virulence in mouse; macrophage-downregulated ||" 1 0.05 -0.59 0.64
1017 "|| orf19.2290 || TOR1 || || Protein similar to TOR family phosphatidylinositol kinases; mutation confers resistance to rapamycin; involved in regulation of ribosome biogenesis, starvation response, and adhesion ||" 1 0.01 0.10
1018 || orf19.1888 || || || Putative nicotinamide riboside hydrolase; cleaves N-glycosidic bonds in nucleosides; pyrimidine salvage and nicotinamide riboside salvage pathways; Spider biofilm induced || 1 0.02 0.15
1019 "|| orf19.3821 || || || Ortholog of C. dubliniensis CD36 : Cd36_44290, C. parapsilosis CDC317 : CPAR2_500740, Candida tenuis NRRL Y-1498 : CANTEDRAFT_137302 and Debaryomyces hansenii CBS767 : DEHA2F07326g ||" 1 0.03 -0.20 0.28
1020 "|| orf19.2710 || || || Ortholog(s) have enzyme activator activity, role in chromosome segregation and cytoplasm, nucleus localization ||" 1 0.06 -0.39 0.47
1021 "|| orf19.2001 || || || Has domain(s) with predicted L-ascorbic acid binding, iron ion binding, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen and 2-oxoglutarate as one donor, more ||" 1 0.04 0.25
1022 "|| orf19.3084 || || || Ortholog(s) have histone acetyltransferase activity, role in chromatin silencing at telomere and SAS acetyltransferase complex, nuclear chromatin localization ||" 1 0.07 0.43
1023 || orf19.735 || || || Putative DNA-binding transcription factor; putative TFIID subunit; flucytosine repressed; merged with orf19.6193 in Assembly 20 || 1 0.05 -0.31 0.32
1024 || orf19.3335 || || || Plasma membrane protein of unknown function; colony morphology-related gene regulation by Ssn6; repressed by nitric oxide || 1 0.07 -0.24 0.26
1025 || orf19.580 || || || Protein of unknown function; mutants are viable; Spider biofilm induced || 1 0.08 0.29
1026 || orf19.12693 || RIB3 || || || 1 0.17 -0.50 0.57
1027 "|| orf19.2302 || || || Ortholog(s) have enzyme regulator activity, role in cellular calcium ion homeostasis and integral to endoplasmic reticulum membrane localization ||" 1 0.03 0.09
1028 "|| orf19.7490 || || || Predicted membrane transporter; fucose:proton symporter family member, MFS superfamily; flow model biofilm induced ||" 1 0.12 -0.43 0.44
1029 || orf19.4394 || || || Protein of unknown function; induced by alpha pheromone in SpiderM medium || 1 0.11 0.40
1030 "|| orf19.3932 || || || Predicted RNA binding protein; stationary phase enriched; induced in core caspofungin response; induced by nitric oxide independent of Yhb1; repressed in ssr1 null; ketoconazole, hypoxia induced; Spider biofilm induced ||" 1 0.13 -0.32 0.33
1031 || orf19.6780 || MET8 || || Putative bifunctional dehydrogenase and ferrochelatase with a predicted role in siroheme biosynthesis; regulated by Gcn2p and Gcn4p || 1 0.04 0.11
1032 || orf19.347 || RSN1 || || Protein of unknown function; flow model biofilm induced; Spider biofilm induced; induced during the mating process; Hap43-repressed || 1 0.12 -0.38 0.27
1033 || orf19.7570 || UGA3 || || Zn(II)2Cys6 transcription factor; required for utilization of gamma-aminobutyrate (GABA) as a nitrogen source; mutants display decreased CFU in mouse kidneys; Spider biofilm induced || 1 0.07 -0.26 0.16
1034 || orf19.4758 || || || Putative reductase or dehydrogenase; Hap43-repressed gene; alkaline repressed || 1 -0.01 -0.20 0.11
1035 || orf19.5078 || || || Protein of unknown function; Hap43-repressed gene; rat catheter biofilm repressed || 1 -0.06 0.60
1036 "|| orf19.6132 || || || Ortholog of C. dubliniensis CD36 : Cd36_33000, C. parapsilosis CDC317 : CPAR2_701740, Candida tenuis NRRL Y-1498 : CANTEDRAFT_93887 and Debaryomyces hansenii CBS767 : DEHA2E04554g ||" 1 -0.04 0.38
1037 || orf19.8049 || || || || 1 -0.07 -0.31 0.56
1038 "|| orf19.5765 || NUP82 || || Linker nucleoporin of the nuclear pore complex; role in mRNA andexport from nucleus, protein import into nucleus, ribosomal large subunit export from nucleus, ribosomal small subunit export from nucleus; rat catheter biofilm repressed ||" 1 -0.06 0.44
1039 || orf19.5960 || NCE102 || || Non classical protein export protein; localized to plasma membrane; Hap43-induced gene; flow model biofilm induced; Spider biofilm induced || 1 -0.11 -0.43 0.73
1040 || orf19.7567 || || || Protein of unknown function; induced by alpha pheromone in SpiderM medium || 1 -0.08 -0.28 0.46
1041 || orf19.6887 || || || Predicted ORF from Assembly 19; repressed by nitric oxide; removed from Assembly 20; subsequently reinstated in Assembly 21 based on comparative genome analysis || 1 -0.06 -0.20 0.30
1042 "|| orf19.6793 || || || Protein of unknown function; Sef1, Sfu1, and Hap43 regulated; rat catheter and Spider biofilm induced ||" 1 -0.03 -0.26 0.39
1043 "|| orf19.6600 || || || Ortholog(s) have phosphatidic acid transporter activity and role in cardiolipin metabolic process, phospholipid transport, positive regulation of phosphatidylcholine biosynthetic process ||" 1 0.01 -0.20 0.27
1044 || orf19.12152 || MLP1 || || || 1 0.01 -0.22 0.35
1045 "|| orf19.458 || || || Ortholog(s) have protein transmembrane transporter activity and role in chaperone-mediated protein complex assembly, mitochondrial respiratory chain complex III assembly, protein insertion into mitochondrial membrane from inner side ||" 1 0.00 0.22
1046 || orf19.4032 || RPN5 || || Putative COP9 signalosome component; macrophage/pseudohyphal-repressed || 1 0.00 -0.26 0.25
1047 "|| orf19.4525 || || || Ortholog(s) have endoplasmic reticulum, nuclear pore localization ||" 1 0.01 0.46
1048 || orf19.4135 || PRC2 || || Putative carboxypeptidase; induced by human neutrophils; Spider biofilm induced || 1 0.01 0.83
1049 "|| orf19.945 || VPS2 || || Ortholog(s) have role in intralumenal vesicle formation, protein retention in Golgi apparatus, protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway ||" 1 0.01 0.33
1050 || orf19.4443 || YPD1 || || Phosphohistidine intermediate protein in a phosphorelay signal transduction pathway; residue His69 is the phosphoacceptor histidine; predicted to be soluble and cytosolic; functional homolog of S. cerevisiae Ypd1p || 1 0.00 -0.36 0.62
1051 || orf19.3351 || || || Protein of unknown function; Hap43-induced; Spider biofilm induced || 1 0.01 -0.20 0.36
1052 "|| orf19.1834 || || || Ortholog of C. dubliniensis CD36 : Cd36_09960, C. parapsilosis CDC317 : CPAR2_212580, Debaryomyces hansenii CBS767 : DEHA2G11770g and Pichia stipitis Pignal : PICST_51041 ||" 1 0.04 -0.17 0.31
1053 "|| orf19.2091 || || || Putative NADH dehydrogenase; repressed by nitric oxide, Hap43p-repressed ||" 1 0.03 0.24
1054 || orf19.4025 || PRE1 || || Putative beta 4 subunit of the 20S proteasome; Rim101-induced at acid pH; flucytosine induced; amphotericin B repressed || 1 0.04 0.29
1055 || orf19.1840 || || || Predicted lipid-binding ER protein; involved in ER-plasma membrane tethering; Spider biofilm induced || 1 0.06 -0.26 0.49
1056 || orf19.338 || || || Putative glycoside hydrolase; stationary phase enriched protein; Hog1p-downregulated; shows colony morphology-related gene regulation by Ssn6p || 1 0.12 -0.44 0.85
1057 || orf19.922 || ERG11 || || Lanosterol 14-alpha-demethylase; cytochrome P450 family; role in ergosterol biosynthesis; target of azole antifungals; may contribute to drug resistance; azole or flow model biofilm induced; drug treated biofilm induced; hypoxia regulated || 1 0.02 0.14
1058 || orf19.1549 || || || Plasma membrane-associated protein identified in detergent-resistant membrane fraction (possible lipid raft component); repressed by nitric oxide; predicted transmembrane helix || 1 0.07 -0.13 0.37
1059 || orf19.3947 || || || Ortholog(s) have rDNA binding activity || 1 0.04 0.19
1060 "|| orf19.7600 || FDH3 || || Glutathione-dependent formaldehyde dehydrogenase; glycine catabolism; repressed by Efg1 in yeast, not hyphal growth conditions; induced by Mnl1 under weak acid stress; Spider biofilm repressed ||" 1 0.07 -0.16 0.38
1061 "|| orf19.2728 || || || Ortholog(s) have DNA clamp loader activity, role in DNA damage checkpoint, nucleotide-excision repair, reciprocal meiotic recombination and Rad17 RFC-like complex, nucleus localization ||" 1 0.02 -0.04
1062 "|| orf19.393 || APS3 || || Component of the adaptor complex AP-3, which is involved in vacuolar protein sorting ||" 1 0.00 0.11
1063 "|| orf19.744 || GDB1 || || Putative glycogen debranching enzyme; expression is regulated upon white-opaque switch; regulated by Nrg1, Tup1; rat catheter biofilm repressed ||" 1 0.01 -0.14 0.33
1064 "|| orf19.5139 || || || Ortholog of C. dubliniensis CD36 : Cd36_72800, Candida tropicalis MYA-3404 : CTRG_05211 and Candida albicans WO-1 : CAWG_05649 ||" 1 -0.02 0.47
1065 "|| orf19.3135 || || || Ortholog(s) have protein binding, bridging activity and role in ER-associated ubiquitin-dependent protein catabolic process, lipid particle organization ||" 1 -0.01 0.26
1066 "|| orf19.5961 || || || Ortholog(s) have role in proteasome regulatory particle assembly, proteolysis and cytosol, nucleus, proteasome regulatory particle localization ||" 1 -0.03 -0.24 0.76
1067 || orf19.6059 || TTR1 || || Putative glutaredoxin; described as a glutathione reductase; induced by human neutrophils and benomyl treatment; alkaline repressed; regulated by Gcn2 and Gcn4; required for virulence in mouse model; Spider biofilm induced || 1 -0.04 -0.18 0.56
1068 || orf19.7193 || || || Specificity factor required for ubiquitination; role in protein targeting to vacuole; involved in ubiquitin-dependent protein catabolism via the multivesicular body sorting pathway; Spider biofilm induced || 1 -0.01 -0.07 0.27
1069 "|| orf19.4488 || || || Predicted ortholog of S. cerevisiae Swi3, subunit of the SWI/SNF chromatin remodeling complex; possibly an essential gene, disruptants not obtained by UAU1 method ||" 1 -0.04 -0.11 0.46
1070 || orf19.5799 || || || Ortholog(s) have cytoplasm localization || 1 -0.01 0.11
1071 || orf19.1130 || || || Predicted ORF from Assembly 19; removed from Assembly 20 || 1 -0.04 -0.16 0.40
1072 || orf19.6449 || || || Ortholog of C. dubliniensis CD36 : Cd36_34310 || 1 -0.05 -0.16 0.37
1073 "|| orf19.3949 || || || Ortholog(s) have chromatin binding, histone binding activity ||" 1 -0.02 -0.04 0.11
1074 "|| orf19.6385 || ACO1 || || Aconitase; induced in high iron; 2 upstream CCAAT motifs; amino acid starvation (3-AT), amphotericin B, phagocytosis, farnesol induced; Hap43, fluconazole-repressed; Gcn4-regulated; antigenic in infection; flow and Spider biofilm repressed ||" 1 -0.07 -0.14 0.38
1075 || orf19.9738 || GDH2 || || || 1 -0.12 -0.23 0.64
1076 || orf19.4649 || ZCF27 || || Putative Zn(II)2Cys6 transcription factor || 1 -0.04 -0.09 0.19
1077 || orf19.2769 || || || Putative protease B inhibitor; hyphal-induced expression; Cyr1p- and Ras1p-repressed || 1 -0.23 -0.32 0.78
1078 || orf19.4102 || RPN10 || || Putative 19S regulatory particle of the 26S proteasome; macrophage/pseudohyphal-repressed; regulated by Gcn2 and Gcn4; Spider biofilm repressed || 1 -0.10 -0.14 0.32
1079 || orf19.7012 || || || Ortholog(s) have structural constituent of ribosome activity and mitochondrial small ribosomal subunit localization || 1 -0.06 -0.09 0.20
1080 || orf19.5077 || || || Protein of unknown function; Hap43-repressed gene; repressed by nitric oxide || 1 -0.12 -0.19 0.41
1081 "|| orf19.2852 || || || Ortholog(s) have structural constituent of ribosome activity, role in mitochondrial translational initiation and mitochondrial small ribosomal subunit localization ||" 1 -0.02 0.07
1082 || orf19.4220 || || || Predicted pyridoxal 5'-phosphate synthase; regulated by Gcn4; repressed by amino acid starvation (3-AT treatment); rat catheter biofilm repressed || 1 -0.08 0.38
1083 || orf19.6810 || || || Ortholog(s) have protein serine/threonine phosphatase activity || 1 -0.05 -0.06 0.22
1084 "|| orf19.1993 || || || Ortholog(s) have structural molecule activity, role in proteasome assembly, ubiquitin-dependent protein catabolic process and nucleus, proteasome regulatory particle, lid subcomplex, proteasome storage granule localization ||" 1 -0.07 0.31
1085 "|| orf19.7206 || OCA6 || || Putative protein phosphatase of the PTP family (tyrosine-specific), similar to S. cerevisiae Oca6p; mutant shows virulence defect ||" 1 -0.12 0.50
1086 || orf19.791 || RIM11 || || Ortholog of S. cerevisiae Rim11; a protein kinase involved in meiosis and sporulation in S. cerevisiae; mutant is viable || 1 -0.10 -0.12 0.44
1087 || orf19.3150 || GRE2 || || Putative reductase; Nrg1 and Tup1-regulated; benomyl- and hyphal-induced; macrophage/pseudohyphal-repressed; repressed by low iron; possibly involved in osmotic stress response; stationary phase enriched protein; Spider biofilm induced || 1 -0.15 -0.12 0.49
1088 "|| orf19.7224 || || || Ortholog(s) have ubiquitin-protein ligase activity and role in histone catabolic process, histone ubiquitination ||" 1 -0.14 0.46
1089 || orf19.4449 || CCS1 || || Copper chaperone involved in activation and protection of superoxide dismutase Sod1p || 1 -0.07 -0.09 0.23
1090 || orf19.8240 || || || || 1 -0.16 -0.16 0.50
1091 || orf19.3026 || MAS1 || || Putative mitochondrial processing protease; Hap43-repressed; transcript regulated by Nrg1; oxidative stress-induced via Cap1 || 1 -0.31 -0.25 0.70
1092 "|| orf19.886 || PAN1 || || Essential protein involved in endocytosis and polarized growth; ortholog of S. cerevisiae Pan1, which is a part of a complex that regulates actin cytoskeleton; Spider biofilm repressed ||" 1 -0.11 0.25
1093 || orf19.11705 || || || || 1 -0.21 -0.26 0.49
1094 || orf19.7678 || ATP16 || || Subunit of the mitochondrial F1F0 ATP synthase; sumoylation target; protein newly produced during adaptation to the serum; Spider biofilm repressed || 1 -0.19 -0.23 0.46
1095 || orf19.7178 || PRE5 || || Alpha6 subunit of the 20S proteasome; regulated by Gcn4; induced in response to amino acid starvation (3-AT); Spider biofilm repressed || 1 -0.18 0.46
1096 "|| orf19.6049 || || || Ortholog(s) have protein kinase activator activity, role in protein phosphorylation, regulation of cytokinesis and chromosome passenger complex, kinetochore microtubule, spindle midzone localization ||" 1 -0.08 -0.18 0.20
1097 "|| orf19.6440 || || || Ortholog(s) have ubiquitin-protein ligase activity, role in ubiquitin-dependent protein catabolic process and endoplasmic reticulum membrane, nuclear inner membrane localization ||" 1 -0.08 0.18
1098 "|| orf19.5671 || || || Ortholog(s) have role in actin cortical patch assembly, septin cytoskeleton organization and cellular bud neck, cellular bud tip, mating projection base, mating projection tip localization ||" 1 -0.17 -0.18 0.41
1099 || orf19.5408 || HRK1 || || Putative serine/threonine kinase; predicted role in cellular ion homeostasis; Spider biofilm repressed || 1 -0.18 0.41
1100 || orf19.2515 || || || ZZ-type zinc finger protein; rat catheter and Spider biofilm induced || 1 -0.16 -0.24 0.36
1101 || orf19.3053 || || || Protein of unknown function; present in exponential and stationary phase yeast; identified in extracts from biofilm and planktonic cells; flow model biofilm induced gene; GlcNAc-induced protein || 1 -0.13 -0.21 0.39
1102 || orf19.3930 || YUH2 || || Putative ubiquitin C-terminal hydrolase; sumoylation target || 1 -0.09 -0.15 0.27
1103 "|| orf19.4850 || || || Ortholog(s) have cytosol, nucleus localization ||" 1 -0.11 -0.21 0.38
1104 "|| orf19.7064 || GLN4 || || Putative tRNA-Gln synthetase; genes encoding ribosomal subunits, translation factors, tRNA synthetases are downregulated upon phagocytosis by murine macrophage; protein present in exponential and stationary growth phase yeast cultures ||" 1 -0.27 -0.53 0.92
1105 || orf19.7057 || GUS1 || || Putative glutamine-tRNA ligase; stationary phase enriched protein; Spider biofilm repressed || 1 -0.02 -0.04 0.06
1106 || orf19.5345 || || || Putative ubiquitin-like polyubiquitin-binding protein; induced by nitric oxide independent of Yhb1; Spider biofilm repressed || 1 -0.10 0.37
1107 "|| orf19.7611 || TRX1 || || Thioredoxin; involved in response to reactive oxygen species; biofilm, benomyl, flucytosine, peroxide, Hap43 induced; amphotericin B, caspofungin repressed; induced by human neutrophils; macrophage-repressed gene ||" 1 -0.09 -0.21 0.31
1108 "|| orf19.4491 || ERG20 || || Putative farnesyl pyrophosphate synthetase involved in isoprenoid and sterol biosynthesis, based on similarity to S. cerevisiae Erg20p; likely to be essential for growth, based on an insertional mutagenesis strategy ||" 1 -0.09 -0.22 0.32
1109 "|| orf19.1835 || PEA2 || || Putative coiled-coil polarisome; predicted role in polarized morphogenesis, cell fusion, and low affinity Ca2+ influx; rat catheter biofilm induced ||" 1 -0.12 -0.27 0.41
1110 "|| orf19.6605 || || || Ortholog(s) have fungal-type vacuole, mitochondrion localization ||" 1 -0.22 -0.49 0.75
1111 "|| orf19.357 || || || Ortholog(s) have role in inner mitochondrial membrane organization, mitochondrion inheritance, mitochondrion morphogenesis, negative regulation of proteolysis, protein folding, replicative cell aging ||" 1 -0.19 -0.38 0.58
1112 "|| orf19.3047 || || || Protein kinase-related protein, required for normal sensitivity to caspofungin ||" 1 -0.18 -0.35 0.58
1113 || orf19.2150 || || || Putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-alpha; Spider biofilm repressed || 1 -0.06 0.18
1114 "|| orf19.3678 || || || Ortholog of C. dubliniensis CD36 : Cd36_02060, C. parapsilosis CDC317 : CPAR2_106200, Candida tenuis NRRL Y-1498 : CANTEDRAFT_96322 and Debaryomyces hansenii CBS767 : DEHA2C02310g ||" 1 -0.22 0.68
1115 "|| orf19.2903 || AGO1 || || Putative Argonaute protein involved in RNA silencing; hyphal-induced expression; regulated by Cyr1, Ras1, Efg1, Nrg1, Tup1; rat catheter biofilm repressed ||" 1 -0.14 0.42
1116 || orf19.6062 || || || Putative TIM23 translocase complex subunit; membrane-localized; Hap43-repressed || 1 -0.13 -0.33 0.38
1117 "|| orf19.1220 || RVS167 || || SH3-domain- and BAR domain-containing protein involved in endocytosis; null mutant exhibits defects in hyphal growth, virulence, cell wall integrity, and actin patch localization; cosediments with phosphorylated Myo5p ||" 1 -0.10 0.31
1118 "|| orf19.4307 || || || Ortholog(s) have role in late endosome to vacuole transport via multivesicular body sorting pathway, protein targeting to vacuole and late endosome localization ||" 1 -0.13 -0.29 0.37
1119 || orf19.7341 || || || Protein of unknown function; flow model biofilm induced; ketoconazole-repressed || 1 -0.22 -0.48 0.60
1120 || orf19.6030 || || || Protein of unknown function; transcript detected on high-resolution tiling arrays || 1 -0.07 -0.15 0.18
1121 || orf19.2067 || || || Protein with a predicted role in mitochondrial iron metabolism; Hap43-repressed; expression upregulated during growth in the mouse cecum; Spider biofilm induced || 1 -0.15 -0.27 0.35
1122 "|| orf19.1109 || || || Ortholog of C. dubliniensis CD36 : Cd36_53580, C. parapsilosis CDC317 : CPAR2_303030, Debaryomyces hansenii CBS767 : DEHA2G07766g and Pichia stipitis Pignal : psti_CGOB_00176 ||" 1 -0.03 -0.06 0.07
1123 "|| orf19.6602 || || || Ortholog(s) have role in aerobic respiration, ubiquinone biosynthetic process and mitochondrial inner membrane localization ||" 1 -0.09 -0.06 0.17
1124 || orf19.356 || GTT13 || || Putative glutathione S-transferase; opaque-specific transcript; repressed by alpha pheromone in SpiderM medium; Spider biofilm induced || 1 -0.34 0.63
1125 || orf19.6991 || PRE3 || || Putative beta-1 proteasome subunit; macrophage-induced protein; regulated by Gcn2p and Gcn4p; GlcNAc-induced protein || 1 -0.29 -0.08 0.58
1126 || orf19.3548 || || || Ortholog(s) have mitochondrion localization || 1 -0.27 0.55
1127 "|| orf19.7451 || FUN31 || || Putative PAS kinase involved in cell wall damage response; similar to S. cerevisiae Psk1p, a putative serine/threonine protein kinase; induced by Mnl1 under weak acid stress; rat catheter and Spider biofilm induced ||" 1 -0.21 -0.05 0.45
1128 || orf19.5261 || || || Predicted ORF from Assembly 19; merged with orf19.5260 in Assembly 20 || 1 -0.15 -0.06 0.34
1129 "|| orf19.7304 || || || Protein of unknown function; Hap43-induced; transcript induced early in infection of reconstituted human epithelium, while expression of the C. dubliniensis ortholog is not upregulated; mutants are viable; rat catheter biofilm repressed ||" 1 -0.30 -0.03 0.80
1130 || orf19.12988 || SAP6 || || || 1 -0.10 0.28
1131 "|| orf19.6406 || || || Ortholog(s) have role in regulation of sporulation resulting in formation of a cellular spore and cytosol, mitochondrial ribosome, nucleus localization ||" 1 -0.09 -0.00 0.26
1132 || orf19.2233 || PRE2 || || Putative proteasome beta-5 subunit; macrophage-induced protein || 1 -0.09 -0.00 0.29
1133 || orf19.13739 || || || || 1 -0.06 -0.06 0.42
1134 "|| orf19.5351 || TIF11 || || Translation initiation factor eIF1a; possibly transcriptionally regulated upon hyphal formation; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage ||" 1 -0.06 -0.04 0.35
1135 || orf19.900 || NSP1 || || Essential component of the nuclear pore complex; sumoylation target; stationary phase enriched protein; rat catheter biofilm repressed || 1 -0.10 -0.05 0.49
1136 || orf19.6063 || UBP6 || || Putative ubiquitin-specific protease of the 26S proteasome; oxidative stress-induced via Cap1p || 1 -0.13 -0.08 0.59
1137 || orf19.2747 || RGT1 || || Zn(II)2Cys6 transcription factor; transcriptional repressor involved in the regulation of glucose transporter genes; ortholog of S. cerevisiae Rgt1; mutants display decreased colonization of mouse kidneys || 1 -0.06 -0.03 0.19
1138 "|| orf19.3083 || || || Putative lipid phosphatase of the endoplasmic reticulum; role in DNA repair, actin cytoskeleton organization, cellular manganese ion homeostasis; Spider biofilm repressed ||" 1 -0.19 -0.09 0.65
1139 || orf19.8635 || STR2 || || || 1 -0.08 0.32
1140 "|| orf19.1555 || SAC3 || || Putative nuclear pore-associated protein, required for small ribosomal subunit biogenesis; possibly an essential gene, disruptants not obtained by UAU1 method ||" 1 -0.05 -0.03 0.18
1141 "|| orf19.1468 || CDC55 || || Ortholog(s) have protein phosphatase type 2A regulator activity, protein serine/threonine phosphatase activity ||" 1 -0.13 -0.08 0.52
1142 || orf19.1474 || SLA1 || || Protein required for assembly of the cortical actin cytoskeleton; contains three SH3 domains; transcription is regulated by Nrg1 and Mig1; flow model biofilm repressed || 1 -0.09 0.38
1143 || orf19.2422 || ARC1 || || Putative G4 nucleic acid binding protein; macrophage/pseudohyphal-repressed; protein enriched in stationary phase yeast-form cultures; Spider biofilm repressed || 1 -0.06 -0.06 0.25
1144 "|| orf19.2706 || CRH11 || || GPI-anchored cell wall transglycosylase, putative ortholog of S. cerevisiae Crh1p; predicted glycosyl hydrolase domain; similar to Csf4p and to antigenic A. fumigatus Aspf9; predicted Kex2p substrate; caspofungin-induced ||" 1 0.08 0.00 0.47
1145 || orf19.1299 || RPN6 || || Putative 26S proteasome subunit; Hap43p-induced gene; regulated by Gcn2p and Gcn4p || 1 0.06 -0.01 0.37
1146 || orf19.2768 || AMS1 || || Putative alpha-mannosidase; transcript regulated by Nrg1; induced during cell wall regeneration; flow model biofilm induced; Spider biofilm induced || 1 0.09 -0.04 0.56
1147 || orf19.2954 || || || Protein of unknown function; Hap43-repressed gene; repressed by nitric oxide || 1 0.04 -0.02 0.28
1148 || orf19.2341 || HNT1 || || Protein with similarity to protein kinase C inhibitor-I; protein level decreases in stationary phase cultures || 1 0.12 -0.02 0.47
1149 "|| orf19.6478 || YCF1 || || Putative glutathione S-conjugate transporter; MRP/CFTR-subfamily, ABC type transporter; human neutrophil-induced; oxidative stress-induced via Cap1; possible association with multidrug resistance; possibly essential; Spider biofilm induced ||" 1 0.07 -0.08 0.53
1150 || orf19.2289 || ARP3 || || Protein with Myo5p-dependent localization to cortical actin patches at hyphal tip; mutation confers hypersensitivity to cytochalasin D; Spider biofilm repressed || 1 0.02 -0.04 0.49
1151 || orf19.1593 || || || Protein similar to S. cerevisiae Rim11p; merged with orf19.791 in Assembly 20 || 1 0.03 -0.06 0.49
1152 || orf19.1545 || || || Ortholog(s) have structural constituent of ribosome activity and mitochondrial small ribosomal subunit localization || 1 0.06 0.90
1153 "|| orf19.7200 || || || Ortholog of C. dubliniensis CD36 : Cd36_73480, Pichia stipitis Pignal : PICST_30727, Candida tropicalis MYA-3404 : CTRG_05165 and Candida albicans WO-1 : CAWG_05712 ||" 1 0.03 -0.10 0.48
1154 || orf19.2484 || || || Has domain(s) with predicted peptidase activity and role in proteolysis || 1 0.04 0.61
1155 || orf19.5973 || PHB2 || || Prohibitin 2; plasma membrane localized || 1 0.05 -0.08 0.58
1156 || orf19.816 || DCK2 || || Protein similar to S. cerevisiae Ylr422wp; transposon mutation affects filamentous growth; induced by Mnl1p under weak acid stress || 1 0.03 -0.03 0.31
1157 || orf19.3862 || || || Putative intracellular transport protein; heterozygous null mutant displays sensitivity to rapamycin; expression upregulated during growth in the mouse cecum || 1 0.02 -0.02 0.30
1158 || orf19.12021 || HOL4 || || || 1 0.07 -0.04 0.86
1159 "|| orf19.1381 || || || Ortholog of S. cerevisiae/S. pombe Lsb5; predicted role in actin cortical patch localization, actin filament organization, endocytosis; flow model biofilm induced; Spider biofilm repressed ||" 1 -0.02 -0.04 0.72
1160 "|| orf19.3607 || || || Ortholog of C. dubliniensis CD36 : Cd36_22860, C. parapsilosis CDC317 : CPAR2_806540, Candida tenuis NRRL Y-1498 : CANTEDRAFT_108823 and Debaryomyces hansenii CBS767 : DEHA2B13596g ||" 1 -0.02 -0.04 0.53
1161 || orf19.3003 || || || Putative lipid-binding protein with a predicted role in calcium-dependent phospholipid-binding || 1 -0.03 -0.06 0.53
1162 "|| orf19.7292 || ARP2 || || Component of the Arp2/3 complex; required for virulence, hyphal growth, cell wall/cytoskeleton organization, not for endocytosis; mutation confers hypersensitivity to cytochalasin D; regulated by Gcn2 and Gcn4; Spider biofilm repressed ||" 1 -0.01 -0.10 0.54
1163 || orf19.7281 || PDK2 || || Putative pyruvate dehydrogenase kinase; mutation confers hypersensitivity to amphotericin B || 1 -0.15 0.02 0.72
1164 || orf19.157 || || || Predicted ORF from Assembly 19; merged with orf19.156 in Assembly 20 || 1 -0.09 0.44
1165 || orf19.1339 || CPY1 || || Carboxypeptidase Y; transcript regulated at yeast-hypha transition or macrophage response; induced human neutrophils; regulated by Gcn2 and Gcn4; putative N-glycosylation || 1 -0.16 0.01 0.71
1166 "|| orf19.307 || || || Ortholog(s) have transcription coactivator activity, role in histone acetylation, transcription from RNA polymerase II promoter and Ada2/Gcn5/Ada3 transcription activator complex, SAGA complex, SLIK (SAGA-like) complex localization ||" 1 -0.10 0.45
1167 || orf19.7605 || PUP1 || || Putative beta 2 subunit of the 20S proteasome; macrophage/pseudohyphal-repressed; Spider biofilm repressed || 1 -0.18 0.04 0.66
1168 || orf19.482 || RPT4 || || 26S proteasome regulatory subunit; regulated by Gcn2p and Gcn4p; protein level decreases in stationary phase cultures || 1 -0.11 0.08 0.46
1169 || orf19.9430 || || || || 1 -0.08 0.04 0.37
1170 || orf19.1089 || PEX11 || || Putative peroxisomal membrane protein; role in fatty acid oxidation; expression is Tac1-regulated; Hms1p-dependent induction by geldamycin; Spider biofilm induced || 1 -0.07 0.05 0.37
1171 || orf19.7025 || MCM1 || || Transcription factor; regulator of hyphal growth; may act with Wor1p; canonical and non-canonical binding sites; MADS domain DNA-binding motif; similar to S. cerevisiae Mcm1p; greater expression in white than opaque cells; intron in 5'-UTR || 1 -0.05 0.05 0.32
1172 || orf19.3488 || || || Predicted ORF from Assembly 19; merged with orf19.1985 in Assembly 20 || 1 -0.07 0.46
1173 || orf19.2156 || NAG1 || || Glucosamine-6-phosphate deaminase; required for normal hyphal growth and mouse virulence; converts glucosamine 6-P to fructose 6-P; reversible reaction in vitro; gene and protein is GlcNAc-induced; Spider biofilm induced || 1 -0.06 0.38
1174 "|| orf19.359 || GTT12 || || Ortholog(s) have glutathione peroxidase activity, glutathione transferase activity, role in glutathione metabolic process and endoplasmic reticulum, mitochondrial outer membrane, plasma membrane localization ||" 1 -0.04 0.05 0.24
1175 || orf19.3445 || HOC1 || || Protein with similarity to mannosyltransferases; similar to S. cerevisiae Hoc1p and C. albicans Och1p || 1 -0.07 0.39
1176 || orf19.7082 || || || S-adenosylmethionine transporter of the mitochondrial inner membrane; mitochondrial carrier family; predicted role in biotin biosynthesis and respiratory growth; Spider biofilm repressed || 1 0.02 0.74
1177 "|| orf19.5886 || CUP5 || || Putative proteolipid subunit of the vacuolar H(+)-ATPase V0 sector; required for vacuolar acidification, secretion, filamentous growth; caspofungin repressed ||" 1 -0.01 0.00 0.32
1178 || orf19.1252 || YME1 || || Ortholog(s) have ATP-dependent peptidase activity || 1 0.00 0.00 0.20
1179 || orf19.2667 || RPF1 || || Putative nucleolar protein with a predicted role in the assembly and export of the large ribosomal subunit; essential for growth; rat catheter and Spider biofilm induced || 1 0.00 0.03 0.46
1180 "|| orf19.7061 || || || Ortholog(s) have ATPase activity and cytosol, nucleus localization ||" 1 -0.01 0.04 0.78
1181 || orf19.3312 || || || Protein of unknown function; flow model and Spider biofilm repressed || 1 -0.01 0.63
1182 "|| orf19.7290 || || || Ortholog(s) have RNA cap binding activity, role in deadenylation-dependent decapping of nuclear-transcribed mRNA and cytoplasmic mRNA processing body, cytosol, mRNA cap binding complex, nucleus localization ||" 1 -0.00 0.03 0.21
1183 || orf19.6435 || || || Highly conserved subunit of mitochondrial pyruvate carrier; Hap43-repressed; Spider biofilm repressed || 1 -0.03 0.05 0.36
1184 || orf19.4609 || || || Putative dienelactone hydrolase; protein abundance is affected by URA3 expression in the CAI-4 strain background; protein present in exponential and stationary growth phase yeast cultures; rat catheter biofilm repressed || 1 -0.08 0.97
1185 "|| orf19.5660 || || || Ortholog(s) have ubiquitin-protein ligase activity, role in protein import into peroxisome matrix, protein ubiquitination and endoplasmic reticulum, peroxisomal membrane localization ||" 1 -0.02 0.33
1186 || orf19.2078 || || || Ortholog(s) have role in Golgi to vacuole transport and AP-1 adaptor complex localization || 1 -0.00 0.04
1187 "|| orf19.3007 || || || Ortholog(s) have role in endosome organization, regulation of protein localization and BLOC-1 complex localization ||" 1 -0.02 0.32
1188 "|| orf19.2132 || || || Ortholog of C. dubliniensis CD36 : Cd36_65220, C. parapsilosis CDC317 : CPAR2_213740, Candida tenuis NRRL Y-1498 : CANTEDRAFT_92162 and Debaryomyces hansenii CBS767 : DEHA2A01056g ||" 1 -0.02 0.03 0.34
1189 || orf19.6676 || || || Has domain(s) with predicted diphthine synthase activity and role in peptidyl-diphthamide biosynthetic process from peptidyl-histidine || 1 -0.01 0.24
1190 || orf19.3287 || BUD22 || || Protein with a predicted role in 18S rRNA maturation and small ribosomal subunit biogenesis; repressed in core stress response; repressed by prostaglandins || 1 -0.00 0.02 0.04
1191 || orf19.3823 || ZDS1 || || Nonessential protein; similar to S. cerevisiae Zds1p || 1 -0.65 -0.05 -0.28
1192 "|| orf19.1441 || || || Ortholog of C. dubliniensis CD36 : Cd36_16230, C. parapsilosis CDC317 : CPAR2_213950, Candida tenuis NRRL Y-1498 : CANTEDRAFT_112720 and Debaryomyces hansenii CBS767 : DEHA2A01848g ||" 1 -0.11 -0.05
1193 "|| orf19.5076 || PFY1 || || Profilin; functional homolog of S. cerevisiae Pfy1; hyphae, macrophage/pseudohyphal-induced; regulated by Nrg1, Tup1; gene lacks intron (unlike S. cerevisiae PFY1); complements growth of S. cerevisiae srv2 mutant; nonessential ||" 1 -0.33 -0.04 -0.13
1194 || orf19.1761 || || || Predicted olichyl-diphosphooligosaccharide-protein glycotransferase; role in protein N-linked glycosylation; Spider biofilm repressed || 1 -0.59 -0.12 -0.31
1195 || orf19.1294 || || || Predicted ORF from Assembly 19; merged with orf19.2629 in Assembly 20 || 1 -0.43 -0.16 -0.27
1196 "|| orf19.2143 || || || Ortholog(s) have role in endocytic recycling and cytosol, endosome, nucleus localization ||" 1 -0.35 -0.10 -0.20
1197 || orf19.6031 || VPS27 || || Putative ESCRT-0 complex protein with a role in multivesicular body (MVB) trafficking || 1 -0.65 -0.24 -0.34
1198 || orf19.10912 || SEC12 || || || 1 -0.58 -0.28 -0.33
1199 || orf19.4066 || || || Putative glycerol-3-phosphate acyltransferase; Hog1-repressed || 1 -0.66 -0.38
1200 || orf19.4739 || MSS116 || || Putative DEAD-box protein; required for efficient splicing of mitochondrial Group I and II introns; Hap43-induced; rat catheter biofilm induced || 1 -0.45 -0.24 -0.26
1201 "|| orf19.6028 || HGC1 || || Hypha-specific G1 cyclin-related protein involved in regulation of morphogenesis, biofilm formation; Cdc28-Hgc1 maintains Cdc11 S394 phosphorylation during hyphal growth; required for virulence in mice; regulated by Nrg1, Tup1, farnesol ||" 1 -0.76 -0.43 -0.47
1202 || orf19.11755 || MNN1 || || || 1 -0.27 -0.17 -0.19
1203 || orf19.3037 || || || Putative poly(A)-binding protein; regulated by Gcn4p; induced in response to amino acid starvation (3-AT treatment); protein present in exponential and stationary growth phase yeast cultures || 1 -0.35 -0.21 -0.26
1204 "|| orf19.4937 || CHS3 || || Major chitin synthase of yeast and hyphae; synthesizes short-chitin fibrils; Chs4-activated; transcript induced at yeast-hyphal transition; Chs1 and Chs2, but not Chs3, are inhibited by the protoberberine HWY-289; Spider biofilm induced ||" 1 -0.56 -0.32 -0.43
1205 || orf19.6176 || SEC61 || || ER protein-translocation complex subunit; essential; 10 predicted transmembrane regions; chimeric mutant partially functionally complements S. cerevisiae sec61 defects; Spider biofilm repressed || 1 -0.93 -0.50 -0.66
1206 || orf19.3288 || NMA111 || || Putative serine protease and general molecular chaperone; macrophage-induced gene; repressed in core stress response; merged with orf19.3288.1 in Assembly 21 || 1 -0.40 -0.19 -0.27
1207 || orf19.1690 || TOS1 || || Protein similar to alpha agglutinin anchor subunit; secreted; exogenously expressed protein is a substrate for Kex2 processing in vitro; fluconazole-induced; induced by alpha pheromone in SpiderM medium; Hap43-induced || 1 -0.52 -0.28 -0.44
1208 "|| orf19.7350 || RCT1 || || Fluconazole-induced protein; Ras1, Cyr1 repressed and Efg1 induced; regulated by Nrg1, Tup1, Tbf1, Ssn6; induced in oralpharyngeal candidasis; rat catheter biofilm repressed ||" 1 -0.29 -0.16 -0.24
1209 || orf19.2622 || YPT31 || || Protein required for resistance to toxic ergosterol analog || 1 -0.40 -0.24 -0.34
1210 "|| orf19.4382 || || || Ortholog(s) have role in retrograde vesicle-mediated transport, Golgi to ER and COPI vesicle coat, cytosol, nucleus localization ||" 1 -0.45 -0.27 -0.40
1211 || orf19.10841 || || || || 1 -0.08 -0.07 -0.09
1212 || orf19.1172 || || || Protein similar to phosphate transporters; merged with orf19.655 in Assembly 20 || 1 -0.70 -0.66
1213 || orf19.4772 || SSU81 || || Predicted adaptor protein involved in activation of MAP kinase-dependent signaling pathways; links response to oxidative stress to morphogenesis and cell wall biosynthesis; caspofungin repressed || 1 -0.26 -0.41 -0.25
1214 || orf19.10875 || || || || 1 -0.16 -0.16
1215 || orf19.3462 || SAR1 || || Functional homolog of S. cerevisiae Sar1; which is required for ER-to-Golgi protein transport; binds GTP; similar to small GTPase superfamily proteins; gene has intron; Hap43-induced; rat catheter biofilm repressed || 1 -0.52 -0.23 -0.53
1216 || orf19.3291 || HMT1 || || Major type I protein arginine methyltransferase (PRMT); involved in asymmetric dimethylation of arginine residues; involved in nuclear export of Npl3p; Spider biofilm repressed || 1 -0.14 -0.15
1217 || orf19.7489 || || || Ortholog(s) have Rho GTPase activator activity || 1 -0.23 -0.24
1218 || orf19.6092 || KEL1 || || Kelch repeat domain-containing protein; localizes to sites of polarized growth; mutant colonies exhibit slightly decreased filamentation ratio; not required for buccal epithelial cell adherence or virulence in mice || 1 -0.53 -0.31 -0.54
1219 "|| orf19.1618 || GFA1 || || Glucosamine-6-phosphate synthase, homotetrameric enzyme of chitin/hexosamine biosynthesis; inhibited by UDP-GlcNAc, FMDP, N-acyl peptide, kanosamine-6-P; functional homolog of S. cerevisiae Gfa1p; Cagrowth-phase regulated; catalytic Cys ||" 1 -0.62 -0.36 -0.54
1220 || orf19.2969 || RAD16 || || Ortholog of S. cerevisiae Rad16; a protein that recognizes and binds damaged DNA; flucytosine induced; rat catheter and Spider biofilm induced || 1 -0.35 -0.31
1221 "|| orf19.3541 || ERF1 || || Putative translation release factor 1, which interacts with stop codons and promotes release of nascent peptides from ribosomes; Hap43p-induced gene ||" 1 -0.44 -0.29 -0.41
1222 || orf19.12194 || SEC24 || || || 1 -0.62 -0.42 -0.70
1223 "|| orf19.7298 || CHS2 || || Chitin synthase; nonessential; required for wild-type chitin deposition in hyphae; transcript regulated during dimorphic transition; Chs1 and Chs2, but not Chs3, are inhibited by the protoberberine HWY-289; flow model biofilm repressed ||" 1 -0.26 -0.18 -0.31
1224 || orf19.2924 || || || Predicted ORF from Assembly 19; merged with orf19.4715 in Assembly 20 || 1 -0.38 -0.20 -0.45
1225 "|| orf19.5195 || URA6 || || Ortholog(s) have adenylate kinase activity, uridylate kinase activity, role in 'de novo' pyrimidine nucleobase biosynthetic process and cytosol, mitochondrion, nucleus localization ||" 1 -0.09 -0.11
1226 || orf19.4594 || CLC1 || || Clathrin light chain; subunit of the major coat protein involved in intracellular protein transport and endocytosis; rat cathetr and Spider biofilm repressed || 1 -0.34 -0.13 -0.40
1227 || orf19.2746 || EMP70 || || Protein with a role in endosome-to-vacuole sorting; rat catheter biofilm repressed || 1 -0.46 -0.06 -0.51
1228 || orf19.3334 || RPS21 || || Protein component of the small (40S) subunit; repressed upon phagocytosis by murine macrophage; positively regulated by Tbf1; Spider biofilm repressed || 1 -0.20 -0.22
1229 || orf19.4109 || PMT4 || || Protein mannosyltransferase; required for WT cell wall composition and virulence in mice; roles in hyphal growth and drug sensitivity; one of 5 family members; Axl2 a substrate; Spider biofilm repressed; Bcr1-repressed in RPMI a/a biofilm || 1 -0.63 -0.13 -0.76
1230 "|| orf19.5015 || MYO2 || || Class V myosin; nonessential; sole class V myosin in C. albicans; required for WT actin cytoskeletal polarity, nuclear organization, migration, hyphal growth; conserved myosin ATPase/tail domains; Hap43-induced; flow model biofilm repressed ||" 1 -0.81 -0.24 -0.94
1231 || orf19.8085 || SFL1 || || || 1 -0.22 -0.06 -0.23
1232 || orf19.6052 || CNS1 || || Putative co-chaperone; Hap43p-induced gene; mutation confers hypersensitivity to radicicol || 1 -0.31 -0.07
1233 || orf19.4966 || AGC1 || || Putative mitochondrial carrier protein; transcript is alkaline upregulated rat catheter biofilm induced || 1 -0.18 -0.26
1234 "|| orf19.4931 || || || Putative tRNA-Cys synthetase; induced by alpha pheromone in SpiderM medium; ribosomal subunits, translation factors, tRNA synthetases are downregulated upon phagocytosis by murine macrophage ||" 1 -0.30 -0.13 -0.36
1235 "|| orf19.3914 || || || Has domain(s) with predicted translation initiation factor activity, role in translational initiation and cytoplasm localization ||" 1 -0.14 -0.06 -0.17
1236 "|| orf19.3843 || || || Ortholog(s) have role in filamentous growth, posttranslational protein targeting to membrane, translocation and Sec62/Sec63 complex localization ||" 1 -0.37 -0.15 -0.42
1237 || orf19.12155 || || || || 1 -0.12 -0.06 -0.11
1238 || orf19.5466 || RPS24 || || Predicted ribosomal protein; hyphal downregulated; repressed upon phagocytosis by murine macrophage; transcriptionally activated by Tbf1; Spider biofilm repressed || 1 -0.25 -0.11 -0.22
1239 || orf19.6431 || || || Protein of unknown function; Spider biofilm induced || 1 -0.20 -0.10 -0.19
1240 || orf19.7328 || || || Protein with a Staphylococcal nuclease domain; transcript regulated by Mig1 and Tup1; flow model and Spider biofilm repressed || 1 -0.70 -0.33 -0.70
1241 "|| orf19.3765 || RAX2 || || Plasma membrane protein involved in establishment of bud sites and linear direction of hyphal growth; filament induced, repressed by Rim101, Tup1; Hap43-induced; Spider biofilm induced ||" 1 -0.41 -0.14 -0.42
1242 "|| orf19.1301 || || || Ortholog(s) have cytoplasm, nucleus, ribosome localization ||" 1 -0.22 -0.07 -0.21
1243 || orf19.1261 || CGT1 || || mRNA 5' guanylyltransferase; small subunit of mRNA capping enzyme; binds an RNA Pol II C-terminal domain peptide; Cet1p and Cgt1p form a 2:1 complex; functional homolog of S. cerevisiae Ceg1p || 1 -0.54 -0.16 -0.48
1244 || orf19.1713 || || || Putative ARF GTP/GDP exchange factor; merged with orf19.1712 in Assembly 20 || 1 -0.34 -0.31
1245 || orf19.1487 || || || Predicted ORF from Assembly 19; removed from Assembly 20 || 1 -0.32 -0.09
1246 || orf19.5292 || AXL2 || || Ortholog of S. cerevisiae Axl2; a plasma membrane protein involved in determination of budding pattern; O-glycosylated by Pmt4; mutant is viable || 1 -0.58 -0.42
1247 || orf19.96 || TOP1 || || DNA topoisomerase I; required for wild-type growth and for wild-type mouse virulence; sensitive to camptothecin; induced upon adherence to polystyrene; rat catheter biofilm induced || 1 -0.35 -0.11 -0.27
1248 || orf19.6663 || RPS25B || || Ribosomal protein; macrophage/pseudohyphal-induced after 16 h; repressed upon phagocytosis by murine macrophage; transcript positively regulated by Tbf1; 5'-UTR intron; Hap43-induced; Spider biofilm repressed || 1 -0.42 -0.46 -0.26
1249 || orf19.1334 || || || Protein of unknown function; repressed by alpha pheromone in SpiderM medium || 1 -0.59 -0.63 -0.36
1250 || orf19.6738 || VAN1 || || Member of Mnn9 family of mannosyltransferases; ortholog of S. cerevisiae Van1p; fungal-specific (no human or murine homolog) || 1 -0.63 -0.55 -0.29
1251 || orf19.1114 || || || Cytochrome c oxidase subunit; membrane-localized protein; rat catheter biofilm induced || 1 -0.60 -0.53 -0.32
1252 || orf19.9265 || || || || 1 -0.23 -0.12
1253 || orf19.6090 || || || Putative nucleolar protein with a predicted role in pre-rRNA processing and ribosome biogenesis; repressed by nitric oxide; required for flow model biofilm formation; Spider biofilm repressed || 1 -0.61 -0.37 -0.31
1254 "|| orf19.2803 || HEM13 || || Coproporphyrinogen III oxidase; antigenic; on yeast cell surface, not hyphae; iron-regulated expression; Hap43, macrophage-repressed; farnesol-induced; possibly essential; flow model biofilm induced; rat catheter, Spider biofilm repressed ||" 1 -0.92 -0.75 -0.50
1255 || orf19.92 || || || Protein with a predicted thioredoxin-like domain; Hap43-repressed; induced by prostaglandins || 1 -0.23 -0.21 -0.14
1256 "|| orf19.5634 || FRP1 || || Ferric reductase; alkaline-induced by Rim101; iron-chelation-induced by CCAAT-binding factor; fluconazole-repressed; ciclopirox-, hypoxia-, Hap43-induced; colony morphology-related regulation by Ssn6; Spider and flow model biofilm induced ||" 1 -0.68 -0.60 -0.44
1257 || orf19.1055 || CDC3 || || Septin; essential for viability; functional homolog of S. cerevisiae Cdc3p; down-regulation associated with azole resistance; macrophage/pseudohyphal-repressed; virulence-group-correlated expression; gene has intron || 1 -0.55 -0.50 -0.37
1258 "|| orf19.2843 || RHO1 || || Small GTPase of Rho family; regulates beta-1,3-glucan synthesis activity and binds Gsc1p; essential; expected to be geranylgeranylated by geranylgeranyltransferase type I; plasma membrane-localized ||" 1 -0.36 -0.34 -0.26
1259 "|| orf19.3642 || SUN41 || || Cell wall glycosidase; role in biofilm formation and cell separation; possibly secreted; hypoxia, hyphal induced; caspofungin repressed; Efg1, Cph1 regulated; O-glycosylated, possible Kex2 substrate; 5'-UTR intron; Spider biofilm induced ||" 1 -0.37 -0.32 -0.26
1260 "|| orf19.1483 || || || Ortholog(s) have copper ion binding activity, role in mitochondrial respiratory chain complex IV assembly and extrinsic to mitochondrial inner membrane, mitochondrial intermembrane space localization ||" 1 -0.32 -0.28 -0.26
1261 || orf19.2432 || HAC1 || || bZIP transcription factor; role in unfolded protein response and control of morphology; transcript undergoes atypical splicing at C terminus under ER stress; induced during mating and by caspofungin; mRNA binds She3; Spider biofilm induced || 1 -0.66 -0.58 -0.57
1262 "|| orf19.655 || PHO84 || || High-affinity phosphate transporter; transcript regulated by white-opaque switch; Hog1, ciclopirox olamine or alkaline induced; caspofungin, stress repressed; upregulated in RHE model; Spider and flow model biofilm induced, Hap43-induced ||" 1 -0.69 -0.63
1263 || orf19.559 || FGR14 || || Protein encoded in retrotransposon Zorro3 with similarity to retroviral endonuclease-reverse transcriptase proteins; lacks an ortholog in S. cerevisiae; transposon mutation affects filamentous growth || 1 -0.18 -0.16
1264 "|| orf19.4265 || UAP1 || || UDP-N-acetylglucosamine pyrophosphorylase, catalyzes biosynthesis of UDP-N-acetylglucosamine from UTP and N-acetylglucosamine 1-phosphate; functional homolog of S. cerevisiae Qri1p; alkaline upregulated ||" 1 -0.45 -0.44 -0.41
1265 || orf19.593 || FGR32 || || Protein similar to S. cerevisiae Swa2p; induced upon adherence to polystyrene; transposon mutation affects filamentous growth; Hap43p-repressed gene || 1 -0.35 -0.48 -0.29
1266 "|| orf19.3128 || || || Ortholog(s) have syntaxin binding activity and role in ER to Golgi vesicle-mediated transport, positive regulation of SNARE complex assembly, retrograde vesicle-mediated transport, Golgi to ER, vesicle fusion with Golgi apparatus ||" 1 -0.38 -0.32
1267 || orf19.5949 || FAS2 || || Alpha subunit of fatty-acid synthase; required for virulence in mouse systemic infection and rat oropharyngeal infection models; regulated by Efg1; fluconazole-induced; amphotericin B repressed; flow model and Spider biofilm repressed || 1 -0.72 -0.62 -0.60
1268 "|| orf19.2967 || TIF34 || || Putative translation initiation factor eIF3, p39 subunit; mutation confers hypersensitivity to roridin A, verrucarin A; downregulated upon phagocytosis by murine macrophages; Spider biofilm repressed ||" 1 -0.29 -0.24
1269 || orf19.9505 || VPS1 || || || 1 -0.43 -0.31 -0.35
1270 "|| orf19.3647 || SEC8 || || Predicted subunit of the exocyst complex, involved in exocytosis; localizes to a crescent on the surface of the hyphal tip ||" 1 -0.15 -0.12
1271 || orf19.9184 || || || || 1 -0.14 -0.20 -0.10
1272 "|| orf19.6905 || || || Ortholog of S. cerevisiae : YNL011C, C. glabrata CBS138 : CAGL0H03619g, C. dubliniensis CD36 : Cd36_71090, C. parapsilosis CDC317 : CPAR2_300420 and Candida tenuis NRRL Y-1498 : CANTEDRAFT_111980 ||" 1 -0.23 -0.37 -0.21
1273 || orf19.3350 || MRP20 || || Component of mitochondrial ribosome; decreased expression in hyphae compared to yeast-form cells || 1 -0.16 -0.28 -0.19
1274 "|| orf19.649 || || || Ortholog of C. dubliniensis CD36 : Cd36_30530, C. parapsilosis CDC317 : CPAR2_203340, Candida tenuis NRRL Y-1498 : CANTEDRAFT_117008 and Debaryomyces hansenii CBS767 : DEHA2G24244g ||" 1 -0.12 -0.23 -0.19
1275 || orf19.2994 || RPL13 || || Putative ribosomal subunit; antigenic during murine infection; downregulated upon phagocytosis by murine macrophage; Spider biofilm repressed || 1 -0.18 -0.39 -0.42
1276 || orf19.5927 || RPS15 || || Putative ribosomal protein; macrophage/pseudohyphal-induced after 16 h; repressed upon phagocytosis by murine macrophage; Spider biofilm repressed || 1 -0.25 -0.46 -0.52
1277 || orf19.4336 || RPS5 || || Ribosomal protein S5; macrophage/pseudohyphal-induced after 16 h; downregulated upon phagocytosis by murine macrophage; Hap43-induced; Spider biofilm repressed || 1 -0.13 -0.20 -0.23
1278 || orf19.7217 || RPL4B || || Ribosomal protein 4B; repressed upon phagocytosis by murine macrophage; Spider biofilm repressed || 1 -0.10 -0.14 -0.19
1279 || orf19.172 || RPC19 || || Putative RNA polymerases I and III subunit AC19; Hap43-induced; rat catheter biofilm induced || 1 -0.16 -0.19 -0.28
1280 "|| orf19.4266 || SPR28 || || Septin; similar to S. cerevisiae meiotic/sporulation septin; mutant has no obvious phenotype; two introns with noncanonical branch site and 5' splice site, respectively; splicing inhibited upon exposure to alpha-factor ||" 1 -0.12 -0.15 -0.24
1281 "|| orf19.1486 || || || Protein with a life-span regulatory factor domain; regulated by Sef1, Sfu1, and Hap43; flow model biofilm induced; Spider biofilm induced ||" 1 -0.21 -0.31 -0.48
1282 || orf19.7018 || RPS18 || || Predicted ribosomal protein; repressed upon phagocytosis by murine macrophage; repressed by nitric oxide; Hap43-induced; Spider biofilm repressed || 1 -0.15 -0.25 -0.36
1283 || orf19.6375 || RPS20 || || Putative ribosomal protein; repressed upon phagocytosis by murine macrophage; transcript positively regulated by Tbf1; Spider biofilm repressed || 1 -0.21 -0.34 -0.58
1284 "|| orf19.1700 || RPS7A || || Ribosomal protein S7; genes encoding cytoplasmic ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage; Spider biofilm repressed ||" 1 -0.15 -0.20 -0.37
1285 || orf19.4413 || CMD1 || || Calmodulin; calmodulin inhibitors cause a defect in hyphal growth; transcript not regulated by yeast-hyphal transition; mutation confers hypersensitivity to cytochalasin D and high concentrations of tunicamycin; gene has intron || 1 -0.24 -0.28 -0.52
1286 || orf19.5505 || HIS7 || || Putative imidazole glycerol phosphate synthase; histidine biosynthesis; no human/murine homolog; transcription induced by histidine starvation; regulated by Gcn2p and Gcn4p; higher protein level in stationary phase || 1 -0.13 -0.12 -0.21
1287 || orf19.7901 || SES1 || || || 1 -0.38 -0.37 -0.57
1288 "|| orf19.1460 || || || Putative glutamine-dependent NAD synthetase, involved in NAD salvage pathway ||" 1 -0.35 -0.38 -0.49
1289 || orf19.7638 || PRO1 || || Putative gamma-glutamyl kinase; transcript regulated by Nrg1; regulated by Gcn2 and Gcn4; Hap43-repressed gene; early-stage flow model biofilm induced gene || 1 -0.17 -0.23 -0.27
1290 "|| orf19.3166 || || || Ortholog(s) have role in Golgi to endosome transport, cell morphogenesis, cleistothecium development, conidium formation and endoplasmic reticulum organization, more ||" 1 -0.26 -0.41
1291 || orf19.4878 || || || Protein of unknown function; Hap43-repressed; rat catheter biofilm repressed || 1 -0.22 -0.35
1292 || orf19.656 || DPP1 || || Putative diacylglycerol pyrophosphate phosphatase of diacylglycerol production for phospholipid biosynthesis; downregulation correlates with clinical development of fluconazole resistance || 1 -0.42 -0.49
1293 || orf19.671 || PSP1 || || Protein repressed during the mating process || 1 -0.04 -0.05 -0.05
1294 || orf19.4796 || || || Putative eIF-4E-binding repressor of CAP-dependent translation; stationary phase enriched protein || 1 -0.40 -0.51
1295 || orf19.6285 || GLC7 || || Putative catalytic subunit of type 1 serine/threonine protein phosphatase; regulated by Shp1; induced in high iron; alternatively spliced intron in 5' UTR || 1 -0.17 -0.42 -0.22
1296 || orf19.8964 || || || || 1 -0.09 -0.41 -0.37
1297 "|| orf19.4715 || || || Ortholog(s) have tubulin binding activity, role in microtubule cytoskeleton organization, mitochondrial fission, mitochondrion inheritance, nuclear migration along microtubule and cell cortex, cellular bud tip, mitochondrion localization ||" 1 -0.00 -0.53 -0.48
1298 || orf19.6121 || MNL1 || || Transcription factor; induces transcripts of stress response genes via SLE (STRE-like) elements; required for adaptation to weak acid stress; activates a subset of the genes that are repressed by Nrg1 || 1 0.03 -0.37 -0.32
1299 || orf19.5372 || || || Predicted ORF (Assembly 19); orf19.5372 and orf19.5373 are similar to Tca2 (pCal) retrotransposon present in strain hOG1042 as 50 to 100 copies of a linear dsDNA; removed from Assembly 20; Tbf1-induced; rat catheter biofilm repressed || 1 0.06 -0.33 -0.27
1300 "|| orf19.4044 || MUM2 || || Protein similar to S. cerevisiae Mum2, a protein essential for meiotic DNA replication and sporulation; induced by alpha pheromone in SpiderM medium; transcript regulated by Tup1 ||" 1 0.11 -0.53
1301 "|| orf19.3700 || TOM70 || || Ortholog(s) have mitochondrion targeting sequence binding, protein channel activity and role in protein import into mitochondrial inner membrane, protein import into mitochondrial matrix ||" 1 0.04 -0.17 -0.20
1302 || orf19.6085 || RPL16A || || Ribosomal protein; transposon mutation affects filamentous growth; repressed upon phagocytosis by murine macrophages; Hap43-induced; Spider biofilm repressed || 1 0.07 -0.48 -0.60
1303 "|| orf19.1470 || RPS26A || || Ribosomal protein; regulated by Nrg1, Tup1; repressed upon phagocytosis by murine macrophage; alternatively spliced intron in 5'-UTR; Spider biofilm repressed ||" 1 0.02 -0.27 -0.39
1304 || orf19.4632 || RPL20B || || Ribosomal protein L20; repressed upon phagocytosis by murine macrophage; alternatively spliced intron in 5' UTR; Hap43-induced; Spider biofilm repressed || 1 -0.01 -0.40 -0.50
1305 || orf19.2994.1 || RPS16A || || Putative 40S ribosomal subunit; macrophage/pseudohyphal-induced after 16 h; Spider biofilm repressed || 1 -0.02 -0.27 -0.38
1306 "|| orf19.1378 || SUP35 || || Translation factor eRF3; shows prion-like aggregation in some, not all, studies; partially complements S. cerevisiae sup35 mutant translation defect; species barrier with S. cerevisiae Sup35p prion; gene not regulated by yeast-hyphal switch ||" 1 -0.02 -0.17 -0.22
1307 || orf19.4004 || CCT3 || || Putative cytosolic chaperonin Cct ring complex subunit; mutation confers hypersensitivity to cytochalasin D || 1 -0.02 -0.13 -0.19
1308 "|| orf19.2973 || || || Ortholog(s) have RNA binding, flap-structured DNA binding activity and role in nuclear-transcribed mRNA poly(A) tail shortening, positive regulation of endodeoxyribonuclease activity ||" 1 -0.03 -0.18
1309 || orf19.1233 || ADE4 || || Putative phosphoribosylpyrophosphate amidotransferase; flucytosine induced || 1 -0.04 -0.18 -0.28
1310 || orf19.4641 || NMT1 || || Myristoyl-CoA:protein N-myristoyltransferase; attaches the fatty acid myristate to a small number of proteins at an N-terminal Gly; essential; antifungal drug target; functional homolog of S. cerevisiae Nmt1p || 1 -0.05 -0.09 -0.20
1311 || orf19.4280 || || || Protein of unknown function; Spider biofilm induced; rat catheter biofilm repressed || 1 -0.02 -0.09
1312 || orf19.5647 || SUB2 || || Putative TREX complex component with a predicted role in nuclear mRNA export; transcription is regulated by Mig1; Hap43-induced gene; Spider biofilm repressed || 1 -0.02 -0.13 -0.23
1313 "|| orf19.4045 || EST1 || || Telomerase subunit; allosteric activator of catalytic activity, but not required for catalytic activity; has TPR domain ||" 1 -0.01 -0.06 -0.12
1314 "|| orf19.1661 || DBP5 || || Ortholog(s) have RNA helicase activity, RNA-dependent ATPase activity, inositol hexakisphosphate binding activity and role in mRNA export from nucleus, translational termination ||" 1 -0.01 -0.07
1315 "|| orf19.1392 || || || Ortholog(s) have chaperone binding, protein disulfide isomerase activity, unfolded protein binding activity and role in ER-associated ubiquitin-dependent protein catabolic process, protein retention in ER lumen ||" 1 -0.02 -0.10
1316 || orf19.7270 || || || Protein of unknown function; Spider biofilm repressed || 1 -0.08 -0.12 -0.48
1317 || orf19.6265 || RPS22A || || Predicted ribosomal protein; repressed upon phagocytosis by murine macrophage; Spider biofilm repressed || 1 -0.06 -0.11 -0.45
1318 || orf19.13011 || || || || 1 -0.01 -0.09
1319 "|| orf19.5373 || || || Predicted ORF; orf19.5372 and orf19.5373 are similar to Tca2 (pCal) retrotransposon, present in strain hOG1042 as 50 to 100 copies of a linear dsDNA; clade-associated gene expression; removed from Assembly 20; rat catheter biofilm repressed ||" 1 -0.03 -0.12 -0.31
1320 "|| orf19.2672 || NCP1 || || NADPH-cytochrome P450 reductase, acts with Erg11p in sterol 14 alpha-demethylation in ergosterol biosynthesis; subject to hypoxic regulation; ketoconazole-induced; caspofungin repressed ||" 1 -0.01 -0.12 -0.26
1321 "|| orf19.7195 || RAD6 || || Functional ortholog of S. cerevisiae Rad6; negative regulator of hyphal growth; required for wild-type UV resistance; acts in pathway with Efg1; ; transcript is UV-induced, slightly repressed during hyphal growth; gene has two introns ||" 1 0.02 -0.33 -0.59
1322 || orf19.8186 || || || || 1 0.06 -0.28 -0.58
1323 "|| orf19.4774 || AOX1 || || Alternative oxidase; low abundance; constitutively expressed; one of two isoforms (Aox1p and Aox2p); involved in a cyanide-resistant respiratory pathway present in plants, protists, and some fungi, absent in S. cerevisiae; Hap43p-repressed ||" 1 0.13 -0.52 -1.03
1324 "|| orf19.6134 || || || Ortholog(s) have role in ER-dependent peroxisome organization, retrograde vesicle-mediated transport, Golgi to ER and Dsl1p complex, endoplasmic reticulum membrane, nuclear envelope, peroxisome localization ||" 1 0.06 -0.10 -0.24
1325 "|| CaalfMp07 || ATP8 || || Subunit 8 of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis ||" 1 0.14 -0.23 -0.51
1326 || orf19.2232 || RPL11 || || Ribosomal protein; repressed by phagocytosis; colony morphology-related gene regulation by Ssn6; Hap43-induced; Spider biofilm repressed || 1 0.23 -0.31 -0.59
1327 "|| orf19.2929 || GSC1 || || Essential beta-1,3-glucan synthase subunit; gsc1 allele determines resistance/sensitivity to echinocandins; 16 predicted membrane-spanning regions; mRNA abundance declines after yeast-to-hypha transition; Spider biofilm induced ||" 1 0.18 -0.25 -0.33
1328 || orf19.1906 || || || Protein of unknown function; flow model biofilm induced || 1 0.11 -0.22
1329 "|| orf19.6928 || SAP9 || || Secreted aspartyl protease; roles in adhesion, cell surface integrity; induced by antifungal drugs, stationary phase, or in white-phase cells; farnesol-downregulated in biofilm; autocatalytic processing; GPI-anchor; Spider biofilm induced ||" 1 0.15 -0.29 -0.33
1330 "|| orf19.6785 || RPS12 || || Acidic ribosomal protein S12; regulated by Gcn4, activated by Tbf1; repressed by amino acid starvation (3-AT); protein abundance is affected by URA3 expression in CAI-4 strain background; sumoylation target; Spider biofilm repressed ||" 1 0.13 -0.17 -0.51
1331 "|| orf19.1635 || RPL12 || || Ribosomal protein L12, 60S ribosomal subunit; downregulated by human whole blood or polymorphonuclear cells; genes encoding cytoplasmic ribosomal subunits are downregulated upon phagocytosis by macrophage; Tbf1p-activated; Hap43p-induced ||" 1 0.11 -0.12 -0.45
1332 || orf19.3465 || RPL10A || || Predicted ribosomal protein; downregulated upon phagocytosis by murine macrophages; Hap43-induced; Spider biofilm repressed || 1 0.06 -0.07 -0.31
1333 || orf19.4718 || TRP5 || || Predicted tryptophan synthase; identified in detergent-resistant membrane fraction (possible lipid raft component); predicted N-terminal acetylation; Gcn4p-regulated; S. cerevisiae ortholog is Gcn4p regulated; upregulated in biofilm; || 1 0.04 -0.03 -0.14
1334 || orf19.2778 || || || Protein of unknown function; transcript is upregulated in clinical isolates from HIV+ patients with oral candidiasis || 1 0.04 -0.13
1335 "|| orf19.5928 || RPP2B || || Conserved acidic ribosomal protein; possibly involved in regulation of translation elongation; interacts with Rpp1A; 1 of 4 similar C. albicans proteins (Rpp1A, Rpp1B, Rpp2A, Rpp2B); macrophage/pseudohyphal-induced; Spider biofilm repressed ||" 1 0.25 -0.13 -0.84
1336 || orf19.2179.2 || RPS10 || || Ribosomal protein S10; downregulated in the presence of human whole blood or PMNs; Spider biofilm repressed || 1 0.13 -0.04 -0.33
1337 "|| orf19.4304 || GAP1 || || Amino acid permease; antigenic in human/mouse; 10-12 transmembrane regions; regulated by nitrogen source; alkaline, GlcNAc, phagocytosis induced; WT virulence in mice; Spider and flow model biofilm induced ||" 1 0.15 -0.07 -0.35
1338 "|| orf19.3732 || ERG25 || || Putative C-4 methyl sterol oxidase; C4-demethylation of ergosterol biosynthesis intermediates, based on similarity to S. cerevisiae Erg25; fluconazole-induced; induced in azole-resistant strain; rat catheter and Spider biofilm induced ||" 1 0.26 -0.01 -0.39
1339 || orf19.4560 || BFR1 || || Protein involved in the maintenance of normal ploidy; S. cerevisiae ortholog cofers Brefeldin A resistance; stationary phase enriched protein; Spider biofilm repressed || 1 0.25 -0.02 -0.47
1340 "|| orf19.3370 || DOT4 || || Protein similar to ubiquitin C-terminal hydrolase; localizes to cell surface of hyphal cells, but not yeast-form cells; repressed upon high-level peroxide; Hap43p-induced; rat catheter biofilm induced ||" 1 0.14 -0.02 -0.26
1341 "|| orf19.4242 || CST20 || || Protein kinase of Ste20p/p65PAK family, required for wild-type mating efficiency and virulence in a mouse model; Cst20p-Hst7p-Cek1p-Cph1p MAPK pathway regulates some hyphal growth; involved in Cdc42p growth regulation ||" 1 0.15 -0.27
1342 || orf19.3757 || ATP20 || || Putative mitochondrial ATP synthase; shows colony morphology-related gene regulation by Ssn6p; flucytosine induced; caspofungin repressed; macrophage/pseudohyphal-induced || 1 0.10 -0.04 -0.18
1343 "|| orf19.657 || SAM2 || || S-adenosylmethionine synthetase; localizes to surface of hyphae, not yeast cells; alkaline, Hog1-induced; farnesol-downregulated; F-12/CO2 early biofilm induced; Spider biofilm repressed ||" 1 0.25 -0.06 -1.00
1344 || orf19.2953 || TOM20 || || Putative mitochondrial primary import receptor || 1 0.03 -0.00 -0.12
1345 || orf19.386 || SAM4 || || Putative S-adenosylmethionine-homocysteine methyltransferase; Hap43-repressed; alkaline induced; Spider biofilm repressed || 1 0.20 -0.04 -0.61
1346 "|| orf19.6782 || BMT1 || || Beta-mannosyltransferase, required for addition of the 1st beta-mannose residue to acid-stable fraction of cell wall phosphopeptidomannan; 9-gene family member; mutants induce higher levels of inflammatory cytokines in mouse dendritic cells ||" 1 0.19 -0.02 -0.53
1347 || orf19.300 || AIP2 || || Putative actin interacting protein; regulated by Gcn4; induced in response to amino acid starvation (3-AT); repressed by elevated CO2; flow model biofilm repressed || 1 0.12 -0.01 -0.29
1348 || orf19.827.1 || RPL39 || || Ribosomal protein L39; transcript induced upon germ tube formation; colony morphology-related gene regulation by Ssn6; Hap43-induced || 1 0.26 -0.01 -0.62
1349 || orf19.12415 || || || || 1 0.05 0.00 -0.13
1350 || orf19.451 || SOK1 || || Protein kinase: mutants are sensitive to growth on hydrogen peroxide medium; induced by alpha pheromone in SpiderM medium; rat catheter and Spider biofilm induced || 1 0.12 0.01 -0.35
1351 "|| orf19.2992 || RPP1A || || Conserved acidic ribosomal protein; likely role in regulation of translation elongation; interacts with Rpp2B; 1 of 4 similar C. albicans ribosomal proteins (Rpp1A, Rpp1Bp, Rpp2A, Rpp2B); Hap43-induced; Spider biofilm repressed ||" 1 0.25 0.02 -0.74
1352 || orf19.5904 || RPL19A || || Ribosomal protein L19; repressed upon phagocytosis by murine macrophages; Hap43-induced gene; Spider biofilm repressed || 1 0.27 0.04 -0.76
1353 "|| orf19.1435 || TEF1 || || Translation elongation factor 1-alpha; at cell surface; binds human plasminogen; macrophage/pseudohyphal-induced; induced in RHE model of oral candidiasis, in clinical oral candidiasis isolates; possibly essential; Spider biofilm repressed ||" 1 0.29 0.03 -0.77
1354 || orf19.2053 || || || Predicted ORF from Assembly 19; merged with orf19.2051 in Assembly 20 || 1 0.05 -0.12
1355 || orf19.3504 || RPL23A || || Ribosomal protein; downregulated upon phagocytosis by murine macrophage; Hap43-induced; sumoylation target; Spider biofilm repressed || 1 0.29 0.05 -0.72
1356 "|| orf19.1435 || TEF1 || || Translation elongation factor 1-alpha; at cell surface; binds human plasminogen; macrophage/pseudohyphal-induced; induced in RHE model of oral candidiasis, in clinical oral candidiasis isolates; possibly essential; Spider biofilm repressed ||" 1 0.24 0.10 -0.69
1357 || orf19.4334 || PGA58 || || Putative GPI-anchored protein; transcription is positively regulated by Tbf1p || 1 0.14 0.04 -0.49
1358 "|| orf19.4001 || || || Ortholog(s) have role in protein insertion into mitochondrial membrane from inner side and extrinsic to mitochondrial inner membrane, mitochondrial matrix localization ||" 1 0.04 0.01 -0.16
1359 "|| orf19.4490 || RPL17B || || Ribosomal protein L17; mutation confers hypersensitivity to 5-FU, tubercidin; repressed upon phagocytosis by macrophage; Hap43-induced; Spider biofilm repressed ||" 1 0.12 0.09 -0.73
1360 || orf19.2222 || || || Putative casein kinase; plasma membrane-localized || 1 0.03 -0.18
1361 || orf19.710 || || || Putative beta subunit of succinate-CoA ligase; transcript regulated by Mig1 and Tup1; induced in high iron; merged with orf19.1860 in Assembly 20 || 1 0.14 0.17 -0.75
1362 "|| orf19.2138 || ILS1 || || Putative isoleucyl-tRNA synthetase, the target of drugs including the cyclic beta-amino acid icofungipen/PLD-118/BAY-10-8888 and mupirocin; protein present in exponential and stationary growth phase yeast cultures ||" 1 0.06 0.07 -0.26
1363 "|| orf19.191 || KIC1 || || Member of the GCK-III subfamily of eukaryotic Ste20p kinases; in RAM cell wall integrity signaling network; role in cell separation, azole sensitivity; required for hyphal growth; constitutive expression is MTL, white-opaque independent ||" 1 0.05 0.05 -0.21
1364 "|| orf19.57 || PSF2 || || Ortholog(s) have role in DNA-dependent DNA replication, cellular protein localization, double-strand break repair via break-induced replication, meiotic chromosome segregation ||" 1 0.09 -0.38
1365 || orf19.412 || SSH1 || || Protein with a role in protein translocation across membranes || 1 0.09 0.07 -0.37
1366 || orf19.9180 || ILV2 || || || 1 0.31 0.28 -0.96
1367 || orf19.3567 || BIO32 || || Putative class III aminotransferase with a predicted role in biotin biosynthesis; Spider biofilm induced || 1 0.43 0.55 -1.39
1368 || orf19.4885 || MIR1 || || Putative mitochondrial phosphate transporter; caspofungin repressed; expression is increased in a fluconazole-resistant isolate; induced upon adherence to polystyrene || 1 0.10 0.21 -0.42
1369 || orf19.2917 || || || Putative GTPase; heterozygous null mutant exhibits resistance to parnafungin in the C. albicans fitness test; Hap43p-induced gene || 1 0.03 0.27 -0.45
1370 || orf19.5341 || RPS4A || || Predicted ribosomal protein; repressed upon phagocytosis by murine macrophage; positively regulated by Tbf1; Spider biofilm repressed || 1 0.02 0.27 -0.51
1371 "|| orf19.3268 || TMA19 || || Cell wall protein, ortholog of S. cerevisiae Tma19p (Ykl065cp) ||" 1 -0.01 0.51 -0.96
1372 "|| orf19.4662 || RLM1 || || Putative transcription factor; required for wild-type resistance to cell wall perturbation, caspofungin treatment; regulates caspofungin induction of PGA13 ||" 1 -0.00 0.08 -0.15
1373 "|| orf19.24 || RTA2 || || Flippase; sphingolipid long chain base release; mediates calcineurin-dependent resistance to azoles; stress-associate; Plc1, Ca2+, calcineurin-regulated; ketoconazole, caspofungin induced; Spider biofilm induced; flow biofilm repressed ||" 1 0.05 0.20 -0.46
1374 "|| orf19.4223 || GCD11 || || Gamma subunit of translation initiation factor eIF2; involved in identification of the start codon; likely essential for growth, based on an insertional mutagenesis strategy; Spider biofilm repressed ||" 1 0.09 0.20 -0.61
1375 || orf19.1990 || SNX4 || || Putative sorting nexin; induced during the mating process || 1 0.02 0.05 -0.18
1376 "|| orf19.4152 || CEF3 || || Translation elongation factor 3; antigenic in humans; predicted C-term nucleotide-binding active site; protein on surface of yeast, not hyphae; polystyrene adherence induced; higher protein amount in stationary phase; possibly essential ||" 1 0.06 0.33 -1.00
1377 || orf19.6022 || NRM1 || || Transcriptional regulator of cell cycle gene expression; regulates expression of genes involved in DNA replication stress; interacts with Swi4 and Swi6; repressed during core stress response; Spider biofilm repressed || 1 0.01 0.14 -0.46
1378 || orf19.6114 || || || Protein of unknown function; transcript detected on high-resolution tiling arrays || 1 -0.01 0.24 -0.80
1379 || orf19.922 || ERG11 || || Lanosterol 14-alpha-demethylase; cytochrome P450 family; role in ergosterol biosynthesis; target of azole antifungals; may contribute to drug resistance; azole or flow model biofilm induced; drug treated biofilm induced; hypoxia regulated || 1 -0.02 0.03 -0.18
1380 || orf19.12980 || || || || 1 -0.03 0.08 -0.37
1381 || orf19.1508 || || || Protein of unknown function; transcript detected on high-resolution tiling arrays || 1 -0.00 0.01 -0.02
1382 "|| orf19.1195 || || || Ortholog(s) have metalloendopeptidase activity, role in cellular iron ion homeostasis, protein processing involved in protein targeting to mitochondrion and mitochondrion localization ||" 1 -0.03 0.12 -0.37
1383 || orf19.4825 || || || Mitochondrial matrix protein; required for assembly/stability of the F1 sector of mitochondrial F1F0 ATP synthase at high temperature; rat catheter biofilm repressed || 1 -0.12 -1.12
1384 || orf19.11452 || || || || 1 -0.05 0.29 -0.48
1385 || orf19.2960 || FRS2 || || Putative tRNA-Phe synthetase; downregulated upon phagocytosis by murine macrophage; protein present in exponential and stationary growth phase yeast cultures; Spider biofilm repressed || 1 -0.05 0.19 -0.39
1386 "|| orf19.6213 || SUI2 || || Translation initiation factor eIF2, alpha chain; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage; stationary phase enriched protein ||" 1 -0.05 -0.37
1387 || orf19.9377 || || || || 1 -0.08 0.18 -0.52
1388 "|| orf19.3259 || || || Ortholog(s) have peptidase activity, role in protein targeting to ER, signal peptide processing and signal peptidase complex localization ||" 1 -0.09 0.16 -0.46
1389 "|| orf19.4635 || NIP1 || || Putative translation initiation factor; mutation confers hypersensitivity to roridin A and verrucarin A; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage ||" 1 -0.17 -0.02 -0.35
1390 || orf19.5561 || STE23 || || Ortholog of S. cerevisiae Ste23 metalloprotease; role in N-terminal processing of pro-a-factor to the mature form; Tn mutation affects filamentous growth; Spider biofilm induced || 1 -0.05 -0.10
1391 || orf19.5073 || DPM1 || || Putative dolichol phosphate mannose synthase; filament induced; Tup1-regulated; flow model and rat catheter biofilm repressed || 1 -0.45 -0.04 -0.84
1392 "|| orf19.7445 || || || Ortholog of S.c. Vid24; a peripheral membrane protein located at Vid (vacuole import and degradation) vesicles; regulated by Sef1, Sfu1, and Hap43; Spider biofilm induced ||" 1 -0.20 -0.00 -0.35
1393 "|| orf19.3013 || CDC12 || || Septin; essential for viability; forms ring at sites of cell division and also forms filaments in mature chlamydospore; filamentous growth induced; regulated by Nrg1, Tup1, tyrosol and cell density; rat catheter biofilm repressed ||" 1 -0.48 -0.05 -0.75
1394 || orf19.2937 || PMM1 || || Phosphomannomutase; enzyme of O- and N-linked mannosylation; interconverts mannose-6-phosphate and mannose-l-phosphate; functional homolog of S. cerevisiae Sec53; antigenic in mice; Hap43-induced; flow model and Spider biofilm repressed || 1 -0.62 -0.13 -0.91
1395 "|| orf19.1559 || HOM2 || || Aspartate-semialdehyde dehydrogenase; forms a homodimer; conserved in bacteria, archaea, and fungi but not in mammals; ketoconazole-repressed; protein present in exponential and stationary growth phase yeast cultures; GlcNAc-induced protein ||" 1 -0.06 -0.03 -0.09
1396 "|| orf19.548 || CDC10 || || Septin, required for wild-type cell, hyphal, or chlamydospore morphology; role in virulence and kidney tissue invasion in mouse infection; forms ring at sites of cell division and filaments in mature chlamydospore; Spider biofilm repressed ||" 1 -0.41 -0.15 -0.61
1397 || orf19.4181 || SPC2 || || Signal peptidase complex component; role in ER protein translocation; transcript is induced upon filamentous growth || 1 -0.32 -0.11 -0.53
1398 "|| orf19.6082 || || || Ortholog(s) have unfolded protein binding activity, role in protein folding, protein localization to cell surface and integral to endoplasmic reticulum membrane, mitochondrial outer membrane localization ||" 1 -0.38 -0.16 -0.71
1399 || orf19.528 || SEC26 || || Secretory vesicles coatomer complex protein || 1 -0.40 -0.15 -0.68
1400 || orf19.3098 || || || Predicted RNA-dependent ATPase RNA helicase; Hap43-induced gene || 1 -0.08 -0.14
1401 || orf19.2183 || KRE30 || || YEF3-subfamily ABC family protein; predicted not to be a transporter; repressed in core stress response; mutation confers hypersensitivity to amphotericin B || 1 -0.34 -0.51
1402 || orf19.6327 || HET1 || || Putative sphingolipid transfer protein; involved in localization of glucosylceramide which is important for virulence; Spider biofilm repressed || 1 -0.57 -0.27 -0.84
1403 || orf19.8671 || RPN4 || || || 1 -0.17 -0.15 -0.31
1404 || orf19.7537 || BNR1 || || Formin; probable role in hyphal cytoskeletal polarity; synthetic lethality if Bnr1p and Bni1p are absent || 1 -0.09 -0.09 -0.22
1405 "|| orf19.6319 || || || Ortholog(s) have mRNA binding, ubiquitin-specific protease activity and role in protein deubiquitination, regulation of ER to Golgi vesicle-mediated transport, regulation of response to osmotic stress, ribophagy ||" 1 -0.06 -0.05 -0.15
1406 "|| orf19.5691 || CDC11 || || Septin; cell and hyphal morphology, agar-invasive growth, full virulence and kidney tissue invasion in mouse, but not kidney colonization, immunogenicity; hyphal and cell-cycle-regulated phosphorylation; rat catheter biofilm repressed ||" 1 -0.40 -0.31 -0.91
1407 || orf19.2558 || || || Has domain(s) with predicted zinc ion binding activity and nucleus localization || 1 -0.08 -0.16
1408 || orf19.491 || || || Endoplasmic reticulum (ER) protein-translocation complex subunit || 1 -0.44 -0.19 -0.92
1409 "|| orf19.6975 || YST1 || || Ribosome-associated protein; antigenic in mice; complements S. cerevisiae yst1 yst2 mutant; similar to laminin receptor; predicted S/T phosphorylation, N-glycosylation, myristoylation, Hap43-, Gcn4-regulated; Spider biofilm repressed ||" 1 -0.25 -0.18 -0.66
1410 || orf19.9241 || || || || 1 -0.25 -0.24 -0.89
1411 "|| orf19.2826 || || || Ortholog of C. dubliniensis CD36 : Cd36_27680, C. parapsilosis CDC317 : CPAR2_801140, Candida tenuis NRRL Y-1498 : CANTEDRAFT_129982 and Debaryomyces hansenii CBS767 : DEHA2E09526g ||" 1 -0.05 -0.18
1412 || orf19.4871 || ERO1 || || Ortholog of S. cerevisiae Ero1; role in formation of disulfide bonds in the endoplasmic reticulum; fluconazole-induced; induced by Mnl1 under weak acid stress; Spider biofilm induced || 1 -0.18 -0.21 -0.65
1413 "|| orf19.5817 || || || Ortholog(s) have Rab guanyl-nucleotide exchange factor activity, role in ER to Golgi vesicle-mediated transport, intra-Golgi vesicle-mediated transport and TRAPP complex, cis-Golgi network membrane, cytosol, nucleus localization ||" 1 -0.05 -0.05 -0.19
1414 || orf19.3759 || || || Putative elongator complex subunit; for modification of wobble nucleosides in tRNA; Spider biofilm induced || 1 0.02 -0.07 -0.57
1415 || orf19.3758 || || || Ortholog(s) have fungal-type vacuole membrane localization || 1 0.04 -0.05 -0.70
1416 "|| orf19.2629 || USO1 || || Ortholog(s) have role in ER to Golgi vesicle-mediated transport, Golgi vesicle docking, SNARE complex assembly and ER to Golgi transport vesicle membrane, Golgi membrane localization ||" 1 -0.01 0.11 -0.81
1417 || orf19.6627 || || || Protein of unknown function; possibly transcriptionally regulated upon hyphal formation || 1 0.01 0.03 -0.20
1418 || orf19.5788 || EFT2 || || Elongation Factor 2 (eEF2); GTPase; essential; highly expressed; target of sordarin antifungals; antigenic in human/mouse; lacks site for regulatory phosphorylation by eEF2 kinase; GCN-regulated; higher protein amount in stationary phase || 1 0.00 0.02 -0.27
1419 "|| orf19.5830 || LHS1 || || Protein similar to S. cerevisiae Hsp70p; predicted Kex2p substrate; possibly essential, disruptants not obtained by UAU1 method; flow model biofilm repressed ||" 1 -0.03 0.08 -1.12
1420 || orf19.915 || || || Protein of unknown function; Spider biofilm induced || 1 -0.02 -0.00 -0.33
1421 || orf19.3496 || CHC1 || || Clathrin heavy chain; subunit of the major coat protein; role in intracellular protein transport and endocytosis; flow model and rat catheter biofilm repressed || 1 -0.12 0.05 -0.65
1422 "|| orf19.1665 || MNT1 || || Alpha-1,2-mannosyl transferase; predicted type II Golgi membrane protein; adds 2nd mannose during cell-wall mannoprotein biosynthesis; required for wild-type virulence and adherence to epithelial cells; Hap43-induced ||" 1 -0.15 0.08 -0.76
1423 || orf19.11029 || || || || 1 -0.31 -0.05 -0.99
1424 || orf19.680 || TIM50 || || Predicted component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in mitochondrial protein import; Spider biofilm repressed || 1 -0.10 -0.31
1425 "|| orf19.2886 || CEK1 || || ERK-family protein kinase; required for wild-type yeast-hypha switch, mating efficiency, virulence in mice; Cst20-Hst7-Cek1-Cph1 MAPK pathway regulates mating, and invasive hyphal growth under some conditions; Spider biofilm induced ||" 1 -0.16 -0.06 -0.55
1426 || orf19.6496 || TRS33 || || Putative TRAPP complex subunit; constitutive expression independent of MTL or white-opaque status || 1 -0.03 -0.13
1427 || orf19.5130 || PDI1 || || Putative protein disulfide-isomerase; antigenic in human infection; soluble protein in hyphae; induced by filamentous growth; protein present in exponential and stationary growth phase yeast cultures; flow model biofilm repressed || 1 -0.27 -0.01 -0.99
1428 "|| orf19.2712 || HCA4 || || Putative role in regulation of cell wall biogenesis; Hap43p-induced gene; possibly an essential gene, disruptants not obtained by UAU1 method; flow model and rat catheter biofilm induced ||" 1 -0.13 -0.48
1429 || orf19.3756 || CHR1 || || Predicted DEAD-box ATP-dependent RNA helicase; functional homolog of S. cerevisiae Rok1; Hap43-induced; Spider biofilm induced || 1 -0.20 -0.14 -0.79
1430 "|| orf19.7308 || TUB1 || || Alpha-tubulin; gene has intron; complements cold-sensitivity of S. cerevisiae tub1 mutant; C. albicans has single alpha-tubulin gene, whereas S. cerevisiae has two (TUB1, TUB3); farnesol-upregulated in biofilm; sumoylation target ||" 1 -0.19 -0.12 -0.82
1431 || orf19.7330 || || || Protein with a predicted heme oxygenase domain; Spider biofilm induced || 1 -0.13 -0.10 -0.65
1432 || orf19.4180 || SEC72 || || ER protein-translocation complex component; regulated by Gcn4p; repressed in response to amino acid starvation (3-aminotriazole treatment); sumoylation target || 1 -0.19 -0.13 -0.98
1433 "|| orf19.3438 || || || Ortholog(s) have chaperone binding activity, role in ER-associated ubiquitin-dependent protein catabolic process, protein folding in endoplasmic reticulum, response to unfolded protein and endoplasmic reticulum lumen localization ||" 1 -0.08 -0.08 -0.77
1434 "|| orf19.5908 || TEC1 || || TEA/ATTS transcription factor; white cell pheromone response, hyphal gene regulation; required for Spider and RPMI biofilm formation; regulates BCR1; Cph2 regulated transcript; alkaline, rat catheter, Spider, flow model biofilm induced ||" 1 -0.04 -0.04 -0.33
1435 "|| orf19.4433 || CPH1 || || Transcription factor; for mating, filamentation on solid media, pheromone-stimulated biofilms; in pathway with Ess1, Czf1; required with Efg1 for host cytokine response; regulates galactose metabolism genes; rat cathether biofilm repressed ||" 1 -0.08 -0.10 -0.68
1436 || orf19.4264 || || || Protein of unknown function; induced during chlamydospore formation in both C. albicans and C. dubliniensis; flow model biofilm induced || 1 -0.05 -0.06 -0.42
1437 || orf19.6447 || ARF1 || || ADP-ribosylation factor; probable GTPase involved in intracellular transport; one of several C. albicans ADP-ribosylation factors; N-myristoylprotein; substrate of Nmt1; Spider biofilm induced || 1 -0.02 -0.08 -0.53
1438 || orf19.5751 || ORM1 || || Putative endoplasmic reticulum membrane protein; Hap43p-repressed gene; mutation confers hypersensitivity to aureobasidin A || 1 -0.03 -0.06 -0.25
1439 "|| orf19.6610 || || || Ortholog(s) have microtubule plus-end binding, structural constituent of cytoskeleton activity ||" 1 -0.13 0.02 -0.46
1440 "|| orf19.4152 || CEF3 || || Translation elongation factor 3; antigenic in humans; predicted C-term nucleotide-binding active site; protein on surface of yeast, not hyphae; polystyrene adherence induced; higher protein amount in stationary phase; possibly essential ||" 1 -0.29 0.08 -0.97
1441 || orf19.2340 || CDC48 || || Putative microsomal ATPase; plasma membrane-localized; regulated by Gcn2 and Gcn4; induced by amino acid starvation (3-AT); macrophage/pseudohyphal-repressed; protein levels decrease in stationary phase yeast; Spider biofilm repressed || 1 -0.12 0.01 -0.31
1442 "|| orf19.759 || SEC21 || || Ortholog(s) have role in ER to Golgi vesicle-mediated transport, retrograde vesicle-mediated transport, Golgi to ER and COPI vesicle coat, cytosol, endosome localization ||" 1 -0.24 0.02 -0.65
1443 "|| orf19.3558 || || || Ortholog(s) have Golgi apparatus, endoplasmic reticulum localization ||" 1 -0.22 0.02 -0.69
1444 "|| orf19.3829 || PHR1 || || Cell surface glycosidase; may act on cell-wall beta-1,3-glucan prior to beta-1,6-glucan linkage; role in systemic, not vaginal virulence (neutral, not low pH); high pH or filamentation induced; Bcr1-repressed in RPMI a/a biofilm ||" 1 -0.22 -0.01 -0.65
1445 || orf19.1254 || SEC23 || || Putative GTPase-activating protein; regulated upon yeast-hypha switch; Spider biofilm repressed || 1 -0.42 -0.04 -1.08
1446 || orf19.586 || ERV46 || || Putative ER-derived vesicle protein; COPII-coated vesicle complex subunit; transcript induced by filamentous growth; Spider biofilm repressed || 1 -0.45 0.08 -0.92
1447 "|| orf19.670 || SMT3 || || SUMO, small ubiquitin-like protein; Smt3p-conjugated proteins localize to septation site and mother side of bud neck; C. albicans septins appear not to be Smt3p-modified, in contrast to S. cerevisiae septins ||" 1 -0.05 0.01 -0.11
1448 || orf19.9471 || MPP10 || || || 1 -0.19 0.06 -0.46
1449 || orf19.3467 || SEC27 || || Ortholog(s) have ubiquitin binding activity || 1 -0.32 0.12 -0.80
1450 || orf19.5281 || || || Predicted essential RNA-binding G protein; ortholog an effector of mating response pathway in S. cerevisiae; mainly associated with nuclear envelope and ER; flow model and Spider biofilm repressed || 1 -0.23 0.19 -0.56
1451 "|| orf19.687 || || || Ortholog of C. dubliniensis CD36 : Cd36_62090, C. parapsilosis CDC317 : CPAR2_602150, Candida tenuis NRRL Y-1498 : CANTEDRAFT_112751 and Debaryomyces hansenii CBS767 : DEHA2F11814g ||" 1 -0.12 0.07 -0.27
1452 || orf19.5685 || THS1 || || Putative threonyl-tRNA synthetase; transcript regulated by Mig1 and Tup1; repressed upon phagocytosis by murine macrophages; stationary phase enriched protein; Spider biofilm repressed || 1 -0.25 0.12 -0.81
1453 || orf19.6749 || KRS1 || || Putative tRNA-Lys synthetase; repressed upon phagocytosis by murine macrophages; stationary phase enriched protein; Spider biofilm repressed || 1 -0.22 0.11 -0.65
1454 || orf19.4869 || SFU1 || || GATA-type transcription factor; regulator of iron-responsive genes; represses iron utilization genes if iron is present; Hap43-repressed; promotes gastrointestinal commensalism in mice; Spider biofilm induced || 1 -0.09 -0.27
1455 || orf19.556 || || || Protein of unknown function; regulated by Ssn6 || 1 -0.04 0.04 -0.10
1456 "|| orf19.2748 || ARG83 || || GAL4-like Zn(II)2Cys6 transcription factor; clade-associated expression; null shows abnormal regulation of invasive colony growth, is unable to utilize proline as a nitrogen source; flow model biofilm induced ||" 1 -0.05 0.06 -0.21
1457 "|| orf19.1387 || || || Ortholog(s) have 4 iron, 4 sulfur cluster binding activity, role in iron-sulfur cluster assembly, tRNA wobble uridine modification and cytoplasm localization ||" 1 -0.12 0.07 -0.20
1458 "|| orf19.2844 || APL4 || || Predicted gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; that binds clathrin and is involved in vesicle mediated transport; induced in core caspofungin response; rat catheter biofilm repressed ||" 1 -0.31 0.12 -0.52
1459 "|| orf19.2615 || MDL1 || || Putative mitochondrial, half-size MDR-subfamily ABC transporter ||" 1 -0.26 0.08 -0.45
1460 || orf19.7517 || CHT1 || || Chitinase; putative N-terminal catalytic domain; has secretory signal sequence; lacks S/T region and N-glycosylation motifs of Chs2p and Chs3p; alkaline downregulated; expression not detected in yeast-form or hyphal cells || 1 -0.28 0.07 -0.40
1461 || orf19.3031 || SEC62 || || Putative endoplasmic reticulum (ER) protein-translocation complex subunit || 1 -0.54 0.09 -0.75
1462 "|| orf19.5171 || PMT1 || || Protein mannosyltransferase; required for virulence in mice and for adhesion to epithelial cells; role in hyphal growth and drug sensitivity; Als1, Sec20, Kre9, Pir1 are substrates; 1 of 5 PMT family members ||" 1 -0.67 0.12 -1.07
1463 "|| orf19.2017 || || || Ortholog(s) have RNA polymerase I activity and role in regulation of cell size, transcription elongation from RNA polymerase I promoter, transcription of nuclear large rRNA transcript from RNA polymerase I promoter ||" 1 -0.19 0.01 -0.27
1464 || orf19.4596 || || || Protein of unknown function; Spider biofilm induced || 1 -0.25 0.06 -0.30
1465 "|| orf19.4813 || GUA1 || || Putative GMP synthase, involved in the final step of guanine biosynthesis; soluble protein in hyphae; flucytosine induced; macrophage-downregulated protein abundance; protein level decreases in stationary phase cultures ||" 1 -0.16 0.05 -0.18
1466 "|| orf19.2677 || || || Putative GPI transamidase component; possibly an essential gene, disruptants not obtained by UAU1 method ||" 1 -0.13 -0.16
1467 "|| orf19.4346 || || || Ortholog(s) have protein anchor activity, role in COPII vesicle coating, protein localization to endoplasmic reticulum exit site and ER to Golgi transport vesicle membrane, endoplasmic reticulum exit site localization ||" 1 -0.11 0.04 -0.14
1468 || orf19.9293 || || || || 1 -0.19 0.18 -0.34
1469 "|| orf19.3225 || CWH43 || || Putative sensor/transporter protein with a predicted role in cell wall biogenesis; possibly an essential gene, disruptants not obtained by UAU1 method; flow model and rat catheter biofilm repressed ||" 1 -0.16 0.19 -0.29
1470 "|| orf19.4201 || NHX1 || || Protein similar to S. cerevisiae Nhx1p, which is an Na+/H+ exchanger required for intracellular sequestration of Na+ ||" 1 -0.21 0.23 -0.29
1471 || orf19.9349 || YOR1 || || || 1 -0.24 -0.32
1472 || orf19.467 || WOR3 || || Transcription factor; modulator of white-opaque switch; induced in opaque cells; promoter bound by Wor1; overexpression at 25 degr shifts cells to opaque state; deletion stabilizes opaque cells at higher temperatures; Spider biofilm induced || 1 -0.10 0.09 -0.13
1473 || orf19.5500 || MAK16 || || Putative constituent of 66S pre-ribosomal particles; Hap43-induced; repressed by prostaglandins; Spider biofilm induced || 1 -0.16 0.15 -0.16
1474 "|| orf19.3333 || || || Ortholog(s) have poly(A) RNA binding activity, role in mRNA polyadenylation, poly(A)+ mRNA export from nucleus, regulation of mRNA stability and cytoplasm, nucleus localization ||" 1 -0.24 -0.25
1475 || orf19.1630 || || || Ortholog(s) have cytoplasm localization || 1 -0.29 0.19 -0.29
1476 || orf19.7614 || || || Protein of unknown function; Hap43-induced gene; mutant is viable || 1 -0.26 0.16 -0.27
1477 || orf19.5921 || || || Ortholog(s) have glyoxysome localization || 1 -0.23 0.14 -0.26
1478 || orf19.8001 || CNH1 || || || 1 -0.32 0.21 -0.27
1479 "|| orf19.3809 || BAS1 || || Putative Myb-like transcription factor; ortholog S. cerevisiae Bas1, a regulator of purine biosynthetic genes; mutant exhibits adenine auxotrophy and abnormal colony morphology ||" 1 -0.46 0.57 -0.35
1480 || orf19.4190 || PAM18 || || Predicted component of the presequence translocase-associated import motor (PAM complex) involved in protein import into mitochondrial matrix; rat catheter biofilm induced || 1 -0.15 0.22 -0.12
1481 "|| orf19.145 || RPB4 || || Protein similar to S. cerevisiae Rpb4p, which is a component of RNA polymerase II; transposon mutation affects filamentous growth ||" 1 -0.27 -0.20
1482 || orf19.4261 || TIF5 || || Putative translation initiation factor; repressed upon phagocytosis by murine macrophage; Spider biofilm repressed || 1 -0.25 0.27 -0.18
1483 "|| orf19.5676 || || || Ortholog(s) have cytosol, nucleus localization ||" 1 -0.24 -0.18
1484 || orf19.6573 || BEM2 || || Putative Rho1p GTPase activating protein (GAP); serum-induced transcript; Spider biofilm induced; flow model biofilm repressed || 1 -0.54 0.44 -0.38
1485 || orf19.11335 || || || || 1 -0.51 -0.36
1486 "|| orf19.5160 || || || Ortholog(s) have role in G1/S transition of mitotic cell cycle, TOR signaling cascade, dephosphorylation, regulation of mitotic sister chromatid segregation, tRNA wobble uridine modification ||" 1 -0.13 -0.09
1487 "|| orf19.2669 || || || ORF in retrotransposon Tca4; similar to Pol region of retrotransposons encoding reverse transcriptase, protease, integrase; downstream of RHD2, similar to the Gag region encoding nucleocapsid-like protein; rat catheter biofilm induced ||" 1 -0.30 -0.19
1488 "|| orf19.1804 || || || Ortholog(s) have role in cellular response to cadmium ion, detoxification of cadmium ion and mitochondrion localization ||" 1 -0.11 -0.07
1489 || orf19.3622 || ANP1 || || Putative mannosyltransferase of Golgi; member of Mnn9p family; similar to S. cerevisiae Anp1p; fungal-specific (no human or murine homolog) || 1 -0.16 0.20 -0.10
1490 "|| orf19.5539 || || || Ortholog(s) have role in retrograde vesicle-mediated transport, Golgi to ER and SNARE complex, integral to cytosolic side of endoplasmic reticulum membrane localization ||" 1 -0.74 0.57 -0.36
1491 || orf19.10366 || || || || 1 -0.23 -0.11
1492 "|| orf19.3411 || || || Ortholog(s) have role in cellular bud site selection and cytosol, nucleus localization ||" 1 -0.36 -0.17
1493 || orf19.1633 || UTP4 || || Putative U3 snoRNA-associated protein; Hap43-induced; physically interacts with TAP-tagged Nop1; Spider biofilm induced || 1 -0.15 0.21 -0.09
1494 || orf19.3219 || || || Ortholog of S. cerevisiae Sia1; involved in activation of the Pma1 plasma membrane H+-ATPase by glucose in S. cerevisiae; Spider biofilm induced || 1 -0.46 0.53 -0.27
1495 || orf19.4793 || || || Putative ribosome-associated protein; ortholog of S. cerevisiae Tma16; Hap43-induced gene; Spider biofilm induced || 1 -0.25 -0.14
1496 "|| orf19.7088 || || || Ortholog(s) have single-stranded telomeric DNA binding activity, role in regulation of translational fidelity, telomere maintenance, threonylcarbamoyladenosine metabolic process and cytosol, nucleus localization ||" 1 -0.56 0.32
1497 || orf19.3538 || FRE9 || || Ferric reductase; alkaline induced; ciclopirox olamine; Hap43-induced || 1 -0.03 -0.16
1498 || orf19.248 || APL5 || || Ortholog of S. cerevisiae and S. pombe Apl5; subunit of the AP-3 adaptor complex involved in Golgi-to-vacuole transport; phosphorylated protein; mutant is viable; || 1 -0.00 -0.06
1499 || orf19.7657 || POP3 || || Putative RNase MRP and nuclear RNase P component; decreased repressed by prostaglandins; Spider biofilm induced || 1 -0.28 0.22
1500 "|| orf19.3344 || VPS17 || || Ortholog(s) have phosphatidylinositol-3-phosphate binding, protein transporter activity ||" 1 -0.52 -0.21
1501 || orf19.5340 || || || Putative Rab GTPase activator; role in ER to Golgi vesicle-mediated transport; Spider biofilm induced || 1 -0.68 -0.28
1502 || orf19.833 || || || Predicted ORF from Assembly 19; merged with orf19.832 in Assembly 20 || 1 -0.64 -0.26
1503 || orf19.2459 || || || Protein of unknown function; mRNA binds to She3; Hap43 repressed gene; Spider biofilm induced || 1 -0.37 -0.17
1504 || orf19.2735 || SEN2 || || Putative tRNA splicing endonuclease subunit; mutation confers hypersensitivity to toxic ergosterol analog and to amphotericin B; 5'-UTR intron; Hap43-induced; Spider biofilm induced || 1 -0.83 0.50 -0.51
1505 || orf19.6783 || || || Putative geranylgeranyltransferase regulatory component || 1 -0.26 0.17 -0.17
1506 "|| orf19.7094 || HGT12 || || Glucose, fructose, mannose transporter; major facilitator superfamily; role in macrophage-induced hyphal growth; detected at germ tube plasma membrane by mass spectrometry; Snf3p-induced; 12 probable transmembrane segments ||" 1 -1.06 0.79 -0.78
1507 "|| orf19.4634 || || || Protein required for thiolation of uridine at wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation; S. cerevisiae ortholog has a role in invasive and pseudohyphal growth ||" 1 -0.56 0.32 -0.25
1508 || orf19.11823 || || || || 1 -0.24 -0.10
1509 || orf19.6955 || HBR3 || || Essential protein; regulated by hemoglobin; S. cerevisiae ortholog is essential; Hap43p-induced gene || 1 -0.82 -0.27
1510 || orf19.250 || SLC1 || || Putative fatty acyltransferase; protein repressed during the mating process || 1 -0.15 0.41 -0.05
1511 "|| orf19.3553 || RPF2 || || Putative pre-rRNA processing protein; Hap43p-induced gene; mutation confers hypersensitivity to 5-fluorocytosine (5-FC), 5-fluorouracil (5-FU), and tubercidin (7-deazaadenosine) ||" 1 -0.19 0.11 -0.05
1512 "|| orf19.4788 || ARG5,6 || || Arginine biosynthetic enzyme; processed in S. cerevisiae into 2 polypeptides with acetylglutamate kinase (Arg6) activity and acetylglutamate-phosphate reductase (Arg5) activity; Gcn4 regulated; alkaline repressed; Spider biofilm induced ||" 1 -0.54 0.33 -0.11
1513 "|| orf19.5736 || ALS5 || || ALS family adhesin; highly variable; expression in S. cerevisiae causes adhesion to human epithelium, endothelium or ECM, endothelial invasiveness by endocytosis and, at high abundance, ECM-induced aggregation; can form amyloid fibrils ||" 1 -0.40 -0.04
1514 "|| orf19.1828 || BUD16 || || Putative pyridoxal kinase; a key enzyme in pyridoxal 5'-phosphate synthesis, the active form of vitamin B6; involved in bud-site selection and genome integrity in S. cerevisiae; induced by alpha pheromone in SpiderM medium ||" 1 -0.15 0.18
1515 || orf19.5485 || MEC3 || || Putative DNA damage and meiotic pachytene checkpoint protein; increased transcription is observed upon benomyl treatment || 1 -0.06 0.09
1516 || orf19.4603 || ARL1 || || Putative GTPase; mutation confers dose-dependent sensitivity to Brefeldin A || 1 -0.50 -0.04
1517 "|| orf19.4630 || CPA1 || || Putative carbamoyl-phosphate synthase subunit; alkaline repressed; rat catheter, Spider and flow model biofilm induced ||" 1 -0.66 0.22 -0.13
1518 || orf19.2574 || || || Ortholog(s) have Golgi apparatus localization || 1 -0.73 0.22 -0.15
1519 "|| orf19.2059 || || || Protein with homology to magnesium-dependent endonucleases and phosphatases; regulated by Sef1, Sfu1, and Hap43; Spider biofilm induced ||" 1 -0.95 0.26 -0.19
1520 "|| orf19.5022 || || || Ortholog(s) have inorganic cation transmembrane transporter activity and role in cellular cobalt ion homeostasis, cellular manganese ion homeostasis, cobalt ion transport, manganese ion transport ||" 1 -0.24 0.09 -0.06
1521 "|| orf19.880 || || || Ortholog(s) have role in cargo loading into COPII-coated vesicle and COPII vesicle coat, cytosol, mating projection tip localization ||" 1 -0.46 0.17 -0.15
1522 "|| orf19.3341 || || || Putative tRNA-Arg synthetase; essential; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage; downregulated by growth in the mouse cecum ||" 1 -0.31 0.13 -0.11
1523 || orf19.719 || || || Ortholog(s) have ubiquitin-protein ligase activity || 1 -0.24 -0.08
1524 || orf19.1169 || || || Putative DnaJ-like molecular chaperone; Spider biofilm induced || 1 -0.79 0.23 -0.26
1525 || orf19.3393 || || || Putative DEAD-box helicase; Hap43-induced; Spider biofilm induced || 1 -0.30 -0.01 -0.06
1526 "|| orf19.1402 || CCT2 || || Chaperonin of the cytosolic TCP1 ring complex; protein present in exponential and stationary-phase yeast cells, but higher amounts in stationary phase; GlcNAc-induced protein ||" 1 -0.23 -0.00 -0.06
1527 || orf19.2286 || || || Putative deoxyhypusine hydroxylase; ketoconazole-induced; protein level decreases in stationary phase cultures; required for biofilm formation; Spider biofilm repressed || 1 -0.11 -0.03
1528 "|| orf19.163 || PAN6 || || Ortholog(s) have pantoate-beta-alanine ligase activity, role in pantothenate biosynthetic process and cytosol, nucleus localization ||" 1 -0.51 -0.14
1529 "|| orf19.7347 || || || Ortholog(s) have ubiquitin-protein ligase activity, role in ER-associated ubiquitin-dependent protein catabolic process and endoplasmic reticulum membrane localization ||" 1 -0.53 0.01 -0.15
1530 || orf19.2443 || RGD1 || || GTPase activator protein; transcript induced in low iron; alkaline upregulated; localized to the bud emergence area in G1 phase and in the bud tip during S and G2 phases || 1 -0.28 0.02 -0.08
1531 || orf19.1029 || RPP1 || || Putative ortholog of S. cerevisiae Rpp1; subunit of both RNase MRP and nuclear RNase P; rat catheter and Spider biofilm induced || 1 -0.24 0.03 -0.09
1532 "|| orf19.7349 || CHS4 || || Activator of Chs3p chitin synthase; required for wild-type wall chitin content, but not for hyphal growth; mutant resistant to Calcofluor white; prenylation and 2 transmembrane segments predicted; functional homolog of S. cerevisiae Chs4p ||" 1 -0.51 -0.19
1533 "|| orf19.906 || ROM2 || || Putative GDP/GTP exchange factor; possibly an essential gene, disruptants not obtained by UAU1 method; Spider biofilm induced ||" 1 -0.35 0.03
1534 "|| orf19.7479 || NTH1 || || Neutral trehalase; hyphal induction in mutant delayed but not reduced overall; not required for virulence in mice; possible regulatory cAMP-dependent phosphorylation at S10,S213; Hap43-repressed gene; Spider biofilm induced ||" 1 -0.59 -0.27
1535 || orf19.7125 || || || Protein of unknown function; Spider biofilm repressed || 1 -0.36 0.01 -0.16
1536 || orf19.1203 || SRO77 || || Protein with a predicted role in docking and fusion of post-Golgi vesicles with the plasma membrane; filament induced; fungal-specific (no human or murine homolog) || 1 -0.29 -0.01 -0.15
1537 "|| orf19.6812 || PMT2 || || Protein mannosyltransferase (PMT) with roles in hyphal growth and drug sensitivity; member of the PMT family which includes Pmt1p, Pmt2p, Pmt4p, Pmt5p, and Pmt6p; induced during cell wall regeneration; essential ||" 1 -0.61 -0.02 -0.72
1538 "|| orf19.3962 || HAS1 || || Functional homolog of S. cerevisiae Has1p, which is a nucleolar protein of the DEAD-box ATP-dependent RNA helicase family that is involved in biogenesis of the ribosome, particularly the small (40S) subunit; caspofungin-downregulated ||" 1 -0.17 0.04 -0.18
1539 "|| orf19.1585 || ZRT2 || || Zinc transporter; ciclopirox olamine, fluconazole, alkaline repressed; transcript induced by amphotericin B, interaction with macrophages; possibly essential (UAU1 method); induced in oralpharyngeal candidiasis; Spider biofilm induced ||" 1 -0.74 -0.72
1540 "|| orf19.5085 || || || Ortholog(s) have nuclear localization sequence binding, protein transporter activity and role in mRNA export from nucleus, protein import into nucleus, regulation of mitosis, regulation of protein desumoylation ||" 1 -0.82 0.12 -0.81
1541 || orf19.5550 || MRT4 || || Putative mRNA turnover protein; Hap43-induced; mutation confers hypersensitivity to tubercidin (7-deazaadenosine); rat catheter biofilm induced || 1 -0.17 0.02 -0.14
1542 "|| orf19.4993 || SEC18 || || Functional homolog of S. cerevisiae Sec18p, which acts in protein transport; conserved ATP binding site; not glycosylated ||" 1 -0.61 -0.02 -0.52
1543 "|| orf19.5857 || || || Ortholog of C. dubliniensis CD36 : Cd36_84070, C. parapsilosis CDC317 : CPAR2_102720, Candida tenuis NRRL Y-1498 : CANTEDRAFT_98617 and Debaryomyces hansenii CBS767 : DEHA2D07392g ||" 1 -0.94 -0.80
1544 "|| orf19.401 || TCP1 || || Chaperonin-containing T-complex subunit, induced by alpha pheromone in SpiderM medium; stationary phase enriched protein ||" 1 -0.31 -0.01 -0.23
1545 || orf19.1923 || RRN3 || || Protein with a predicted role in recruitment of RNA polymerase I to rDNA; caspofungin induced; flucytosine repressed; repressed in core stress response; repressed by prostaglandins || 1 -0.27 -0.02 -0.17
1546 "|| orf19.1168 || ZCF3 || || Zn(II)2Cys6 domain transcription factor; required for filamentous growth, resistance to rapamycin and flucytosine; possibly an essential gene, disruptants not obtained by UAU1 method; Hap43-repressed; Spider and flow model biofilm induced ||" 1 -0.36 0.02 -0.23
1547 || orf19.7571 || UBC4 || || Ortholog(s) have ubiquitin binding activity || 1 -0.07 0.01 -0.04
1548 || orf19.3301 || || || Putative ubiquitin ligase complex component; induced by heavy metal (cadmium) stress; Hog1-induced; transcript induced by Mnl1p under weak acid stress; flow model biofilm induced; Spider biofilm induced || 1 -0.20 0.03 -0.11
1549 || orf19.11970 || KTR2 || || || 1 -0.05 -0.03
1550 "|| orf19.6458 || || || Ortholog of C. dubliniensis CD36 : Cd36_72260, C. parapsilosis CDC317 : CPAR2_702840, Candida tenuis NRRL Y-1498 : CANTEDRAFT_115664 and Debaryomyces hansenii CBS767 : DEHA2B05940g ||" 1 -0.26 0.06 -0.16
1551 || orf19.3300 || ZPR1 || || Protein with putative zinc finger; regulated by Gcn4p; repressed in response to amino acid starvation (3-aminotriazole treatment); upregulation correlates with clinical development of fluconazole resistance || 1 -0.13 0.03 -0.09
1552 || orf19.6701 || || || Protein with similarity to amino acid-tRNA ligase; stationary phase enriched protein; GlcNAc-induced protein || 1 -0.32 0.07 -0.22
1553 "|| orf19.7112 || FRP2 || || Putative ferric reductase; alkaline induced by Rim101; fluconazole-downregulated; upregulated in the presence of human neutrophils; possibly adherence-induced; regulated by Sef1, Sfu1, and Hap43 ||" 1 -0.47 0.09 -0.34
1554 || orf19.1694 || || || Putative transcription factor with zinc finger DNA-binding motif; merged with orf19.1693 in Assembly 20 || 1 -0.50 0.14 -0.40
1555 "|| orf19.1816 || ALS3 || || Cell wall adhesin; epithelial adhesion, endothelial invasion; alleles vary in adhesiveness; immunoprotective in mice; binds SspB adhesin of S. gordonii in mixed biofilm; induced in/required for Spider biofilm; flow model biofilm repressed ||" 1 -0.83 0.27 -0.58
1556 || orf19.8949 || || || || 1 -0.38 -0.24
1557 || orf19.18 || IMH3 || || Inosine monophosphate (IMP) dehydrogenase; enzyme of GMP biosynthesis; target of mycophenolic acid and mizoribine monophosphate; antigenic during infection; repressed in core stress response; snoRNA snR54 encoded within IMH3 intron || 1 -0.39 0.14 -0.26
1558 || orf19.7579 || FGR34 || || Protein lacking an ortholog in S. cerevisiae; transposon mutation affects filamentous growth || 1 -0.55 -0.38
1559 || orf19.2442 || || || Ortholog of S. cerevisiae Shg1; a COMPASS (Set1C) complex subunit that methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; repressed in an azole-resistant strain overexpressing MDR1 || 1 -0.42 0.23
1560 "|| orf19.2795 || LHP1 || || Ortholog(s) have tRNA binding activity, role in regulation of ascospore formation, tRNA 3'-trailer cleavage, endonucleolytic and nucleolus, nucleoplasm localization ||" 1 -0.16 0.09 -0.13
1561 || orf19.7371 || ZCF35 || || Zn(II)2Cys6 transcription factor; Hap43-induced; Spider biofilm induced || 1 -0.55 0.21 0.18
1562 || orf19.5507 || ENP1 || || Protein required for pre-rRNA processing and 40S ribosomal subunit synthesis; associated with U3 and U14 snoRNAs; transposon mutation affects filamentous growth; repressed by prostaglandins; Spider biofilm induced || 1 -0.09 0.03
1563 || orf19.5980 || || || Protein of unknown function; Hap43-repressed gene || 1 0.17 0.06
1564 "|| orf19.3912 || GLN3 || || GATA transcription factor, involved in regulation of nitrogen starvation-induced filamentous growth; regulates transcription of Mep2 ammonium permease; regulated by Gcn2 and Gcn4; mRNA binds She3; Spider biofilm induced ||" 1 -0.35 0.18
1565 "|| orf19.3583 || || || Ortholog(s) have role in protein export from nucleus, regulation of chromatin silencing at telomere, ribosomal small subunit export from nucleus and cytosol, nuclear pore localization ||" 1 -0.33 0.17
1566 || orf19.5201 || || || Ortholog(s) have structural constituent of ribosome activity and mitochondrial small ribosomal subunit localization || 1 -0.31 0.13
1567 || orf19.4866 || CPP1 || || VH1 family MAPK phosphatase; regulates Cst20-Hst7-Cek1-Cph1 filamentation pathway; represses yeast-hyphal switch; required for virulence in mice; yeast-enriched; induced by alpha pheromone in SpiderM medium; Spider biofilm induced || 1 -0.12 0.07 0.06
1568 || orf19.2439 || || || Fatty acid biosynthetic protein; shows colony morphology-related gene regulation by Ssn6p; protein newly produced during adaptation to the serum || 1 -0.23 0.11 0.12
1569 "|| orf19.7305 || || || Ortholog of C. dubliniensis CD36 : Cd36_34510, Candida tropicalis MYA-3404 : CTRG_05938 and Candida albicans WO-1 : CAWG_02183 ||" 1 -0.55 0.27 0.28
1570 || orf19.6875 || VPS35 || || Putative role in vacuolar sorting; downregulated in biofilm; induced upon adherence to polystyrene || 1 -0.10 0.05
1571 || orf19.2943 || || || Predicted ORF from Assembly 19; merged with orf19.2942 in Assembly 20 || 1 -0.23 0.15 0.11
1572 || orf19.5679 || || || Predicted ORF from Assembly 19; merged with orf19.980 in Assembly 20 || 1 -0.17 0.08
1573 "|| orf19.7361 || || || Ortholog(s) have tRNA-intron endonuclease activity, role in tRNA-type intron splice site recognition and cleavage and mitochondrial outer membrane, tRNA-intron endonuclease complex localization ||" 1 -0.16 0.13 0.07
1574 "|| orf19.5392 || NGT1 || || N-acetylglucosamine (GlcNAc)-specific transporter; role in GlcNAc (but not serum) induced hyphal growth; localizes to plasma membrane; induced by GlcNAc, macrophage engulfment; 12 transmembrane, major facilitator superfamily ||" 1 -0.27 0.20 0.18
1575 || orf19.7108 || || || D-ribulose-5-phosphate 3-epimerase; stationary phase enriched protein || 1 -0.31 0.29 0.20
1576 || orf19.4009 || CNB1 || || Regulatory subunit of calcineurin B (Ca[2+]-calmodulin-regulated S/T protein phosphatase); required for wild-type resistance to fluconazole or to SDS; micafungin is fungicidal to null mutant || 1 -0.58 0.38
1577 || orf19.7279 || NIT2 || || Putative carbon-nitrogen hydrolase; rat catheter biofilm repressed || 1 -0.43 0.57
1578 || orf19.7545 || || || Protein similarity to mutator-like element (MULE) transposase || 1 -0.27 0.27 0.10
1579 "|| orf19.4643 || || || Ortholog of C. dubliniensis CD36 : Cd36_41430, Candida tropicalis MYA-3404 : CTRG_00187 and Candida albicans WO-1 : CAWG_03642 ||" 1 -0.51 0.43 0.16
1580 "|| orf19.5720 || || || Predicted membrane transporter, member of the monocarboxylate porter (MCP) family, major facilitator superfamily (MFS); ketoconazole or caspofungin repressed; Spider biofilm induced ||" 1 -0.15 0.12 -0.01
1581 "|| orf19.3744 || || || Ortholog(s) have tRNA binding activity, role in tRNA export from nucleus and cytoplasm, nuclear pore localization ||" 1 -0.43 0.36 0.03
1582 || orf19.7401 || ISW2 || || Ortholog of S. cerevisiae Isw2; an ATPase involved in chromatin remodeling; required for chlamydospore formation; Hap43-induced gene; repressed by high-level peroxide stress || 1 -0.41 0.33 0.06
1583 || orf19.6053 || CIS2 || || Putative role in regulation of biogenesis of the cell wall; upregulated in biofilm; Gcn4p-regulated || 1 -0.23 0.09
1584 || orf19.8768 || || || || 1 -0.47 0.22
1585 || orf19.3230 || BOI2 || || Putative SH3-domain-containing protein; mutation confers hypersensitivity to toxic ergosterol analog; Spider biofilm induced || 1 -0.37 0.21 0.09
1586 || orf19.6883 || || || Putative oxysterol binding protein family; probable peripheral membrane protein of the Golgi complex; flow model and Spider biofilm repressed || 1 -0.57 0.11
1587 "|| orf19.5971 || || || Ortholog of S. cerevisiae : MTC6, C. glabrata CBS138 : CAGL0I01892g, C. dubliniensis CD36 : Cd36_84990, C. parapsilosis CDC317 : CPAR2_405620 and Candida tenuis NRRL Y-1498 : CANTEDRAFT_99433 ||" 1 -0.13 0.24 0.02
1588 || orf19.2061 || || || Ortholog of Candida albicans WO-1 : CAWG_03846 || 1 -0.74 0.79 -0.20
1589 || orf19.1594 || || || Predicted ORF from Assembly 19; merged with orf19.792 in Assembly 20 || 1 -0.25 0.31 -0.09
1590 || orf19.2498 || || || Predicted ubiquitin-protein ligase; Hap43-repressed gene; oxidative stress-induced via Cap1; flow model biofilm induced || 1 -0.42 0.55 -0.12
1591 || orf19.13157 || || || || 1 -0.46 -0.14
1592 || orf19.3941 || URA7 || || CTP synthase 1; flucytosine induced; protein present in exponential and stationary growth phase yeast cultures || 1 -0.39 0.55 -0.12
1593 || orf19.4998 || ROB1 || || Zn(II)2Cys6 transcription factor; required for Spider model biofilm formation; mutant displays abnormal colony morphology and invasive growth; caspofungin repressed; flow model biofilm induced; rat catheter biofilm repressed || 1 -0.22 0.30 -0.05
1594 "|| orf19.7384 || NOG1 || || Putative GTPase; mutation confers hypersensitivity to 5-fluorocytosine (5-FC), 5-fluorouracil (5-FU), and tubercidin (7-deazaadenosine); repressed by prostaglandins; Hap43-induced ||" 1 -0.47 0.72 -0.17
1595 "|| orf19.2496 || ATO2 || || Putative fungal-specific transmembrane protein; fluconazole repressed, Hap43-repressed; flow model biofilm induced; Spider biofilm induced ||" 1 -0.58 0.95 -0.23
1596 || orf19.1537 || || || Predicted ORF from Assembly 19; merged with orf19.1536 in Assembly 20 || 1 -0.09 0.16 -0.06
1597 || orf19.8342 || BCR1 || || || 1 -0.29 0.37 -0.15
1598 || orf19.4125 || PZF1 || || C2H2 transcription factor; Hap43-induced; rat catheter and Spider biofilm induced || 1 -0.16 -0.09
1599 || orf19.74 || SEC5 || || Predicted exocyst component; ortholog of S. cerevisiae Sec5p; merged with orf19.75 in Assembly 21 || 1 -0.07 -0.04
1600 "|| orf19.5198 || NOP4 || || Putative nucleolar protein; Hap43-induced; mutation confers hypersensitivity to 5-fluorocytosine (5-FC), 5-fluorouracil (5-FU), and tubercidin (7-deazaadenosine); represses in core stress response ||" 1 -0.25 0.55 -0.14
1601 "|| orf19.6861 || || || Ortholog(s) have ubiquitin-protein ligase activity and role in anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process, chromatin assembly, protein ubiquitination ||" 1 -0.25 0.56 -0.15
1602 || orf19.2663 || || || Ortholog of Pichia stipitis Pignal : PICST_29216 and Candida albicans WO-1 : CAWG_00788 || 1 -0.21 0.51 -0.08
1603 "|| orf19.7332 || ELF1 || || Putative mRNA export protein; Walker A and B (ATP/GTP binding) motifs; required for wild-type morphology, growth; expressed in hyphal, pseudohyphal, and yeast form; Hap43-induced; Spider and flow model biofilm induced ||" 1 -0.41 -0.10
1604 || orf19.6141 || HGT16 || || Putative glucose transporter of the major facilitator superfamily; the C. albicans glucose transporter family comprises 20 members; 12 probable membrane-spanning segments; gene has intron; expressed in rich medium with 2% glucose || 1 -0.16 0.73 -0.04
1605 || orf19.7466 || ACC1 || || Putative acetyl-coenzyme-A carboxylases; regulated by Efg1; amphotericin B repressed; caspofungin repressed; 5'-UTR intron; gene used for strain identification by multilocus sequence typing; Hap43-induced; flow model biofilm repressed || 1 -0.40 -0.07
1606 "|| orf19.7655 || RPO21 || || RNA polymerase II; ortholog of S. cerevisiae Rpo21, transposon mutation affects filamentous growth; flow model biofilm repressed ||" 1 -0.13 0.53
1607 "|| orf19.5958 || CDR2 || || Multidrug transporter, ATP-binding cassette (ABC) superfamily; transports phospholipids, in-to-out direction; overexpressed in azole-resistant isolates; repressed in young biofilms ||" 1 -0.02 -0.03
1608 || orf19.6920 || || || Protein of unknown function; induced during chlamydospore formation in both C. albicans and C. dubliniensis; Hap43-induced gene; Spider biofilm induced; F-12/CO2 early biofilm induced || 1 -0.37 0.34
1609 "|| orf19.6673 || HEX1 || || Beta-N-acetylhexosaminidase/chitobiase, highly glycosylated enzyme that is secreted to the periplasm and culture medium; required for full virulence; may have role in carbon or nitrogen scavenging; possibly an essential gene (UAU1 method) ||" 1 -0.60 -0.09
1610 || orf19.3425 || || || RING/FYVE/PHD zinc finger protein; Spider biofilm induced || 1 -0.24 0.74 -0.03
1611 "|| orf19.7110 || || || Ortholog(s) have tRNA-specific adenosine-37 deaminase activity, role in tRNA modification and cytosol, nucleus localization ||" 1 -0.53 0.98 -0.04
1612 "|| orf19.978 || BDF1 || || Bromodomain transcription factor; repressed upon adherence to polystyrene; reduced mRNA abundance detected in null mutant; macrophage/pseudohyphal-repressed; possibly essential, disruptants not obtained by UAU1 method ||" 1 -0.18 0.37 0.00
1613 || orf19.5723 || POX1 || || Predicted acyl-CoA oxidase; regulated upon white-opaque switch; upregulated upon phagocytosis; Spider biofilm induced || 1 -0.27 0.01
1614 || orf19.7068 || MAC1 || || Copper fist transcription factor; regulator of CTR1 copper transporter; induces CTR1 in low-copper conditions; ectopic expression causes copper-sensitive stimulation of filamentation in S. cerevisiae; Spider biofilm induced || 1 -0.57 0.65 0.04
1615 || orf19.6534 || || || Ortholog of Candida albicans WO-1 : CAWG_05537 || 1 -0.23 0.02
1616 || orf19.7175 || HLJ1 || || Putative HSP40 co-chaperone; repressed during the mating process || 1 -0.79 0.05
1617 || orf19.3711 || || || Protein with monooxygenase domains; flow model biofilm induced || 1 -0.56 1.32
1618 || orf19.7047 || RTF1 || || Putative RNA polymerase II-associated Paf1 complex subunit; induced during the mating process || 1 -0.19 0.42 0.00
1619 || orf19.3215 || || || Putative plasma membrane protein; in S. cerevisiae it is localized to the cell bud and mating projection membrane; repressed by alpha pheromone in SpiderM medium || 1 -0.08 0.21 0.00
1620 || orf19.2996 || || || Ortholog(s) have cytoplasm localization || 1 -0.33 0.00
1621 || orf19.837 || GNA1 || || Glucosamine-6-phosphate acetyltransferase; enzyme of UDP-GlcNAc biosynthesis; required for viability in absence of GlcNAc supplementation; required for persistent infection and wild-type virulence in mouse systemic infection || 1 -0.23 0.00
1622 || orf19.661 || KRR1 || || Putative nucleolar protein; repressed benomyl treatment or in an azole-resistant strain that overexpresses MDR1; F-12/CO2 early biofilm induced || 1 -0.35 0.31 -0.03
1623 || orf19.1102 || || || Predicted ORF from Assembly 19; removed from Assembly 20 || 1 -0.37 -0.04
1624 "|| orf19.7344 || || || Ortholog(s) have DNA binding, chromatin binding, histone deacetylase activity ||" 1 -0.13 0.25 -0.02
1625 "|| orf19.1642 || || || Ortholog of S. cerevisiae Loc1, a nuclear protein involved in asymmetric localization of ASH1 mRNA in S. cerevisiae; Hap43-induced gene; Spider biofilm induced ||" 1 -0.14 0.22 -0.01
1626 || orf19.9778 || || || || 1 -0.21 0.42 -0.00
1627 "|| orf19.7153 || || || Putative exportin, member of the Exportin-T family; flow model biofilm repressed ||" 1 -0.35 -0.01
1628 || orf19.5759 || SNQ2 || || Protein similar to S. cerevisiae Snq2p transporter; member of PDR subfamily of ABC family; transposon mutation affects filamentation; benomyl-induced transcription; detected at yeast-form cell plasma membrane by mass spec || 1 -0.37 -0.01
1629 "|| orf19.2922 || || || Ortholog(s) have double-stranded DNA binding activity, role in reciprocal meiotic recombination, synapsis and condensed nuclear chromosome localization ||" 1 -0.78 1.11
1630 "|| orf19.1464 || BMT5 || || Putative beta-mannosyltransferase involved in beta-1,2-mannosylation of phospholipomannan; 9-member family includes Bmt1, Bmt2, Bmt3, and Bmtp with roles in mannosylation of cell wall phosphopeptidomannan; Spider biofilm induced ||" 1 -0.94 0.09
1631 || orf19.12240 || LYS143 || || || 1 -0.13 0.42
1632 "|| orf19.2102 || CKB1 || || Regulatory subunit of protein kinase CK2 (casein kinase II), beta subunit; null mutants are hypersensitive to caspofungin and hydrogen peroxide medium ||" 1 -0.58 0.08
1633 || orf19.6068 || SVF1 || || Putative survival factor; stationary phase enriched protein; fluconazole-induced; regulated by Gcn4p; repressed in response to amino acid starvation (3-AT treatment); fungal-specific (no human or murine homolog) || 1 -0.23 0.31 0.06
1634 || orf19.3206 || CCT7 || || Cytosolic chaperonin Cct ring complex; protein is present in exponential and stationary growth phase yeast cultures; sumoylation target || 1 -0.22 0.24 0.02
1635 "|| orf19.5221 || || || Ortholog(s) have phosphatidylinositol-4,5-bisphosphate binding activity ||" 1 -0.24 0.30 0.14
1636 || orf19.487 || SPT14 || || Putative DNA-binding transcription factor; predicted role in regulation of biogenesis of the cell wall; upregulated in biofilm; protein newly produced during adaptation to the serum || 1 -0.03 0.06 0.02
1637 "|| orf19.7244 || || || Putative fumarylacetoacetate hydrolase; induced by nitric oxide independent of Yhb1; regulated by Sef1, Sfu1, Hap43; flow model biofilm induced ||" 1 -0.31 0.55 0.23
1638 || orf19.7261 || GDI1 || || Putative Rab GDP-dissociation inhibitor; GlcNAc-induced protein; Spider biofilm repressed || 1 -0.38 0.27
1639 || orf19.1365 || || || Putative monooxygenase; mutation confers hypersensitivity to toxic ergosterol analog; constitutive expression independent of MTL or white-opaque status || 1 -0.29 0.72
1640 || orf19.4399 || NCS2 || || Putative cytosolic thiouridylase subunit; Spider biofilm induced || 1 -0.20 0.12
1641 "|| orf19.2923 || || || Predicted membrane transporter, member of the drug:proton antiporter (14 spanner) (DHA2) family, MFS superfamily; induced by alpha pheromone in SpiderM medium ||" 1 -0.40 1.09
1642 "|| orf19.782 || || || Ortholog(s) have serine hydrolase activity, triglyceride lipase activity, role in lipid homeostasis and lipid particle localization ||" 1 -0.42 0.17
1643 "|| orf19.5395 || || || Ortholog(s) have role in early endosome to late endosome transport, regulation of protein complex assembly, vacuolar acidification and RAVE complex, extrinsic to membrane localization ||" 1 -0.49 0.20
1644 "|| orf19.1674 || CDC53 || || Cullin, a scaffold subunit of the SCF ubiquitin-ligase complexes; depletion leads to increased filamentous growth and premature cell death ||" 1 -0.15 0.40 0.06
1645 "|| orf19.1728 || || || Ortholog of C. dubliniensis CD36 : Cd36_81190, C. parapsilosis CDC317 : CPAR2_503840, Debaryomyces hansenii CBS767 : DEHA2A09042g and Pichia stipitis Pignal : PICST_42519 ||" 1 -0.13 0.30 0.04
1646 "|| orf19.5040 || || || Ortholog(s) have nucleocytoplasmic transporter activity, phospholipid binding, single-stranded DNA binding activity ||" 1 -0.35 0.09
1647 || orf19.9563 || NOT3 || || || 1 -0.14 0.64
1648 "|| orf19.6716 || ABD1 || || SAM-dependent RNA methyltransferase; methylates mRNA 5' cap; binds phosphorylated RNA Pol II C-term domain peptide; does not bind mRNA TPase and mRNA GTase (Cet1,Cgt1); functional homolog of S. cerevisiae Abd1; rat catheter biofilm induced ||" 1 -0.29 0.06
1649 "|| orf19.7635 || DRS1 || || Putative nucleolar DEAD-box protein; Hap43-induced; mutation confers hypersensitivity to 5-fluorouracil (5-FU), tubercidin (7-deazaadenosine); Tbf1-induced; repressed in core stress response ||" 1 -0.34 0.13
1650 "|| orf19.4332 || || || Ortholog of C. dubliniensis CD36 : Cd36_52800, C. parapsilosis CDC317 : CPAR2_303110, Candida tenuis NRRL Y-1498 : CANTEDRAFT_92321 and Debaryomyces hansenii CBS767 : DEHA2G07964g ||" 1 -0.13 0.73
1651 || orf19.12147 || || || || 1 -0.04 0.02
1652 || orf19.1404 || || || Predicted tRNA dihydrouridine synthase; Spider biofilm induced || 1 -0.55 0.29
1653 || orf19.253 || || || Predicted ORF from Assembly 19; merged with orf19.252 in Assembly 20 || 1 -0.06 0.20 0.04
1654 "|| orf19.2084 || CDH1 || || Protein involved in regulation of mitosis; similar to S. cerevisiae Cdh1, which is an APC/C component; transcriptionally induced by Mnl1 under weak acid stress ||" 1 -0.43 0.30
1655 "|| orf19.3523 || CRK1 || || Protein kinase of the Cdc2 subfamily involved in hyphal development, virulence; promotes hyphal development independently of Cph1 and Efg1; functionally complements pheromone hypersensitivity of S. cerevisiae sgv1 mutant; Hap43p-repressed ||" 1 -0.42 1.22
1656 || orf19.6734 || TCC1 || || Putative transcription factor/corepressor; regulation of filamentation and virulence; interacts with Tup1; regulates hypha-specific gene expression; contains 4 tetratricopeptide repeat (TPR) motifs; flucytosine repressed; Tbp1-induced || 1 -0.25 0.22
1657 "|| orf19.3241 || || || Ortholog(s) have Seh1-associated complex, extrinsic to fungal-type vacuolar membrane localization ||" 1 -0.07 0.53 0.07
1658 || orf19.976 || BRE1 || || Putative transcription factor with C3HC4 zinc finger DNA-binding motif; similar to S. cerevisiae Bre1p; transposon mutation affects filamentous growth || 1 -0.14 0.67 0.06
1659 "|| orf19.6776 || GCD2 || || Putative translation initiation factor; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage ||" 1 -0.50 0.17
1660 || orf19.4376 || || || Protein of unknown function; Spider biofilm induced || 1 -0.12 1.27
1661 "|| orf19.5680 || || || Protein with predicted hydrolase domains; similar to a universal stress protein family protein; possibly essential, disruptants not obtained by UAU1 method; Spider biofilm repressed ||" 1 -0.43 0.24
1662 "|| orf19.275 || || || Ortholog(s) have RNA binding, ribonuclease MRP activity, ribonuclease P activity, role in intronic box C/D snoRNA processing, mRNA cleavage and endoplasmic reticulum, nucleolar ribonuclease P complex, ribonuclease MRP complex localization ||" 1 -0.18 0.10
1663 || orf19.1718 || ZCF8 || || Predicted Zn(II)2Cys6 transcription factor; repressed by fluphenazine treatment; required for yeast cell adherence to silicone substrate || 1 -0.07 0.79
1664 "|| orf19.7414 || ALS6 || || ALS family protein; expression in S. cerevisiae confers adhesion to gelatin; macrophage-induced gene; N-terminal adhesion domain; ALS family includes cell-surface glycoproteins, some with adhesin function ||" 1 -0.33 0.05
1665 || orf19.1041 || || || Ortholog(s) have cyclin-dependent protein serine/threonine kinase activity || 1 -0.05 0.22 0.02
1666 || orf19.8124 || || || || 1 -0.12 0.45 0.01
1667 || orf19.9175 || ALR1 || || || 1 -0.06 0.27 0.00
1668 "|| orf19.7293 || MPS1 || || Monopolar spindle protein, a putative kinase; essential for growth; periodic mRNA expression, peak at cell-cycle S/G2 phase ||" 1 -0.01 0.60 0.14
1669 "|| orf19.7067 || || || Ortholog(s) have RNA polymerase II core binding, RNA polymerase II transcription factor binding transcription factor activity, triplex DNA binding activity ||" 1 -0.13 0.75 0.16
1670 || orf19.8003 || || || || 1 -0.05 0.34 0.07
1671 || orf19.9102 || SNF2 || || || 1 -0.05 0.35 0.11
1672 "|| orf19.6295 || MAS2 || || Putative processing peptidase, catalytic (alpha) subunit; protein level decreases in stationary phase cultures ||" 1 -0.04 0.11
1673 || orf19.4578 || CYT2 || || Cytochrome c1 heme lyase; transcript regulated by Nrg1; induced in high iron || 1 -0.19 0.31
1674 || orf19.6391 || || || Protein of unknown function; transcript upregulated in azole-resistant strain overexpressing MDR1; Spider biofilm induced || 1 -0.31 1.22
1675 "|| orf19.7144 || || || Ortholog(s) have GTPase activity, ribosome binding activity, role in nonfunctional rRNA decay, nuclear-transcribed mRNA catabolic process, no-go decay, ribosome disassembly and cytosol localization ||" 1 -0.40 0.50
1676 "|| orf19.6284 || || || Ortholog(s) have GTP binding, signal recognition particle binding activity, role in protein targeting to ER and integral to endoplasmic reticulum membrane localization ||" 1 -0.15 0.01 0.23
1677 || orf19.922 || ERG11 || || Lanosterol 14-alpha-demethylase; cytochrome P450 family; role in ergosterol biosynthesis; target of azole antifungals; may contribute to drug resistance; azole or flow model biofilm induced; drug treated biofilm induced; hypoxia regulated || 1 -0.04 0.01 0.06
1678 "|| orf19.5133 || ZCF29 || || Zn(II)2Cys6 transcription factor; mutants sensitive to caffeine and menadione, resistant to fenpropimorph; Hap43-repressed; mutants have decreased CFU in mouse kidneys and defects in filamentous growth; Spider biofilm induced ||" 1 -0.22 0.32
1679 "|| orf19.4290 || TRR1 || || Thioredoxin reductase; regulated by Tsa1/Tsa1B, Hap43; induced by nitric oxide, peroxide; oxidative stress-induce via Cap1; induced by human neutrophils; stationary phase enriched protein ||" 1 -0.06 0.02 0.09
1680 || orf19.6801 || RPD31 || || Putative histone deacetylase; involved in regulation of white-opaque switch; Spider biofilm repressed || 1 -0.15 0.05 0.23
1681 "|| orf19.4611 || || || Ortholog(s) have ribose phosphate diphosphokinase activity, role in 5-phosphoribose 1-diphosphate biosynthetic process, cytokinesis, fungal-type cell wall organization and cytosol localization ||" 1 -0.27 0.39
1682 || orf19.6561 || LAT1 || || Putative dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex; sumoylation target; Spider biofilm repressed || 1 -0.10 0.06 0.15
1683 "|| orf19.5158 || || || Protein with similarity to a human gene associated with colon cancer and to orf19.5158; regulated by Gcn4, Cyr1; induced by amino acid starvation; macrophage-induced protein, macrophage-repressed; Spider biofilm induced ||" 1 -0.44 0.61
1684 || orf19.7355 || SSN8 || || Ortholog of S. cerevisiae Ssn8; a component of RNA polymerase II holoenzyme; mutants are viable and are sensitive to hydrogen peroxide medium || 1 -0.29 0.09 0.40
1685 "|| orf19.7033 || || || Putative dual specificity protein phosphatase, similar to S. cerevisiae Pps1p ||" 1 -0.18 0.25
1686 || orf19.441 || RPT1 || || Putative 26S proteasome regulatory subunit 7; Hap43p-repressed gene; regulated by Gcn2p and Gcn4p; overlaps orf19.442 || 1 -0.06 0.02 0.07
1687 || orf19.473 || TPO4 || || Putative sperimidine transporter; fungal-specific (no human or murine homolog); Spider biofilm induced; promoter bound by Tec1 and Ndt80; Bcr1-repressed in RPMI a/a biofilms || 1 -0.17 0.10 0.21
1688 "|| orf19.1548 || || || Ortholog(s) have role in mRNA splicing, via spliceosome and U4/U6 x U5 tri-snRNP complex localization ||" 1 -0.37 0.47
1689 || orf19.5150 || || || Predicted ORF from Assembly 19; merged with orf19.5148 in Assembly 20 || 1 -0.19 0.24
1690 || orf19.2695 || UBR1 || || Protein similar to S. cerevisiae Ubr1p ubiquitin-protein ligase; transposon mutation affects filamentous growth; Spider biofilm induced || 1 -0.14 0.08 0.19
1691 || orf19.3544 || || || Putative protein of unknown function; Hap43p-repressed gene || 1 -0.12 0.18
1692 || orf19.566 || || || Predicted ORF from Assembly 19; shows colony morphology-related gene regulation by Ssn6p; clade-associated gene expression; removed from Assembly 20 || 1 -0.18 0.10 0.27
1693 || orf19.3439 || || || Protein of unknown function; Cyr1-repressed; rat catheter and Spider biofilm induced || 1 -0.17 0.06 0.28
1694 || orf19.5049 || || || Putative U3-containing 90S preribosome processome complex subunit; Hap43-induced gene; rat catheter and Spider biofilm induced; F-12/CO2 early biofilm induced || 1 -0.08 0.14
1695 || orf19.3981 || MAL31 || || Putative high-affinity maltose transporter; transcript is upregulated in clinical isolates from HIV+ patients with oral candidiasis; alkaline induced; Spider biofilm induced || 1 -0.42 0.17 0.74
1696 "|| orf19.7643 || || || Ortholog(s) have 4-hydroxybenzoate octaprenyltransferase activity, antioxidant activity and role in cellular response to cadmium ion, detoxification of cadmium ion, ubiquinone biosynthetic process ||" 1 -0.33 0.59
1697 "|| orf19.4153 || || || Ortholog(s) have NEDD8 activating enzyme activity, role in protein neddylation and cytosol, nucleus localization ||" 1 -0.55 0.17
1698 "|| orf19.492 || ADE17 || || 5-Aminoimidazole-4-carboxamide ribotide transformylase, enzyme of adenine biosynthesis; antigenic in human; soluble protein in hyphae; not induced during GCN response, in contrast to the S. cerevisiae ortholog ||" 1 -0.32 0.78
1699 "|| orf19.7306 || || || Aldo-keto reductase; increased transcript associated with MDR1 overexpression, benomyl or long-term fluconazole treatment; overexpression does not affect drug or oxidative stress sensitivity; stationary phase enriched; flow biofim repressed ||" 1 -0.25 0.06 0.50
1700 "|| orf19.7527 || || || Ortholog of C. dubliniensis CD36 : Cd36_25130, C. parapsilosis CDC317 : CPAR2_800100, Candida tenuis NRRL Y-1498 : CANTEDRAFT_107256 and Debaryomyces hansenii CBS767 : DEHA2E18370g ||" 1 -0.27 0.58
1701 || orf19.73 || || || Putative metalloprotease; associates with ribosomes and is involved in ribosome biogenesis; Spider biofilm induced || 1 -0.21 0.07 0.45
1702 || orf19.5215 || TES15 || || Putative acyl-CoA thioesterase; Hap43-repressed; Spider biofilm induced || 1 -0.23 0.50
1703 "|| orf19.4240 || || || Ortholog(s) have role in GPI anchor biosynthetic process, cellular manganese ion homeostasis and endoplasmic reticulum, fungal-type vacuole membrane localization ||" 1 -0.21 0.04 0.45
1704 "|| orf19.3076 || || || Ortholog(s) have role in vesicle-mediated transport and COPI-coated vesicle, integral to Golgi membrane localization ||" 1 -0.05 0.11
1705 || orf19.1251 || BRN1 || || Putative condensin complex subunit; cell-cycle regulated periodic mRNA expression || 1 -0.11 0.06 0.26
1706 "|| orf19.4979 || KNS1 || || Protein kinase involved in negative regulation of PolIII transcription; effector kinase of the TOR signaling pathway, phosphorylates Rpc53p to regulate ribosome and tRNA biosynthesis; Spider and flow model biofilm induced ||" 1 -0.12 0.31
1707 || orf19.12077 || || || || 1 -0.18 0.46
1708 "|| orf19.1424 || || || Predicted membrane transporter, member of the oxalate:formate antiporter (OFA) family, major facilitator superfamily (MFS) ||" 1 -0.17 0.08 0.53
1709 || orf19.6075 || || || Putative CCR4-Not complex transcription factor; ortholog of S. cerevisiae Cdc36; Hap43-repressed gene || 1 -0.16 0.14 0.48
1710 || orf19.7335 || PRE8 || || Putative alpha-2_sc subunit of proteasome; macrophage-induced protein; regulated by Gcn2p and Gcn4p; transcription is positively regulated by Tbf1p; stationary phase enriched protein || 1 -0.14 0.10 0.38
1711 || orf19.5833 || || || Ortholog(s) have polyubiquitin binding activity || 1 -0.21 0.16 0.43
1712 || orf19.7421 || CYP5 || || Putative peptidyl-prolyl cis-trans isomerase; macrophage-downregulated protein level; protein level decrease in stationary phase cultures; predicted endoplasmic reticulum (ER) localization || 1 -0.27 0.16 0.52
1713 "|| orf19.6418 || || || Ortholog(s) have role in ribosomal large subunit biogenesis and cytoplasm, nucleus localization ||" 1 -0.22 0.12 0.24
1714 || orf19.1115 || GUK1 || || Putative guanylate kinase; identified in extracts from biofilm and planktonic cells; protein level decrease in stationary phase cultures; Hap43p-induced gene || 1 -0.44 0.24
1715 "|| orf19.5443 || BNA4 || || Putative kynurenine 3-monooxygenase, involved in NAD biosynthesis; transposon mutation affects filamentous growth; Hap43p-repressed gene; oral infection upregulated; mutants have reduced capacity to damage oral epithelial cells ||" 1 -0.60 0.55
1716 "|| orf19.6923 || || || Ortholog(s) have chromatin binding activity, role in RNA polymerase II transcriptional preinitiation complex assembly and transcription factor TFIID complex localization ||" 1 -0.44 0.37
1717 "|| orf19.5514 || || || Ortholog of S. pombe SPCC550.08, an N-acetyltransferase; transcript induced during growth in the mouse cecum ||" 1 -0.44 0.19 0.37
1718 || orf19.3978 || || || Protein required for maturation of 18S rRNA; rat catheter biofilm repressed || 1 -0.14 0.07 0.09
1719 "|| orf19.1466 || REX2 || || Putative 3'-5' RNA exonuclease with a predicted role in 3'-end processing of U4 and U5 snRNAs, 5S and 5.8S rRNAs; rat catheter biofilm induced ||" 1 -0.51 0.38
1720 "|| orf19.1980 || GIT4 || || Glycerophosphocholine transporter; fungal-specific (no human or murine homolog); possibly an essential gene, disruptants not obtained by UAU1 method; Hap43p-repressed gene ||" 1 -0.11 0.19 0.09
1721 || orf19.6660 || || || Protein of unknown function; mRNA binds to She3; Hap43-repressed; rat catheter and flow model biofilm induced || 1 -0.23 0.17
1722 || orf19.13228 || ALD5 || || || 1 -0.39 0.20 0.30
1723 "|| orf19.4191 || RLP24 || || Putative ribosomal protein; Hap43-induced; essential gene; heterozygous mutation confers hypersensitivity to 5-fluorocytosine (5-FC), 5-fluorouracil (5-FU), and tubercidin (7-deazaadenosine); Spider biofilm induced ||" 1 -0.11 0.08 0.12
1724 "|| orf19.2258 || || || Ortholog of C. dubliniensis CD36 : Cd36_21310, C. parapsilosis CDC317 : CPAR2_406650, Candida tenuis NRRL Y-1498 : CANTEDRAFT_130046 and Debaryomyces hansenii CBS767 : DEHA2F24134g ||" 1 -0.31 0.30
1725 || orf19.5814 || || || Protein of unknown function; Spider biofilm induced || 1 -0.05 0.12 0.05
1726 "|| orf19.6900 || || || Ortholog(s) have role in establishment or maintenance of cell polarity, mitochondrial genome maintenance, mitochondrion inheritance, phospholipid transport, protein import into mitochondrial outer membrane ||" 1 -0.03 0.10 0.10
1727 "|| orf19.6178 || FBP1 || || Fructose-1,6-bisphosphatase; key gluconeogenesis enzyme; regulated by Efg1, Ssn6; induced by phagocytosis; effects switch from glycolysis to gluconeogenesis in macrophage; rat flow model biofilm induced; overlaps orf19.6179 ||" 1 -0.15 0.40 0.43
1728 "|| orf19.949 || || || Ortholog of C. dubliniensis CD36 : Cd36_50420, C. parapsilosis CDC317 : CPAR2_304100, Candida tenuis NRRL Y-1498 : CANTEDRAFT_98299 and Debaryomyces hansenii CBS767 : DEHA2B07634g ||" 1 -0.04 0.13 0.14
1729 || orf19.2806 || || || Predicted ORF from Assembly 19; merged with orf19.2805 in Assembly 20 || 1 -0.05 0.20
1730 || orf19.9088 || FAB1 || || || 1 -0.04 0.19 0.17
1731 || orf19.1890 || || || Ortholog(s) have role in medium-chain fatty acid biosynthetic process || 1 -0.05 0.33 0.37
1732 "|| orf19.212 || VPS28 || || ESCRT I protein sorting complex subunit; involved in Rim8 processing and proteolytic activation of Rim101, which regulates pH response; role in echinocandin, azole sensitivity ||" 1 -0.03 0.20
1733 || orf19.1719 || SGA1 || || Putative glucoamylase; induced in oralpharyngeal candidasis; rat catheter and Spider biofilm induced || 1 -0.07 0.42 0.31
1734 || orf19.5486 || || || Putative endoribonuclease; heterozygous null mutant exhibits hypersensitivity to parnafungin and cordycepin in the C. albicans fitness test || 1 -0.04 0.21 0.13
1735 "|| orf19.4393 || CIT1 || || Citrate synthase; induced by phagocytosis; induced in high iron; Hog1-repressed; Efg1-regulated under yeast, not hyphal growth conditions; present in exponential and stationary phase; Spider biofilm repressed; rat catheter biofilm induced ||" 1 -0.11 0.47 0.28
1736 "|| orf19.6142 || || || Ortholog(s) have double-stranded DNA binding activity, role in reciprocal meiotic recombination and condensed nuclear chromosome localization ||" 1 -0.25 1.16
1737 || orf19.3327 || TRM2 || || Putative tRNA methyltransferase; repressed by prostaglandins; Spider biofilm induced || 1 -0.78 0.74
1738 || orf19.6187 || || || possible pseudouridine monophosphate glycosidase; overlaps orf19.6185 and orf19.618; has intron; Spider biofilm repressed || 1 -0.10 0.09 0.11
1739 "|| orf19.6919 || || || Ortholog of C. dubliniensis CD36 : Cd36_71210, C. parapsilosis CDC317 : CPAR2_702710, Candida tenuis NRRL Y-1498 : CANTEDRAFT_116256 and Debaryomyces hansenii CBS767 : DEHA2E17732g ||" 1 -0.14 0.16 0.14
1740 "|| orf19.6399 || ATS1 || || Protein required for modification of wobble nucleosides in tRNA; induced upon adherence to polystyrene; regulated by Sef1, Sfu1, and Hap43 ||" 1 -0.18 0.16
1741 || orf19.1072 || || || Predicted ORF from Assembly 19; removed from Assembly 20 || 1 0.28 0.31
1742 || orf19.6404 || GSH2 || || Putative glutathione synthase; induced in high iron; heavy metal (cadmium) stress-induced || 1 -0.09 0.27
1743 || orf19.11128 || || || || 1 -0.33 0.33
1744 || orf19.7282 || PEX13 || || Protein required for peroxisomal protein import mediated by PTS1 and PTS2 targeting sequences; transcript induced in an RHE model of oral candidiasis; Hap43-repressed gene || 1 -0.19 0.30 0.27
1745 || orf19.12706 || SNT1 || || || 1 -0.09 0.20 0.21
1746 || orf19.6691 || || || Putative ember of the multi-drug and toxin extrusion (MATE) family of the multidrug/oligosaccharidyl-lipid/polysaccharide exporter superfamily; Spider biofilm induced || 1 -0.18 0.42
1747 || orf19.10611 || TRP4 || || || 1 -0.06 0.10 0.15
1748 || orf19.1628 || LAP41 || || Putative aminopeptidase yscI precursor; mutant is viable; protein present in exponential and stationary growth phase yeast cultures; Spider biofilm repressed || 1 -0.01 0.53
1749 || orf19.1772 || || || Ortholog(s) have mitochondrion localization || 1 -0.50 0.27
1750 "|| orf19.5447 || HGT19 || || Putative MFS glucose/myo-inositol transporter; 20 member family; 12 transmembrane segments, extended N terminus; expressed in rich medium; Hap43, phagocytosis, rat catheter, Spider and flow model biofilm induced ||" 1 -0.55 0.82
1751 || orf19.6346 || || || Putative nuclear export protein; Hap43p-induced gene; decreased transcription is observed in an azole-resistant strain that overexpresses MDR1 || 1 -0.40 0.40
1752 || orf19.567 || TFB3 || || Putative C3HC4 zinc finger transcription factor; transcript positively regulated by Tbf1; Spider biofilm induced || 1 -0.20 0.19 0.24
1753 "|| orf19.5821 || || || Ortholog of S. cerevisiae : YML002W, C. glabrata CBS138 : CAGL0L07634g, C. dubliniensis CD36 : Cd36_17530, C. parapsilosis CDC317 : CPAR2_212430 and Candida tenuis NRRL Y-1498 : CANTEDRAFT_128807 ||" 1 -0.31 0.41
1754 "|| orf19.4324 || || || Has domain(s) with predicted NADH dehydrogenase (ubiquinone) activity, electron carrier activity and membrane localization ||" 1 -0.30 0.40
1755 "|| orf19.4521 || || || S. cerevisiae ortholog Env9 has similarity to oxidoreductases and is proposed to have vacuolar functions, found in lipid particles; hyphal-induced expression ||" 1 -0.27 0.35
1756 "|| orf19.3840 || || || Putative serine/threonine kinase similar to S. cerevisiae Sak1; possibly an essential gene, disruptants not obtained by UAU1 method; Spider biofilm induced ||" 1 -0.12 0.27 0.16
1757 || orf19.3129 || || || Putative chromatin remodelling complex protein; heterozygous null mutant displays sensitivity to virgineone; Spider biofilm repressed || 1 -0.11 0.33 0.16
1758 || orf19.14132 || || || || 1 -0.39 0.56
1759 || orf19.164 || || || Ortholog(s) have lipase activity and peroxisomal matrix localization || 1 -0.27 0.44
1760 "|| orf19.3298 || CCH1 || || Voltage-gated Ca2+ channel of the high affinity calcium uptake system; roles in thigmotropism, establishment of galvanotropism; transcript regulated by Nrg1 and Mig1; flow model biofilm repressed ||" 1 -0.12 0.26 0.20
1761 || orf19.10831 || || || || 1 -0.23 0.39
1762 "|| orf19.1356 || || || Ortholog(s) have thiosulfate sulfurtransferase activity, role in tRNA wobble position uridine thiolation and mitochondrion localization ||" 1 -0.13 0.25 0.20
1763 || orf19.13250 || || || || 1 -0.22 0.35
1764 || orf19.6302 || PGA39 || || Putative GPI-anchored protein || 1 -0.12 0.17 0.19
1765 "|| orf19.4186 || PCT1 || || Putative choline-phosphate cytidylyl transferase, antigenic during human oral infection ||" 1 -0.14 0.20 0.25
1766 || orf19.5000 || CYB2 || || Putative cytochrome b2 precursor; induced in high iron; alkaline repressed; colony morphology-related gene regulation by Ssn6; Hap43-repressed; pider biofilm induced || 1 -0.26 0.55
1767 || orf19.13656 || || || || 1 -0.27 0.51
1768 || orf19.394 || || || Putative kynureninase; predicted role in NAD biosynthesis; Hap43-repressed gene; flow model biofilm induced || 1 -0.06 0.14 0.17
1769 "|| orf19.3577 || COQ5 || || Putative methyltransferase of ubiquinone biosynthesis; regulated by Gcn4; repressed by amino acid starvation (3-AT), Hap43; induced upon adherence to polystyrene; Spider biofilm repressed ||" 1 -0.10 0.19 0.25
1770 || orf19.2895 || VMA8 || || Putative vacuolar H+-ATPase subunit; regulated by Nrg1 and Mig1; transcript increases in populations of cells exposed to fluconazole over multiple generations; rat catheter and Spider biofilm repressed || 1 -0.06 0.14 0.20
1771 "|| orf19.4567 || || || Catechol 1,2-dioxygenase (1,2-CTD), involved in degradation of aromatic compounds; Spider biofilm induced ||" 1 -0.17 0.19
1772 || orf19.448 || CUE5 || || Predicted ubiquitin-binding protein; rat catheter biofilm repressed || 1 -0.04 0.36
1773 "|| orf19.7044 || RIM15 || || Ortholog(s) have protein kinase activity and role in age-dependent response to oxidative stress involved in chronological cell aging, conidiophore development, hyphal growth, protein phosphorylation, regulation of meiosis ||" 1 -0.10 0.18 0.36
1774 "|| orf19.6065 || || || RNA polymerase II holoenzyme/mediator subunit; regulated by Mig1, Tup1; amphotericin B, caspofungin repressed; protein present in exponential and stationary growth phase yeast; Hap43-repressed; Spider biofilm repressed ||" 1 -0.18 0.27 0.55
1775 || orf19.935 || AGA1 || || Protein with some similarity to agglutinin subunit; expression regulated upon white-opaque switch; Spider biofilm induced || 1 -0.01 0.06 0.08
1776 || orf19.6308 || || || Ortholog of Candida albicans WO-1 : CAWG_01818 || 1 -0.01 0.15
1777 || orf19.3244 || || || Ortholog(s) have role in mitochondrial respiratory chain complex assembly and mitochondrion localization || 1 -0.02 0.28
1778 "|| orf19.5125 || || || Protein of unknown function; induced by ketoconazole; Spider, F-12/CO2 and flow model biofilm induced ||" 1 -0.04 0.18 0.51
1779 "|| orf19.2770 || || || Ortholog of C. dubliniensis CD36 : Cd36_42220, C. parapsilosis CDC317 : CPAR2_500340, Debaryomyces hansenii CBS767 : DEHA2G17754g and Pichia stipitis Pignal : PICST_31424 ||" 1 -0.06 0.58
1780 "|| orf19.1576 || || || Ortholog(s) have nuclear localization sequence binding, ubiquitin binding activity, role in response to ethanol and cytosol localization ||" 1 -0.02 0.20 0.16
1781 || orf19.3203 || RCY1 || || Putative F-box protein involved in endocytic membrane traffic and/or recycling; fungal-specific (no human or murine homolog) || 1 -0.02 0.10
1782 "|| orf19.4656 || || || Ortholog of C. dubliniensis CD36 : Cd36_41300, C. parapsilosis CDC317 : CPAR2_400390, Candida tenuis NRRL Y-1498 : CANTEDRAFT_94704 and Debaryomyces hansenii CBS767 : DEHA2B02992g ||" 1 -0.03 0.20
1783 || orf19.346 || ALT1 || || Putative alanine transaminase; mutation confers hypersensitivity to 5-fluorocytosine (5-FC); rat catheter and flow model biofilm induced || 1 -0.03 0.08 0.17
1784 || orf19.8825 || || || || 1 0.00 0.05 0.12
1785 || orf19.3569 || || || Protein of unknown function; S. cerevisiae YLR407W mutants have abnormal budding; constitutive expression independent of MTL or white-opaque status; Spider biofilm induced || 1 -0.01 0.32
1786 || orf19.7287 || || || Predicted ORF from Assembly 19; merged with orf19.7286 in Assembly 20 || 1 -0.02 0.15 0.41
1787 || orf19.5763 || || || Has domain(s) with predicted oxidoreductase activity and role in metabolic process || 1 -0.03 0.37
1788 || orf19.9080 || || || || 1 -0.03 0.16 0.36
1789 || orf19.3915 || || || Putative metallodipeptidase; protein present in exponential and stationary growth phase yeast; Hog1-induced; Hap43-repressed; sumoylation target; Spider biofilm repressed || 1 -0.04 0.10 0.23
1790 || orf19.326 || || || Protein of unknown function; Spider biofilm repressed || 1 -0.06 0.33
1791 "|| orf19.4848 || SKI3 || || Ortholog(s) have role in negative regulation of G2/M transition of mitotic cell cycle, nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay, nuclear-transcribed mRNA catabolic process, non-stop decay ||" 1 -0.08 0.18 0.46
1792 "|| orf19.4633 || || || Ortholog(s) have carbonyl reductase (NADPH) activity, oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor activity and cytosol, nucleus, ribosome localization ||" 1 -0.03 0.10 0.29
1793 "|| orf19.1214 || || || Ortholog(s) have metalloaminopeptidase activity, role in protein initiator methionine removal involved in protein maturation and cytosol, nucleus localization ||" 1 -0.03 0.32
1794 || orf19.10082 || || || || 1 -0.02 0.07 0.15
1795 || orf19.12690 || || || || 1 -0.02 0.14
1796 || orf19.7286 || RPN7 || || Subunit of the proteasome regulatory particle; regulated by Gcn2p and Gcn4p; protein present in exponential and stationary growth phase yeast cultures || 1 -0.03 0.05 0.21
1797 || orf19.372 || || || Putative protein of unknown function; Hap43p-repressed gene || 1 0.01 0.16 0.22
1798 "|| orf19.273 || || || Ortholog(s) have unfolded protein binding activity, role in sterol biosynthetic process and endoplasmic reticulum localization ||" 1 0.00 0.18 0.24
1799 "|| orf19.7086 || || || Ortholog(s) have protein transporter activity, role in transcription factor import into nucleus and cytosol, nuclear envelope localization ||" 1 -0.01 0.53 0.67
1800 || orf19.12437 || || || || 1 0.04 0.16 0.10
1801 || orf19.4642 || || || Protein of unknown function; Hap43-induced gene || 1 0.13 0.35
1802 || orf19.2176 || IFM3 || || Protein with a 2-hydroxyacid dehydrogenase catalytic domain; Hap43-repressed; Plc1-regulated; overlaps orf19.2177 || 1 0.24 0.64
1803 || orf19.4034 || || || Predicted ORF from Assembly 19; merged with orf19.4032 in Assembly 20 || 1 0.12 0.16 0.33
1804 || orf19.7078 || || || Ortholog(s) have role in meiosis and cytoplasm localization || 1 0.31 0.33 0.71
1805 || orf19.2483 || RIM1 || || Putative single-stranded DNA-binding protein; protein level decreases in stationary phase cultures; rat catheter biofilm repressed || 1 0.17 0.18 0.38
1806 "|| orf19.7404 || || || Catabolic L-serine (L-threonine) deaminase;, catalyzes degradation of L-serine and L-threonine; required to use serine or threonine as a sole nitrogen source; Spider biofilm repressed ||" 1 0.59 0.85 1.82
1807 "|| orf19.388 || CAF16 || || ABC family protein, predicted not to be a transporter; Hap43, caspofungin repressed; rat catheter and Spider biofilm repressed ||" 1 0.06 0.18
1808 || orf19.3021 || || || Putative protein of unknown function; Hap43-repressed gene; Spider biofilm induced || 1 0.38 0.29 1.18
1809 "|| orf19.2244 || || || Similar to oxidoreductases and to S. cerevisiae Yjr096wp; Sfu1 repressed; induced by benomyl treatment, Ssr1; Hap43-repressed; flow model biofilm repressed ||" 1 0.29 0.46 1.11
1810 || orf19.2351 || NIT3 || || Putative nitrilase; regulated by Gcn2p and Gcn4p; protein present in exponential and stationary growth phase yeast cultures || 1 0.35 0.57 1.42
1811 || orf19.1969 || CCW14 || || Putative mannoprotein of cell wall with role in response to stress; increased mRNA abundance observed in cyr1 homozygous mutant (hyphal or yeast-form cells) and in ras1 homozygous mutant (yeast-form cells) || 1 0.05 0.20
1812 || orf19.5378 || SCL1 || || Proteasome subunit YC7alpha; protein present in exponential and stationary growth phase yeast cultures; flow model and Spider biofilm repressed || 1 0.05 0.21 0.15
1813 || orf19.13640 || BPH1 || || || 1 0.13 0.39
1814 || orf19.2209 || YVC1 || || Putative vacuolar cation channel shock; repressed by alpha pheromone in SpiderM medium; flow model biofilm repressed || 1 0.05 0.17 0.21
1815 || orf19.4898 || || || Putative protein of unknown function; induced by prostaglandins || 1 0.03 0.25 0.28
1816 "|| orf19.511 || || || Ortholog(s) have ribosylnicotinamide kinase activity, role in NAD biosynthesis via nicotinamide riboside salvage pathway, nicotinamide riboside metabolic process and cytosol, nucleus localization ||" 1 0.01 0.05
1817 "|| orf19.2697 || || || Ortholog(s) have role in protein monoubiquitination, regulation of dipeptide transmembrane transport by regulation of transcription from RNA polymerase II promoter and cytoplasm, nucleus localization ||" 1 0.20 0.59 1.24
1818 || orf19.3441 || FRP6 || || Putative ammonia transport protein; regulated by Nrg1 and Tup1; regulated by Ssn6; induced by human neutrophils || 1 0.06 0.16 0.42
1819 "|| orf19.6820 || || || Has domain(s) with predicted protein heterodimerization activity, role in DNA-dependent transcription, initiation and transcription factor TFIID complex localization ||" 1 0.32 1.12 2.56
1820 "|| orf19.1160 || || || Ortholog(s) have COPII adaptor activity and role in ER to Golgi vesicle-mediated transport, fungal-type cell wall organization, protein glycosylation, protein retention in Golgi apparatus ||" 1 0.03 0.22
1821 || orf19.5182 || POL3 || || Large subunit of DNA polymerase III; partially complements defects of an S. cerevisiae cdc2 mutant; differing reports about periodic (G1/S) or non-periodic mRNA expression through cell cycle; Hap43p-repressed || 1 0.13 0.30 0.92
1822 "|| orf19.4815 || YTM1 || || Protein similar to S. cerevisiae Ytm1p, which is involved in biogenesis of the large ribosomal subunit; transposon mutation affects filamentous growth; protein level decreases in stationary phase cultures; Hap43p-induced gene ||" 1 0.74 1.41 2.04
1823 || orf19.6066 || || || Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; Spider biofilm induced || 1 0.12 0.33
1824 "|| orf19.4478 || || || Ortholog(s) have aspartate-tRNA ligase activity, role in mitochondrial aspartyl-tRNA aminoacylation and mitochondrion localization ||" 1 0.13 0.37
1825 || orf19.558 || GUT1 || || Putative glycerol kinase; downregulated upon adherence to polystyrene; greater mRNA abundance observed in a cyr1 homozygous null mutant than in wild type || 1 0.05 0.18 0.14
1826 || orf19.6470 || AHP2 || || Putative thiol-specific peroxiredoxin; macrophage-downregulated gene || 1 0.13 0.34 0.35
1827 || orf19.7603 || || || Protein with a predicted role in cytochrome c oxidase assembly; rat catheter biofilm induced || 1 0.17 0.33 0.39
1828 "|| orf19.6725 || || || Putative fumarate hydratase, enzyme of citric acid cycle; fluconazole-downregulated; downregulated by Efg1p; merged with orf19.6724 in Assembly 20; protein present in exponential and stationary growth phase yeast cultures ||" 1 0.24 0.39 0.45
1829 || orf19.11750 || PUT1 || || || 1 0.25 0.35 0.46
1830 "|| orf19.3184 || || || Ortholog(s) have Golgi apparatus, fungal-type vacuole membrane localization ||" 1 0.06 0.11
1831 "|| orf19.1590 || || || Ortholog of C. dubliniensis CD36 : Cd36_18970, C. parapsilosis CDC317 : CPAR2_212800, Debaryomyces hansenii CBS767 : DEHA2F08690g and Candida guilliermondii ATCC 6260 : PGUG_01488 ||" 1 0.05 0.08 0.09
1832 "|| orf19.213 || || || Ortholog(s) have role in ubiquitin-dependent protein catabolic process and nucleus, proteasome regulatory particle, lid subcomplex, proteasome storage granule localization ||" 1 0.13 0.22 0.22
1833 || orf19.5026 || || || C2H2 transcription factor; Spider biofilm induced || 1 0.25 0.41 0.43
1834 "|| orf19.3402 || FPG1 || || Formamidopyrimidine DNA glycosylase, involved in repair of gamma-irradiated DNA; Hap43p-repressed gene ||" 1 0.10 0.15 0.16
1835 || orf19.1287 || || || Protein of unknown function; flow model biofilm induced; Spider biofilm induced || 1 0.05 0.15 0.07
1836 || orf19.510 || || || Protein of unknown function; Spider biofilm induced || 1 0.09 0.11
1837 || orf19.2368 || || || Predicted component of U5 snRNP; Spider biofilm induced || 1 0.04 0.12 0.05
1838 "|| orf19.6558 || || || Has domain(s) with predicted zinc ion binding activity, role in ER to Golgi vesicle-mediated transport, intracellular protein transport and COPII vesicle coat localization ||" 1 0.11 0.16
1839 || orf19.7906 || || || || 1 0.29 0.68 0.42
1840 || orf19.11172 || || || || 1 0.07 0.21 0.12
1841 || orf19.5282 || || || Protein of unknown function; Hap43-repressed gene; mRNA binds to She3; repressed in hyphae; Efg1 and Efh1 regulated; 5'-UTR intron; induced by Mnl1 under weak acid stress; rat catheter biofilm induced || 1 0.10 0.22 0.17
1842 || orf19.6324 || VID27 || || Protein similar to S. cerevisiae Vid27p; transposon mutation affects filamentous growth; mutation confers hypersensitivity to toxic ergosterol analog; fungal-specific (no human or murine homolog) || 1 0.07 0.19 0.15
1843 || orf19.11846 || || || || 1 0.18 0.54 0.39
1844 "|| orf19.6362 || SPA2 || || Protein involved in cell polarity, Spitzenkorper formation; required for mouse virulence; localizes to hyphal tip; cell-cycle regulated localization in yeast-form cells; functional domains conserved with S. cerevisiae ; Hap43p-induced gene ||" 1 0.16 0.52 0.37
1845 || orf19.12421 || RPN1 || || || 1 0.05 0.16 0.11
1846 "|| orf19.7498 || LEU1 || || 3-isopropylmalate dehydratase; antigenic in humans; repressed in hyphae; alkaline repressed; upregulated by human whole blood or PMNs; regulated by Sef1, Sfu1, and Hap43; rat catheter biofilm induced, Spider biofilm repressed ||" 1 0.10 0.19
1847 || orf19.14180 || RFC1 || || || 1 0.21 0.43 0.41
1848 || orf19.7437 || || || Putative protein of unknown function; Hap43p-repressed gene; ortholog of S. cerevisiae YJL218W || 1 0.00 0.27 0.30
1849 || orf19.26 || || || Putative peptide N-glycanase; induced by nitric oxide independent of Yhb1p || 1 0.00 0.19
1850 || orf19.5260 || RPN2 || || Putative 26S proteasome subunit; transcript regulated by Mig1; caspofungin repressed; regulated by Gcn2 and Gcn4; gene used for strain identification by multilocus sequence typing || 1 0.01 0.27 0.12
1851 || orf19.6729 || TIP120 || || Protein similar to human CAND1 (Cullin-Associated Nedd8-Dissociated) protein involved in regulation of SCF complexes; binds unnedddylated cullin Cdc53; mutants are viable || 1 0.02 0.32
1852 || orf19.820 || SDS22 || || Putative protein serine-threonine phosphatase; macrophage/pseudohyphal-repressed || 1 0.01 0.31 0.09
1853 "|| orf19.2219 || ORF298 || || Predicted ORF in retrotransposon Tca3; similar to Gag-Pol; a-specific transcript, alpha-factor induced; rat catheter biofilm repressed; mRNA binds She3 ||" 1 0.04 0.39
1854 || orf19.6588 || NBP2 || || Protein containing an SH3 domain; involved in vacuolar fusion in hyphae; mutants form multiple germ tubes; Spider biofilm induced || 1 0.04 0.24 0.20
1855 || orf19.4808 || NUP188 || || Putative nuclear pore complex subunit; transcript regulated by Nrg1 and Mig1 || 1 0.06 0.51 0.31
1856 || orf19.7949 || || || || 1 0.08 0.36
1857 || orf19.1722 || || || Ortholog of Candida albicans WO-1 : CAWG_02462 || 1 0.01 0.11 0.06
1858 "|| orf19.554 || DIT2 || || Monooxygenase of the cytochrome P450 family; produces N,N'-bisformyl dityrosine from N-formyltyrosine; regulated by Nrg1, Mig1, and Tup1; role in chlamydospore formation; Spider biofilm induced ||" 1 0.01 0.25 0.13
1859 || orf19.1414 || || || Protein of unknown function; transcript is upregulated in an RHE model of oral candidiasis; Hap43-repressed || 1 0.01 0.32 0.19
1860 || orf19.2182 || BLM3 || || Putative proteasome activator; binds core proteasome and stimulates proteasome-mediated protein degradation by inducing gate opening; ortholog of S. cerevisiae Blm10; transcript regulated by Nrg1 and Mig1 || 1 -0.01 0.21 0.13
1861 "|| orf19.2089 || || || Ortholog of Nyv1, v-SNARE component of the vacuolar SNARE complex involved in vesicle fusion in S. cerevisiae; Hap43-repressed gene ||" 1 -0.09 0.34
1862 "|| orf19.2408 || || || Ortholog(s) have tRNA methyltransferase activity, role in tRNA methylation, wybutosine biosynthetic process and cytosol, nucleus localization ||" 1 -0.09 0.78 0.34
1863 || orf19.4580 || || || Protein of unknown function; Hap43-repressed gene || 1 -0.03 0.12
1864 "|| orf19.775 || || || Ortholog of C. dubliniensis CD36 : Cd36_04450, C. parapsilosis CDC317 : CPAR2_105460, Debaryomyces hansenii CBS767 : DEHA2D07128g and Pichia stipitis Pignal : PICST_80203 ||" 1 -0.16 0.59
1865 "|| orf19.6423 || || || Ortholog(s) have fructose-2,6-bisphosphate 2-phosphatase activity, role in glucose metabolic process and cytoplasm localization ||" 1 -0.03 0.24
1866 || orf19.9311 || HEM4 || || || 1 -0.06 0.56
1867 "|| orf19.4551 || CTN1 || || Carnitine acetyl transferase; required for growth on nonfermentable carbon sources, not for hyphal growth or virulence in mice; induced in macrophage; macrophage/pseudohyphal-repressed after 16 hr; rat catheter, Spider biofilm induced ||" 1 -0.06 0.87 0.62
1868 || orf19.2516 || || || Has domain(s) with predicted role in cell redox homeostasis || 1 -0.03 0.26
1869 || orf19.9896 || URA2 || || || 1 0.06 1.06 0.42
1870 || orf19.195 || || || Predicted ORF from Assembly 19; merged with orf19.156 in Assembly 20 || 1 0.07 0.31
1871 || orf19.826 || MED1 || || RNA polymerase II mediator complex subunit; RNA polymerase II transcription cofactor || 1 0.08 0.71 0.37
1872 "|| orf19.4023 || MRP2 || || Protein similar to S. cerevisiae Mrp2p, which is a component of the small subunit of the mitochondrial ribosome; transposon mutation affects filamentous growth ||" 1 0.05 0.20
1873 || orf19.7077 || || || Putative ferric reductase; induced by Mac1 under copper starvation; Plc1-regulated; Rim101-repressed || 1 0.06 0.74 0.22
1874 || orf19.1903 || || || Protein similar to TOR family phosphatidylinositol kinases; mutation confers resistance to rapamycin; merged with orf19.2290 in Assembly 20 || 1 0.03 0.10
1875 || orf19.1963 || GDS1 || || Putative mitochondrial protein; Hap43-repressed gene; Spider biofilm induced || 1 0.08 0.67
1876 "|| orf19.1223 || DBF2 || || Essential serine/threonine protein kinase involved in mitotic spindle formation and cytokinesis; required for septum formation, exit from mitosis, and normal hyphal morphogenesis; virulence-group-correlated expression ||" 1 0.19 0.43
1877 || orf19.823 || || || Protein of unknown function; Spider biofilm induced || 1 0.34 1.30
1878 || orf19.5323 || MDH1-3 || || Predicted malate dehydrogenase; farnesol regulated; protein present in exponential and stationary growth phase yeast; Hap43p-repressed gene || 1 0.15 0.45
1879 || orf19.2824 || || || Predicted ORF from Assembly 19; merged with orf19.2823 in Assembly 20 || 1 0.07 0.61 0.15
1880 || orf19.2699 || ABP1 || || Ortholog of S. cerevisiae Abp1; actin-binding protein of the cortical actin cytoskeleton; caspofungin induced; protein only detected in stationary phase yeast-form cultures; Spider biofilm repressed || 1 -0.04 0.17 -0.07
1881 || orf19.10340 || || || || 1 -0.13 0.70 -0.31
1882 || orf19.765 || || || Predicted ORF from Assembly 19; merged with orf19.764 in Assembly 20 || 1 -0.09 -0.21
1883 || orf19.5083 || DRG1 || || Member of the DRG family of GTP-binding proteins; involved in regulation of invasive filamentous growth || 1 -0.08 0.33 -0.18
1884 "|| orf19.7362 || SKN1 || || Protein with a role in beta-1,6-glucan synthesis; probable N-glycosylated type II membrane protein; transcript and mRNA length change induced by yeast-hypha transition; induced by Rim101, caspofungin; rat catheter and Spider biofilm induced ||" 1 -0.14 0.58 -0.30
1885 || orf19.7922 || KRE5 || || || 1 -0.15 0.51 -0.26
1886 "|| orf19.1697 || || || Ortholog(s) have role in cytoplasmic translation and cytoplasm, polysomal ribosome localization ||" 1 -0.10 0.35 -0.17
1887 || orf19.6834 || || || Predicted ORF from Assembly 19; removed from Assembly 20 || 1 -0.33 1.18 -0.52
1888 "|| orf19.6584 || PRT1 || || Putative translation initiation factor eIF3; mutation confers hypersensitivity to roridin A, verrucarin A; genes encoding ribosomal subunits, translation factors, tRNA synthetases are downregulated upon phagocytosis by murine macrophages ||" 1 -0.12 0.46 -0.17
1889 "|| orf19.7111 || || || Putative mitochondrial outer membrane protein membrane fission effector; possibly an essential gene, disruptants not obtained by UAU1 method ||" 1 -0.31 1.18 -0.37
1890 "|| orf19.4723 || FAD1 || || Ortholog(s) have ATP binding, FMN adenylyltransferase activity, magnesium ion binding activity, role in FAD biosynthetic process and cytosol, nucleus localization ||" 1 -0.15 0.31 -0.14
1891 "|| orf19.3973 || || || Ortholog of Hua1, a zinc finger domain protein with sequence similarity to Type I J-proteins; flow model biofilm induced ||" 1 -0.09 0.20 -0.09
1892 || orf19.9252 || PPH21 || || || 1 -0.25 -0.26
1893 || orf19.10265 || || || || 1 -0.13 0.37 -0.14
1894 "|| orf19.1376 || || || Ortholog(s) have SNAP receptor activity, phosphatidic acid binding activity ||" 1 -0.14 -0.18
1895 "|| orf19.2270 || SMF12 || || Ortholog of S. cerevisiae Smf1; manganese transporter; Gcn4-regulated; Hap43, alkaline induced; caspofungin repressed; mutants are viable ||" 1 -0.44 0.73 -0.58
1896 "|| orf19.4451 || RIA1 || || Putative translation elongation factor; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage ||" 1 -0.08 0.16 -0.13
1897 "|| orf19.1488 || || || Ortholog of C. dubliniensis CD36 : Cd36_16630, C. parapsilosis CDC317 : CPAR2_210300, Candida tenuis NRRL Y-1498 : CANTEDRAFT_116870 and Debaryomyces hansenii CBS767 : DEHA2B04334g ||" 1 -0.21 -0.32
1898 || orf19.10683 || || || || 1 -0.35 0.66 -0.54
1899 || orf19.11418 || || || || 1 -0.23 0.56 -0.43
1900 || orf19.304 || || || Putative transporter similar to MDR proteins; fungal-specific; Spider biofilm induced || 1 -0.05 0.14 -0.11
1901 "|| orf19.4328 || CCC2 || || Copper-transporting P-type ATPase of Golgi; required for wild-type iron assimilation (indirect effect via Fet3p); induced by iron starvation, ciclopirox olamine; caspofungin repressed; not required for virulence in mouse systemic infection ||" 1 -0.15 0.43 -0.32
1902 || orf19.6004 || || || Predicted ORF from Assembly 19; removed from Assembly 20 || 1 -0.38 1.10 -0.81
1903 || orf19.3138 || NOP1 || || Nucleolar protein; flucytosine induced; Hap43-induced; Spider biofilm repressed || 1 -0.23 0.63 -0.45
1904 || orf19.6036 || RIC1 || || Ortholog of S. cerevisiae Ric1 guanyl-nucleotide exchange factor; mutant is viable; rat catheter biofilm repressed || 1 -0.04 0.14
1905 "|| orf19.2288 || CCT5 || || T-complex protein 1, epsilon subunit; protein present in exponential and stationary growth phase yeast cultures; Spider biofilm repressed ||" 1 -0.20 -0.11
1906 || orf19.6277 || || || Has domain(s) with predicted phosphatidylinositol binding activity and role in cell communication || 1 -0.14 0.16 -0.13
1907 "|| orf19.6073 || HMX1 || || Heme oxygenase; utilization of hemin iron; transcript induced by heat, low iron, or hemin; repressed by Efg1; induced by low iron; upregulated by Rim101 at pH 8; Hap43-induced; Spider and flow model biofilm induced ||" 1 -0.31 0.41 -0.31
1908 || orf19.4188 || NMD5 || || Karyopherin; carrier protein involved in nuclear import of proteins; repressed in core stress response; Hap43-induced; Spider biofilm induced || 1 -0.25 0.39 -0.27
1909 || orf19.4536 || CYS4 || || Cystathionine beta-synthase; sulfur amino acid biosynthesis; antigenic in mouse; flow model biofilm induced; alkaline induced; macrophage/pseudohyphal-induced; present in exponential and stationary growth phase yeast cultures || 1 -0.11 0.12 -0.11
1910 "|| orf19.1609 || || || Ortholog(s) have role in endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and mitotic spindle pole body, nucleolus localization ||" 1 -0.15 0.23 -0.22
1911 || orf19.4738 || || || Ortholog(s) have role in protein folding in endoplasmic reticulum and integral to endoplasmic reticulum membrane localization || 1 -0.10 0.14 -0.22
1912 "|| orf19.1011 || MNN21 || || Ortholog(s) have alpha-1,2-mannosyltransferase activity, role in cell wall mannoprotein biosynthetic process and Golgi apparatus localization ||" 1 -0.10 -0.22
1913 || orf19.6032 || SPE1 || || Ornithine decarboxylase; enzyme of polyamine biosynthesis; mutant is viable; functionally complements polyamine auxotrophy of S. cerevisiae spe1 mutant; downregulated upon adherence to polystyrene || 1 -0.22 0.38 -0.53
1914 || orf19.4479 || || || Putative U3-containing 90S preribosome subunit; Hap43-induced; repressed in core stress response; Spider biofilm induced || 1 -0.08 -0.23
1915 "|| orf19.2573 || FRS1 || || Phenylalanyl-tRNA synthetase; possible role in early cell wall biosynthesis; downregulated by phagocytosis by macrophages; possibly essential gene, disruptants not obtained by UAU1 method; protein present in exponential and stationary phase ||" 1 -0.14 0.34 -0.43
1916 || orf19.1833 || || || Ortholog(s) have pseudouridine synthase activity || 1 -0.15 0.40 -0.57
1917 "|| orf19.3087 || UBI3 || || Fusion of ubiquitin with the S34 protein of the small ribosomal subunit; mRNA decreases upon heat shock, appears to be degraded; functional homolog of S. cerevisiae RPS31; Hap43-induced; Spider biofilm repressed ||" 1 -0.05 0.45 -0.69
1918 || orf19.3974 || PUT2 || || Putative delta-1-pyrroline-5-carboxylate dehydrogenase; alkaline upregulated; protein present in exponential and stationary growth phase yeast cultures; flow model biofilm induced; Spider biofilm induced || 1 -0.02 0.16 -0.23
1919 "|| orf19.6034 || TUB2 || || Beta-tubulin; functional homolog of ScTub2; overproduction makes S. cerevisiae inviable; has two introns; GlcNAc, hypha fluconazole-induced; slow growth, ectopic expression increases white-to opaque switch; rat catheter biofilm repressed ||" 1 -0.10 0.29 -0.48
1920 || orf19.493 || RPL15A || || Putative ribosomal protein; repressed upon phagocytosis by murine macrophage; positively regulated by Tbf1; Spider biofilm repressed || 1 -0.02 -0.15
1921 || orf19.3324 || TIF || || Translation initiation factor; upregulated in highly virulent strain compared to less virulent strain; antigenic in human; flucytosine induced; downregulated upon phagocytosis by macrophages; Spider biofilm repressed || 1 -0.10 0.24 -0.63
1922 || orf19.3435 || || || Ortholog of Candida albicans WO-1 : CAWG_05215 || 1 -0.07 0.32 -0.62
1923 "|| orf19.5716 || SAP4 || || Secreted aspartyl proteinase; sap4,5,6 mutant defective in protein utilization for nitrogen; virulence role complicated by URA3 effects; expressed during mucosal and systemic infections; N-glycosylated; rat catheter, Spider biofilm induced ||" 1 -0.02 -0.15
1924 "|| orf19.925 || SAM51 || || Component of the SAM complex involved in mitochondrial protein import, involved in beta-barrel protein assembly; member of the Omp85 protein family ||" 1 -0.04 0.29 -0.36
1925 || orf19.13701 || RPG1A || || || 1 -0.04 0.41 -0.53
1926 || orf19.11074 || || || || 1 -0.01 0.22 -0.26
1927 "|| orf19.1601 || RPL3 || || Ribosomal protein, large subunit; induced by ciclopirox olamine treatment; genes encoding cytoplasmic ribosomal subunits are downregulated upon phagocytosis by murine macrophages; Hap43-induced gene; Spider biofilm repressed ||" 1 -0.03 0.54 -0.60
1928 || orf19.7250 || || || Protein of unknown function; rat catheter and Spider biofilm induced || 1 -0.00 0.18 -0.18
1929 || orf19.9248 || || || || 1 -0.02 0.36 -0.33
1930 "|| orf19.4755 || KEX2 || || Subtilisin-like protease (proprotein convertase); processes aspartyl proteinase Sap2; required for hyphal growth and wild-type virulence in mice; functional homolog of S. cerevisiae Kex2, which processes alpha-factor; Tup1-repressed ||" 1 -0.02 0.27 -0.24
1931 "|| orf19.7195 || RAD6 || || Functional ortholog of S. cerevisiae Rad6; negative regulator of hyphal growth; required for wild-type UV resistance; acts in pathway with Efg1; ; transcript is UV-induced, slightly repressed during hyphal growth; gene has two introns ||" 1 -0.03 -0.23
1932 "|| orf19.1663 || MNT2 || || Alpha-1,2-mannosyl transferase; adds 3rd mannose in cell-wall mannoprotein biosynthesis; partially redundant with Mnt1; role in adherence and virulence; expressed in yeast and hyphae; fungal-specific; Hap43-induced; Spider biofilm induced ||" 1 -0.08 0.50 -0.65
1933 || orf19.3463 || || || Putative GTPase; role in 60S ribosomal subunit biogenesis; Spider biofilm induced || 1 -0.04 0.22 -0.23
1934 || orf19.10173 || || || || 1 -0.06 0.26 -0.23
1935 || orf19.8421 || UGA1 || || || 1 -0.14 1.02 -0.82
1936 "|| orf19.30 || SPF1 || || P-type calcium-transporting ATPase, involved in control of calcium homeostasis, response to ER stress, hyphal growth, biofilm formation and virulence ||" 1 -0.06 0.43 -0.34
1937 || orf19.807 || CHS5 || || Putative chitin biosynthesis protein; fungal-specific; repressed upon yeast-to-hypha switch; rat catheter biofilm repressed || 1 0.06 0.41 -0.49
1938 || orf19.4051 || HTS1 || || Putative tRNA-His synthetase; downregulated upon phagocytosis by murine macrophage; stationary phase enriched protein; Spider biofilm repressed || 1 0.06 0.30 -0.32
1939 || orf19.2214 || || || Ortholog(s) have structural constituent of ribosome activity and mitochondrial large ribosomal subunit localization || 1 0.04 0.23 -0.20
1940 || orf19.13050 || || || || 1 0.10 -0.44
1941 || orf19.676 || || || Microtubule-binding protein of the cortical microtubule; delays exit from mitosis when the spindle is abnormally oriented; Spider biofilm repressed || 1 0.06 -0.26
1942 || orf19.5684 || || || Ortholog(s) have structural constituent of ribosome activity and mitochondrial large ribosomal subunit localization || 1 0.05 0.19 -0.30
1943 || orf19.3243 || SRP54 || || Putative signal recognition particle (SRP) subunit; induced in ssr1 null; Spider biofilm repressed || 1 0.05 -0.30
1944 || orf19.7165 || MED9 || || RNA polymerase II mediator complex subunit; Hap43p-repressed gene || 1 0.05 0.22 -0.32
1945 || orf19.7622 || SPT3 || || Functional homolog of S. cerevisiae Spt3p; required for virulence in mouse systemic infection; homozygous null mutant is hyperfilamentous || 1 0.08 0.15 -0.15
1946 || orf19.6126 || KGD2 || || Putative dihydrolipoamide S-succinyltransferase; induced in high iron; Hap43-repressed; Spider biofilm repressed || 1 0.06 0.12 -0.12
1947 || orf19.8632 || || || || 1 0.22 0.56 -0.53
1948 "|| orf19.2614 || RSR1 || || RAS-related protein; GTP/GDP cycling required for wild-type polar bud site selection, hyphal growth guidance; role in systemic virulence in mouse; geranylgeranylation predicted; suppresses S. cerevisiae cdc24-4 mutant heat sensitivity ||" 1 0.08 0.26 -0.21
1949 || orf19.4472 || || || Ortholog of Candida albicans WO-1 : CAWG_00996 || 1 0.05 0.14 -0.11
1950 "|| orf19.2810 || AAP1 || || Putative amino acid permease; fungal-specific; possibly essential, disruptants not obtained by UAU1 method; Spider biofilm induced ||" 1 0.27 0.90 -0.64
1951 || orf19.5832 || HPT1 || || Putative hypoxanthine-guanine phosphoribosyltransferase; protein abundance affected by URA3 expression in the CAI4 strain background; protein level decreases in stationary phase; Spider biofilm induced || 1 0.07 0.17 -0.12
1952 || orf19.3426 || ANB1 || || Translation initiation factor eIF-5A; repressed in hyphae vs yeast cells; downregulated upon phagocytosis by murine macrophage; Hap43-induced; GlcNAc-induced protein; Spider biofilm repressed || 1 0.19 0.60 -0.34
1953 "|| orf19.6367 || SSB1 || || HSP70 family heat shock protein; mRNA in yeast and germ tubes; at yeast cell surface, not hyphae; antigenic in human/mouse infection; macrophage, GCN-induced; possibly essential; sumoylation target; Hap43-induced; Spider biofilm repressed ||" 1 0.19 0.59 -0.33
1954 "|| orf19.7363 || KRE6 || || Essential beta-1,6-glucan synthase subunit; change in mRNA length, not abundance, at yeast-hypha transition; alkaline induced by Rim101, on cell wall regeneration; Spider biofilm induced; Bcr1-repressed in RPMI a/a biofilms ||" 1 0.19 1.04 -0.64
1955 "|| orf19.5506 || PLC1 || || Phosphoinositide-specific phospholipase C (PI-PLC), delta-form; essential; roles in stress resistance, hyphal growth; upregulated in biofilm; predicted N-linked glycosylation; lacks conserved EF-hand domain ||" 1 0.10 0.58 -0.32
1956 || orf19.4281 || || || Transcription factor; forms a heterodimer with Fhl11 that is tethered to promoters by Tbf1; positively regulates rRNA and ribosomal protein gene transcription; merged with orf19.4282; Spider biofilm induced || 1 0.15 0.89 -0.48
1957 || orf19.1673 || PPT1 || || Putative serine/threonine phosphatase; induced in high iron || 1 0.05 0.27 -0.14
1958 || orf19.5067 || || || Predicted nuclear exosome-associated nucleic acid binding protein; rat catheter and Spider biofilm induced || 1 0.11 0.55 -0.31
1959 "|| orf19.5609 || || || Ortholog of C. dubliniensis CD36 : Cd36_63840, C. parapsilosis CDC317 : CPAR2_601510, Debaryomyces hansenii CBS767 : DEHA2A06270g and Pichia stipitis Pignal : PICST_31363 ||" 1 0.11 0.52 -0.27
1960 || orf19.2616 || UGT51C1 || || UDP-glucose:sterol glucosyltransferase; enzyme of sterol glucoside (membrane-bound lipid) biosynthesis; has UDP-sugar binding domain; activity is UDP-glucose-specific in vitro; enzyme does not use UDP-mannose; Mig1-regulated || 1 0.08 0.39 -0.19
1961 "|| orf19.3202 || || || Ortholog of C. dubliniensis CD36 : Cd36_51590, C. parapsilosis CDC317 : CPAR2_303610, Candida tenuis NRRL Y-1498 : CANTEDRAFT_135127 and Debaryomyces hansenii CBS767 : DEHA2E19074g ||" 1 0.04 0.23 -0.11
1962 "|| orf19.1036 || MNS1 || || Alpha-1,2-mannosidase; processes Man9GlcNAc2 to Man8GlcNAc2 isomer B; member of ER localized glycosyl hydrolase family 47; ER form is converted by Kex2 to cytosolic form; flow model biofilm repressed ||" 1 -0.02 0.38 -0.22
1963 || orf19.9534 || GIT2 || || || 1 0.02 0.72 -0.39
1964 || orf19.69 || || || Protein of unknown function; induced by Mnl1 under weak acid stress || 1 0.01 0.41 -0.24
1965 || orf19.306 || USO5 || || Putative type II myosin heavy chain; transcription is induced upon filamentous growth and in response to alpha pheromone in SpiderM medium || 1 0.01 0.16 -0.09
1966 "|| orf19.2715 || RPC53 || || Ortholog(s) have RNA polymerase III activity, role in tRNA transcription from RNA polymerase III promoter and DNA-directed RNA polymerase III complex localization ||" 1 0.05 -0.38
1967 "|| orf19.1499 || CTF1 || || Putative zinc-finger transcription factor, similar to A. nidulans FarA and FarB; activates genes required for fatty acid degradation; induced by oleate; null mutant displays carbon source utilization defects and slightly reduced virulence ||" 1 0.04 0.55 -0.27
1968 || orf19.7409 || ERV25 || || Component of COPII-coated vesicles; transcript induced upon filamentous growth; rat catheter biofilm repressed || 1 0.06 -0.44
1969 || orf19.7486 || MRPL6 || || Putative mitochondrial ribosomal protein || 1 0.04 0.51 -0.31
1970 || orf19.4853 || HCM1 || || Protein with forkhead domain; similar to S. cerevisiae Hcm1p; Hap43p-induced gene || 1 0.02 0.78 -0.51
1971 "|| orf19.6312 || RPS3 || || Ribosomal protein S3; Hog1, Hap43-induced; grepressed upon phagocytosis by murine macrophage; present in exponential and stationary phase cells; Spider biofilm repressed ||" 1 0.01 0.47 -0.33
1972 "|| orf19.6109 || TUP1 || || Transcriptional corepressor; represses filamentous growth; regulates switching; role in germ tube induction, farnesol response; in repression pathways with Nrg1, Rfg1; farnesol upregulated in biofilm; rat catheter, Spider biofilm repressed ||" 1 0.01 0.11 -0.11
1973 "|| orf19.2179 || SIT1 || || Transporter of ferrichrome siderophores, not ferrioxamine B; required for human epithelial cell invasion in vitro, not for mouse systemic infection; regulated by iron, Sfu1, Rfg1, Tup1, Hap43; rat catheter and Spider biofilm induced ||" 1 0.05 1.25 -1.10
1974 "|| orf19.4029 || || || Ortholog(s) have role in ribosomal large subunit assembly and cytosolic ribosome, nucleus localization ||" 1 0.05 0.28 -0.25
1975 || orf19.2875 || || || Ortholog of S. pombe SPAC1071.09c DNAJ domain protein; Hap43-induced gene || 1 0.07 -0.44
1976 || orf19.2694 || TYS1 || || Putative tRNA-Tyr synthetase; downregulated upon phagocytosis by murine macrophages; stationary phase enriched protein; Spider biofilm repressed || 1 0.03 -0.20
1977 || orf19.9808 || RCK2 || || || 1 0.00 0.24 -0.02
1978 "|| orf19.4377 || KRE1 || || Cell wall glycoprotein; beta glucan synthesis; increases glucan content in S. cerevisiae kre1, complements killer toxin sensitivity; caspofungin induced; Spider/rat catheter/flow model biofilm induced; Bcr1-repressed in RPMI a/a biofilms ||" 1 0.02 0.24 -0.04
1979 || orf19.1031 || HMG1 || || HMG-CoA reductase; enzyme of sterol pathway; inhibited by lovastatin; gene not transcriptionally regulated in response to lovastatin and fluconazole || 1 0.01 0.17 -0.02
1980 || orf19.13072 || || || || 1 0.02 0.46 -0.03
1981 || orf19.7337 || || || Protein with a nischarin related domain and leucine rich repeats; Spider biofilm induced || 1 -0.01 0.86 -0.05
1982 || orf19.10399 || MNN4 || || || 1 0.04 0.81 0.02
1983 || orf19.1755 || SET2 || || Ortholog(s) have histone methyltransferase activity (H3-K36 specific) activity || 1 0.01 0.24 0.01
1984 || orf19.2942 || DIP5 || || Dicarboxylic amino acid permease; mutation confers hypersensitivity to toxic ergosterol analog; induced upon phagocytosis by macrophage; Gcn4-regulated; upregulated by Rim101 at pH 8; rat catheter and Spider biofilm induced || 1 -0.05 0.46 0.00
1985 "|| orf19.1084 || CDC39 || || Protein similar to S. cerevisiae Cdc39p, which is part of the CCR4-NOT transcription regulatory complex; transposon mutation affects filamentous growth ||" 1 -0.04 0.29 0.00
1986 || orf19.9111 || || || || 1 -0.11 0.38 -0.07
1987 || orf19.4729 || || || Predicted ORF from Assembly 19; merged with orf19.4728 in Assembly 20 || 1 -0.06 0.24 -0.08
1988 "|| orf19.4785 || PTC1 || || Putative protein phosphatase of the Type 2C-related family (serine/threonine-specific), similar to S. cerevisiae Ptc1p; mutant shows virulence defect ||" 1 -0.02 -0.02
1989 "|| orf19.6203 || PUT3 || || Zn(II)2Cys6 transcription factor; has similarity to S. cerevisiae Put3, a transcription factor involved in the regulation of proline utilization genes ||" 1 -0.17 1.06
1990 || orf19.6254 || ANT1 || || Peroxisomal adenine nucleotide transporter; role in beta-oxidation of medium-chain fatty acid and peroxisome proliferation; rat catheter biofilm induced || 1 -0.27 -0.21
1991 || orf19.4843 || || || Putative iron/copper reductas; involved in iron homeostasis; rat catheter and Spider biofilm induced || 1 -0.20 -0.14
1992 || orf19.4829 || DOA1 || || WD repeat protein; required for ubiquitin-mediated protein degradation; role in control of cellular ubiquitin levels; may promote efficient NHEJ in postdiauxic/stationary phase; Spider biofilm repressed || 1 -0.21 -0.15
1993 "|| orf19.5422 || || || Ortholog of C. dubliniensis CD36 : Cd36_80400, Candida tropicalis MYA-3404 : CTRG_06188 and Candida albicans WO-1 : CAWG_02379 ||" 1 -0.06 0.72 -0.04
1994 || orf19.718 || RRN11 || || Putative RNA polymerase I subunit; rat catheter biofilm induced; Spider biofilm induced || 1 -0.14 1.12 -0.18
1995 || orf19.6110 || || || Ortholog of Candida albicans WO-1 : CAWG_01361 || 1 -0.27 1.09
1996 "|| orf19.6001 || SAP3 || || Secreted aspartyl proteinase, acts in utilization of protein as nitrogen source; assessment of virulence role complicated by URA3 effects; regulated by growth phase; produced by opaque phase cells; alpha-pheromone repressed ||" 1 -0.04 -0.16
1997 || orf19.5746 || ALA1 || || Alanyl-tRNA synthetase; translational regulation generates cytoplasmic and mitochondrial forms; Gcn4p-regulated; repressed by amino acid starvation (3-AT); translation-related genes downregulated upon phagocytosis by murine macrophages || 1 -0.05 0.60 -0.27
1998 || orf19.11450 || || || Predicted ORF from Assembly 19; not essential for viability; removed from Assembly 20 || 1 -0.04 1.38 -0.62
1999 "|| orf19.3269 || GSL2 || || Protein similar to beta-1,3-glucan synthase; 16 predicted membrane-spanning regions; transcript regulated by Nrg1; very low gene expression in yeast-form and hyphal cells ||" 1 -0.02 1.02 -0.40
2000 || orf19.6983 || || || Protein of unknown function; Hap43-repressed gene; repressed by nitric oxide; Spider biofilm induced || 1 0.00 0.13 -0.05
2001 || orf19.4826 || IDH1 || || Putative mitochondrial NAD-isocitrate dehydrogenase subunit 1; soluble protein in hyphae; protein level decrease in stationary phase cultures || 1 0.03 0.82 -0.34
2002 "|| orf19.3519 || SUA72 || || Predicted transcription factor; induced during planktonic growth, whereas related SUA71 is downregulated ||" 1 0.01 -0.06
2003 || orf19.7274 || || || Predicted ORF in retrotransposon Zorro2 with similarity to retroviral reverse transcriptase proteins || 1 0.00 0.30 -0.01
2004 || orf19.5213 || || || Putative protein of unknown function; transcript is upregulated in clinical isolates from HIV+ patients with oral candidiasis || 1 0.01 -0.16
2005 || orf19.12424 || || || || 1 -0.00 0.17 -0.05
2006 || orf19.1362 || SMM1 || || Putative dihydrouridine synthase; Hap43-induced gene; rat catheter biofilm induced; Spider biofilm induced || 1 -0.04 0.46 -0.13
2007 "|| orf19.5516 || || || Ortholog(s) have signal sequence binding activity, role in protein targeting to ER and cytosol, nucleus, signal recognition particle, endoplasmic reticulum targeting localization ||" 1 -0.02 0.14 -0.03
2008 || orf19.4033 || PRP22 || || Putative RNA-dependent ATPase; induced upon adherence to polystyrene; induced by Mnl1p under weak acid stress || 1 -0.05 0.65 -0.15
2009 || orf19.4282 || IFH1 || || Transcription factor; forms a heterodimer with Fhl11 that is tethered to promoters by Tbf1; positively regulates rRNA and ribosomal protein gene transcription; Spider biofilm induced || 1 -0.03 0.64 -0.14
2010 || orf19.3440 || FRP5 || || Protein with a GPR1/FUN34/yaaH family domain; flucytosine repressed || 1 -0.03 0.71 -0.12
2011 || orf19.4470 || || || Protein of unknown function; Hap43-repressed gene || 1 0.10 0.73 -0.14
2012 "|| orf19.854 || UGA11 || || Putative gamma-aminobutyrate (GABA) transaminase; macrophage-induced; overlaps orf19.854.1, which is a region annotated as a blocked reading frame; Spider biofilm induced ||" 1 0.16 1.28
2013 "|| orf19.6702 || DED81 || || Putative tRNA-Asn synthetase; genes encoding ribosomal subunits, translation factors, tRNA synthetases are downregulated upon phagocytosis by murine macrophage; protein enriched in stationary phase yeast cultures ||" 1 0.07 -0.30
2014 || orf19.5595 || SHE3 || || mRNA-binding protein that localizes specific mRNAs to daughter yeast cells and to hyphal tips; required for normal filamentation and host epithelial cell damage; ortholog of S. cerevisiae She3 but target mRNAs differs || 1 0.09 1.06 -0.43
2015 || orf19.1479 || || || Ortholog of the mitochondria localized S. cerevisiae Pib2 protein of unknown function; has a FYVE zinc finger domain; Spider biofilm induced || 1 0.06 0.58 -0.25
2016 || orf19.3466 || || || Predicted methyltransferase; downregulated by fluphenazine treatment or in an azole-resistant strain that overexpresses CDR1 and CDR2 || 1 0.25 1.24 -0.55
2017 || orf19.3115 || || || Protein of unknown function; rat catheter and Spider biofilm induced || 1 0.09 -0.19
2018 "|| orf19.1250 || || || Ortholog(s) have role in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and cytoplasm, nucleolus localization ||" 1 0.05 0.30 -0.08
2019 || orf19.804 || || || Putative mitochondrial carrier family transporter; rat catheter biofilm induced || 1 0.06 0.33 -0.09
2020 || orf19.9930 || || || || 1 0.16 0.84 -0.22
2021 || orf19.7085 || || || Protein of unknown function; induced in core stress response; induced by cadmium stress via Hog1; oxidative stress-induced via Cap1; induced by Mnl1 under weak acid stress; macrophage-repressed; rat catheter and Spider biofilm induced || 1 0.71 1.21 -0.09
2022 || orf19.11718 || || || || 1 0.42 0.73 -0.07
2023 || orf19.1064 || ACS2 || || Acetyl-CoA synthetase; antigenic during human and murine infection; induced by Efg1; macrophage-induced protein; soluble protein in hyphae; gene contains intron; flow model and Spider biofilm repressed || 1 0.47 0.85 -0.13
2024 || orf19.4910 || FGR41 || || Putative GPI-anchored adhesin-like protein; transposon mutation affects filamentous growth; Spider biofilm repressed || 1 0.64 0.99 -0.16
2025 || orf19.10723 || RCF3 || || || 1 0.35 0.54 -0.09
2026 "|| orf19.3536 || || || Ortholog(s) have acetylglucosaminyltransferase activity, role in protein N-linked glycosylation and Golgi medial cisterna localization ||" 1 0.06 -0.02
2027 "|| orf19.6455 || || || Protein of unknown function, transcript is upregulated in clinical isolates from HIV+ patients with oral candidiasis ||" 1 0.11 0.13 -0.03
2028 "|| orf19.6011 || SIN3 || || Protein similar to S. cerevisiae Sin3p (transcriptional corepressor involved in histone deacetylase recruitment); has paired amphipathic helix PAH1 domain; interacts with ScOpi1p, not CaOpi1p; transposon mutation affects filamentous growth ||" 1 0.14 -0.04
2029 "|| orf19.442 || || || Ortholog of Candida guilliermondii ATCC 6260 : PGUG_05525, Candida lusitaniae ATCC 42720 : CLUG_03378 and Candida albicans WO-1 : CAWG_00876 ||" 1 0.17 0.33 -0.05
2030 "|| orf19.3618 || YWP1 || || Secreted yeast wall protein; possible role in dispersal in host; mutation increases adhesion and biofilm formation; propeptide; growth phase, phosphate, Ssk1/Ssn6/Efg1/Efh1/Hap43 regulated; mRNA binds She3; flow and Spider biofilm repressed ||" 1 0.35 0.54 -0.14
2031 || orf19.1539 || || || Protein of unknown function; F-12/CO2 early biofilm induced || 1 0.36 0.58 -0.15
2032 || orf19.1446 || CLB2 || || B-type mitotic cyclin (cyclin-dependent protein kinase regulatory subunit); essential; required for wild-type mitotic exit; role in cell polarization; interacts with catalytic subunit Cdk1; Spider biofilm repressed || 1 0.51 0.89 -0.28
2033 || orf19.7784 || SNU114 || || || 1 0.59 1.07 -0.32
2034 "|| orf19.1259 || || || Ortholog(s) have DNA binding, ubiquitin-protein ligase activity and role in histone catabolic process, histone ubiquitination, regulation of transcription from RNA polymerase II promoter in response to oxidative stress ||" 1 0.29 0.52 -0.12
2035 "|| orf19.31 || || || Ortholog of C. parapsilosis CDC317 : CPAR2_201960, C. dubliniensis CD36 : Cd36_20900, Candida tropicalis MYA-3404 : CTRG_04756 and Candida albicans WO-1 : CAWG_04394 ||" 1 0.31 0.57 -0.14
2036 "|| orf19.5107 || NOT5 || || Protein with similarity to S. cerevisiae Not5p, a member of the transcription regulatory CCR4-NOT complex; required for hyphal growth; antigenic during human oral infection; greater expression in yeast-form cells than hyphae ||" 1 0.37 0.69 -0.16
2037 || orf19.3858 || || || Protein of unknown function; rat catheter and Spider biofilm induced || 1 0.20 0.48 -0.07
2038 || orf19.1731 || || || Predicted ORF from Assembly 19; merged with orf19.1730 in Assembly 20 || 1 0.20 -0.10
2039 "|| orf19.699 || || || Protein of unknown function; flow model, rat catheter, Spider biofilm induced ||" 1 0.61 1.06 -0.29
2040 || orf19.9081 || || || || 1 0.37 0.79 -0.26
2041 "|| orf19.7269 || || || Putative polyamine acetyltransferase; acetylates polyamines (e.g. putrescine, spermidine, spermine) and aralkylamines (e.g. tryptamine, phenylethylamine); Spider biofilm repressed ||" 1 0.29 0.61 -0.16
2042 "|| orf19.7028 || || || Predicted ORF in Assemblies 19, 20 and 21; merged with orf19.7027 in Assembly 21 ||" 1 0.45 0.96 -0.22
2043 || orf19.12366 || || || || 1 0.29 0.72 -0.16
2044 || orf19.3793 || || || Protein of unknown function; mRNA binds She3; regulated by Nrg1; upregulated in a cyr1 or ras1 mutant || 1 0.37 0.94 -0.24
2045 "|| orf19.3171 || ACH1 || || Acetyl-coA hydrolase; acetate utilization; nonessential; soluble protein in hyphae; antigenic in human; induced on polystyrene adherence; farnesol-, ketoconazole-induced; no human or murine homolog; stationary phase-enriched protein ||" 1 0.23 0.63 -0.16
2046 || orf19.2964 || || || Ortholog(s) have DNA translocase activity || 1 0.21 -0.14
2047 || orf19.1786 || || || Predicted ORF from Assembly 19; merged with orf19.1291 in Assembly 20 || 1 0.70 1.07 -0.45
2048 "|| orf19.7037 || YAE1 || || Ortholog(s) have role in ribosomal large subunit biogenesis, translational initiation and cytoplasm, nucleus localization ||" 1 0.65 1.00 -0.77
2049 || orf19.3928 || || || Putative transcription factor with zinc finger DNA-binding motif || 1 0.14 -0.16
2050 || orf19.3983 || || || Protein with a predicted transcription factor BTF3 domain; flow model biofilm induced || 1 0.62 1.53 -0.75
2051 "|| orf19.4775 || CTA8 || || Essential transcription factor, mediates heat shock transcriptional induction; in the absence of heat stress, Cta8p levels are modulated by growth temperature to regulate basal expression of genes involved in protein folding ||" 1 0.28 0.82 -0.33
2052 || orf19.813 || || || Protein of unknown function; mutants are viable; Hap43-induced gene; oxidative stress-induced via Cap1; rat catheter and Spider biofilm induced || 1 0.19 0.56 -0.24
2053 || orf19.1560 || POB3 || || Protein involved in chromatin assembly and disassembly; ortholog of S. cerevisiae Pob3; transposon mutation affects filamentous growth; rat catheter biofilm repressed || 1 0.16 0.51 -0.23
2054 || orf19.7828 || ASN1 || || || 1 0.56 -0.66
2055 "|| orf19.1067 || GPM2 || || Putative phosphoglycerate mutase; repressed in hyphae; macrophage/pseudohyphal-repressed; induced by high levels of peroxide stress, farnesol; flow model biofilm induced; rat catheter and Spider biofilm repressed ||" 1 0.27 1.55
2056 "|| orf19.4420 || || || Predicted component of the core factor rDNA transcription factor complex; required for transcription of 35S rRNA genes by RNA polymerase I in S. cerevisiae; possibly an essential gene, disruptants not obtained by UAU1 method ||" 1 0.16 0.68 -0.30
2057 "|| orf19.7052 || || || Putative polyphosphatidylinositol phosphatase; possibly an essential gene, disruptants not obtained by UAU1 method ||" 1 0.13 0.59 -0.24
2058 "|| orf19.114 || || || Ortholog of C. dubliniensis CD36 : Cd36_61190, C. parapsilosis CDC317 : CPAR2_603230, Candida tenuis NRRL Y-1498 : cten_CGOB_00054 and Debaryomyces hansenii CBS767 : DEHA2E21142g ||" 1 0.08 0.34 -0.13
2059 || orf19.695 || RGS2 || || Protein of RGS superfamily; mutants are viable; rat catheter and Spider biofilm induced || 1 0.19 0.74 -0.29
2060 || orf19.506 || YDJ1 || || Putative type I HSP40 co-chaperone; heavy metal (cadmium) stress-induced || 1 0.14 0.51 -0.19
2061 || orf19.4235 || PDE1 || || Low affinity cyclic nucleotide phosphodiesterase; mediates cAMP signaling in response to glucose or intracellular acidification; macrophage-repressed; Spider biofilm induced || 1 0.14 0.51 -0.18
2062 "|| orf19.1065 || SSA2 || || HSP70 family chaperone; cell wall fractions; antigenic; beta-defensin peptides impport; ATPase domain binds histatin 5; at hyphal surface, not yeast; farnesol-repressed in biofilm; flow model, Spider biofilm repressed; caspofungin repressed ||" 1 0.68 2.18 -0.81
2063 "|| orf19.5170 || ENA21 || || Predicted P-type ATPase sodium pump; Gcn4p-regulated; flucytosine, amphotericin B, or ketoconazole-induced; osmotic stress-induced; overlaps orf19.5170.1, which is annotated as a blocked reading frame; Spider biofilm induced ||" 1 0.55 1.71 -0.64
2064 || orf19.12593 || || || || 1 0.41 1.25 -0.47
2065 || orf19.6583 || || || Protein of unknown function; induced by alpha pheromone in SpiderM medium || 1 0.34 0.93 -0.32
2066 "|| orf19.6494 || WHI3 || || Putative RNA binding protein; induced during infection of murine kidney, compared to growth in vitro; has murine homolog ||" 1 0.17 0.45 -0.14
2067 || orf19.8880 || || || || 1 0.13 -0.10
2068 "|| orf19.5074 || UBA2 || || Ortholog(s) have SUMO activating enzyme activity, role in protein sumoylation and SUMO activating enzyme complex localization ||" 1 0.13 0.41 -0.09
2069 || orf19.10725 || || || || 1 0.23 0.81 -0.24
2070 || orf19.11402 || || || || 1 0.13 0.48 -0.14
2071 || orf19.1285 || || || Plasma membrane-localized protein of unknown function; Hap43p-repressed gene || 1 0.10 0.42 -0.13
2072 || orf19.3274 || || || Predicted ORF from Assembly 19; merged with orf19.3273 in Assembly 20 || 1 0.21 0.92 -0.19
2073 "|| orf19.6137 || || || Ortholog of C. dubliniensis CD36 : Cd36_32940, Candida tenuis NRRL Y-1498 : CANTEDRAFT_134955, Debaryomyces hansenii CBS767 : DEHA2E04422g and Pichia stipitis Pignal : PICST_33357 ||" 1 0.30 1.37 -0.27
2074 "|| orf19.2031 || VPS24 || || Protein similar to S. cerevisiae Vps24p, which is a member of the ESCRT III protein sorting complex; downregulated upon adherence to polystyrene ||" 1 0.11 0.51 -0.06
2075 "|| orf19.130 || || || Ortholog(s) have protein serine/threonine kinase activity, ubiquitin binding activity ||" 1 0.18 -0.10
2076 "|| orf19.1318 || || || Ortholog of C. dubliniensis CD36 : Cd36_43350, C. parapsilosis CDC317 : CPAR2_403560, Debaryomyces hansenii CBS767 : DEHA2A08250g and Pichia stipitis Pignal : PICST_29838 ||" 1 0.05 0.33 -0.03
2077 "|| orf19.3946 || || || Ortholog(s) have membrane insertase activity, role in protein insertion into mitochondrial membrane from inner side, respiratory chain complex IV assembly and integral to mitochondrial inner membrane localization ||" 1 0.17 -0.09
2078 || orf19.6276 || || || Protein of unknown function; rat catheter biofilm repressed || 1 0.30 0.87 -0.14
2079 || orf19.6837 || FMA1 || || Putative oxidoreductase; induced by ciclopirox olamine; upregulation correlates with clinical development of fluconazole resistance; Spider biofilm repressed || 1 0.22 -0.10
2080 "|| orf19.1263 || CFL1 || || Protein similar to ferric reductase Fre10p; possible functional homolog of S. cerevisiae Fre1p (reports differ); transcription is negatively regulated by Sfu1p, copper, amphotericin B, caspofungin; induced by ciclopirox olamine ||" 1 0.08 0.69
2081 "|| orf19.4457 || BNI4 || || Protein required for wild-type cell wall chitin distribution, morphology, hyphal growth; not essential; similar to S. cerevisiae Bni4p (targeting subunit for Glc7p phosphatase, involved in bud-neck localization of chitin synthase III) ||" 1 0.02 0.18 -0.01
2082 "|| orf19.1324 || RAD2 || || Ortholog of S. cerevisiae Rad2, a nucleotide excision repair nuclease; null mutant is extremely sensitive to UV irradiation; transcript induced by interaction with macrophages ||" 1 0.04 0.30 -0.01
2083 "|| orf19.29 || || || Ortholog of S. cerevisiae Tah11, a DNA replication licensing factor required for pre-replication complex assembly; rat catheter, flow model and Spider biofilm induced ||" 1 0.07 0.45 -0.04
2084 "|| orf19.1727 || PMC1 || || Vacuolar calcium P-type ATPase; transcript regulated by calcineurin and fluconazole; mutant shows increased resistance to fluconazole, lithium; increased sensitivity to calcium; Spider biofilm induced ||" 1 0.09 0.62 -0.06
2085 || orf19.6731 || || || Protein of unknown function; repressed by alpha pheromone in SpiderM medium; Spider biofilm induced || 1 0.12 0.60 -0.04
2086 || orf19.4367 || SMC1 || || Protein similar to chromosomal ATPases; RNA abundance regulated by tyrosol and cell density; cell-cycle regulated periodic mRNA expression || 1 0.12 0.70 -0.02
2087 "|| orf19.2990 || XOG1 || || Exo-1,3-beta-glucanase; 5 glycosyl hydrolase family member; affects sensitivity to chitin and glucan synthesis inhibitors; not required for yeast-to-hypha transition or for virulence in mice; Hap43-induced; Spider biofilm induced ||" 1 0.01 0.96
2088 "|| orf19.5645 || MET15 || || O-acetylhomoserine O-acetylserine sulfhydrylase; sulfur amino acid synthesis; immunogenic; Hog1, adherence-induced; brown color of mutant in Pb(2+) medium a visual selection; chlamydospore formation induced, F-12/CO2 biofilm induced ||" 1 0.45 -0.08
2089 "|| orf19.1484 || || || Ortholog of S, cerevisiae Spc24; a component of the conserved kinetochore-associated Ndc80 complex involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering; Hap43-induced gene ||" 1 0.05 0.20 -0.02
2090 || orf19.1226 || || || Predicted ORF from Assembly 19; merged with orf19.2778 in Assembly 20 || 1 0.12 0.43 -0.01
2091 || orf19.7288 || || || Protein with predicted oxidoreductase and dehydrogenase domains; Hap43-repressed; Spider biofilm induced || 1 0.39 1.11 -0.11
2092 || orf19.635 || || || Protein of unknown function; induced by alpha pheromone in SpiderM medium || 1 0.17 0.46 -0.03
2093 || orf19.12167 || MDN1 || || || 1 0.25 0.61 -0.03
2094 || orf19.3559 || || || S. cerevisiae ortholog Mrps35p is a structural constituent of ribosome and localizes to mitochondrial small ribosomal subunit; the snoRNA CD39 is encoded within the MRPS35 intron || 1 0.12 0.32 0.01
2095 "|| orf19.7473 || || || Ortholog(s) have role in endocytosis and actin cortical patch, cellular bud neck, cytoplasm localization ||" 1 0.13 0.33 0.03
2096 || orf19.5747 || || || Ortholog(s) have structural constituent of ribosome activity and mitochondrial small ribosomal subunit localization || 1 0.13 0.37 0.04
2097 || orf19.3984 || || || Protein of unknown function; induced in core caspofungin response; induced in ssr1 mutant; induced by nitric oxide independent of Yhb1; Spider biofilm induced || 1 0.18 0.50 0.07
2098 || orf19.3097 || PDA1 || || Putative pyruvate dehydrogenase alpha chain; fluconazole-induced; protein present in exponential and stationary growth phase yeast cultures; Hap43-induced; Spider biofilm repressed || 1 0.29 0.12
2099 || orf19.1565 || || || Protein of unknown function || 1 0.26 1.00 0.11
2100 || orf19.4646 || UEC1 || || Protein required for damage to oral epithelial cells and for normal hyphal growth and stress resistance; transcription induced on contact with vascular endothelial cells; not highly conserved || 1 0.12 0.47 0.07
2101 "|| orf19.6953 || IRS4 || || Protein with roles in cell wall integrity, systemic (but not oral) murine infection, adherence, hyphal growth, and agar-embedded filamentous growth; antigenic in human infection; similar to S. cerevisiae Irs4p ||" 1 0.07 0.26 0.05
2102 "|| orf19.4913 || || || Ortholog(s) have ubiquitin binding activity, role in cellular protein localization, positive regulation of deubiquitinase activity and cell cortex of cell tip, cell division site, cytosol localization ||" 1 0.20 0.99 0.08
2103 || orf19.7457 || || || Protein with Mob2p-dependent hyphal regulation || 1 0.06 0.34 0.02
2104 "|| orf19.6719 || || || Putative nucleosome assembly protein; homozygous transposon insertion causes decreased colony wrinkling under filamentous growth-inducing conditions, but does not block true hyphal formation in liquid media ||" 1 0.08 0.35 0.01
2105 || orf19.6287 || AAT21 || || Putative aspartate aminotransferase; stationary phase enriched protein; Gcn4-regulated; Spider biofilm induced || 1 0.26 0.07
2106 "|| orf19.1264 || CFL2 || || Oxidoreductase; iron utilization; Sfu1/Sef1/Hap43/Nrg1/Tup1/Rim101 regulated; alkaline/low iron/fluphenazine/ciclopirox olamine, flucytosine, fluconazole, Spider/flow model/rat catheter biofilm induced; caspofungin/amphotericin B repressed ||" 1 0.21 1.84
2107 || orf19.1158 || || || Ortholog of S. cerevisiae Yft2 required for normal ER membrane biosynthesis; Hap43-repressed gene || 1 0.24 0.07
2108 || orf19.5642 || || || Ortholog of S. cerevisiae Dif1; which regulates nuclear localization of Rnr2 and Rnr4; colony morphology-related gene regulation by Ssn6; induced in cyr1 mutant; Spider biofilm induced || 1 0.08 0.17 0.03
2109 "|| orf19.5612 || BMT4 || || Beta-mannosyltransferase; for elongation of beta-mannose chains on the acid-labile fraction of cell wall phosphopeptidomannan; 9-gene family member; regulated by Tsa1, Tsa1B; flow model biofilm induced; rat catheter biofilm repressed ||" 1 0.11 0.23 0.00
2110 "|| orf19.6948 || CCC1 || || Manganese transporter; required for normal filamentous growth; mRNA binds She3, localized to hyphal tips; repressed by NO, alkaline pH; colony morphology-related regulation by Ssn6; regulated by Sef1, Sfu1, Hap43; Spider biofilm induced ||" 1 0.26 0.56 0.01
2111 || orf19.5494 || || || Predicted ORF from Assembly 19; removed from Assembly 20 || 1 0.41 0.82 0.06
2112 || orf19.6408 || || || Putative DnaJ-like heat shock/chaperone; Hap43-repressed; Spider and F-12/CO2 biofilm induced || 1 0.25 0.45 -0.01
2113 || orf19.3208 || DAL52 || || Putative allantoate permease; mutant is viable; similar but not orthologous to S. cerevisiae Dal5 || 1 0.10 0.01
2114 || orf19.11790 || || || || 1 0.21 0.02
2115 || orf19.912 || || || Predicted ORF from Assembly 19; merged with orf19.5776 in Assembly 20 || 1 0.36 0.39 0.03
2116 "|| orf19.7365 || || || Ortholog(s) have ubiquitin-protein ligase activity and role in negative regulation of apoptotic process, negative regulation of gluconeogenesis, proteasome-mediated ubiquitin-dependent protein catabolic process ||" 1 0.22 0.39 0.00
2117 || orf19.11210 || || || || 1 0.46 0.01
2118 "|| orf19.2884 || CDC68 || || Functional homolog of S. cerevisiae Cdc68, a transcription elongation factor; essential; possible drug target ||" 1 0.28 0.32 -0.03
2119 "|| orf19.2772 || HOS3 || || Histone deacetylase; similar to S. cerevisiae Hos3p; greater expression and longer mRNA in white cells, compared to opaque cells; has conserved deacetylation motif ||" 1 0.33 0.31 -0.05
2120 || orf19.7042 || || || Protein of unknown function; induced by benomyl or in an azole-resistant strain overexpressing MDR1; induced by nitric oxide; Spider biofilm induced || 1 0.47 0.47 -0.04
2121 "|| orf19.7447 || JEN1 || || Lactate transporter; induced by lactic acid, activated by Cat8; alkaline repressed by Rim101; localizes to plasma membrane; Spider biofilm induced ||" 1 1.13 1.07 -0.12
2122 "|| orf19.242 || SAP8 || || Secreted aspartyl protease; regulated by growth phase, temperature, white-opaque switch; highly expressed in opaque cells and upon deep epidermal invasion; greater expression in vaginal than oral infection; prominent role in biofilms ||" 1 0.34 0.31 -0.03
2123 || orf19.3089 || || || Predicted mitochondrial intermembrane space protein; predicted role in phospholipid metabolism; rat catheter and Spider biofilm induced || 1 0.46 0.41 -0.04
2124 "|| orf19.2947 || SNZ1 || || Stationary phase protein; vitamin B synthesis; induced byyeast-hypha switch, 3-AT or in azole-resistant strain overexpressing MDR1; soluble in hyphae; regulated by Gcn4, macrophage; Spider biofilm induced; rat catheter biofilm repressed ||" 1 1.08 0.96 -0.05
2125 || orf19.10465 || SNO1 || || || 1 0.89 0.73 0.06
2126 "|| orf19.8 || || || Ortholog of C. dubliniensis CD36 : Cd36_32690, C. parapsilosis CDC317 : CPAR2_204290, Candida tenuis NRRL Y-1498 : CANTEDRAFT_121459 and Debaryomyces hansenii CBS767 : DEHA2E03938g ||" 1 0.44 -0.01
2127 || orf19.4907 || || || Putative protein of unknown function; Hap43p-repressed gene; increased transcription is observed upon fluphenazine treatment; possibly transcriptionally regulated by Tac1p; induced by nitric oxide; fungal-specific (no human/murine homolog || 1 0.58 0.41 -0.01
2128 "|| orf19.3675 || GAL7 || || Putative galactose-1-phoshphate uridyl transferase; downregulated by hypoxia, upregulated by ketoconazole; macrophage/pseudohyphal-repressed ||" 1 1.08 0.88 -0.22
2129 || orf19.11943 || || || || 1 0.27 -0.05
2130 || orf19.10867 || || || || 1 0.48 -0.09
2131 "|| orf19.1701 || RKI1 || || Ortholog(s) have ribose-5-phosphate isomerase activity, role in pentose-phosphate shunt, pyridoxine biosynthetic process and cytoplasm, nucleus localization ||" 1 0.33 0.31 -0.06
2132 || orf19.3861 || SIS1 || || Putative Type II HSP40 co-chaperone; macrophage/pseudohyphal-repressed; heavy metal (cadmium) stress-induced; heterozygous null mutant displays sensitivity to virgineone; rat catheter biofilm induced || 1 0.83 0.93 -0.13
2133 || orf19.6139 || FRE7 || || Copper-regulated cupric reductase; repressed by ciclopirox olamine or 17-beta-estradiol; induced by alkaline conditions or interaction with macrophage; Spider biofilm induced || 1 0.89 1.10 -0.22
2134 "|| orf19.1400 || || || Ortholog of C. dubliniensis CD36 : Cd36_23640, C. parapsilosis CDC317 : CPAR2_406130, Candida tenuis NRRL Y-1498 : CANTEDRAFT_116273 and Debaryomyces hansenii CBS767 : DEHA2B11176g ||" 1 0.27 0.40 -0.05
2135 "|| orf19.6515 || HSP90 || || Essential chaperone, regulates several signal transduction pathways and temperature-induced morphogenesis; activated by heat shock, stress; localizes to surface of hyphae, not yeast cells; mediates echinocandin and biofilm azole resistance ||" 1 0.46 0.59 -0.08
2136 || orf19.1818 || || || Predicted ORF from Assembly 19; removed from Assembly 20 || 1 0.37 -0.07
2137 "|| orf19.1120 || FAV2 || || Adhesin-like protein; induced by mating factor in MTLa/a opaque cells, in cyr1 null, in filaments; regulated by Nrg1, Rfg1, Tup1, Tec1, Efg1, Ntd80, Rob1, Brg1; induced in oralpharyngeal candidasis; Spider biofilm induced ||" 1 0.16 0.35 -0.03
2138 || orf19.11416 || CAR1 || || || 1 0.73 1.00 -0.26
2139 || orf19.3451 || || || Predicted ORF from Assembly 19; merged with orf19.139 in Assembly 20 || 1 0.20 0.27 -0.07
2140 || orf19.2227 || || || Protein of unknown function; flow model biofilm induced; nitric oxide-repressed || 1 0.32 0.40 -0.13
2141 || orf19.396 || EAF6 || || Subunit of the NuA4 histone acetyltransferase complex; Hap43-repressed; Spider biofilm repressed || 1 0.51 0.56 -0.19
2142 "|| orf19.3601 || || || Has domain(s) with predicted ATP binding, nucleoside-triphosphatase activity ||" 1 0.13 0.13 -0.04
2143 || orf19.7882 || || || || 1 0.79 0.82 -0.24
2144 "|| orf19.3817 || || || Ortholog(s) have cytoplasm, nucleolus localization ||" 1 0.28 0.31 -0.07
2145 || orf19.3575 || CDC19 || || Pyruvate kinase at yeast cell surface; Gcn4/Hog1/GlcNAc regulated; Hap43/polystyrene adherence induced; repressed by phagocytosis/farnesol; hyphal growth role; stationary phase enriched; flow model biofilm induced; Spider biofilm repressed || 1 1.11 -0.26
2146 "|| orf19.2876 || CBF1 || || Transcription factor; binds ribosomal protein gene promoters and rDNA locus with Tbf1; regulates sulfur starvation-response, respiratory, glycolytic genes; does not bind to centromeres as does S. cerevisiae Cbf1; Spider biofilm repressed ||" 1 0.69 0.33 -0.19
2147 || orf19.2166 || VMA5 || || Putative vacuolar H(+)-ATPase; plasma membrane localized; rat catheter biofilm repressed || 1 0.16 0.08 -0.05
2148 || orf19.12536 || || || || 1 0.18 -0.06
2149 "|| orf19.5024 || GND1 || || 6-phosphogluconate dehydrogenase; soluble in hyphae; farnesol, macrophage-induced protein; antigenic in mice; dual localization to cytosol and peroxisomes depends on alternative splicing; rat catheter and Spider biofilm repressed ||" 1 0.92 0.26 -0.12
2150 "|| orf19.5025 || MET3 || || ATP sulfurlyase; sulfate assimilation; repressed by Met, Cys, Sfu1, or in fluconazole-resistant isolate; Hog1, caspofungin, white phase-induced; induced on biofilm formation, even in presence of Met and Cys; Spider, F-12/CO2 biofilm induced ||" 1 0.23 -0.03
2151 || orf19.5098 || NTG1 || || Protein with strong similarity to both S. cerevisiae Ntg1 and Ntg2 DNA repair glycosylases; transcript induced by iron; Hap43-repressed gene; Spider biofilm induced || 1 0.21 0.10 -0.03
2152 "|| orf19.772 || LYS21 || || Homocitrate synthase; lysine biosynthesis; expression increased in a fluconazole-resistant isolate; colony morphology-related gene regulation by Ssn6; ketoconazole-repressed; regulated by Gcn2, Gcn4, Hap43 ||" 1 0.32 0.14 -0.03
2153 || orf19.709 || PUP2 || || Alpha5 subunit of the 20S proteasome; macrophage/pseudohyphal-repressed; regulated by Gcn2p and Gcn4p; protein present in exponential and stationary growth phase yeast cultures || 1 0.22 0.08 -0.00
2154 || orf19.6601 || || || Protein of unknown function; rat catheter and flow model biofilm induced || 1 0.49 0.30 -0.09
2155 || orf19.7597 || PGA12 || || Putative GPI-anchored protein || 1 0.30 0.18 -0.05
2156 "|| orf19.4737 || TPO3 || || Putative polyamine transporter; MFS-MDR family; induced by Sfu1, regulated upon white-opaque; decreased expression in hyphae vs yeast-form cells; regulated by Nrg1; Spider biofilm repressed ||" 1 1.67 1.10 -0.21
2157 || orf19.1352 || TIM22 || || Mitochondrial inner membrane protein; predicted role in protein import; Hap43-repressed gene; flow model biofilm induced; Spider biofilm repressed || 1 0.35 0.23 -0.03
2158 || orf19.13020 || || || || 1 0.32 0.23 -0.03
2159 || orf19.11675 || || || || 1 0.54 0.40 -0.03
2160 || orf19.11835 || || || || 1 0.53 0.42 -0.06
2161 || orf19.3071 || MIH1 || || Putative protein phosphatase of the PTP family (tyrosine-specific); ortholog of S. cerevisiae Mih1; mRNA binds She3 || 1 0.34 0.30 -0.13
2162 "|| orf19.7436 || AAF1 || || Possible regulatory protein; possible adhesin-like; Glu-rich domain; production in S. cerevisiae increases endothelial cell adherence and flocculence; flow model biofilm, alkaline or caspofungin induced ||" 1 0.20 0.16 -0.05
2163 || orf19.5750 || SHM2 || || Cytoplasmic serine hydroxymethyltransferase; complements glycine auxotrophy of S. cerevisiae shm1 shm2 gly1-1 mutant; antigenic; farnesol-upregulated in biofilm; stationary-phase enriched protein; rat catheter and Spider biofilm repressed || 1 0.62 0.46 -0.19
2164 || orf19.1789.1 || LYS1 || || Saccharopine dehydrogenase (biosynthetic); enzyme of alpha-aminoadipate lysine biosynthesis pathway; functionally complements S. cerevisiae lys1 mutation; fungal-specific (no human or murine homolog) || 1 0.45 0.32 -0.13
2165 "|| CaalfMp12 || NAD4L || || Subunit 4L of NADH:ubiquinone oxidoreductase (NADH:ubiquinone dehydrogenase), a multisubunit enzyme complex (complex I) of the mitochondrial inner membrane that catalyzes the first step in mitochondrial respiration ||" 1 0.55 0.38 -0.15
2166 || orf19.944 || IFG3 || || Putative D-amino acid oxidase; Spider biofilm induced || 1 0.93 0.65 -0.22
2167 || orf19.2951 || HOM6 || || Putative homoserine dehydrogenase; Gcn4-regulated; induced by amino acid starvation (3-ATtreatment); macrophage-induced protein; protein level decreases in stationary phase cultures; flow model biofilm repressed || 1 1.08 0.68 -0.43
2168 || orf19.2623 || ECM22 || || Zn(II)2Cys6 transcription factor; rat catheter and Spider biofilm induced || 1 0.85 0.53 -0.31
2169 "|| orf19.4980 || HSP70 || || Putative hsp70 chaperone; role in entry into host cells; heat-shock, amphotericin B, cadmium, ketoconazole-induced; surface localized in yeast and hyphae; antigenic in host; farnesol-downregulated in biofilm; Spider biofilm induced ||" 1 0.86 0.58 -0.31
2170 || orf19.4012 || PCL5 || || Putative cyclin for Pho85 kinase; Gcn4-induced; suppresses toxicity of C. albicans Gcn4 overproduction in S. cerevisiae via increased Pho85-dependent phosphorylation and degradation of Gcn4; rat catheter and Spider biofilm induced || 1 0.48 0.31 -0.16
2171 || orf19.5654 || STE24 || || Prenyl-dependent protease || 1 0.36 0.20 -0.12
2172 "|| orf19.822 || HSP21 || || Small heat shock protein; role in stress response and virulence; fluconazole-downregulated; induced in cyr1 or ras1 mutant; stationary phase enriched protein; detected in some, not all, biofilm extracts; Spider biofilm induced ||" 1 0.36 0.19 -0.12
2173 || orf19.5305 || RHD3 || || GPI-anchored yeast-associated cell wall protein; induced in high iron; clade-associated gene expression; not essential for cell wall integrity; fluconazole-repressed; flow model and Spider biofilm repressed || 1 0.65 -0.25
2174 "|| orf19.2212 || || || Ortholog of C. dubliniensis CD36 : Cd36_21980, Debaryomyces hansenii CBS767 : DEHA2F19734g, Pichia stipitis Pignal : psti_CGOB_00208 and Spathaspora passalidarum NRRL Y-27907 : spas_CGOB_00029 ||" 1 0.15 -0.05
2175 || orf19.8485 || RAD32 || || || 1 0.18 -0.07
2176 || orf19.3357 || || || Ortholog(s) have mitochondrion localization || 1 0.14 0.16 -0.05
2177 || orf19.5145 || SSP96 || || Putative flavin-containing monooxygenase; F-12/CO2 early biofilm induced || 1 0.21 0.23 -0.10
2178 || orf19.3358 || LSC1 || || Putative succinate-CoA ligase subunit; induced by high iron; fluconazole-induced; protein present in exponential and stationary growth phase yeast cultures; Spider biofilm repressed || 1 0.42 -0.20
2179 || orf19.415 || || || Putative protein of unknown function; Hap43p-repressed gene || 1 0.11 -0.05
2180 || orf19.6197 || DHH1 || || Putative RNA helicase || 1 0.12 0.09 -0.06
2181 || orf19.5256 || || || Protein of unknown function; Hap43-repressed gene; induced by alpha pheromone in SpiderM medium || 1 0.37 0.24 -0.18
2182 || orf19.3191 || || || Predicted ORF from Assembly 19; merged with orf19.3192 in Assembly 20; protein present in exponential and stationary growth phase yeast cultures || 1 0.48 0.30 -0.28
2183 || orf19.11949 || || || || 1 0.22 0.19 -0.10
2184 "|| orf19.6273 || || || Ortholog of C. dubliniensis CD36 : Cd36_05960, C. parapsilosis CDC317 : CPAR2_301790, Candida tenuis NRRL Y-1498 : CANTEDRAFT_112420 and Debaryomyces hansenii CBS767 : DEHA2G15290g ||" 1 0.65 0.61 -0.32
2185 || orf19.1032 || SKO1 || || bZIP transcription factor; involved in cell wall damage response; represses the yeast-to-hypha transition; mutants are caspofungin sensitive; induced by osmotic stress via Hog1; induced by Mnl1 under weak acid stress || 1 0.87 0.85 -0.47
2186 "|| orf19.3646 || CTR1 || || Copper transporter; transcribed in low copper; induced Mac1, Tye7, macrophage interaction, alkaline pH via Rim101; 17-beta-estradiol repressed; complements S. cerevisiae ctr1 ctr3 copper transport mutant; flow model/Spider biofilm induced ||" 1 0.30 0.32 -0.16
2187 || orf19.844 || STE11 || || Protein similar to S. cerevisiae Ste11p; mutants are sensitive to growth on H2O2 medium || 1 0.59 0.68 -0.30
2188 || orf19.937 || || || Ortholog of Candida albicans WO-1 : CAWG_04446 || 1 0.36 0.40 -0.17
2189 "|| orf19.4211 || FET3 || || Multicopper oxidase; for growth in low iron, prostaglandin E2 synthesis; ketoconazole/caspofungin/amphotericin B repressed; Sef1/Sfu1/Hap43 regulated; reports differ if functional homolog of ScFet3; rat catheter and Spider biofilm induced ||" 1 0.73 0.75 -0.32
2190 "|| orf19.5641 || CAR2 || || Ornithine aminotransferase; arginine metabolism; alkaline induced; mutant sensitivite to toxic ergosterol analog, to amphotericin B; exponential and stationary phase yeast; flow model biofilm induced; rat catheter, Spider biofilm repressed ||" 1 0.64 0.76 -0.45
2191 "|| orf19.5510 || || || Ortholog(s) have role in chromatin silencing at telomere, negative regulation of transcription from RNA polymerase II promoter by pheromones and CHRAC localization ||" 1 1.07 1.15 -0.68
2192 "|| orf19.4884 || WOR1 || || Transcription factor (""master switch"") of white-opaque phenotypic switching; required to establish and maintain the opaque state; opaque-specific, nuclear; regulates its own expression; suggested role in regulation of adhesion factors ||" 1 0.16 0.16 -0.11
2193 || orf19.632 || || || Predicted ORF from Assembly 19; merged with orf19.1808 in Assembly 20 || 1 0.52 0.51 -0.34
2194 || orf19.12613 || || || || 1 0.91 0.92 -0.63
2195 || orf19.2571 || SEC4 || || Small GTPase of Rab family; role in post-Golgi secretion; possible C-terminal palmitoylation; downregulated on adherence to polystyrene; localizes to the Spitzenkorper during hyphal growth; functional homolog of S. cerevisiae Sec4p || 1 0.97 0.94 -0.70
2196 "|| orf19.1087 || || || Ortholog of C. parapsilosis CDC317 : CPAR2_601130, C. dubliniensis CD36 : Cd36_64620, Lodderomyces elongisporus NRLL YB-4239 : LELG_04885 and Candida orthopsilosis Co 90-125 : CORT_0F02130 ||" 1 0.25 0.33 -0.17
2197 || orf19.5401 || || || Putative adhesin-like protein; mutation confers hypersensitivity to toxic ergosterol analog; decreased transcription is observed upon fluphenazine treatment; overlaps orf19.5402; merged with orf19.5404 into orf19.5404.1 || 1 0.35 0.49 -0.25
2198 || orf19.263 || || || Predicted ORF from Assembly 19; merged with orf19.262 in Assembly 20 || 1 0.28 0.40 -0.19
2199 || orf19.2435 || MSI3 || || Essential HSP70 family protein; required for fluconazole resistance and calcineurin-dependent transcription; interacts with Cgr1; transcript regulated by iron; rat catheter biofilm induced; farnesol repressed in biofilm; sumoylation target || 1 0.88 1.20 -0.56
2200 || orf19.12420 || || || || 1 0.36 0.48 -0.18
2201 || orf19.10728 || || || || 1 0.59 0.82 -0.32
2202 || orf19.4064 || GPI7 || || Protein involved in attachment of GPI-linked proteins to cell wall; member of major facilitator superfamily; phosphodiesterase/nucleotide pyrophosphatase domain; similar to S. cerevisiae Gpi7p || 1 0.26 0.37 -0.13
2203 "|| orf19.4890 || CLA4 || || Ste20p family Ser/Thr kinase required for wild-type filamentous growth, organ colonization and virulence in mouse systemic infection; role in chlamydospore formation; functional homolog of S. cerevisiae Cla4p; mutant caspofungin sensitive ||" 1 0.40 0.60 -0.21
2204 || orf19.7322 || || || Protein of unknown function; S. cerevisae ortholog Ypl225w interacts with ribosomes; rat catheter biofilm induced || 1 0.42 0.67 -0.28
2205 || orf19.3256 || SLN1 || || Histidine kinase involved in a two-component signaling pathway that regulates cell wall biosynthesis; mutants are sensitive to growth on H2O2 medium; rat catheter and Spider biofilm induced || 1 0.87 1.48 -0.67
2206 || orf19.7860 || || || || 1 0.16 0.32 -0.14
2207 "|| orf19.22 || || || Protein with homology to peroxisomal membrane proteins; Sef1p-, Sfu1p-, and Hap43p-regulated gene ||" 1 0.18 0.35 -0.16
2208 || orf19.7654 || CPR6 || || Putative peptidyl-prolyl cis-trans isomerase; macrophage/pseudohyphal-repressed; heavy metal (cadmium) stress-induced; heterozygous null mutant displays sensitivity to virgineone; rat catheter biofilm induced || 1 0.08 0.19 -0.08
2209 "|| orf19.3197 || PAP1 || || Poly(A) polymerase, likely involved in mRNA polyadenylation; PAP is inhibited by parnafungin antifungals; non-sex gene located within the MTLa mating-type-like locus ||" 1 0.28 0.70 -0.31
2210 || orf19.5294 || PDB1 || || Putative pyruvate dehydrogenase; fluconazole-induced; protein level decreases in stationary phase cultures; Spider biofilm repressed || 1 0.28 -0.31
2211 || orf19.767 || ERG3 || || C-5 sterol desaturase; introduces C-5(6) double bond into episterol; some clinical isolates show increased azole resistance and defects in hyphal growth and virulence; Efg1p-repressed; fluconazole-induced || 1 0.35 0.76 -0.41
2212 "|| orf19.4927 || BNI1 || || Formin; role in cytoskeletal organization, cell polarity; role in systemic virulence in mouse; cell-cycle regulated localization to site of polarized growth, bud neck; localizes to Spitzenkorper of hyphae, minor localization at septum ||" 1 0.13 0.29 -0.15
2213 "|| orf19.4474 || || || Ortholog(s) have cytoplasm, nucleus localization ||" 1 0.14 0.29 -0.15
2214 || orf19.4176 || || || Ortholog(s) have structural constituent of ribosome activity and mitochondrial small ribosomal subunit localization || 1 0.26 0.52 -0.25
2215 "|| orf19.5504 || || || Ortholog of C. dubliniensis CD36 : Cd36_73400, C. parapsilosis CDC317 : CPAR2_703180, Candida tenuis NRRL Y-1498 : CANTEDRAFT_104803 and Debaryomyces hansenii CBS767 : DEHA2A04466g ||" 1 0.37 0.70 -0.40
2216 || orf19.1917 || || || Protein of unknown function; Spider biofilm repressed || 1 0.14 0.28 -0.16
2217 "|| orf19.2618 || MET2 || || Homoserine acetyltransferase; Hap43p-, Gcn4p-regulated; macrophage/pseudohyphal-repressed; not highly biofilm induced, in contrast to many sulfur amino acid metabolic genes; no human or murine homolog; virulence-group-correlated expression ||" 1 0.05 0.13 -0.07
2218 "|| orf19.2412 || || || Ortholog(s) have role in late endosome to vacuole transport via multivesicular body sorting pathway and Golgi apparatus, Vps55/Vps68 complex, fungal-type vacuole membrane, late endosome localization ||" 1 0.45 0.89
2219 || orf19.2525 || LYS12 || || Homoisocitrate dehydrogenase; catalyzes 4th step in the alpha-aminoadipate pathway of lysine biosynthesis; clade-associated gene expression; protein level decreases in stationary phase cultures; Spider biofilm repressed || 1 0.48 -0.56
2220 || orf19.12670 || || || || 1 0.57 0.98 -0.60
2221 || orf19.13636 || GLT1 || || || 1 0.38 0.63 -0.39
2222 || orf19.4482 || IFI3 || || Protein of unknown function; constitutive expression independent of MTL or white-opaque status || 1 0.27 0.45 -0.26
2223 || orf19.12696 || || || || 1 0.20 0.37 -0.32
2224 "|| orf19.2784 || || || Ortholog of C. dubliniensis CD36 : Cd36_07090, Candida tenuis NRRL Y-1498 : cten_CGOB_00237, Debaryomyces hansenii CBS767 : DEHA2F25542g and Pichia stipitis Pignal : psti_CGOB_00186 ||" 1 0.23 0.35 -0.30
2225 "|| orf19.5757 || || || Ortholog(s) have cytoplasm, nucleus localization ||" 1 0.19 0.28 -0.22
2226 "|| orf19.4155 || KAP114 || || Protein similar to S. cerevisiae Kap114p, which is involved in protein nuclear import; cdc73 kap114 double transposon mutation affects filamentous growth; removed from Assembly 20 ||" 1 0.58 0.90 -0.68
2227 "|| orf19.797 || BAT21 || || Putative branched chain amino acid aminotransferase; regulated by Gcn4, Gcn2; induced in response to amino acid starvation (3-aminotriazole treatment); early-stage flow model biofilm formation ||" 1 0.60 -0.71
2228 || orf19.11660 || || || || 1 0.29 0.74 -0.34
2229 || orf19.6032 || SPE1 || || Ornithine decarboxylase; enzyme of polyamine biosynthesis; mutant is viable; functionally complements polyamine auxotrophy of S. cerevisiae spe1 mutant; downregulated upon adherence to polystyrene || 1 0.29 0.87 -0.39
2230 || orf19.2250 || SPE3 || || Putative spermidine synthase; predicted role in pantothenate and spermidine biosynthesis; Spider biofilm repressed || 1 0.49 -0.66
2231 || orf19.6869 || || || Putative lipid raft associated protein; Spider biofilm induced || 1 0.05 0.11 -0.07
2232 || orf19.1592 || || || Protein of unknown function; Spider biofilm induced || 1 0.68 0.91 -0.59
2233 || orf19.200 || || || Putative nuclear RNA-binding protein; Spider biofilm repressed || 1 0.53 0.71 -0.48
2234 "|| orf19.4076 || MET10 || || Sulfite reductase; role in sulfur amino acid metabolism; induced by human whole blood or PMNs; Hog1-induced; possibly adherence-induced; flow model, Spider model, F-12/CO2 biofilm induced ||" 1 0.17 -0.17
2235 "|| orf19.5639 || HIS4 || || Multifunctional enzyme that catalyzes three steps of histidine biosynthesis, with phosphoribosyl-AMP cyclohydrolase, phosphoribosyl-ATP diphosphatase, and histidinol dehydrogenase activities; required for wild-type adhesion to human calls ||" 1 0.78 0.62 -0.79
2236 || orf19.2562 || CDC60B || || Putative tRNA-Leu synthetase; merged with orf19.2560 in Assembly 20 || 1 0.38 0.52 -0.88
2237 || orf19.754 || YBN5 || || P-loop ATPase with similarity to human OLA1 and bacterial YchF; Spider biofilm repressed || 1 0.16 0.15 -0.30
2238 || orf19.6798 || SSN6 || || Functional homolog of S. cerevisiae Cyc8/Ssn6; hyphal growth regulator; repressed during hyphal growth; Ssn6 and Tup1 regulate distinct sets of genes; overexpression or mutation causes avirulence in mouse IV infection; TPR motifs || 1 0.27 0.22 -0.39
2239 || orf19.1795 || PUF3 || || Ortholog os S. cerevisiae Puf3; mRNA-binding protein involved in RNA catabolism; mutant is viable || 1 0.08 0.07 -0.11
2240 || orf19.4060 || ARO4 || || 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; aromatic amino acid biosynthesis; GCN-regulated; feedback-inhibited by tyrosine if produced in S. cerevisiae Aro3p and Aro4p catalyze same reaction; protein decreases in stationary phase || 1 1.12 1.09 -1.63
2241 || orf19.10080 || TRP2 || || || 1 0.38 -0.59
2242 "|| orf19.1358 || GCN4 || || bZIP transcription factor; amino acid control response; required for Efg1-dependent pseudohyphal induction by amino acid starvation, not by serum; human whole blood and PMN induced; required for biofilm formation; Spider biofilm induced ||" 1 0.40 0.36 -0.62
2243 "|| orf19.4960 || || || Ortholog(s) have spermine synthase activity, role in pantothenate biosynthetic process, spermine biosynthetic process and cytoplasm localization ||" 1 0.09 0.10 -0.16
2244 "|| orf19.5834 || || || Ortholog(s) have protein transporter activity, role in mRNA export from nucleus and cytoplasm, nucleus localization ||" 1 0.16 0.20 -0.27
2245 || orf19.5184 || || || Putative Ran guanyl-nucleotide exchange factor; probable signal transducer; Spider biofilm repressed || 1 0.14 0.20 -0.25
2246 "|| orf19.2797 || || || Has domain(s) with predicted ATP binding, DNA binding, helicase activity ||" 1 0.08 0.11 -0.11
2247 "|| orf19.3955 || MES1 || || Cytoplasmic methionyl-tRNA synthetase; zinc-binding motif; ribosomal subunits, translation factors, tRNA synthetases are downregulated upon phagocytosis by murine macrophage; protein present in exponential and stationary phase yeast ||" 1 0.24 0.26 -0.30
2248 || orf19.94 || || || Protein of unknown function; Spider biofilm induced || 1 0.19 0.21 -0.24
2249 || orf19.3560 || || || Predicted ORF from Assembly 19; merged with orf19.3559 in Assembly 20 || 1 0.20 0.24 -0.25
2250 || orf19.1108 || HAM1 || || Putative deoxyribonucleoside triphosphate pyrophosphohydrolase; caspofungin repressed; regulated by Gcn2p and Gcn4p || 1 0.61 0.69 -0.72
2251 || orf19.1144 || || || Protein with SEL-1 like protein domain; early-stage flow model biofilm induced || 1 0.20 0.20 -0.16
2252 "|| orf19.3670 || GAL1 || || Galactokinase; galactose, Mig1, Tup1, Hap43 regulated; fluconazole, ketoconazole-induced; stationary phase enriched protein; GlcNAc-induced protein; farnesol, hypoxia-repressed in biofilm; rat catheter and Spider biofilm induced ||" 1 0.36 0.35 -0.33
2253 || orf19.819 || || || Ortholog(s) have role in lipoate biosynthetic process and mitochondrion localization || 1 0.20 0.18 -0.21
2254 || orf19.1591 || ERG10 || || Acetyl-CoA acetyltransferase; role in ergosterol biosynthesis; soluble in hyphae; changes in protein abundance associated with azole resistance; fluconazole or ketoconazole induced; macrophage-downregulated protein; GlcNAc-induced protein || 1 0.26 0.20 -0.23
2255 "|| orf19.4975 || HYR1 || || GPI-anchored hyphal cell wall protein; macrophage-induced; repressed by neutrophils; resistance to killing by neutrophils, azoles; regulated by Rfg1, Efg1, Nrg1, Tup1, Cyr1, Bcr1, Hap43; Spider and flow model biofilm induced ||" 1 0.45 0.27 -0.31
2256 || orf19.4650 || ILV6 || || Putative regulatory subunit of acetolacetate synthase; alkaline induced; regulated by Gcn2 and Gcn4; protein present in exponential and stationary growth phase yeast; Spider biofilm repressed || 1 0.70 0.42 -0.50
2257 || orf19.5858 || EGD2 || || Nascent polypeptide associated complex protein alpha subunit; soluble protein in hyphae; macrophage/pseudohyphal-induced; protein level decrease in stationary phase cultures; GlcNAc-induced protein; Spider biofilm repressed || 1 0.82 0.53 -0.59
2258 || orf19.158 || || || Ortholog of S. cerevisiae Apd1; required for normal localization of actin patches and normal tolerance of sodium ions and hydrogen peroxide; Hap43-induced; Spider biofilm induced || 1 0.42 0.27 -0.32
2259 "|| orf19.2386 || || || Ortholog(s) have role in endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA and LSU-rRNA), more ||" 1 0.12 0.09 -0.11
2260 || orf19.7247 || RIM101 || || Transcription factor; alkaline pH response; required for alkaline-induced hyphal growth; role in virulence in mice; activated by C-terminal proteolytic cleavage; mediates both positive and negative regulation; Spider biofilm induced || 1 0.37 0.23 -0.31
2261 "|| orf19.1684 || || || Ortholog of C. dubliniensis CD36 : Cd36_81500, C. parapsilosis CDC317 : CPAR2_503620, Candida tenuis NRRL Y-1498 : CANTEDRAFT_93693 and Debaryomyces hansenii CBS767 : DEHA2D15268g ||" 1 0.19 -0.15
2262 "|| orf19.4078 || || || Ortholog(s) have role in U1 snRNA 3'-end processing, U4 snRNA 3'-end processing and U5 snRNA 3'-end processing, more ||" 1 0.27 0.15 -0.22
2263 || orf19.6594 || PLB3 || || GPI-anchored cell surface phospholipase B; possibly secreted; fungal-specific (no mammalian homolog); induced by Tbf1; fluconazole-induced; possible essential gene (UAU1 method); Spider and flow model biofilm induced || 1 0.29 0.18 -0.32
2264 || orf19.4089 || SGT1 || || Putative co-chaperone protein with a predicted role in kinetochore assembly; mutation confers hypersensitivity to radicicol; sumoylation target || 1 0.12 0.07 -0.17
2265 || orf19.7613 || HCR1 || || Putative translation initiation factor; repressed upon phagocytosis by murine macrophage; Spider biofilm repressed || 1 0.16 -0.22
2266 || orf19.2765 || PGA62 || || Adhesin-like cell wall protein; putative GPI-anchor; fluconazole-induced; induced in high iron; induced during cell wall regeneration; Cyr1 or Ras1 repressed; Tbf1 induced || 1 0.35 0.17 -0.47
2267 || orf19.11037 || AAT1 || || || 1 0.76 0.29 -0.86
2268 || orf19.7733 || ILV5 || || || 1 0.86 0.23 -1.02
2269 "|| orf19.118 || FAD2 || || Delta-12 fatty acid desaturase, involved in production of linoleic acid, which is a major component of membranes ||" 1 0.08 0.01 -0.12
2270 "|| orf19.409 || || || Ortholog of S. cerevisiae Aim38/Rcf2, cytochrome c oxidase subunit; plasma membrane localized; Hap43-repressed; induced in oralpharyngeal candidasis; flow model biofilm induced; Spider biofilm repressed ||" 1 0.42 0.08 -0.67
2271 "|| orf19.3014 || BMH1 || || Sole 14-3-3 protein in C. albicans; role in hyphal growth; possibly regulated by host interaction; localizes to yeast-form cell surface, not hyphae; alternatively spliced 5' UTR intron; Spider biofilm repressed ||" 1 0.10 0.01 -0.18
2272 "|| orf19.4026 || HIS1 || || ATP phosphoribosyl transferase; enzyme of histidine biosynthesis; acid upregulated/alkaline repressed by Rim101; regulated by Gcn2, Gcn4; strain CA9 is a his1 mutant; flow model biofilm induced; Spider biofilm repressed ||" 1 0.29 0.08 -0.60
2273 || orf19.3812 || SSZ1 || || Putative HSP70 chaperone; protein level decreases in stationary phase cultures; Spider biofilm repressed || 1 0.15 0.06 -0.29
2274 || orf19.1839 || RPA190 || || Putative RNA polymerase I subunit A190; Hap43p-induced gene; flucytosine induced || 1 0.07 0.03 -0.12
2275 || orf19.171 || DBP2 || || Putative DEAD-box family ATP-dependent RNA helicase; flucytosine induced; repressed in core stress response || 1 0.28 0.11 -0.45
2276 "|| orf19.437 || GRS1 || || Putative tRNA-Gly synthetase; genes encoding ribosomal subunits, translation factors, tRNA synthetases are downregulated upon phagocytosis by murine macrophage; stationary phase enriched protein ||" 1 0.22 -0.33
2277 || orf19.5101 || CCR4 || || Component of the Ccr4-Pop2 mRNA deadenylase; transposon mutation affects filamentous growth || 1 0.13 0.08 -0.20
2278 "|| orf19.1363 || || || Putative protein of unknown function; Plc1-regulated; transcript induced by Mnl1 under weak acid stress; flow model, rat catheter, Spider biofilm induced ||" 1 0.26 0.09 -0.21
2279 || orf19.3415 || PTK2 || || Putative protein kinase of polyamine import; mutation confers hypersensitivity to high concentrations of tunicamycin; YPD flow model biofilm induced; rat catheter and Spider biofilm induced || 1 0.24 0.10 -0.17
2280 || orf19.1154 || EGD1 || || Putative GAL4 DNA-binding enhancer protein; soluble protein in hyphae; biofilm induced; macrophage/pseudohyphal-induced; equal level of protein in exponential and stationary growth phase yeast cultures; Spider biofilm repressed || 1 0.59 0.14 -0.35
2281 || orf19.6493 || || || Ortholog of C. dubliniensis CD36 : Cd36_72020 and Candida albicans WO-1 : CAWG_05570 || 1 0.46 0.08 -0.31
2282 "|| orf19.1770 || CYC1 || || Cytochrome c; complements defects of S. cerevisiae cyc1 cyc7 double mutant; induced in high iron; alkaline repressed; repressed by nitric oxide; Hap43-dependent repression in low iron; regulated by Sef1, Sfu1 ||" 1 0.33 0.11 -0.19
2283 || orf19.1750 || SLR1 || || Protein similar to mammalian SR-like RNA splicing factor; involved in filamentous growth and virulence; gene has intron; Spider biofilm repressed || 1 0.50 0.19 -0.29
2284 "|| orf19.691 || GPD2 || || Surface protein similar to glycerol 3-P dehydrogenase; binds host Factor H, FHL-1, plasminogen; regulated by Ssn6, Nrg1, Efg1; induced by cell wall regeneration, macrophage/pseudohyphal growth, core stress response; Spider biofilm induced ||" 1 0.52 0.25 -0.32
2285 "|| orf19.4980 || HSP70 || || Putative hsp70 chaperone; role in entry into host cells; heat-shock, amphotericin B, cadmium, ketoconazole-induced; surface localized in yeast and hyphae; antigenic in host; farnesol-downregulated in biofilm; Spider biofilm induced ||" 1 0.72 0.36 -0.41
2286 "|| orf19.3911 || SAH1 || || S-adenosyl-L-homocysteine hydrolase; sulfur amino acid metabolism; antigenic in human; alkaline-, fluconazole-induced expression; Gcn4-regulated; amino acid starvation (3-AT) repressed; flow model biofilm induced; Spider biofilm repressed ||" 1 0.47 0.21 -0.21
2287 || orf19.3838 || EFB1 || || Translation elongation factor EF-1 beta; repressed by human whole blood or PMNs; macrophage/pseudohyphal-induced; antigenic in mouse; farnesol-downregulated; snoRNA snR18 is encoded within the EFB1 intron; Spider biofilm repressed || 1 0.09 0.05 -0.04
2288 "|| orf19.132 || || || Ortholog(s) have role in histone deacetylation, negative regulation of chromatin silencing at telomere, negative regulation of meiosis, positive regulation of stress-activated MAPK cascade ||" 1 0.17 -0.07
2289 || orf19.10685 || || || || 1 1.01 0.35 -0.42
2290 || orf19.798 || TAF14 || || Putative DNA-binding transcription factor; TFIIF subunit; macrophage-induced protein; possibly required for yeast cell adherence to silicone substrate; mutant has pleiotrophic effects || 1 0.58 0.22 -0.26
2291 "|| orf19.6246 || || || Ortholog(s) have peptide alpha-N-acetyltransferase activity, role in N-terminal peptidyl-methionine acetylation, cytoskeleton organization, mitochondrion inheritance and NatB complex, cytosol, nucleus localization ||" 1 0.53 0.21 -0.22
2292 "|| orf19.7446 || OPI3 || || Phosphatidylethanolamine N-methyltransferase; phosphatidylcholine biosynthesis; downregulation correlates with clinical development of fluconazole resistance; amphotericin B, caspofungin repressed; Hap43-induced; Spider biofilm repressed ||" 1 0.73 0.27 -0.27
2293 "|| orf19.4961 || STP2 || || Amino-acid-regulated transcription factor; activates transcription of amino acid permease genes; activated by amino-acid-induced proteolytic processing (Ssy1, Csh3 dependent); required for alkalinization of medium; Spider biofilm induced ||" 1 0.13 0.04 -0.03
2294 || orf19.3669 || SHA3 || || Putative ser/thr kinase involved in glucose transport; Tn mutation affects filamentous growth; fluconazole-induced; ketoconazole-repressed; induced in by alpha pheromone in SpiderM; possibly essential; flow model biofilm induced || 1 0.29 0.06 -0.09
2295 || orf19.13213 || IDH2 || || || 1 0.22 0.04 -0.08
2296 || orf19.911 || || || Predicted ORF from Assembly 19; merged with orf19.5776 in Assembly 20 || 1 0.37 0.02 -0.12
2297 || orf19.5379 || ERG4 || || Protein similar to sterol C-24 reductase; shows Mob2p-dependent hyphal regulation; fluconazole-induced; caspofungin repressed; rat catheter biofilm repressed || 1 0.18 0.00 -0.04
2298 || orf19.5190 || || || Ortholog of Candida albicans WO-1 : CAWG_05610 || 1 0.34 0.07 0.18
2299 || orf19.3224 || || || Predicted ORF from Assembly 19; merged with orf19.3223 in Assembly 20 || 1 0.35 0.07 0.16
2300 "|| orf19.2722 || CGR1 || || Negative regulator of yeast-form growth; HSP70 family member; induced by growth cessation at yeast-hyphal transition or in planktonic growth; physically interacts with Msi3p; similar to rat anti-aging gene, SMP30, stationary phase enriched ||" 1 0.16 0.02 0.04
2301 "|| orf19.411 || || || Protein similar to GTPase regulators; induced in low iron; transcript activated by Mnl1 under weak acid stress; Hap43-, Sfu1- and Sef1-regulated; flow model biofilm induced, Spider biofilm induced ||" 1 0.46 0.08 0.18
2302 || orf19.1355 || || || Putative protein of unknown function; stationary phase enriched protein || 1 0.24 0.06 0.09
2303 "|| orf19.3153 || MSS4 || || Phosphatidylinositol-4-phosphate 5-kinase; activity induced by phosphatidic acid (Pld1 product); macrophage/pseudohyphal-repressed; mRNA binds to She3, localized to yeast cell buds and hyphal tips; Hap43-induced; Spider biofilm induced ||" 1 0.18 0.05 0.07
2304 "|| orf19.3396 || HCH1 || || Ortholog of S. cerevisiae Hch1, a regulator of heat shock protein Hsp90; regulated by Gcn4; induced in response to amino acid starvation (3-aminotriazole treatment); mutants are viable ||" 1 0.54 0.16 0.17
2305 || orf19.997 || SNL1 || || Ribosome-associated protein predicted to function in protein synthesis; 1 predicted transmembrane domain; rat catheter biofilm repressed || 1 0.44 0.14
2306 || orf19.3579 || ATP4 || || Putative F0-ATP synthase subunit 4; macrophage/pseudohyphal-induced; present in exponential and stationary growth phases || 1 0.33 0.09 0.09
2307 || orf19.6452 || RBP1 || || Peptidyl-prolyl cis-trans isomerase; rapamycin-binding protein; homozygous null mutation confers rapamycin resistance; regulated by Gcn4p; macrophage-induced protein; repressed in response to 3-AT; functional homolog of S. cerevisiae Rbp1p || 1 0.36 0.09 0.09
2308 "|| orf19.7046 || MET28 || || Predicted bZIP domain-containing transcription factor; protein induced during the mating process; possibly essential, disruptants not obtained by UAU1 method; Hap43-repressed; rat catheter biofilm induced ||" 1 0.89 0.12 0.16
2309 "|| orf19.2314 || || || Protein with a role in nucleolar integrity and processing of pre-rRNA; mutation confers hypersensitivity to 5-fluorocytosine (5-FC), 5-fluorouracil (5-FU), and tubercidin (7-deazaadenosine); Hap43-induced; Spider biofilm induced ||" 1 0.08 0.01
2310 || orf19.1552 || CPR3 || || Putative peptidyl-prolyl cis-trans isomerase; macrophage-induced protein; protein levels decrease in stationary phase yeast cultures; predicted mitochondrial localization; overlaps orf19.1551 || 1 0.73 0.17 0.15
2311 "|| orf19.5033 || || || Ortholog(s) have Atg8 ligase activity, protein tag activity ||" 1 0.93 0.29 0.14
2312 "|| orf19.3612 || PST2 || || Putative NADH:quinone oxidoreductase; similar to 1,4-benzoquinone reductase; immunogenic in mice; induced by benomyl, oxidative stress via Cap1; fungal-specific; farnesol-repressed; Spider biofilm induced ||" 1 0.59 0.24 0.09
2313 "|| orf19.5035 || HPC2 || || Ortholog(s) have DNA binding, nucleosome binding activity ||" 1 0.51 0.22 0.14
2314 || orf19.1826 || MDM34 || || Putative zinc finger transcription factor; macrophage-downregulated; flow model biofilm induced; flow model and Spider biofilm induced || 1 0.09 0.04 0.03
2315 "|| orf19.4623.3 || NHP6A || || Putative non-histone chromatin component; RNA abundance regulated by tyrosol,cell density; Hap43-induced; amphotericin B, caspofungin repressed; 5'-UTR intron; rat catheter and Spider biofilm repressed ||" 1 0.92 0.48 0.25
2316 || orf19.5819 || || || Predicted ORF from Assembly 19; removed from Assembly 20 || 1 0.32 0.08 0.03
2317 || orf19.6127 || LPD1 || || Putative dihydrolipoamide dehydrogenase; soluble in hyphae; antigenic in human oral infection and murine systemic infection; macrophage-induced protein; protein present in exponential and stationary phase yeast cultures; Hap43p-repressed || 1 0.44 0.10 0.02
2318 "|| orf19.7186 || CLB4 || || B-type mitotic cyclin; nonessential; negative regulator of pseudohyphal growth; dispensible for mitotic exit, cytokinesis; Fkh2-represed; flow model biofilm repressed; farnesol-upregulated in biofilm; reduced total RNA in clb4 mutant ||" 1 0.46 0.13 0.02
2319 || orf19.7448 || LYS9 || || Saccharopine dehydrogenase; lysine biosynthesis; soluble protein in hyphae; amphotericin B repressed; Gcn4-regulated; colony morphology-related gene regulation by Ssn6; protein present in exponential and stationary growth phase yeast || 1 1.10 0.25 -0.06
2320 || orf19.119 || || || Ortholog(s) have protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity || 1 0.73 -0.04
2321 "|| orf19.6472 || CYP1 || || Peptidyl-prolyl cis-trans isomerase; cyclosporin A sensitive activity; soluble in hyphae; biofilm induced, macrophage-induced protein; downregulated upon treatment of biofilm with farnesol; present in exponential and stationary phase cells ||" 1 0.54 0.11 -0.02
2322 "|| orf19.7417 || TSA1 || || TSA/alkyl hydroperoxide peroxidase C (AhPC) family protein; similar to thiol-dependent peroxidases of oxidative stress signaling; antigenic; hyphal surface, nucleus; yeast-form nucleus, cytoplasm; biofilm, phagocytosis, peroxide induced ||" 1 0.78 0.31 0.03
2323 || orf19.11411 || || || || 1 0.17 0.01
2324 "|| orf19.6554 || || || Regulator of calcineurin; regulated by calcineurin-Crz1 pathway; feedback regulator of calcineurin-dependent signaling; Hap43-repressed; induced by ketoconazole, hypoxia, during growth in the mouse cecum; Spider biofilm induced ||" 1 0.65 0.43 0.05
2325 "|| orf19.1273 || || || Ortholog(s) have tubulin binding activity, role in tubulin complex assembly and prefoldin complex localization ||" 1 0.26 0.17 0.00
2326 "|| orf19.5665 || || || Ortholog(s) have D-arabinose 1-dehydrogenase [NAD(P)+] activity and role in dehydro-D-arabinono-1,4-lactone biosynthetic process ||" 1 0.21 0.13 0.02
2327 || orf19.717 || HSP60 || || Heat shock protein; soluble in hyphae; regulated by Nrg1 and by iron; induced in high iron; heavy metal (cadmium) stress-induced; sumoylation target; protein present in exponential and stationary phase cells; Hap43-repressed || 1 0.61 0.34 0.05
2328 || orf19.6696 || TIM9 || || Predicted protein of the mitochondrial intermembrane space; rat catheter biofilm induced; Spider biofilm repressed || 1 0.54 0.30 0.04
2329 || orf19.2181 || || || Ortholog of Spathaspora passalidarum NRRL Y-27907 : spas_CGOB_00067 and Candida albicans WO-1 : CAWG_05895 || 1 0.14 0.01
2330 "|| orf19.4941 || TYE7 || || bHLH transcription factor; control of glycolysis; required for biofilm formation; hyphally regulated by Cph1, Cyr1; flucytosine, Hog1 induced; amphotericin B, caspofungin repressed; induced in flow model biofilm and planktonic cultures ||" 1 1.00 0.30 0.07
2331 "|| orf19.4701 || || || Ortholog(s) have ATPase activity, tRNA binding activity, role in protein urmylation, regulation of transcription from RNA polymerase II promoter, tRNA wobble uridine modification and Elongator holoenzyme complex localization ||" 1 0.10 0.01
2332 || orf19.7264 || || || Metalloprotease subunit of the 19S regulatory particle of the 26S proteasome lid; couples the deubiquitination and degradation of proteasome substrates; role in fission of mitochondria and peroxisome; Spider biofilm repressed || 1 0.09 0.05 0.01
2333 || orf19.5551 || MIF2 || || Centromere-associated protein; similar to CENP-C proteins; Cse4p and Mif2p colocalize at C. albicans centromeres || 1 0.27 0.14 0.04
2334 || orf19.227 || COX7 || || Putative cytochrome c oxidase; flucytosine induced; repressed by nitric oxide || 1 0.15 0.08 0.03
2335 || orf19.7602 || AHA1 || || Putative Hsp90p co-chaperone; Hap43-repressed; heavy metal (cadmium) stress-induced; oxidative stress-induced via Cap1; rat catheter biofilm induced; flow model biofilm repressed || 1 0.47 0.31 0.13
2336 || orf19.3988 || || || Putative adhesin-like protein; induced by Mnl1 under weak acid stress; rat catheter and Spider biofilm induced || 1 0.99 0.66 0.22
2337 || orf19.3149 || LSP1 || || Eisosome component with a predicted role in endocytosis; protein present in exponential and stationary growth phase yeast cultures; caspofungin repressed; biofilm induced; fungal-specific (no human/murine homolog); sumoylation target || 1 0.34 0.21 0.06
2338 || orf19.6771 || UBI4 || || Ubiquitin precursor (polyubiquitin) contains 3 tandem repeats of the ubiquitin peptide that are processed to individual units; transcript induced by stress; mRNA in yeast and mycelia at similar abundance; Spider biofilm induced || 1 0.74 0.38 0.12
2339 || orf19.239 || || || Putative ATP-dependent helicase; induced by nitric oxide || 1 0.22 0.04
2340 || orf19.11885 || || || || 1 0.32 0.26 0.05
2341 || orf19.5992 || WOR2 || || Zn(II)2Cys6 transcription factor; regulator of white-opaque switching; required for maintenance of opaque state; Hap43-induced || 1 0.34 0.26 0.07
2342 || orf19.6586 || || || Protein of unknown function; transcript induced by benomyl or in azole-resistant strain overexpressing MDR1; Ssn6 colony morphology-related regulation; induced by NO; Hap43-repressed; rat catheter and flow model biofilm induced || 1 0.22 0.41 0.13
2343 || orf19.697 || || || Ortholog(s) have mitochondrial outer membrane localization || 1 0.08 0.16 0.05
2344 "|| orf19.3694 || || || Ortholog of C. dubliniensis CD36 : Cd36_02210, C. parapsilosis CDC317 : CPAR2_106350, Candida tenuis NRRL Y-1498 : CANTEDRAFT_116785 and Debaryomyces hansenii CBS767 : DEHA2C01980g ||" 1 0.17 0.41 0.13
2345 || orf19.4969 || KEM1 || || 5'->3' exoribonuclease of cytoplasmic stress granules; role in filamentous growth; complements slow growth/mating of S. cerevisiae kem1 mutant; required for SD or Spider medium biofilm formation || 1 0.12 0.30 0.09
2346 || orf19.7342 || AXL1 || || Putative endoprotease; induced by alpha factor; transcript is upregulated in an RHE model of oral candidiasis and in clinical isolates from HIV+ patients with oral candidiasis || 1 0.07 0.21 0.06
2347 || orf19.62 || || || Predicted ORF from Assembly 19; merged with orf19.73 in Assembly 20 || 1 0.16 0.66 0.19
2348 || orf19.1231 || || || Predicted ORF from Assembly 19; merged with orf19.1229 in Assembly 20 || 1 0.18 0.19
2349 "|| orf19.3151 || || || Has domain(s) with predicted catalytic activity, coenzyme binding activity and role in cellular metabolic process ||" 1 0.24 0.26
2350 || orf19.7922 || KRE5 || || || 1 0.40 0.97
2351 || orf19.2437 || ARC35 || || Putative ARP2/3 complex subunit; shows colony morphology-related gene regulation by Ssn6p; mutation confers hypersensitivity to cytochalasin D || 1 0.03 0.23
2352 || orf19.6167 || AYR1 || || Putative oxidoreductase; transcriptionally induced by interaction with macrophage; rat catheter biofilm repressed || 1 0.03 0.20
2353 || orf19.847 || YIM1 || || Protein similar to protease of mitochondrial inner membrane; increased transcription is observed upon benomyl treatment; macrophage-downregulated gene || 1 0.49 0.40
2354 "|| orf19.3659 || || || Putative CTD phosphatase; role in dephosphorylation of RNA polymerase II C-terminal domain, transcription from RNA polymerase II promoter; flow model biofilm induced ||" 1 0.40 0.57 0.28
2355 "|| orf19.5793 || PR26 || || Protein with similarity to proteasomal 26S regulatory subunit of S. cerevisiae, H. sapiens, Methanobacterium thermoautotrophicum (Archaebacterium) ||" 1 0.14 0.25 0.14
2356 || orf19.5094 || BUL1 || || Protein similar but not orthologous to S. cerevisiae Bul1; a protein involved in selection of substrates for ubiquitination; mutants are viable; macrophage/pseudohyphal-induced; rat catheter biofilm induced || 1 0.25 0.34 0.19
2357 || orf19.1885 || TAF4 || || Putative TFIID subunit; mutation confers hypersensitivity to toxic ergosterol analog || 1 0.11 0.14 0.10
2358 "|| orf19.6474 || || || Protein with chitin synthesis regulation, resistance to Congo red domain; membrane-localized protein; Spider biofilm induced ||" 1 0.40 0.46 0.31
2359 "|| orf19.4309 || GRP2 || || Methylglyoxal reductase; regulation associated with azole resistance; induced in core stress response or by oxidative stress via Cap1, fluphenazine, benomyl, by Hap43 or with long term fluconazole treatment; Spider biofilm induced ||" 1 0.67 0.92 0.24
2360 || orf19.3604 || || || Ortholog(s) have nucleus localization || 1 0.48 0.63 0.16
2361 || orf19.4170 || CSP2 || || Putative cell wall associated protein; C. albicans and C. dubliniensis specific gene highly induced during chlamydospore development in both species; localized to chlamydospore cell wall; Hap43-repressed; Spider biofilm induced || 1 0.57 0.62 0.16
2362 || orf19.3931 || SFC1 || || Putative succinate-fumarate transporter; involved in repression of growth on sorbose; alkaline induced; rat catheter biofilm induced; Spider biofilm induced || 1 0.20 0.06
2363 || orf19.8967 || || || || 1 0.16 0.28 0.05
2364 || orf19.12686 || IRA2 || || || 1 0.16 0.30 0.07
2365 "|| orf19.2770.1 || SOD1 || || Cytosolic copper- and zinc-containing superoxide dismutase; role in protection from oxidative stress; required for full virulence; alkaline induced by Rim101; induced by human blood; rat catheter, flow model and Spider biofilm repressed ||" 1 0.54 0.89 0.22
2366 "|| orf19.5553 || || || Ortholog(s) have methionine-R-sulfoxide reductase activity, role in cellular response to oxidative stress and cytoplasm, nucleus localization ||" 1 0.37 0.20
2367 || orf19.4229 || || || Putative polyphosphate phosphatase; role in hydrolysis of diphosphorylated inositol polyphosphates and diadenosine polyphosphates; Spider biofilm induced || 1 0.34 0.47 0.18
2368 || orf19.3422 || FMP27 || || Putative mitochondrial protein; mRNA binds She3 || 1 0.30 0.42 0.15
2369 "|| orf19.6340 || || || Ortholog(s) have RNA polymerase I activity, RNA polymerase II activity, RNA polymerase III activity, RNA-directed RNA polymerase activity ||" 1 0.19 0.25 0.08
2370 || orf19.5688 || || || Predicted ORF from Assembly 19; removed from Assembly 20; subsequently reinstated in Assembly 21 based on comparative genome analysis || 1 0.25 0.32 0.11
2371 || orf19.11227 || || || || 1 0.50 0.57 0.22
2372 "|| orf19.6844 || ICL1 || || Isocitrate lyase; glyoxylate cycle enzyme; required for virulence in mice; induced upon phagocytosis by macrophage; farnesol regulated; Pex5-dependent peroxisomal localization; stationary phase enriched; rat catheter, Spider biofilm induced ||" 1 0.61 0.65 0.23
2373 || orf19.1796 || || || Putative glyoxylate reductase; acts on glyoxylate and hydroxypyruvate substrates; Spider biofilm repressed || 1 0.66 0.63 0.26
2374 || orf19.127 || || || Predicted ORF from Assembly 19; merged with orf19.130 in Assembly 20 || 1 0.57 0.21
2375 || orf19.2752 || ADR1 || || C2H2 transcription factor; ortholog of S. cerevisiae Adr1 but mutant phenotype suggests a different set of target genes; transposon mutation affects filamentous growth; Spider biofilm induced || 1 0.03 0.29 0.01
2376 "|| orf19.4473 || SPC19 || || Essential subunit of the Dam1 (DASH) complex, which acts in chromosome segregation by coupling kinetochores to spindle microtubules ||" 1 0.13 0.05
2377 "|| orf19.51 || || || Ortholog(s) have role in mitochondrion organization, translational initiation and eukaryotic translation initiation factor 3 complex localization ||" 1 0.28 0.25 0.10
2378 || orf19.2814 || || || Predicted ORF from Assembly 19; removed from Assembly 20 || 1 0.56 0.57 0.17
2379 "|| orf19.3672 || GAL10 || || UDP-glucose 4-epimerase; galactose utilization; mutant has cell wall defects and increased filamentation; GlcNAc-, fluconazole- and ketoconazole-induced; stationary phase enriched protein; rat catheter and flow model biofilm induced ||" 1 0.83 0.84 0.21
2380 "|| orf19.543 || FUM11 || || Fumarate hydratase; induced in high iron; protein in exponential and stationary-phase yeast cells, but higher in stationary phase; rat catheter biofilm repressed ||" 1 0.66 0.67 0.14
2381 || orf19.884 || || || Predicted ORF from Assembly 19; merged with orf19.882 in Assembly 20 || 1 0.35 0.33 0.08
2382 || orf19.9303 || || || || 1 0.24 0.25 0.04
2383 "|| orf19.4502 || || || Ortholog(s) have ATPase activity, DNA binding, TBP-class protein binding activity ||" 1 0.54 0.59 0.06
2384 || orf19.8369 || || || || 1 0.21 0.16 0.08
2385 "|| orf19.7680 || CTA26 || || Putative transcription factor/activator; Med2 mediator complex ddomain; transcript is upregulated in an RHE model of oral candidiasis; member of a family of telomere-proximal genes; Efg1, Hap43-repressed ||" 1 0.32 0.27 0.19
2386 || orf19.2749 || || || BTB/POZ domain protein; induced by Mnl1 under weak acid stress; flow model biofilm induced; Spider biofilm induced || 1 0.31 0.17
2387 || orf19.10087 || URA5 || || || 1 0.37 0.21
2388 "|| orf19.3965 || || || Ortholog(s) have role in double-strand break repair via homologous recombination, meiotic gene conversion, reciprocal meiotic recombination, replication fork protection and Smc5-Smc6 complex, cytosol, nucleus localization ||" 1 0.10 0.06
2389 || orf19.1443 || PLB4 || || Putative phospholipase B; merged with orf19.1442 in Assembly 20 || 1 0.38 0.24 0.22
2390 || orf19.3752 || RAD51 || || Protein involved in homologous recombination and DNA repair; flucytosine induced; slow growth and increased white-to-opaque switching frequency in null mutant || 1 0.38 0.21 0.23
2391 "|| orf19.3507 || MCR1 || || NADH-cytochrome-b5 reductase; soluble in hyphae; alkaline downregulated; farnesol, ketoconazole or flucytosine induced; protein present in exponential and stationary growth phase yeast; YNB biofilm induced; rat catheter biofilm repressed ||" 1 0.58 0.31 0.33
2392 || orf19.5180 || PRX1 || || Thioredoxin peroxidase; transcriptionally induced by interaction with macrophage; fluconazole induced; Fkh2p-downregulated; caspofungin repressed; protein present in exponential and stationary growth phase yeast cultures || 1 0.74 0.38 0.36
2393 || orf19.3442 || || || Putative oxidoreductase; Hap43-repressed gene || 1 0.54 0.26
2394 || orf19.2175 || || || Putative mitochondrial cell death effector; induced by nitric oxide; Spider biofilm induced; rat catheter biofilm repressed || 1 0.73 0.41 0.37
2395 || orf19.2364 || MIS11 || || Predicted mitochondrial C1-tetrahydrofolate synthase precursor; putative protein of glycine catabolism; repressed by Efg1; fluconazole-induced; stationary phase enriched protein; rat catheter and Spider biofilm repressed || 1 0.51 0.29 0.27
2396 || orf19.4816 || || || Protein of unknown function; induced by nitric oxide || 1 0.52 0.34 0.25
2397 "|| orf19.1777 || || || Ortholog(s) have ubiquitin-specific protease activity, role in endocytosis, protein deubiquitination and cell division site, cytosol, nucleus, peroxisome, transport vesicle localization ||" 1 0.18 0.09 0.07
2398 "|| orf19.2306 || || || Ortholog(s) have acireductone dioxygenase (Ni2+-requiring) activity, role in L-methionine salvage from methylthioadenosine and cytosol, nucleus localization ||" 1 0.23 0.09
2399 || orf19.5576 || || || Putative pantothenate kinase; ortholog of S. cerevisiae Cab1; transposon mutation affects filamentous growth; repressed in core stress response || 1 0.34 0.17 0.14
2400 || orf19.11133 || || || || 1 0.41 0.16 0.23
2401 "|| orf19.4527 || HGT1 || || High-affinity MFS glucose transporter; induced by progesterone, chloramphenicol, benomyl; likely essential for growth; protein newly produced during adaptation to the serum; rat catheter and Spider biofilm induced ||" 1 0.28 0.12 0.18
2402 "|| orf19.3704 || || || Ortholog(s) have role in maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ||" 1 0.39 0.18 0.25
2403 || orf19.11848 || || || || 1 0.30 0.19
2404 "|| orf19.882 || HSP78 || || Heat-shock protein; regulated by macrophage response, Nrg1, Mig1, Gcn2, Gcn4, Mnl1p; heavy metal (cadmium) stress-induced; stationary phase enriched protein; rat catheter and Spider biofilm induced ||" 1 0.18 0.09 0.11
2405 "|| orf19.637 || SDH2 || || Succinate dehydrogenase, Fe-S subunit; localizes to surface of yeast cells, but not hyphae; induced in high iron and during log phase aerobic growth; repressed by nitric oxide, Hap43 ||" 1 0.25 0.15 0.17
2406 || orf19.6899 || || || Putative oxidoreductase; mutation confers hypersensitivity to toxic ergosterol analog; rat catheter and Spider biofilm induced || 1 0.11 0.08
2407 || orf19.3508 || || || Putative protein of unknown function; stationary phase enriched protein || 1 0.51 0.36
2408 "|| orf19.1896 || SSC1 || || Heat shock protein; at yeast-form cell surface, not hyphae; antigenic; Gcn4-regulated; induced by amino acid starvation (3-AT) or by adherence to polystyrene; macrophage-repressed; sumoylation target; possibly essential ||" 1 0.36 0.19 0.26
2409 "|| orf19.3674 || GAL102 || || UDP-glucose 4,6-dehydratase; role in mannosylation of cell wall proteins; mutation confers hypersensitivity to toxic ergosterol analog; overlaps orf19.3673; Spider biofilm induced ||" 1 0.55 0.31 0.44
2410 || orf19.12608 || || || || 1 0.10 0.08
2411 || orf19.843 || || || Putative DNA repair exonuclease; fungal-specific (no human or murine homolog) || 1 0.32 0.30 0.24
2412 || orf19.4763 || || || Protein of unknown function; possibly membrane bound; mutants are viable; rat catheter biofilm repressed || 1 0.21 0.17 0.16
2413 || orf19.5544 || SAC6 || || Fimbrin; actin filament bundling protein; transcript regulated by Nrg1 and Mig1; protein level decreases in stationary phase || 1 0.63 0.49 0.51
2414 || orf19.1051 || HTA2 || || Putative histone H2A; farnesol regulated; rat catheter biofilm repressed; Spider biofilm repressed; Hap43-induced || 1 0.55 0.39 0.43
2415 "|| orf19.3518 || || || Ortholog(s) have dicarboxylic acid transmembrane transporter activity, role in mitochondrial transport and mitochondrial inner membrane localization ||" 1 0.30 0.21 0.28
2416 || orf19.6608 || || || Predicted DDE superfamily endonuclease domain; repression correlates with clinical development of fluconazole resistance; Spider biofilm induced || 1 0.31 0.19 0.27
2417 "|| orf19.2755 || || || Ortholog(s) have role in proteasomal ubiquitin-independent protein catabolic process, proteasome-mediated ubiquitin-dependent protein catabolic process and cytosol, nucleus, proteasome core complex, beta-subunit complex localization ||" 1 0.21 0.12 0.21
2418 || orf19.4602 || MDH1-1 || || Predicted malate dehydrogenase precursor; macrophage-induced transcript; protein present in exponential and stationary growth phase yeast cultures; Spider biofilm repressed || 1 0.63 0.34 0.68
2419 "|| orf19.3446 || || || Ortholog(s) have Ran GTPase binding activity, role in protein import into nucleus and nucleus localization ||" 1 0.05 0.05
2420 "|| orf19.5521 || ISA1 || || Putative mitochondrial iron-sulfur protein; alkaline repressed; induced in high iron; regulated by Sef1, Sfu1, Hap43; Spider biofilm induced ||" 1 0.21 0.06 0.22
2421 || orf19.7428 || APN1 || || Ortholog of S. cerevisiae Apn1; an AP endonuclease; transcript induced by interaction with macrophages; fungal-specific (no human or murine homolog) || 1 0.28 0.15 0.48
2422 || orf19.1970 || || || Putative vacuole biogenesis protein || 1 0.06 0.11
2423 "|| orf19.7060 || || || Ortholog of C. dubliniensis CD36 : Cd36_70070, C. parapsilosis CDC317 : CPAR2_301080, Debaryomyces hansenii CBS767 : DEHA2F22946g and Pichia stipitis Pignal : PICST_46820 ||" 1 0.28 0.18 0.47
2424 || orf19.2956 || MGM101 || || Putative mitochondrial genome maintenance protein; fungal-specific (no human or murine homolog); mutation confers hypersensitivity to tubercidin (7-deazaadenosine) || 1 0.12 0.20
2425 || orf19.11075 || RPT6 || || || 1 0.14 0.07 0.23
2426 || orf19.13821 || || || || 1 0.06 0.11
2427 "|| CaalfMp04 || COX3A || || Subunit III of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; identical to Cox3Bp; one of three mitochondrially-encoded subunits ||" 1 0.38 0.29 0.60
2428 "|| orf19.7314 || CDG1 || || Putative cysteine dioxygenases; role in conversion of cysteine to sulfite; transcript regulated upon white-opaque switch; rat catheter, Spider and flow model biofilm induced ||" 1 0.40 0.25 0.55
2429 "|| orf19.6724 || FUM12 || || Putative fumarate hydratase; enzyme of citric acid cycle; fluconazole, Efg1 repressed; induced in high iron; protein present in exponential and stationary growth phase ||" 1 0.32 0.29 0.42
2430 || orf19.9015 || || || || 1 0.10 0.13
2431 || orf19.3263 || ATO10 || || Putative fungal-specific transmembrane protein; rat catheter and Spider biofilm induced || 1 0.58 0.22 0.75
2432 || orf19.4811 || || || Putative tricarboxylate carrier family protein; localized to the mitochondrial membrane || 1 0.03 0.04
2433 || orf19.6559 || || || RNA polymerase III transcription initiation factor complex (TFIIIC) subunit; growth phase regulated protein; downregulaated in stationary phase yeast cultures; Hap43-repressed; flow model biofilm induced; Spider biofilm repressed || 1 0.21 0.18 0.25
2434 || orf19.9791 || AAH1 || || || 1 0.17 0.16 0.17
2435 || orf19.5546 || || || Predicted ORF from Assembly 19; merged with orf19.5544 in Assembly 20; protein level decreased in stationary phase cultures || 1 0.45 0.47 0.53
2436 "|| orf19.6305 || || || Hydroxytrimethyllysine aldolase, the second enzyme in the carnitine biosynthesis pathway; rat catheter biofilm repressed ||" 1 0.26 0.30 0.32
2437 || orf19.2580 || HST2 || || Putative histone deacetylase; role in regulation of white-opaque switch; Spider biofilm induced || 1 0.33 0.38 0.42
2438 || orf19.11009 || HGT15 || || || 1 0.17 0.21 0.27
2439 || orf19.5577 || || || Predicted ORF from Assembly 19; merged with orf19.5576 in Assembly 20 || 1 0.19 0.13 0.17
2440 || orf19.2610 || || || Putative tRNA binding protein; intron-containing gene; Spider biofilm induced || 1 1.01 0.88
2441 || orf19.6568 || SMC6 || || Putative structural maintenance of chromosomes (SMC) protein; Hap43-induced; cell-cycle regulated periodic mRNA expression; S. cerevisiae ortholog not cell-cycle regulated; Spider biofilm induced || 1 0.32 0.08 0.28
2442 || orf19.6557 || || || Protein with a predicted fatty acid amide hydrolase I domain; induced by Mnl1 under weak acid stress || 1 0.30 0.06 0.24
2443 || orf19.1140 || || || Protein of unknown function; Spider biofilm repressed || 1 0.23 0.18
2444 "|| orf19.4436 || GPX3 || || Putative glutathione peroxidase involved in Cap1p-dependent oxidative stress response, required for Cap1p oxidation in response to H2O2; planktonic growth-induced ||" 1 0.48 0.06 0.38
2445 "|| orf19.2110 || || || Ortholog(s) have arginyltransferase activity, role in protein arginylation and cytosol, nucleus localization ||" 1 0.41 0.05 0.32
2446 || orf19.3127 || CZF1 || || Transcription factor; regulates white-opaque switch; hyphal growth regulator; expression in S. cerevisiae causes dominant-negative inhibition of pheromone response; required for yeast cell adherence to silicone; Spider biofilm induced || 1 0.41 0.09 0.27
2447 || orf19.7868 || CCP1 || || || 1 0.65 0.23 0.50
2448 "|| orf19.778 || PIL1 || || Eisosome component; predicted role in endocytosis; echinocandin-binding protein; localizes to cell surface of hyphae, but not yeast-form cells; Hap43, YNB biofilm induced; rat catheter biofilm repressed ||" 1 0.48 0.13 0.47
2449 "|| orf19.2792 || IST2 || || Ortholog(s) have lipid binding activity, role in endoplasmic reticulum membrane organization, regulation of phosphatidylinositol dephosphorylation and cellular bud membrane, cortical endoplasmic reticulum localization ||" 1 0.35 0.36
2450 "|| orf19.7619 || || || Protein with a mitochondrial distribution and morphology domain; possibly an essential gene, disruptants not obtained by UAU1 method; rat catheter and Spider biofilm induced ||" 1 0.76 0.15 0.78
2451 "|| orf19.3237 || || || Ortholog(s) have cytosol, mitochondrion, nucleus localization ||" 1 0.14 0.16
2452 || orf19.10177 || RMS1 || || || 1 0.18 0.20
2453 || orf19.3836 || || || Ortholog(s) have cytoplasm localization || 1 0.09 0.10
2454 "|| orf19.4317 || GRE3 || || Putative D-xylose reductase; antigenic in murine systemic infection; soluble protein in hyphae; induced by farnesol, macrophage interaction and by Mnl1 under weak acid stress; stationary-phase enriched protein; Spider biofilm induced ||" 1 0.44 0.07 0.50
2455 "|| orf19.5890 || || || Ortholog of C. dubliniensis CD36 : Cd36_84350, C. parapsilosis CDC317 : CPAR2_806070, Candida tenuis NRRL Y-1498 : CANTEDRAFT_133308 and Debaryomyces hansenii CBS767 : DEHA2F11682g ||" 1 0.17 0.21
2456 "|| CaalfMp09 || NAD2 || || Subunit 2 of NADH:ubiquinone oxidoreductase (NADH:ubiquinone dehydrogenase), a multisubunit enzyme complex (complex I) of the mitochondrial inner membrane that catalyzes the first step in mitochondrial respiration ||" 1 0.22 0.08 0.26
2457 || orf19.3696 || TOM22 || || Putative mitochondrial import receptor subunit; colony morphology-related gene regulation by Ssn6 || 1 0.11 0.03 0.14
2458 "|| orf19.6498 || || || Ortholog(s) have role in RNA polymerase II complex localization to nucleus, RNA polymerase III complex localization to nucleus and DNA-directed RNA polymerase II, holoenzyme, cytoplasm localization ||" 1 0.19 0.23
2459 || orf19.526 || NHP2 || || Putative H/ACA snoRNP protein; macrophage/pseudohyphal-induced || 1 0.15 0.03 0.18
2460 "|| orf19.4833 || MLS1 || || Malate synthase; glyoxylate cycle enzyme; no mammalian homolog; regulated upon white-opaque switch; phagocytosis, strong oxidative stress induced; stationary phase enriched; flow model biofilm repressed; rat catheter, Spider biofilm induced ||" 1 0.52 0.06 0.52
2461 || orf19.5815 || SCT2 || || Putative glycerol-3-phosphate acyltransferase; fungal-specific (no human or murine homolog) || 1 0.31 -0.07 0.22
2462 "|| orf19.5629 || QCR7 || || Putative ubiquinol-cytochrome-c reductase, subunit 7; Hap43p-repressed gene ||" 1 0.34 -0.07 0.26
2463 "|| orf19.6156 || || || Ortholog of S. cerevisiae : AIM11, C. glabrata CBS138 : CAGL0I04928g, C. dubliniensis CD36 : Cd36_80770, C. parapsilosis CDC317 : CPAR2_102260 and Candida tenuis NRRL Y-1498 : CANTEDRAFT_114262 ||" 1 0.61 -0.12 0.50
2464 "|| orf19.3340 || SOD2 || || Mitochondrial Mn-containing superoxide dismutase; protection against oxidative stress; homotetramer active; N-terminal 34 amino acids removed on mitochondrial import; H2O2-induced via Cap1p; Hap43p-, alkaline-downregulated, farnesol-induced ||" 1 0.27 -0.05 0.21
2465 || orf19.6211 || || || Protein of unknown function; protein newly produced during adaptation to the serum || 1 0.46 -0.06 0.36
2466 "|| orf19.3859 || || || Putative microsomal beta-keto-reductase; transcript upregulated by treatment with ciclopirox olamine; induced by alpha pheromone in SpiderM medium; regulated by Sef1, Sfu1, and Hap43 ||" 1 0.34 0.27
2467 || orf19.4195.1 || FCA1 || || Cytosine deaminase; enzyme of pyrimidine salvage; functional homolog of S. cerevisiae Fcy1p; mutation is associated with resistance to flucytosine (5-FC) in a clinical isolate; hyphal downregulated; gene has intron || 1 0.21 -0.03 0.15
2468 || orf19.3713 || || || Protein of unknown function; flow model biofilm induced; Spider biofilm induced; induced by Mnl1 under weak acid stress; transcript detected in high-resolution tiling arrays || 1 -0.08 0.20
2469 "|| orf19.2172 || ARA1 || || D-Arabinose dehydrogenase; dehydro-D-arabinono-1,4-lactone synthesis; active on D-arabinose, L-fucose, L-xylose, L-galactose; inhibited by metal ions, thiol group-specific reagents; induced on polystyrene adherence; Spider biofilm induced ||" 1 0.54 0.55
2470 || orf19.4371 || TAL1 || || Transaldolase; protein present in exponential and stationary growth phase yeast cultures; oxidative stress-induced via Cap1; induced by nitric oxide independent of Yhb1p; sumoylation target; rat catheter biofilm repressed || 1 0.52 -0.05 0.43
2471 || orf19.4531 || || || Putative PDR-subfamily ABC transporter; Spider biofilm induced || 1 0.43 -0.01 0.33
2472 "|| orf19.6556 || || || Protein of unknown function; rat catheter, flow model and Spider biofilm induced ||" 1 0.41 0.04 0.26
2473 || orf19.4886 || || || Putative adhesin-like protein; Hap43-repressed; rat catheter and Spider biofilm induced || 1 0.61 0.38
2474 "|| orf19.4827 || ADE12 || || Adenylosuccinate synthase; upregulated in biofilm; decreased expression in hyphae vs yeast-form cells; not induced during GCN response, in contrast to S. cerevisiae ADE12, which is induced by Gcn4p; stationary phase-enriched protein ||" 1 0.20 0.01 0.13
2475 || orf19.4468 || || || Putative succinate dehydrogenase; localized to the mitochondrial membrane; Hap43p-repressed gene || 1 0.41 -0.01 0.20
2476 "|| orf19.6854 || ATP1 || || ATP synthase alpha subunit; antigenic in human/mouse; at hyphal surface; ciclopirox, ketoconazole, flucytosine induced; Efg1, caspofungin repressed; may be essential; sumoylation target; stationary phase-enriched; Spider biofilm repressed ||" 1 0.33 -0.01 0.13
2477 || orf19.8656 || || || || 1 0.22 -0.00 0.07
2478 || orf19.7873 || OXR1 || || || 1 0.31 0.12
2479 || orf19.1653 || || || Has domain(s) with predicted integral to membrane localization || 1 0.15 -0.03 0.06
2480 "|| orf19.4082 || DDR48 || || Immunogenic stress-associated protein; filamentation regulated; induced by benomyl/caspofungin/ketoconazole or in azole-resistant strain; Hog1, farnesol, alkaline repressed; stationary phase enriched; Spider, flow model biofilm induced ||" 1 0.56 -0.25 0.70
2481 || orf19.2079 || PHHB || || Putative 4a-hydroxytetrahydrobiopterin dehydratase; transposon mutation affects filamentous growth; flow model biofilm induced; Spider biofilm induced || 1 0.49 -0.19 0.62
2482 "|| orf19.5112 || TKL1 || || Putative transketolase; localizes to surface of yeast cells, not hyphae; soluble protein in hyphae; transcript regulated by Nrg1, Mig1, and Tup1; antigenic in human or murine infection; possibly essential (by UAU1 method) ||" 1 0.56 -0.17 0.78
2483 "|| orf19.2762 || AHP1 || || Alkyl hydroperoxide reductase; immunogenic; fluconazole-induced; amphotericin B, caspofungin, alkaline repressed; core stress response induced; Ssk1/Nrg1/Tup1/Ssn6/Hog1 regulated; flow model biofilm induced; rat catheter biofilm repressed ||" 1 0.34 -0.07 0.45
2484 "|| orf19.1637 || || || Ortholog(s) have cytosol, nucleus localization ||" 1 0.11 0.14
2485 "|| orf19.7610 || PTP3 || || Putative protein tyrosine phosphatase; hypha induced; alkaline induced; regulated by Efg1, Ras1, cAMP pathways; mutants are viable; Spider biofilm induced; rat catheter biofilm repressed; flow model biofilm repressed ||" 1 0.26 -0.05 0.33
2486 || orf19.4800 || RIM20 || || Protein involved in the pH response pathway; binds to the transcription factor Rim101 and may serve as a scaffold to facilitate the C-terminal proteolytic cleavage that activates Rim101; required for alkaline pH-induced hyphal growth || 1 0.26 0.29
2487 || orf19.5686 || || || Protein of unknown function; Spider biofilm induced || 1 0.47 -0.10 0.51
2488 "|| orf19.1862 || || || Possible stress protein; increased transcription associated with CDR1 and CDR2 overexpression or fluphenazine treatment; regulated by Sfu1, Nrg1, Tup1; stationary phase enriched protein; Spider biofilm induced ||" 1 0.52 -0.05 0.54
2489 "|| orf19.7481 || MDH1 || || Mitochondrial malate dehydrogenase; regulated by Mig1, Tup1, white-opaque switch, phagocytosis; induced in high iron; antigenic during murine and human infection; repressed in Spider biofilms by Bcr1, Tec1, Ndt80, Rob1, Brg1 ||" 1 0.43 -0.01 0.49
2490 || orf19.7297 || || || Putative cystathionine gamma-synthase; decreased levels in stationary phase cultures; Hog1p-induced; Gcn4p-regulated || 1 0.40 -0.01 0.49
2491 || orf19.11284 || MNN22 || || || 1 0.13 -0.01 0.16
2492 || orf19.2611 || MCM6 || || Putative MCM DNA replication initiation complex component; mRNA expression peak at cell-cycle M/G1 phase; regulated by tyrosol and cell density; repressed by alpha pheromone in SpiderM medium; Hap43-induced gene || 1 0.30 -0.03 0.40
2493 "|| orf19.5275 || || || Ortholog(s) have ATPase activator activity, role in late endosome to vacuole transport via multivesicular body sorting pathway, positive regulation of protein oligomerization and endosome membrane, multivesicular body localization ||" 1 0.17 0.23
2494 "|| orf19.5502 || || || Ortholog of C. dubliniensis CD36 : Cd36_73420, Debaryomyces hansenii CBS767 : DEHA2A05456g, Pichia stipitis Pignal : PICST_30999 and Candida guilliermondii ATCC 6260 : PGUG_00155 ||" 1 0.37 -0.04 0.55
2495 || orf19.285 || || || Ortholog of S. cerevisiae Igo2; role in mRNA stabilization of mRNA; Spider biofilm induced || 1 0.52 -0.05 0.89
2496 "|| orf19.6489 || FMP45 || || Predicted membrane protein induced during mating; mutation confers hypersensitivity to toxic ergosterol analog, to amphotericin B; alkaline repressed; repressed by alpha pheromone in SpiderM medium; rat catheter, Spider biofilm induced ||" 1 0.33 -0.08 0.60
2497 "|| orf19.6979 || || || Ortholog(s) have role in cellular manganese ion homeostasis, mitochondrion organization and fungal-type vacuole membrane localization ||" 1 0.25 -0.08 0.44
2498 "|| orf19.6634 || VMA2 || || Vacuolar H(+)-ATPase; protein present in exponential and stationary growth phase yeast cultures; plasma membrane localized; amphotericin B repressed, caspofungin repressed ||" 1 0.16 -0.07 0.32
2499 || orf19.6672 || MDJ1 || || Putative member of the HSP40 (DnaJ) family of chaperones; rat catheter and Spider biofilm induced || 1 0.16 -0.09 0.35
2500 || orf19.2304 || || || Protein similar to S. cerevisiae Gvp36p; transposon mutation affects filamentous growth || 1 0.05 0.10
2501 "|| orf19.6606 || || || Ortholog of C. parapsilosis CDC317 : CPAR2_201040, Candida tenuis NRRL Y-1498 : CANTEDRAFT_112677, Debaryomyces hansenii CBS767 : DEHA2E02420g and Pichia stipitis Pignal : PICST_37559 ||" 1 0.31 -0.09 0.63
2502 || orf19.286 || || || Has a predicted autophagy-related protein domain; transcription repressed by fluphenazine treatment || 1 0.44 -0.14 0.96
2503 "|| orf19.4340 || || || Ortholog of C. dubliniensis CD36 : Cd36_52890, C. parapsilosis CDC317 : CPAR2_501970, Candida tenuis NRRL Y-1498 : CANTEDRAFT_113546 and Debaryomyces hansenii CBS767 : DEHA2E09900g ||" 1 0.11 0.24
2504 || orf19.4860 || || || Predicted ORF from Assembly 19; merged with orf19.4858 in Assembly 20 || 1 -0.03 0.03
2505 "|| CaalfMp02 || NAD6 || || Subunit 6 of NADH:ubiquinone oxidoreductase (NADH:ubiquinone dehydrogenase), a multisubunit enzyme complex (complex I) of the mitochondrial inner membrane that catalyzes the first step in mitochondrial respiration ||" 1 0.05 0.21
2506 || orf19.6582 || PRE10 || || Alpha7 (C8) subunit of the 20S proteasome; multiple phosphorylated residues; transcript induced upon filamentous growth; Spider biofilm repressed || 1 0.18 -0.06 0.56
2507 || orf19.4920 || || || Predicted ORF from Assembly 19; merged with orf19.4919 in Assembly 20 || 1 0.09 0.27
2508 "|| orf19.6578 || || || Predicted membrane transporter; vesicular neurotransmitter (VNT) family, major facilitator superfamily (MFS); repressed in core caspofungin response; induced in oralpharyngeal candidasis; Spider biofilm induced ||" 1 0.20 -0.13 0.61
2509 || orf19.6580 || || || Protein of unknown function; Spider biofilm induced || 1 0.18 -0.12 0.54
2510 "|| orf19.4888 || || || Has domain(s) with predicted nucleic acid binding, nucleotide binding activity ||" 1 0.18 -0.09 0.48
2511 || orf19.2173 || MAF1 || || Putative negative regulator of RNA polymerase III; decreased expression in hyphae vs yeast cells; caspofungin repressed; Spider biofilm repressed || 1 0.27 -0.24 0.79
2512 || orf19.2524 || MGE1 || || Putative mitochondrial matrix cochaperone; macrophage/pseudohyphal-repressed || 1 0.15 -0.13 0.37
2513 "|| orf19.400 || GCF1 || || HMG box mitochondrial protein; binds to mt DNA and the HWP1 promoter; mutant phenotype and functional complementation of an S. cerevisiae abf2 mutation suggest role in mt genome replication, maintenance; flow and Spider biofilm repressed ||" 1 0.07 -0.08 0.13
2514 || orf19.11873 || || || || 1 0.23 0.44
2515 "|| CaalfMp13 || NAD5 || || Subunit 5 of NADH:ubiquinone oxidoreductase (NADH:ubiquinone dehydrogenase), a multisubunit enzyme complex (complex I) of the mitochondrial inner membrane that catalyzes the first step in mitochondrial respiration ||" 1 0.35 -0.32 0.67
2516 || orf19.12521 || || || || 1 0.19 -0.15 0.34
2517 || orf19.5089 || TERT || || Telomerase reverse transcriptase; catalytic protein subunit of telomere synthesis; essential for telomerase activity; has telomerase-specific motif T and other conserved reverse transcriptase motifs || 1 0.52 -0.32 0.76
2518 "|| orf19.6105 || MVD || || Mevalonate diphosphate decarboxylase; functional homolog of S. cerevisiae Erg19; possible drug target; regulated by carbon source, yeast-hypha switch, growth phase, antifungals; gene has intron; rat catheter, Spider biofilm repressed ||" 1 0.46 -0.26 0.76
2519 "|| orf19.4127 || || || Ortholog(s) have actin filament binding activity, role in actin cortical patch localization, actin filament bundle assembly, endocytosis and actin cortical patch localization ||" 1 0.19 -0.14 0.34
2520 "|| orf19.2093 || RFA1 || || Putative DNA replication factor A; RNA abundance regulated by cell cycle, tyrosol and cell density ||" 1 0.82 1.34
2521 || orf19.5666 || || || Ortholog(s) have transcription coactivator activity || 1 0.29 0.46
2522 || orf19.1546 || || || Membrane-localized protein of unknown function || 1 0.09 -0.28 0.15
2523 || orf19.4897 || SFH5 || || Putative phosphatidylinositol transporter; rat catheter and Spider biofilm repressed || 1 0.20 0.26
2524 || orf19.2988 || || || Predicted aminotransferase based on S. pombe ortholog SPBC660.12c; flow model biofilm induced || 1 0.12 -0.10 0.15
2525 "|| CaalfMp06 || ATP6 || || Subunit 6 of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis ||" 1 0.09 -0.11 0.26
2526 || orf19.5419 || ATP5 || || Putative F0-ATP synthase FO subunit B; caspofungin repressed; protein level decreased in stationary phase yeast cultures; Spider biofilm repressed || 1 0.08 -0.13 0.32
2527 "|| orf19.2613 || ECM4 || || Cytoplasmic glutathione S-transferase; regulated by Nrg1, Tup1; induced in core stress response, in cyr1 or ras1 mutant (yeast or hyphal cells); Tn mutation affects filamentous growth; stationary phase enriched; Spider biofilm induced ||" 1 0.16 -0.24 0.61
2528 || orf19.3319 || || || Putative thioredoxin; Spider biofilm repressed || 1 0.11 0.41
2529 "|| orf19.6078 || POL93 || || Predicted ORF in retrotransposon Tca8 with similarity to the Pol region of retrotransposons encoding reverse transcriptase, protease and integrase; downregulated in response to ciclopirox olamine; F-12/CO2 early biofilm induced ||" 1 0.05 -0.11 0.18
2530 || orf19.8326 || APG7 || || || 1 0.10 0.19
2531 || orf19.288 || MET13 || || Putative methionine biosynthesis protein; ketoconazole-induced; amphotericin B repressed; Spider biofilm repressed || 1 0.01 -0.09
2532 "|| orf19.4778 || LYS142 || || Zn(II)2Cys6 transcription factor; has similarity to S. cerevisiae Lys14, involved in the regulation of lysine biosynthesis genes; fungal-specific ||" 1 0.09 0.09
2533 || orf19.7348 || || || Ortholog of Candida albicans WO-1 : CAWG_02878 || 1 -0.10 0.77
2534 "|| orf19.1480 || || || Putative succinate dehydrogenase; enzyme of citric acid cycle; repressed by nitric oxide; Efg1, Hap43 repressed ||" 1 0.05 -0.09 0.31
2535 "|| orf19.3881 || || || Ortholog of C. dubliniensis CD36 : Cd36_31790, C. parapsilosis CDC317 : CPAR2_204900, Candida tenuis NRRL Y-1498 : CANTEDRAFT_136864 and Debaryomyces hansenii CBS767 : DEHA2F13200g ||" 1 0.04 -0.13 0.48
2536 || orf19.6792 || RRD1 || || Putative peptidyl-prolyl cis/trans-isomerase; caspofungin induced || 1 0.07 -0.01 0.21
2537 "|| orf19.753 || MNN15 || || Putative alpha-1,3-mannosyltransferase; predicted role in protein O-linked glycosylation; Spider biofilm induced ||" 1 0.11 0.04 0.27
2538 || orf19.1433 || || || Protein of unknown function; Hap43-repressed; colony morphology-related gene regulation by Ssn6; Spider biofilm induced || 1 0.22 0.08 0.49
2539 || orf19.2522 || || || Predicted ORF from Assembly 19; merged with orf19.2521 in Assembly 20 || 1 0.12 0.28
2540 "|| orf19.3548.1 || WH11 || || White-phase yeast transcript; expression in opaques increases virulence/switching; mutant switches as WT; Hap43, hypoxia, ketoconazol induced; required for RPMI biofilm; Bcr1-induced in RPMI a/a biofilm; rat catheter, Spider biofilm induced ||" 1 0.71 0.14 1.65
2541 "|| orf19.1331 || HSM3 || || Ortholog(s) have role in mismatch repair, proteasome regulatory particle assembly and cytosol, nucleus, proteasome regulatory particle, base subcomplex localization ||" 1 0.29 0.03 0.64
2542 "|| orf19.6623 || || || Ortholog(s) have RNA polymerase II core binding activity, role in regulation of transcription by chromatin organization, transcription elongation from RNA polymerase II promoter and transcription elongation factor complex localization ||" 1 0.12 0.29
2543 || orf19.4722 || RTG1 || || Ortholog(s) have sequence-specific DNA binding RNA polymerase II transcription factor activity || 1 0.11 0.28
2544 "|| orf19.7483 || CRM1 || || Functional homolog of S. cerevisiae Crm1, which acts in protein nuclear export; predicted to be resistant to antifungal drug leptomycin B; partially suppresses signal transduction defects of S. cerevisiae ste20 mutant ||" 1 0.22 0.02 0.53
2545 || orf19.6492 || || || Predicted protein serine/threonine kinase and/or protein tyrosine kinase; Spider biofilm induced || 1 0.10 -0.01 0.22
2546 || orf19.3679 || || || Putative protein of unknown function; stationary phase enriched protein || 1 0.28 0.58
2547 "|| orf19.7073 || || || Ortholog of S. cerevisiae : YCL002C, C. glabrata CBS138 : CAGL0B04719g, C. dubliniensis CD36 : Cd36_70180, C. parapsilosis CDC317 : CPAR2_805360 and Candida tenuis NRRL Y-1498 : cten_CGOB_00114 ||" 1 0.26 0.01 0.54
2548 "|| orf19.6160 || || || Ortholog(s) have role in eisosome assembly and eisosome, membrane raft, mitochondrion, plasma membrane localization ||" 1 0.37 0.07 0.66
2549 || orf19.12020 || SWI4 || || || 1 0.63 1.06
2550 "|| orf19.5825 || NCB2 || || Beta subunit of NC2, heterodimeric regulator of transcription; activates CDR1 transcription; possibly an essential gene, disruptants not obtained by UAU1 method; conditional mutants show decreased susceptibility to azoles ||" 1 0.13 0.03 0.22
2551 "|| orf19.5489 || || || Ortholog of C. dubliniensis CD36 : Cd36_20660, C. parapsilosis CDC317 : CPAR2_104730, Candida tenuis NRRL Y-1498 : CANTEDRAFT_133951 and Debaryomyces hansenii CBS767 : DEHA2F02068g ||" 1 0.48 0.30 1.12
2552 || orf19.6517 || RAD14 || || Putative DNA repair protein; transcription is regulated upon yeast-hyphal switch; flucytosine repressed || 1 0.13 0.05 0.43
2553 || orf19.350 || PRE9 || || Alpha3 (C9) subunit of the 20S proteasome; transcript regulated by Mig1; flow model biofilm repressed || 1 0.12 0.06 0.45
2554 "|| orf19.6863 || VPH1 || || Vacuolar H(+)-ATPase; transcription regulated by Nrg1, Mig1, and Tup1 ||" 1 0.09 0.40
2555 || orf19.11090 || || || || 1 0.06 0.24
2556 "|| orf19.5006 || GCV3 || || Glycine decarboxylase, subunit H; protein level decrease in stationary phase cultures ||" 1 0.04 0.03 0.16
2557 || orf19.12259 || || || || 1 0.09 0.13 0.44
2558 || orf19.6507 || || || Putative curved DNA-binding protein orthologous to S. pombe Cdb4; stationary phase enriched protein; rat catheter and Spider biofilm repressed || 1 0.09 0.08 0.60
2559 || orf19.3963 || || || Ortholog(s) have mitochondrion localization || 1 0.02 0.16
2560 "|| orf19.1451 || SRB9 || || Subunit of the RNA polymerase II mediator complex; transposon mutation affects filamentous growth; suppresses S. cerevisiae diploid filamentous (flo8, ste7, ste12, tec1) or haploid invasive (flo8) mutant growth defects ||" 1 0.05 0.06 0.40
2561 "|| orf19.4893 || || || Ortholog of C. dubliniensis CD36 : Cd36_09630, C. parapsilosis CDC317 : CPAR2_805080, Candida tenuis NRRL Y-1498 : CANTEDRAFT_136811 and Debaryomyces hansenii CBS767 : DEHA2B12364g ||" 1 0.04 0.36
2562 || orf19.12435 || || || || 1 0.03 0.29
2563 || orf19.10201 || || || || 1 0.03 0.05 0.39
2564 || orf19.1564 || || || Plasma membrane-localized protein of unknown function || 1 0.16 -0.31 0.46
2565 || orf19.6553 || || || Membrane-localized protein of unknown function; possibly secreted; fluconazole-induced || 1 0.15 -0.22 0.26
2566 || orf19.2285 || || || Protein of unknown function; transcription induced by benomyl treatment || 1 0.19 -0.26 0.36
2567 || orf19.2353 || || || Predicted ORF from Assembly 19; merged with orf19.1840 in Assembly 20 || 1 0.31 -0.35 0.51
2568 || orf19.3630 || RRP8 || || Ribosomal protein; Hap43-induced; F-12/CO2 early biofilm and rat catheter biofilm induced || 1 0.09 -0.10 0.14
2569 || orf19.1785 || || || Protein with a PI31 proteasome regulator domain; Hap43-repressed; flow model biofilm induced || 1 0.34 -0.22 0.29
2570 || orf19.7014 || || || Putative protein of unknown function; transcription is positively regulated by Tbf1p; overlaps orf19.7015 || 1 0.15 0.13
2571 || orf19.5192 || || || Predicted ORF from Assembly 19; removed from Assembly 20 || 1 0.34 -0.29 0.33
2572 "|| orf19.1742 || HEM3 || || Hydroxymethylbilane synthase; converts 4-porphobilinogen to hydroxymethylbilane in heme biosynthesis; induced in high iron, CO2; alkaline repressed; regulated by Sef1, Sfu1, and Hap43; rat catheter and Spider biofilm induced ||" 1 0.23 -0.20 0.22
2573 || orf19.1375 || LEU42 || || Putative alpha-isopropylmalate synthase; fungal-specific; induced by human blood or polymorphonuclear cells; regulated by Gcn2 and Gcn4; stationary phase enriched protein; Spider biofilm induced || 1 0.21 -0.23 0.18
2574 || orf19.3476 || HRR25 || || Predicted protein serine/threonine kinase; Spider biofilm induced || 1 0.12 -0.17 0.11
2575 || orf19.7201 || SLA2 || || Actin binding protein with roles in growth control and morphogenesis; required for alkaline pH-induced hyphal formation; localized to actin patches; rat catheter biofilm repressed || 1 0.06 -0.08 0.04
2576 "|| orf19.610 || EFG1 || || bHLH transcription factor; required for white-phase cell type, RPMI and Spider biofilm formation, hyphal growth, cell-wall gene regulation; roles in adhesion, virulence; Cph1 and Efg1 have role in host cytokine response; binds E-box ||" 1 0.05 -0.08 0.05
2577 || orf19.6047 || TUF1 || || Translation elongation factor TU; macrophage/pseudohyphal-induced; repressed upon phagocytosis by murine macrophage; levels decrease in stationary phase cells; Spider biofilm repressed || 1 0.12 -0.16 0.08
2578 "|| orf19.2849 || AQY1 || || Aquaporin water channel; osmotic shock resistance, WT freeze tolerance; virulent in mice; flucytosine repressed; flow model/RPMI/Spider/rat catheter biofilm induced; required for RPMI biofilm formation; Bcr1-induced in a/a RPMI biofilms ||" 1 0.22 -0.23 0.13
2579 "|| orf19.2407 || DPS1-1 || || Putative tRNA-Asp synthetase; genes encoding ribosomal subunits, translation factors, tRNA synthetases are downregulated upon phagocytosis by murine macrophage; protein enriched in stationary phase yeast cultures ||" 1 0.10 -0.08 0.06
2580 || orf19.6713 || || || Has domain(s) with predicted nucleic acid binding activity || 1 0.09 -0.15 0.12
2581 || orf19.7501 || || || Nucleosome assembly protein; protein present in exponential and stationary growth phase yeast cultures || 1 0.10 -0.20 0.15
2582 || orf19.7996 || || || || 1 0.11 -0.14 0.11
2583 || orf19.2966 || || || Predicted dienelactone hydrolase domain; clade-associated gene expression; farnesol-downregulated; rat catheter biofilm repressed || 1 0.48 0.51
2584 "|| orf19.7586 || CHT3 || || Major chitinase; secreted; functional homolog of S. cerevisiae Cts1p; 4 N-glycosylation motifs; possible O-mannosylation; putative signal peptide; hyphal-repressed; farnesol upregulated in biofilm; regulated by Efg1p, Cyr1p, Ras1p ||" 1 0.69 -0.31 0.67
2585 "|| orf19.4807 || || || Ortholog(s) have inorganic diphosphatase activity, role in aerobic respiration and mitochondrion localization ||" 1 0.30 0.28
2586 "|| orf19.3371 || JAB1 || || Component of the COP9 signalosome (CSN) complex, provides catalytic activity for deneddylation that cleaves the ubiquitin-like protein tag Rub1p off the cullin (Cdc53p) molecule ||" 1 0.22 0.20
2587 || orf19.3940.1 || CUP1 || || Metallothionein; involved in copper resistance; copper induced; Spider biofilm induced; flow model biofilm repressed || 1 0.81 -0.22 0.76
2588 "|| orf19.7450 || || || Ortholog(s) have role in cytokinesis, septin ring assembly and cellular bud neck septin ring localization ||" 1 0.15 0.14
2589 "|| orf19.1597 || ABG1 || || Vacuolar membrane protein; depletion causes abnormal vacuolar morphology, cell separation defect, sensitivity to cell wall stress, increased hyphal branching; essential, no mammalian homolog; Cyr1-regulated; rat catheter biofilm repressed ||" 1 0.13 -0.08 0.11
2590 "|| orf19.903 || GPM1 || || Phosphoglycerate mutase; surface protein that binds host complement Factor H and FHL-1; antigenic; fluconazole, or amino acid starvation (3-AT) induced, farnesol-repressed; Hap43, flow model biofilm induced; Spider biofilm repressed ||" 1 0.51 -0.32 0.43
2591 "|| orf19.4752 || MSN4 || || Zinc finger transcription factor; similar to S. cerevisiae Msn4, but not a significant stress response regulator in C. albicans; partly complements STRE-activation defect of S. cerevisiae msn2 msn4 double mutant; flow model biofilm induced ||" 1 0.09 -0.05 0.07
2592 || orf19.1707 || || || Ortholog of Candida albicans WO-1 : CAWG_02476 || 1 0.25 0.16
2593 || orf19.477 || || || Ortholog(s) have role in mitochondrial translation and mitochondrion localization || 1 0.35 0.23
2594 || orf19.11256 || || || || 1 0.07 -0.12 0.05
2595 "|| orf19.1221 || ALG2 || || Putative mannosyltransferase involved in cell wall mannan biosynthesis; transcription is elevated in chk1, nik1, and sln1 homozygous null mutants ||" 1 0.02 -0.05 -0.01
2596 "|| orf19.5168 || || || Ortholog(s) have role in maturation of SSU-rRNA and cytosol, nucleolus localization ||" 1 0.08 -0.06
2597 "|| CaalfMp14 || NAD4 || || Subunit 4 of NADH:ubiquinone oxidoreductase (NADH:ubiquinone dehydrogenase), a multisubunit enzyme complex (complex I) of the mitochondrial inner membrane that catalyzes the first step in mitochondrial respiration ||" 1 0.10 -0.13 -0.08
2598 || orf19.8870 || MEC1 || || || 1 0.14 -0.11
2599 || orf19.3133 || GUT2 || || Glycerol-3-phosphate dehydrogenase; Plc1p-regulated; rat catheter biofilm induced; Spider biofilm induced || 1 0.15 -0.16 -0.09
2600 "|| orf19.5105 || MED15 || || RNA polymerase II mediator complex subunit; possibly an essential gene, disruptants not obtained by UAU1 method ||" 1 0.37 -0.41 -0.17
2601 || orf19.5484 || SER1 || || Putative 3-phosphoserine aminotransferase; predicted role in serine and glycine biosynthesis; protein present in exponential and stationary yeast growth phases; Spider biofilm repressed || 1 0.67 -0.31
2602 "|| orf19.6591 || PCD1 || || Ortholog(s) have 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity, role in DNA repair and peroxisome localization ||" 1 0.29 -0.23 -0.09
2603 || orf19.12836 || || || || 1 0.23 -0.06
2604 || orf19.5956 || PIN3 || || Putative SH3-domain-containing protein; predicted role in actin cytoskeleton organization; Spider biofilm repressed || 1 0.23 -0.21 -0.06
2605 "|| orf19.4318 || MIG1 || || C2H2 transcription factor; repressor; regulates genes for carbon source utilization; Tup1-dependent and independent functions; hyphal, Hap43 and caspofungin repressed; Spider and flow model biofilm induced ||" 1 0.31 -0.21 -0.07
2606 || orf19.5113 || ADH2 || || Alcohol dehydrogenase; soluble in hyphae; expression regulated by white-opaque switching; regulated by Ssn6; indued by Mnl1 in weak acid stress; protein enriched in stationary phase yeast cultures; Spider biofilm induced || 1 0.73 -0.47 -0.19
2607 || orf19.13623 || || || || 1 0.41 -0.23 -0.09
2608 || orf19.6835 || || || Predicted ORF from Assembly 19; transcription is negatively regulated by Sfu1p; removed from Assembly 20 || 1 0.35 -0.20 -0.06
2609 "|| orf19.2308 || || || Putative 6-phosphofructo-2-kinase; catalyzes synthesis of fructose-2,6-bisphosphate; Hap43-repressed; flow model, rat catheter and Spider biofilm induced ||" 1 0.45 -0.18 -0.06
2610 "|| orf19.2551 || MET6 || || Essential 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase (cobalamin-independent methionine synthase); antigenic in murine/human systemic infection; heat shock, estrogen, GCN-induced; Spider biofilm repressed ||" 1 0.58 -0.20 0.20
2611 || orf19.2269 || || || Putative 3-phosphoserine phosphatase; induced by benomyl or in azole-resistant strain that overexpresses MDR1; early-stage flow model biofilm induced; Spider biofilm repressed || 1 0.33 0.11
2612 || orf19.3814 || || || Predicted ORF from Assembly 19; merged with orf19.3813 in Assembly 20 || 1 0.24 0.08
2613 || orf19.6604 || || || Ortholog of S. cerevisiae Pba1 that is involved in 20S proteasome assembly; upregulated in a cyr1 null mutant; contains a 5' UTR intron || 1 0.57 -0.25 0.19
2614 || orf19.12525 || SMI1 || || || 1 0.44 -0.20 0.07
2615 "|| orf19.4304 || GAP1 || || Amino acid permease; antigenic in human/mouse; 10-12 transmembrane regions; regulated by nitrogen source; alkaline, GlcNAc, phagocytosis induced; WT virulence in mice; Spider and flow model biofilm induced ||" 1 1.14 -0.40 0.06
2616 || orf19.327 || HTA3 || || Putative histone H2A; amphotericin B repressed; flucytosine induced; RNA abundance regulated by tyrosol and cell density; Spider biofilm repressed || 1 0.42 0.00
2617 "|| orf19.5100 || MLT1 || || Vacuolar membrane transporter; MRP subfamily of ABC family; may transport organic anions conjugated to glutathione, glucuronate, or sulfate; needed for virulence in mouse peritonitis; Spider biofilm induced; flow model biofilm repressed ||" 1 0.25 0.00
2618 || orf19.613 || || || Predicted ORF from Assembly 19; removed from Assembly 20 || 1 0.20 0.00
2619 "|| orf19.2458 || SIP5 || || Protein of unknown function; flow model, rat catheter and Spider biofilm induced ||" 1 0.19 -0.15 0.00
2620 "|| orf19.395 || ENO1 || || Enolase; glycolysis and gluconeogenesis; major cell-surface antigen; binds host plasmin/plasminogen; immunoprotective; Hap43, phagocytosis induced; farnesol-repressed; flow model biofilm induced; Spider biofilm repressed; may be essential ||" 1 1.24 -1.01 0.14
2621 "|| orf19.395 || ENO1 || || Enolase; glycolysis and gluconeogenesis; major cell-surface antigen; binds host plasmin/plasminogen; immunoprotective; Hap43, phagocytosis induced; farnesol-repressed; flow model biofilm induced; Spider biofilm repressed; may be essential ||" 1 1.29 -1.02 0.25
2622 || orf19.12160 || || || || 1 0.22 -0.17 0.06
2623 "|| orf19.5148 || CYR1 || || Class III adenylyl cyclase; mutant lacks cAMP; mutant hyphal growth defect rescued by exogenous cAMP; required for mouse mucosal or systemic infection; role in macrophage sensitivity, apoptosis; downstream of Ras1p and CO2 signaling ||" 1 0.11 -0.09 0.03
2624 "|| orf19.6079 || || || Predicted ORF in retrotransposon Tca8 with similarity to the Gag region encoding nucleocapsid-like protein; repressed by ciclopirox olamine; filament induced; regulated by Rfg1, Tup1; overlaps orf19.6078.1 ||" 1 0.25 -0.30 0.01
2625 "|| orf19.7551 || ALO1 || || D-Arabinono-1,4-lactone oxidase involved in biosynthesis of dehydro-D-arabinono-1,4-lactone, which has a protective role against oxidative damage; plasma membrane-localized;required for full virulence in a mouse model of systemic infection ||" 1 0.15 -0.24 0.03
2626 || orf19.3951 || TIP1 || || Protein with a predicted role in biogenesis of ER-derived COPII transport vesicles; mutation confers hypersensitivity to toxic ergosterol analog || 1 0.11 0.02
2627 || orf19.10847 || || || || 1 0.42 -0.47 0.08
2628 || orf19.8487 || ADAEC || || || 1 0.20 -0.23 0.06
2629 || orf19.3222 || || || Predicted vacuolar protein; rat catheter biofilm repressed; flow model biofilm repressed || 1 0.14 -0.20 0.06
2630 "|| orf19.4679 || AGP2 || || Amino acid permease; hyphal repressed; white-opaque switch regulated; induced in core caspofungin response, during cell wall regeneration, by flucytosine; regulated by Sef1, Sfu1, and Hap43; rat catheter and Spider biofilm induced ||" 1 0.57 -0.17 0.21
2631 "|| orf19.4123 || || || Putative THO complex subunit; possibly an essential gene, disruptants not obtained by UAU1 method; protein newly produced during adaptation to the serum ||" 1 0.17 -0.05 0.06
2632 || orf19.2461 || PRN4 || || Protein with similarity to pirins; induced by benomyl treatment; flow model biofilm repressed || 1 0.66 -0.16 0.21
2633 "|| orf19.5267 || || || Putative cell wall adhesin-like protein; repressed in core caspofungin response and by alpha pheromone in SpiderM medium; transcript reduced in ace2 mutant; flow model, rat catheter and Spider biofilm repressed ||" 1 0.19 -0.05 0.05
2634 || orf19.1820 || || || Predicted ORF from Assembly 19; removed from Assembly 20 || 1 0.59 0.15
2635 "|| orf19.5653 || ATP2 || || F1 beta subunit of F1F0 ATPase complex; antigenic in human, mice; induced by ciclopirox olamine; caspofungin repressed; macrophage/pseudohyphal-induced; detected during exponential and stationary growth phases; Spider biofilm repressed ||" 1 0.43 -0.08 0.11
2636 "|| orf19.3278 || GSY1 || || UDP glucose/starch glucosyltransferase; transcript repressed by yeast-hyphal switch, Efg1-regulated; strong oxidative stress induced; colony morphology-related regulation by Ssn6; stationary phase enriched; flow model biofilm induced ||" 1 0.42 -0.08 0.09
2637 || orf19.3302 || || || Putative type-1 protein phosphatase targeting subunit; transcript repressed by yeast-hyphal switch; transcript induced by Mnl1p under weak acid stress; flow model biofilm induced || 1 0.30 -0.06 0.04
2638 || orf19.1124 || || || Protein of unknown function; flow model biofilm induced; Spider biofilm induced || 1 0.53 -0.01 0.13
2639 || orf19.3767 || PEP1 || || Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between late-Golgi and prevacuolar endosome-like compartments; rat catheter biofilm repressed || 1 0.41 0.10
2640 "|| orf19.853 || SAP99 || || Putative secreted aspartyl protease; possible Kex2 substrate; induced by low iron; repressed by alpha pheromone in SpiderM medium; possibly essential (UAU1 method); regulated by Sef1, Sfu1, and Hap43; Spider biofilm induced ||" 1 0.44 0.10
2641 "|| orf19.5818 || SUR2 || || Putative ceramide hydroxylase; predicted enzyme of sphingolipid biosynthesis; regulated by Tsa1, Tsa1B under H2O2 stress conditions; Spider and flow model biofilm induced ||" 1 0.56 -0.02 0.08
2642 "|| orf19.5522 || || || Ortholog of C. dubliniensis CD36 : Cd36_62760, C. parapsilosis CDC317 : CPAR2_601700, Candida tenuis NRRL Y-1498 : CANTEDRAFT_115220 and Debaryomyces hansenii CBS767 : DEHA2A06666g ||" 1 0.16 0.02
2643 "|| orf19.3651 || PGK1 || || Phosphoglycerate kinase; localizes to cell wall and cytoplasm; antigenic in murine/human infection; flow model biofilm, Hog1-, Hap43-, GCN-induced; repressed upon phagocytosis; repressed in Spider biofilms by Bcr1, Ndt80, Rob1, Brg1 ||" 1 1.16 -0.00 0.14
2644 "|| orf19.5437 || RHR2 || || Glycerol 3-phosphatase; roles in osmotic tolerance, glycerol accumulation in response to salt; Spider/flow model biofilm induced; regulated by macrophage, stress, yeast-hyphal switch, pheromone, Gcn4, Hog1, Nrg1, Tup1 ||" 1 0.69 0.08 0.11
2645 || orf19.9249 || || || || 1 0.27 -0.01 -0.18
2646 || orf19.1830 || || || Protein of unknown function; Hap43-induced; rat catheter and Spider biofilm induced || 1 0.26 -0.06 -0.18
2647 "|| orf19.6000 || CDR1 || || Multidrug transporter of ABC superfamily; transports phospholipids in an in-to-out direction; induced by beta-estradiol, progesterone, corticosteroid, or cholesterol; Spider biofilm induced ||" 1 0.27 -0.05 -0.13
2648 || orf19.12175 || ARO1 || || || 1 0.12 -0.03 -0.06
2649 || orf19.740 || HAP41 || || Putative Hap4-like transcription factor; Hap43-repressed; not required for response to low iron; induced by Mnl1 under weak acid stress; Spider biofilm induced || 1 0.31 -0.09 -0.14
2650 || orf19.1485 || || || Mitochondrial ribosomal protein of the large subunit; rat catheter biofilm induced || 1 0.22 -0.05 -0.07
2651 || orf19.8292 || || || || 1 0.19 -0.12 -0.14
2652 "|| orf19.1280 || SUI1 || || Putative translation initiation factor; flucytosine induced; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage ||" 1 0.06 -0.05 -0.06
2653 || orf19.505 || SRV2 || || Adenylate cyclase-associated protein; regulates adenylate cyclase activity; required for wild-type germ tube formation and for virulence in mice; mutant defects in filamentous growth are rescued by cAMP or dbcAMP; Spider biofilm repressed || 1 0.14 -0.09 -0.18
2654 || orf19.12512 || || || || 1 0.22 -0.15 -0.27
2655 || orf19.3349 || || || Putative RNA polymerase II subunit B150; heterozygous null mutant exhibits resistance to parnafungin in the C. albicans fitness test || 1 0.15 -0.08 -0.14
2656 || orf19.3428 || || || Protein of unknown function; flow model biofilm induced || 1 0.26 -0.12 -0.25
2657 "|| orf19.7585 || INO1 || || Inositol-1-phosphate synthase; antigenic in human; repressed by farnesol in biofilm or by caspofungin; upstream inositol/choline regulatory element; glycosylation predicted; rat catheter, flow model induced; Spider biofilm repressed ||" 1 0.73 -0.20 -0.75
2658 "|| orf19.2709 || ZUO1 || || Ortholog of S. cerevisiae Zuo1; a cytosolic ribosome-associated chaperone; likely to be essential for growth, based on an insertional mutagenesis strategy; Spider biofilm repressed ||" 1 0.13 -0.03 -0.13
2659 || orf19.12135 || || || || 1 0.04 -0.01 -0.05
2660 || orf19.4784 || CRP1 || || Copper transporter; CPx P1-type ATPase; mediates Cu resistance; similar to Menkes and Wilson disease proteins; copper-induced; Tbf1-activated; suppresses Cu sensitivity of S. cerevisiae cup1 mutant; flow model biofilm induced || 1 0.09 -0.02 -0.12
2661 || orf19.5230 || MRPS9 || || Mitochondrial ribosomal protein S9; has N-terminal mitochondrial targeting signal and an S9 consensus motif; overexpression in S. cerevisiae causes respiratory defect that is reversible upon cessation of C. albicans gene expression || 1 0.17 -0.06 -0.24
2662 "|| orf19.789 || PYC2 || || Putative pyruvate carboxylase; binds biotin cofactor; repressed by Ssk1 response regulator, by benomyl treatment, or in an azole-resistant strain overexpressing MDR1; stationary phase enriched protein; flow model biofilm repressed ||" 1 0.20 -0.12 -0.32
2663 || orf19.2193 || PRS5 || || Putative 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; Hap43-induced; repressed during core stress response || 1 0.09 -0.14
2664 "|| orf19.909 || STP4 || || C2H2 transcription factor; induced in core caspofungin response; colony morphology-related gene regulation by Ssn6; induced by 17-beta-estradiol, ethynyl estradiol; rat catheter and Spider biofilm induced ||" 1 0.23 -0.07 -0.35
2665 || orf19.1053 || || || Ortholog(s) have phosphatidylinositol deacylase activity || 1 0.10 -0.15
2666 || orf19.930 || PET9 || || Mitochondrial ADP/ATP carrier protein involved in ATP biosynthesis; possible lipid raft component; 3 predicted transmembrane helices; flucytosine induced; ketoconazole-induced; downregulated by Efg1p || 1 0.01 -0.01 -0.02