Applications are sought for a Research Assistant during a period of 20
months (starting period: fall 2010) with Dr Mathias L. Richard at the
"Institut National de la Recherche Agronomique" to work on the
'Contribution of cell wall proteins to Candida albicans virulence'.
In the host laboratory, the applicant will be part of a team focusing
on the study of C. albicans cell surface proteins: the GPI-anchored
proteins. These proteins are targeted to the plasma membrane and the
cell wall of fungi. This surface localization and results from the
literature suggest that they play a critical role in sensing and
responding to extracellular signals, both biotic and abiotic. We
launched a systematic invalidation program of these genes and, based
on a preliminary phenotypic analysis of 47 mutants we identified 10
genes with potential phenotypes on the cell wall biosynthesis but also
during interaction with the host immune cells. The work of the student
will be to decipher in which mechanisms are involved these proteins,
with biochemical, cell culture and genetic approaches. He/She will
also be asked to perform experiments in the laboratories of other
member of the consortium.
The successful applicant will collaborate with other members of the
FINSysB Network which is dedicated to the 'Pathogenomics and
systems biology of fungal infections - an integrative
approach'.
Please send your application composed of a CV, a covering letter and
reference letters to Dr Mathias L. Richard
(mathias.lavie-richard@grignon.inra.fr).
More details available here.
Research Assistant at INRA, Paris, France (posted July 14, 2010)
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