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CGD Site Map

Contents:

Overview

The CGD site map provides a comprehensive listing of major CGD resources and tools. It is organized by the major categories available at CGD, which correspond to the links located on the left side of the home page. The resources and tools available in that category are listed, followed by a description of the resource and its primary use. A link to the help documentation is also provided, if it is available for that resource.

For more information on how to navigate around CGD, please read the Getting Started page.

Site map

Category Resource Description Primary Use Help Page
Search Options Quick Search and Text Search Search the CGD relational database, including literature guide, colleague information, protein information, and text. Search CGD database using keywords. help page
Advanced Search Find a chromosomal feature (e.g., gene, ORF, centromere) based on selected criteria (e.g., chromosome number, GO-Slim terms, etc.) Find chromosomal features that match specific properties or annotations. help page
Full-text Literature Search Customizable keyword searching of the full-text of over 16,500 Candida journal articles with Textpresso, a tool developed at Wormbase Search full-text of published papers about Candida. help page
Biochemical Pathway Search Search or browse pathway information in CGD, including pathways, reactions, enzymes, and chemical compounds. Find metabolic pathways and related information. help page
Expanded Phenotype Search Search the text of all phenotype information to find phenotypes of interest and view the genes associated with them. Enter keywords associated with a phenotype (e.g., 'hyphal', 'virulence') or experimental condition (e.g., 'Spider', 'mouse') to search for features with a specific phenotype. help page
Search CGD Web Pages Search CGD HTML pages, excludes the relational database. Find CGD web pages using keywords located on the page. help page
List of genome-wide analysis papers Link to a list of genome-wide analysis papers (e.g., microarray analysis publications) curated at CGD. Find CGD curated papers that analyze the entire genome. help page
Category Resource Description Primary Use Help Page
Help Resources Getting Started Common uses of CGD for the first time user. Get a brief overview of navigating around CGD.  
FAQ Answers to some of the most frequently asked questions about CGD. Get an answer to a commonly asked question.  
What's New in CGD Changes and additions to CGD resources. Find new resources at CGD and when they were added.  
SGD's Glossary List of terms and definitions at SGD. Find the definition of a new term.  
Category Resource Description Primary Use Help Page
Analysis & Tools BLAST Search Candida DNA and protein sequence datasets for similarities to a particular sequence. Find similarities between a sequence of interest and Candida DNA or protein sequences. help page
Gene/Sequence Resources Retrieve Candida genomic sequence from CGD or paste in a DNA or protein sequence to analyze it using numerous CGD resources. Display and analyze a Candida sequence (or other sequence) in many ways. help page
GBrowse Genome Browser
C. albicans A21 GBrowse
C. albicans A19 GBrowse
C. glabrata GBrowse
 GBrowse allows viewing and navigation of genomic sequence. The GBrowse tool is part of the Generic Model Organism Database Project. Navigate the Assembly 21 chromosomes and Assembly 19 contig set. View nucleotide and protein sequence. help page
Pattern Matching A pattern matching program that allows ambiguous matches but not gaps. Find short DNA/protein sequence matches in Candida sequences. help page
Design Primers Recommends primers appropriate for either PCR or sequencing of a given gene or DNA sequence, within parameters set by the user (end points, Tm, GC/AT ratios, etc.). Design sequencing and PCR primers for Candida or other input sequences. help page
Genome Restriction Analysis Generates a restriction map of a specified DNA sequence. The restriction map may include all enzymes, or a subset of enzyme types (3' overhangs, 5' overhangs, blunt ends, or enzymes that cut once or twice). Display restriction maps for Candida or other input sequences. help page
SGD's Fungal BLAST Search multiple fungal genomes, including Candida genomes, for similarity to a particular sequence. Find similarities between a sequence of interest and fungal nucleotide or protein sequences. help page
Category Resource Description Primary Use Help Page
GO Resources What is GO? SGD help page that explains the philosophy of GO. Get an overview of Gene Ontology (GO).  
SGD's GO Tutorial Tutorial that highlights pages and tools that use GO annotations to familiarize users with the Gene Ontology (GO). Learn where GO annotations are located on CGD pages and how to use them.  
GO Slim Mapper GO Slim is a set of GO terms that represent major sections of the ontology. Gene products are annotated to the most specific GO term possible. This tool traces the specific annotations to their broader GO Slim terms for a given set of CGD genes. Map a set of CGD genes to broad GO Slim categories. help page
GO Term Finder Gene products are annotated to the most specific GO terms possible. Common parent terms may not be obvious. This tool determines the GO terms that a set of CGD genes shares in common and graphically displays the significant lineage. Find GO terms that are shared by a group of CGD genes. help page
Category Resource Description Primary Use Help Page
Community Info Conferences & Courses Link to a list of conferences & courses. Find an upcoming conference.  
Community News Links to Candida news postings. Find out about items of interest to the research community.  
Candida Laboratories Links to laboratories who have submitted colleague information to CGD. Find a PI (principal investigator) of a Candida laboratory.  
Candida Community Job Postings Announcements of employment opportunities that are related to Candida biology. View job openings.  
External Links List of useful external sites Find a web site for information not available at CGD.  
Category Resource Description Primary Use Help Page
Submit Data Gene Registry Form to register a gene name. Register a gene name at CGD.  
Gene Naming Guidelines Guidelines for choosing and registering a gene name as agreed upon by the members of the C. albicans community. Find information about registering a gene name and determining when the gene name becomes a standard name.  
Colleague Submission/Update Form Form to submit colleague information to CGD. Your information will be available to CGD users. Add or update your information in CGD. help page
Contact CGD Form to submit suggestions or questions to CGD. Send suggestions or questions to CGD.  
Category Resource Description Primary Use Help Page
Download Data Batch Download Tool that allows simultaneous retrieval of DNA sequences, protein sequences, and chromosomal coordinate information for a list of Standard gene names or Feature names. Download information for a list of genes from CGD. help page
Gene Ontology (GO) Annotations File The gene_association.cgd file contains the Gene Ontology (GO) curation from CGD. Download tab-delimited files of GO information from CGD. help page
Chromosomal Feature Files Tab-delimited files of information about current chromosomal features in CGD. Download feature (gene) names, aliases, descriptions, and other information from CGD.
Sequence Files The sequence download directory contains sequence from the Candida sequencing projects, and derivatives thereof. Download current or archived sequence data.
Phenotypes Tab-delimited files containing the CGD phenotype curation. Download phenotype data.
Orthologs and Best Hits This directory contains the mappings among Candida genes, and between Candida albicans genes and the predicted orthologs or BLAST Best Hits in S. cerevisiae, as well as positional orthologs in C. dubliniensis, plus additional associated information. Download homolog data.
Candida GO Slim Annotations File The GOslim_gene_association.cgd file contains GO Slim annotations for Candida genes, using the CGD GO Slim instead of the entire Gene Ontology. Download tab-delimited files of GO information from CGD. help page
Analyses of C. albicans Assembly 21 This directory contains detailed notes about Assembly 21 of the C. albicans genome sequence. The Assembly 21 files were processed at CGD to identify and classify changes that occurred between Assemblies 19, 20, and 21, and to identify other issues, as described in detail on the Sequence documentation page. Download CGD's Assembly 21 analyses.
Analyses of C. albicans Assembly 20 This directory contains detailed notes about Assembly 20 of the C. albicans genome sequence. The Assembly 20 files were processed at CGD to identify and classify changes that occurred between Assembly 19 and Assembly 20, and to identify other issues, as described in detail on the Sequence documentation page. Download CGD's Assembly 20 analyses.
C. albicans Assembly 19 Contig Diagrams These PDF files depict the the assembly of Contig19's from Contig6's by the Stanford Genome Technology Center (SGTC). These files were originally made available from the Candida web server at the SGTC, and copies are archived here at CGD. Download and view the SGTC's diagrams of Assembly 19 contigs and their component contigs from Assembly 6.
C. albicans Assembly 6 Aliases The orf19_orf6_mapping file provides a mapping between the orf6 names assigned during Assembly 6 of the genome sequence and the orf19 names assigned during Assembly 19. Download Assembly 6 aliases.
C. albicans Assembly 4 Aliases The orf4_orf19_mapping file provides a mapping between the identifiers from Assembly 4 of the genome sequence and the orf19 names assigned during Assembly 19. Download Assembly 4 aliases.
Codon Usage Table Table of calculated codon usage frequencies and documentation about how the table was generated. Find codon frequencies for the Candida albicans genome.
Datasets archived at CGD Archive of published and freely available datasets. Download large-scale datasets.  
Category Resource Description Primary Use Help Page
About CGD About CGD About the CGD project. Find out background information on the CGD project.  
CGD Genome Snapshot
C. albicans
C. glabrata		 Annotation statistics, updated daily. Find information about the characterization of the genomes in CGD.
Citing CGD How to cite CGD in publications. References to use in citing CGD.  
Staff Names and addresses and CGD staff. Find out who works at CGD.  

Locus IdGene NameOrganismDescription
orf19.7521REP1Candida albicans SC5314Protein involved in negative regulation of MDR1 transcription; mutants show increased resistance to azole drugs
orf19.7522Candida albicans SC5314Hap43p-repressed gene; mutation confers hypersensitivity to amphotericin B
orf19.7523MKC1Candida albicans SC5314MAP kinase; role in biofilm formation, contact-induced invasive filamentation, systemic virulence in mouse, cell wall structure/maintenance, caspofungin response; phosphorylated on surface contact, membrane perturbation, or cell wall stress
orf19.7527Candida albicans SC5314
orf19.7529EPL1Candida albicans SC5314Subunit of the NuA4 histone acetyltransferase complex
orf19.4980HSP70Candida albicans SC5314Putative hsp70 chaperone; role in entry into host cells; heat-shock, amphotericin B, cadmium, ketoconazole-induced; farnesol-downregulated in biofilm; surface localized in yeast-form and hyphal cells; antigenic in host
orf19.4981Candida albicans SC5314Has domain(s) with predicted role in transmembrane transport and integral to membrane localization
orf19.4982Candida albicans SC5314Has domain(s) with predicted role in lipid metabolic process
orf19.4983Candida albicans SC5314
orf19.4984Candida albicans SC5314Has domain(s) with predicted chitinase activity, cation binding, chitin binding activity and role in cell wall macromolecule catabolic process, chitin catabolic process
orf19.4985GUP1Candida albicans SC5314Putative O-acyltransferase with a role in glycerol uptake; functionally complements growth of S. cerevisiae gup1 mutant under salt stress; required for normal ergosterol distribution, hyphal growth, biofilm formation
orf19.4987NUP49Candida albicans SC5314Nuclear pore protein
orf19.4988Candida albicans SC5314Predicted ORF in Assemblies 19, 20 and 21; greater mRNA abundance observed in a cyr1 homozygous null mutant than in wild type
orf19.1646Candida albicans SC5314Has domain(s) with predicted nucleic acid binding, nucleotide binding activity
orf19.1648RAD50Candida albicans SC5314Putative DNA double-strand break repair factor; involved in response to oxidative stress and drug resistance
orf19.1649RNA1Candida albicans SC5314Putative GTPase-activating protein; protein level decreases in stationary phase cultures
orf19.7534MIS12Candida albicans SC5314Mitochondrial C1-tetrahydrofolate synthase precursor
orf19.7537BNR1Candida albicans SC5314Formin; probable role in hyphal cytoskeletal polarity; synthetic lethality if Bnr1p and Bni1p are absent
orf19.7539INO2Candida albicans SC5314Transcriptional activator that forms a heterodimer with Ino4p; likely regulates genes involved in phosphatidylcholine and phosphatidylinositol biosynthesis, fatty acid beta-oxidation, and peroxisome biogenesis
orf19.4991MPT5Candida albicans SC5314Putative RNA-binding protein; Hap43p-repressed gene; protein induced during the mating process
Locus IdGene NameOrganismDescription
orf19.1650Candida albicans SC5314Ortholog(s) have protein channel activity, role in mitochondrial outer membrane translocase complex assembly, protein import into mitochondrial matrix and mitochondrial outer membrane translocase complex localization
orf19.1651Candida albicans SC5314
orf19.4996Candida albicans SC5314
orf19.4997KIS2Candida albicans SC5314Scaffold protein of Snf1p complex; similar to S. cerevisiae Gal83p and Sip2p; interacts with Snf4p; interaction with Snf1p complex is regulated by carbon source, decreased on ethanol; N-terminal myristoylation; Hog1p-downregulated
orf19.1655PXP2Candida albicans SC5314Putative acyl-CoA oxidase; enzyme of fatty acid beta-oxidation; induced during macrophage infection; expression is opaque specific; has putative peroxisome targeting signal
orf19.1659ALG8Candida albicans SC5314Putative glucosyltransferase involved in cell wall mannan biosynthesis; transcription is elevated in nik1 and sln1 homozygous null mutants, but not in the chk1 null mutant; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.501Candida albicans SC5314Ortholog(s) have preribosome, large subunit precursor localization
orf19.504Candida albicans SC5314Ortholog(s) have ATP-dependent 3'-5' DNA helicase activity, role in nucleosome mobilization and Ino80 complex localization
orf19.506YDJ1Candida albicans SC5314Putative type I HSP40 co-chaperone; heavy metal (cadmium) stress-induced
orf19.7544TLO1Candida albicans SC5314Member of a family of telomere-proximal genes of unknown function; hyphal-induced expression
orf19.7545Candida albicans SC5314Protein similarity to mutator-like element (MULE) transposase
orf19.7546Candida albicans SC5314Ortholog(s) have RNA-dependent ATPase activity and role in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
orf19.4203Candida albicans SC5314Ortholog(s) have role in nuclear pore organization, spindle pole body duplication in nuclear envelope and spindle pole body, NDC1 complex localization
orf19.4204Candida albicans SC5314Ortholog(s) have structural constituent of ribosome activity and mitochondrial small ribosomal subunit localization
orf19.7548Candida albicans SC5314Ortholog(s) have RNA polymerase II transcription corepressor activity, RNA polymerase II transcription coactivator activity, RNA polymerase II repressing transcription factor binding activity
orf19.4206Candida albicans SC5314Ortholog(s) have crossover junction endodeoxyribonuclease activity, role in DNA repair, resolution of meiotic recombination intermediates, DNA topological change and nucleus, Holliday junction resolvase complex localization
orf19.4208RAD52Candida albicans SC5314Required for homologous DNA recombination, repair of UV- or MMS-damaged DNA, telomere length, UV-induced LOH; constitutive expression, MMS-induced; weakly complements S. cerevisiae rad52 mutant; slow growth, increased white-to-opaque switch
orf19.1662Candida albicans SC5314Ortholog(s) have structural constituent of ribosome activity and mitochondrial small ribosomal subunit localization
orf19.1663MNT2Candida albicans SC5314Alpha-1,2-mannosyl transferase; adds third mannose during cell-wall mannoprotein biosynthesis; partially redundant with Mnt1p; role in adherence and virulence; expressed in yeast-form and hyphal cells; fungal-specific; Hap43p-induced
orf19.1665MNT1Candida albicans SC5314Alpha-1,2-mannosyl transferase; adds second mannose during cell-wall mannoprotein biosynthesis; required for wild-type virulence and adherence to epithelial cells; predicted type II Golgi membrane protein; fungal-specific; Hap43p-induced
Locus IdGene NameOrganismDescription
orf19.1667Candida albicans SC5314Hap43p-repressed gene
orf19.1669AFG3Candida albicans SC5314Similar to S. cerevisiae Afg3p, a subunit of the mitochondrial inner membrane m-AAA protease; likely to be essential for growth, based on an insertional mutagenesis strategy
orf19.510Candida albicans SC5314
orf19.514SNP3Candida albicans SC5314Putative U6 snRNA-associated protein; transcription is regulated by Mig1p
orf19.7550IFA14Candida albicans SC5314Putative LPF family protein; Plc1p-regulated; transcription is induced in response to alpha pheromone in SpiderM medium
orf19.515Candida albicans SC5314Has domain(s) with predicted nucleic acid binding, zinc ion binding activity
orf19.7551ALO1Candida albicans SC5314D-Arabinono-1,4-lactone oxidase involved in biosynthesis of dehydro-D-arabinono-1,4-lactone, which has a protective role against oxidative damage; plasma membrane-localized;required for full virulence in a mouse model of systemic infection
orf19.516Candida albicans SC5314S. cerevisiae ortholog Rft1p has role in glycolipid translocation, protein N-linked glycosylation and localizes to endoplasmic reticulum membrane; regulated by Sef1p-, Sfu1p-, and Hap43p
orf19.7552Candida albicans SC5314Putative U3-containing small subunit processome complex protein; Hap43p-induced gene; downregulated during core stress response
orf19.517HAP31Candida albicans SC5314Putative transcription factor that regulates CYC1; required for resistance to rapamycin and copper; transcriptionally regulated by iron; expression greater in high iron; repressed in low iron conditions; Sef1p-, Sfu1p-, and Hap43p-regulated
orf19.7553Candida albicans SC5314
orf19.4210Candida albicans SC5314Ortholog(s) have phospholipase A2 activity, role in cardiolipin acyl-chain remodeling and mitochondrion localization
orf19.518Candida albicans SC5314Ortholog(s) have tRNA (cytosine-5-)-methyltransferase activity, role in tRNA methylation and nucleus localization
orf19.7554Candida albicans SC5314Putative transporter; slightly similar to the Sit1p siderophore transporter; induced by nitric oxide independent of Yhb1p
orf19.4211FET3Candida albicans SC5314Multicopper oxidase; required for growth in low-iron; required for prostaglandin E2 production; functional homolog of S. cerevisiae Fet3p; ketoconazole, caspofungin, amphotericin B repressed; regulated by Sef1p, Sfu1p, and Hap43p
orf19.7555Candida albicans SC5314
orf19.4212FET99Candida albicans SC5314Multicopper oxidase family protein similar to S. cerevisiae Fet3p; does not complement S. cerevisiae fet3 mutant growth under low-iron conditions; iron-repressed transcription; regulated by Tup1p, Rim101p; late-stage biofilm-induced
orf19.7557FGR46Candida albicans SC5314Protein lacking an ortholog in S. cerevisiae; transposon mutation affects filamentous growth
orf19.4214Candida albicans SC5314Protein not essential for viability
orf19.4215FET34Candida albicans SC5314Putative multicopper ferroxidase; expression greater in low iron and reduced in a fluconazole-resistant isolate; downregulated by Sfu1p, Hog1p; alkaline upregulated by Rim101p; ciclopirox olamine, ketoconazole and hypoxia induced
Locus IdGene NameOrganismDescription
orf19.4219RIX7Candida albicans SC5314Protein similar to S. cerevisiae Rix7p which is a putative ATPase of the AAA family required for ribosomal subunit export from the nucleus; mutation impairs hyphal growth and biofilm formation; planktonic growth-induced gene
orf19.1671UTR2Candida albicans SC5314GPI anchored cell wall putative glycosidase; role in adhesion; required for hyphal growth on Spider (not serum) medium; chitin-binding, glycosyl hydrolase domains; induced during cell wall regeneration; mRNA detected in yeast-form cells
orf19.1673PPT1Candida albicans SC5314Putative serine/threonine phosphatase; transcriptionally regulated by iron; expression greater in high iron
orf19.1674CDC53Candida albicans SC5314Cullin, a scaffold subunit of the SCF ubiquitin-ligase complexes; depletion leads to increased filamentous growth and premature cell death
orf19.1676Candida albicans SC5314Ortholog(s) have role in potassium ion transport, proton transport and integral to mitochondrial inner membrane localization
orf19.1678Candida albicans SC5314Predicted ORF in Assemblies 19, 20 and 21; transcription detected in high-resolution tiling array experiments
orf19.520Candida albicans SC5314
orf19.6900Candida albicans SC5314Ortholog(s) have role in protein import into mitochondrial outer membrane, phospholipid transport and ERMES complex localization
orf19.522Candida albicans SC5314Has domain(s) with predicted ATP-dependent peptidase activity, ATP binding, serine-type endopeptidase activity and role in proteolysis
orf19.6902DBP7Candida albicans SC5314Putative ATP-dependent DEAD-box RNA helicase; Hap43p-induced gene; transcription is upregulated in both intermediate and mature biofilms
orf19.524Candida albicans SC5314Has domain(s) with predicted ubiquitin-protein ligase activity, zinc ion binding activity
orf19.6904GCN3Candida albicans SC5314Putative translation initiator; downregulated in the presence of human whole blood or polymorphonuclear (PMN) cells
orf19.6905Candida albicans SC5314Ortholog of S. cerevisiae : YNL011C and C. glabrata CBS138 : CAGL0H03619g
orf19.526NHP2Candida albicans SC5314Putative H/ACA snoRNP protein; macrophage/pseudohyphal-induced
orf19.7564DPB2Candida albicans SC5314Probable subunit of DNA polymerase II (DNA polymerase epsilon), similar to S. cerevisiae Dpb2p; essential for viability
orf19.6908Candida albicans SC5314Dihydrofolate synthetase involved in folic acid biosynthesis
orf19.4221ORC4Candida albicans SC5314Phosphorylated protein similar to S. cerevisiae Orc4p; transcription is induced in response to alpha pheromone in SpiderM medium
orf19.7565GNP3Candida albicans SC5314Putative high-affinity glutamine permease; fungal-specific (no human or murine homolog)
orf19.6909Candida albicans SC5314Has domain(s) with predicted RNA polymerase II transcription cofactor activity, role in regulation of transcription from RNA polymerase II promoter and mediator complex localization
orf19.4223GCD11Candida albicans SC5314Protein similar to S. cerevisiae Gcd11p, which is a subunit of translation initiation factor eIF2; likely to be essential for growth, based on an insertional mutagenesis strategy
Locus IdGene NameOrganismDescription
orf19.7567Candida albicans SC5314Predicted ORF in Assemblies 19, 20 and 21; transcription is induced in response to alpha pheromone in SpiderM medium
orf19.4225LEU3Candida albicans SC5314Predicted zinc-finger protein; has similarity to S. cerevisiae Leu3p, which is involved in regulation of branched-chain amino acid biosynthesis genes; alkaline upregulated; transcriptionally activated by Mnl1p under weak acid stress
orf19.7569SIK1Candida albicans SC5314Putative U3 snoRNP protein; Hap43p-induced gene; physically interacts with TAP-tagged Nop1p
orf19.4228Candida albicans SC5314Ortholog(s) have role in posttranslational protein targeting to membrane, protein insertion into ER membrane and TRC complex localization
orf19.1680TFP1Candida albicans SC5314Subunit of vacuolar H+-ATPase; stationary phase enriched protein; sumoylation target
orf19.1682Candida albicans SC5314Membrane protein; Hap43p-repressed gene; repressed by nitric oxide
orf19.1684Candida albicans SC5314
orf19.1685ZCF7Candida albicans SC5314Predicted zinc-finger protein; null mutant displays reduced colony wrinkling on Spider medium and is unable to utilize mannitol as a carbon source; mutants display increased colonization of mouse kidneys
orf19.6911Candida albicans SC5314
orf19.532RBR2Candida albicans SC5314Cell wall protein; expression is repressed by Rim101p; expression is regulated upon white-opaque switching; transcription is repressed in response to alpha pheromone in SpiderM medium; macrophage-induced gene
orf19.6912Candida albicans SC5314Putative ethanolamine kinase
orf19.533Candida albicans SC5314
orf19.6913GCN2Candida albicans SC5314Translation initiation factor 2-alpha (eIF2alpha) kinase; has nonessential role in amino acid starvation response, in contrast to S. cerevisiae homolog; similar to S. cerevisiae Gcn2p
orf19.7570UGA3Candida albicans SC5314Putative transcription factor with zinc cluster DNA-binding motif, required for utilization of gamma-aminobutyrate (GABA) as a nitrogen source; mutants display decreased colonization of mouse kidneys
orf19.535RBR1Candida albicans SC5314Glycosylphosphatidylinositol (GPI)-anchored cell wall protein required for filamentous growth at acidic pH; expression is repressed by Rim101p and activated by Nrg1p; Hap43p-induced gene
orf19.7571UBC4Candida albicans SC5314Ortholog(s) have ubiquitin binding activity and role in protein monoubiquitination, response to stress, ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway, protein polyubiquitination
orf19.6915MRE11Candida albicans SC5314Putative DNA double-strand break repair factor; involved in response to oxidative stress and drug resistance
orf19.536Candida albicans SC5314Ortholog(s) have ubiquitin binding, chromatin binding activity, role in histone acetylation, transcription from RNA polymerase II promoter and SAGA complex, SLIK (SAGA-like) complex, transcription factor TFIID complex localization
orf19.7572SPT7Candida albicans SC5314Putative SAGA transcriptional regulatory complex subunit; mutation confers hypersensitivity to toxic ergosterol analog, and to amphotericin B
orf19.6916Candida albicans SC5314Ortholog(s) have unfolded protein binding activity, role in mitochondrial proton-transporting ATP synthase complex assembly and mitochondrion localization
Locus IdGene NameOrganismDescription
orf19.537Candida albicans SC5314
orf19.4230Candida albicans SC531420S proteasome subunit (beta7); protein present in exponential and stationary growth phase yeast cultures
orf19.538Candida albicans SC5314Ortholog(s) have role in GPI anchor biosynthetic process and glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex localization
orf19.7574Candida albicans SC5314Ortholog of C. glabrata CBS138 : CAGL0M05137g
orf19.6918Candida albicans SC5314Hap43p-induced gene
orf19.4231PTH2Candida albicans SC5314Putative cAMP-independent regulatory protein; constitutive expression independent of MTL or white-opaque status
orf19.6919Candida albicans SC5314
orf19.539LAP3Candida albicans SC5314Putative aminopeptidase; transcription positively regulated by Sfu1p; transcription repressed by alpha pheromone in SpiderM medium; clade-associated gene expression; virulence-group-correlated expression; Hap43p-induced; biofilm-induced
orf19.7576Candida albicans SC5314Protein not essential for viability
orf19.7577MSS51Candida albicans SC5314Putative mRNA maturation factor; fungal-specific (no human or murine homolog)
orf19.4235PDE1Candida albicans SC5314Cyclic nucleotide phosphodiesterase (PDEase), low affinity; mediates cAMP signaling in response to glucose or intracellular acidification; macrophage-downregulated gene
orf19.7579FGR34Candida albicans SC5314Protein lacking an ortholog in S. cerevisiae; transposon mutation affects filamentous growth
orf19.1691Candida albicans SC5314Plasma-membrane-localized protein; filament induced; Hog1p-, ketoconazole-, fluconazole- and hypoxia-induced; regulated by Nrg1p, Tup1p, Upc2p; increased expression in response to prostaglandins; biofilm- and planktonic growth-induced
orf19.1697Candida albicans SC5314Ortholog(s) have role in cytoplasmic translation and polysomal ribosome, cytoplasm localization
orf19.1698Candida albicans SC5314Ortholog(s) have role in actin cytoskeleton organization and actin cortical patch localization
orf19.540Candida albicans SC5314Has domain(s) with predicted palmitoyl-(protein) hydrolase activity and role in protein modification process
orf19.541Candida albicans SC5314Has domain(s) with predicted oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors activity
orf19.6921Candida albicans SC5314
orf19.6922Candida albicans SC5314
orf19.6923Candida albicans SC5314Has domain(s) with predicted DNA binding activity, role in transcription initiation from RNA polymerase II promoter and nucleus localization
Locus IdGene NameOrganismDescription
orf19.544Candida albicans SC5314Ortholog(s) have ribonuclease P activity, role in intronic box C/D snoRNA processing and nucleolar ribonuclease P complex localization
orf19.7580Candida albicans SC5314
orf19.6924HTA1Candida albicans SC5314Histone H2A; reduced mRNA abundance detected in homozygous fkh2 null mutant; amphotericin B repressed; farnesol regulated; RNA abundance regulated by tyrosol and cell density; Hap43p-induced gene
orf19.6925HTB1Candida albicans SC5314Putative histone H2B; induced upon adherence to polystyrene; amphotericin B or caspofungin repressed; flucytosine or fluconazole induced; regulated by Efg1p; slow growth, increased white-to opaque switching in ectopic expression strains
orf19.547Candida albicans SC5314Ortholog(s) have 5'-3' exonuclease activity, 5'-flap endonuclease activity
orf19.7583ZCF39Candida albicans SC5314Putative transcription factor with zinc cluster DNA-binding motif; not essential for viability; filament induced
orf19.4240Candida albicans SC5314Ortholog(s) have role in GPI anchor biosynthetic process, cellular manganese ion homeostasis and fungal-type vacuole membrane, endoplasmic reticulum localization
orf19.548CDC10Candida albicans SC5314Septin, required for wild-type cell, hyphal, or chlamydospore morphology; role in virulence and kidney tissue invasion in a mouse model of systemic infection; forms ring at sites of cell division and filaments in mature chlamydospore
orf19.7585INO1Candida albicans SC5314Inositol-1-phosphate synthase; inositol biosynthesis; antigenic in human; repressed by farnesol in biofilm or by caspofungin; regulated during biofilm, planktonic growth; upstream inositol/choline regulatory element; glycosylation predicted
orf19.4242CST20Candida albicans SC5314Protein kinase of Ste20p/p65PAK family, required for wild-type mating efficiency and virulence in a mouse model; Cst20p-Hst7p-Cek1p-Cph1p MAPK pathway regulates some hyphal growth; involved in Cdc42p growth regulation
orf19.7586CHT3Candida albicans SC5314Major chitinase; secreted; functional homolog of S. cerevisiae Cts1p; 4 N-glycosylation motifs; possible O-mannosylation; putative signal peptide; hyphal-repressed; farnesol upregulated in biofilm; regulated by Efg1p, Cyr1p, Ras1p
orf19.4243Candida albicans SC5314Ortholog(s) have ubiquitin binding activity
orf19.7588Candida albicans SC5314Ortholog(s) have mitochondrion localization
orf19.4245Candida albicans SC5314Hap43p-repressed gene
orf19.4247Candida albicans SC5314
orf19.550PDX3Candida albicans SC5314Pyridoxamine-phosphate oxidase; transcription regulated by yeast-hyphal switch and by Nrg1p, Mig1p, Tup1p; caspofungin repressed; present in exponential and stationary phase yeast cultures; Hap43p-repressed; planktonic growth-induced
orf19.6930SOL1Candida albicans SC5314Cell cycle regulator; partial functional homolog of S. cerevisiae Sic1p; protein degradation regulated by SCF(CDC4) pathway; CDK phosphorylation predicted
orf19.6931Candida albicans SC5314Putative cleavage factor I subunit; heterozygous null mutant exhibits hypersensitivity to parnafungin and cordycepin in the C. albicans fitness test
orf19.554DIT2Candida albicans SC5314Monooxygenase of the cytochrome P450 family involved in chlamydospore formation; produces N,N'-bisformyl dityrosine from N-formyltyrosine; transcription is regulated by Nrg1p, Mig1p, and Tup1p
orf19.555Candida albicans SC5314Protein similar to S. cerevisiae Cis3p, which has a role cell-wall-related processes; predicted Kex2p substrate; possibly an essential gene, disruptants not obtained by UAU1 method
Locus IdGene NameOrganismDescription
orf19.7592FAA4Candida albicans SC5314Predicted acyl CoA synthase
orf19.6936RAD53Candida albicans SC5314Protein involved in regulation of DNA-damage-induced filamentous growth; putative component of cell cycle checkpoint; ortholog of S. cerevisiae Rad53p, protein kinase required for cell-cycle arrest in response to DNA damage
orf19.7593Candida albicans SC5314Ortholog(s) have role in asparagine catabolic process and intracellular localization
orf19.4250Candida albicans SC5314
orf19.557Candida albicans SC5314Hap43p-repressed gene; planktonic growth-induced gene
orf19.7594Candida albicans SC5314
orf19.6938MEU1Candida albicans SC5314Putative methylthioadenosine phosphorylase; protein level decreases in stationary phase cultures
orf19.4251ZCF22Candida albicans SC5314Predicted zinc-finger protein
orf19.559FGR14Candida albicans SC5314Protein encoded in retrotransposon Zorro3 with similarity to retroviral endonuclease-reverse transcriptase proteins; lacks an ortholog in S. cerevisiae; transposon mutation affects filamentous growth
orf19.7596Candida albicans SC5314Hap43p-repressed gene
orf19.4253Candida albicans SC5314
orf19.7598Candida albicans SC5314
orf19.4255ECM331Candida albicans SC5314GPI-anchored protein; mainly at plasma membrane, also at cell wall; caspofungin induced; Plc1p-regulated; repressed by Rim101p, Hog1p; colony morphology-related regulation by Ssn6p; induced by ketoconazole and by hypoxia; Hap43p-induced
orf19.4257INT1Candida albicans SC5314Integrin-like protein; role in morphogenesis, adhesion, and mouse cecal colonization and systemic virulence; similar to S. cerevisiae Bud4p; structurally similar to alpha-subunit of human leukocyte integrins; Hap43p-induced gene
orf19.6941Candida albicans SC5314Late-stage biofilm-induced gene
orf19.6942ORC3Candida albicans SC5314Protein similar to S. cerevisiae Orc3p, which is a component of the origin recognition complex involved in DNA replication; mutation confers hypersensitivity to toxic ergosterol analog; induced under hydroxyurea treatment
orf19.563RRP15Candida albicans SC5314Putative nucleolar protein, constituent of pre-60S ribosomal particles; Hap43p-induced gene; decreased expression in response to prostaglandins
orf19.3600Candida albicans SC5314Late-stage biofilm-induced gene
orf19.564KAR3Candida albicans SC5314Kinesin-like microtubule motor protein; required for nuclear fusion during mating; C-terminal motor domain; not essential for viability; homozygous null has high-frequency white-opaque switching phenotype
orf19.3601Candida albicans SC5314Has domain(s) with predicted nucleoside-triphosphatase activity, ATP binding activity
Locus IdGene NameOrganismDescription
orf19.6947GTT11Candida albicans SC5314Glutathione S-transferase, localized to ER; induced in exponentially growing cells, under oxidative stress; induced by nitric oxide
orf19.6948CCC1Candida albicans SC5314Manganese transporter required for normal filamentous growth; mRNA binds She3p and is localized to hyphal tips; repressed by nitric oxide and alkaline pH; colony morphology-related regulation by Ssn6p; regulated by Sef1p, Sfu1p, and Hap43p
orf19.3605PEX17Candida albicans SC5314Putative peroxin
orf19.4262Candida albicans SC5314Has domain(s) with predicted RNA binding activity
orf19.4263Candida albicans SC5314
orf19.4264Candida albicans SC5314Biofilm-induced gene
orf19.4265UAP1Candida albicans SC5314UDP-N-acetylglucosamine pyrophosphorylase, catalyzes biosynthesis of UDP-N-acetylglucosamine from UTP and N-acetylglucosamine 1-phosphate; functional homolog of S. cerevisiae Qri1p; alkaline upregulated
orf19.3609UTP15Candida albicans SC5314Small subunit (SSU) processome component; mutation confers resistance to 5-fluorocytosine (5-FC); physically interacts with TAP-tagged Nop1p
orf19.4269Candida albicans SC5314Has domain(s) with predicted protein kinase activity, ATP binding activity and role in protein phosphorylation
orf19.570IFF8Candida albicans SC5314Putative GPI-anchored adhesin-like protein; decreased transcription is observed in an azole-resistant strain that overexpresses MDR1
orf19.6953IRS4Candida albicans SC5314Protein with roles in cell wall integrity, systemic (but not oral) murine infection, adherence, hyphal growth, and agar-embedded filamentous growth; antigenic in human infection; similar to S. cerevisiae Irs4p
orf19.3610Candida albicans SC5314Predicted ORF in Assemblies 19, 20 and 21; upregulation correlates with clinical development of fluconazole resistance; regulated by Sef1p-, Sfu1p-, and Hap43p
orf19.6955HBR3Candida albicans SC5314Essential protein; regulated by hemoglobin; S. cerevisiae ortholog is essential; Hap43p-induced gene
orf19.575HYR3Candida albicans SC5314Putative GPI-anchored protein; adhesin-like protein; similar to Hyr1p; transcriptionally regulated by iron; expression greater in high iron; clade-specific repeat variation
orf19.6956DAL9Candida albicans SC5314Putative allantoate permease; fungal-specific (no human or murine homolog)
orf19.576CTF8Candida albicans SC5314Putative kinetochore protein with a predicted role in sister chromatid cohesion; repressed during the mating process; biofilm-induced gene
orf19.4270Candida albicans SC5314Putative mannosyltransferase; regulated by Sef1p-, Sfu1p-, and Hap43p
orf19.577Candida albicans SC5314Has domain(s) with predicted protein tyrosine phosphatase activity and role in dephosphorylation
orf19.578Candida albicans SC5314Ortholog(s) have Rab GTPase activator activity, role in actin filament organization and polarisome, cellular bud tip, incipient cellular bud site localization
orf19.579FOL1Candida albicans SC5314Putative dihydroneopterin aldolase (dihydro-6-hydroxymethylpterin pyrophosphokinase); fungal-specific (no human or murine homolog)
Locus IdGene NameOrganismDescription
orf19.4273Candida albicans SC5314Hap43p-induced gene
orf19.3617Candida albicans SC5314Putative GTP-binding protein; transcription is upregulated in clinical isolates from HIV+ patients with oral candidiasis; (see Locus History Note for Assembly 19 correction)
orf19.4274PUT1Candida albicans SC5314Putative proline oxidase; alkaline upregulated by Rim101p; biofilm-induced
orf19.3618YWP1Candida albicans SC5314Secreted yeast cell wall protein; possible role in dispersal in host; mutation causes increased adhesion and biofilm formation; stable propeptide; regulated by growth phase, phosphate, Ssk1p, Ssn6p, Efg1p, Efh1p, Hap43p; mRNA binds to She3p
orf19.4275RAD9Candida albicans SC5314Protein involved in regulation of DNA-damage-induced filamentous growth; putative component of DNA damage checkpoint; ortholog of S. cerevisiae Rad9p; transcription is induced in response to alpha pheromone in SpiderM medium
orf19.4278Candida albicans SC5314Has domain(s) with predicted zinc ion binding activity
orf19.4279MNN1Candida albicans SC5314Putative alpha-1,3-mannosyltransferase, a component of mannosyltransferase complex; transcription negatively regulated by Rim101p; transcription elevated in chk1 and nik1 null mutants, but not in sln1 null mutant; biofilm-induced gene
orf19.580Candida albicans SC5314Protein not essential for viability
orf19.581Candida albicans SC5314Putative RNA-binding protein; transcription is upregulated in an RHE model of oral candidiasis
orf19.583Candida albicans SC5314Putative indoleamine 2,3-dioxygenase (IDO); IDO is the rate-limiting enzyme of tryptophan catabolism via kynurenine pathway; enzyme inhibition by 1-methyl-D,L-tryptophan causes increased hyphal growth; expressed in yeast cells and hyphae
orf19.3622ANP1Candida albicans SC5314Putative mannosyltransferase of Golgi; member of Mnn9p family; similar to S. cerevisiae Anp1p; fungal-specific (no human or murine homolog)
orf19.6966Candida albicans SC5314Ortholog(s) have ethanolamine kinase activity, choline kinase activity, role in phosphatidylethanolamine biosynthetic process, phosphatidylcholine biosynthetic process and cytoplasm localization
orf19.3623SMC2Candida albicans SC5314Protein similar to S. cerevisiae Smc2p, which is a component of the condensin complex involved in mitotic chromosome condensation; induced under hydroxyurea treatment
orf19.6967USO6Candida albicans SC5314Putative vesicular transport protein; transcription is induced upon filamentous growth
orf19.587Candida albicans SC5314Ortholog(s) have transcription export complex localization
orf19.6968Candida albicans SC5314Predicted ORF in Assemblies 19, 20 and 21; Hog1p-downregulated
orf19.589VPS21Candida albicans SC5314Late endosomal Rab small monomeric GTPase involved in transport of endocytosed proteins to the vacuole; involved in filamentous growth and virulence
orf19.4283Candida albicans SC5314
orf19.4284BUR2Candida albicans SC5314Protein with similarity to S. cerevisiae Bur2p, contains a cyclin domain; not required for wild-type hyphal growth, adherence to buccal epithelial cells, or virulence in mouse systemic infection
orf19.4286Candida albicans SC5314Late-stage biofilm-induced gene
Locus IdGene NameOrganismDescription
orf19.4288CTA7Candida albicans SC5314Predicted zinc-finger protein; activates transcription in 1-hybrid assay in S. cerevisiae; has similarity to S. cerevisiae Stb4p
orf19.6970Candida albicans SC5314Protein not essential for viability
orf19.6971DIE2Candida albicans SC5314Ortholog(s) have dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity, role in protein N-linked glycosylation and endoplasmic reticulum membrane localization
orf19.592Candida albicans SC5314Ortholog of S. cerevisiae YNL092W; Hap43p-repressed gene
orf19.3630RRP8Candida albicans SC5314Ribosomal protein; Hap43p-induced gene; induced upon biofilm formation
orf19.3631STN1Candida albicans SC5314Protein involved in telomere maintenance; forms a complex with Ten1p
orf19.6976Candida albicans SC5314Predicted membrane transporter; member of the proton coupled folate transporter/heme carrier protein (PCFT/HCP) family, major facilitator superfamily (MFS); virulence-group-correlated expression
orf19.6977GPI1Candida albicans SC5314Putative protein of GPI synthesis; expression is reduced in a fluconazole-resistant isolate
orf19.4290TRR1Candida albicans SC5314Thioredoxin reductase; regulated by Tsa1p/Tsa1Bp, Hap43p; induced by nitric oxide, peroxide; oxidative stress-induce via Cap1p; upregulated by human neutrophils; fungal-specific (no human/murine homolog); stationary phase enriched protein
orf19.6978Candida albicans SC5314Planktonic growth-induced gene
orf19.3635Candida albicans SC5314
orf19.6979Candida albicans SC5314Ortholog(s) have role in cellular manganese ion homeostasis, mitochondrion organization and fungal-type vacuole membrane localization
orf19.4292Candida albicans SC5314Ortholog(s) have SNAP receptor activity, role in Golgi to vacuole transport, vacuole inheritance and endosome, Golgi apparatus localization
orf19.4293Candida albicans SC5314Ortholog(s) have role in ribosomal large subunit export from nucleus, tRNA wobble uridine modification, iron-sulfur cluster assembly and nucleus, cytosol localization
orf19.4294Candida albicans SC5314Ortholog(s) have oxidoreductase activity, role in cytochrome c-heme linkage, mitochondrial membrane organization and extrinsic to mitochondrial inner membrane localization
orf19.4295Candida albicans SC5314Has domain(s) with predicted chromatin binding activity, role in regulation of transcription, DNA-dependent, chromatin modification and nucleus localization
orf19.3639Candida albicans SC5314Ortholog(s) have alkylbase DNA N-glycosylase activity and role in DNA dealkylation involved in DNA repair, base-excision repair, AP site formation
orf19.4299MSW1Candida albicans SC5314Protein similar to S. cerevisiae Msw1p, which is mitochondrial tryptophanyl-tRNA synthetase; Hap43p-repressed gene; likely to be essential for growth, based on an insertional mutagenesis strategy
orf19.6980Candida albicans SC5314Has domain(s) with predicted protein serine/threonine kinase activity, ATP binding activity and role in protein phosphorylation
orf19.6982Candida albicans SC5314Ortholog(s) have mitochondrion localization
Locus IdGene NameOrganismDescription
orf19.6984Candida albicans SC5314
orf19.6985TEA1Candida albicans SC5314Putative transcription factor with zinc cluster DNA-binding motif; has similarity to S. cerevisiae Tea1p; Hap43p-repressed gene
orf19.3642SUN41Candida albicans SC5314Cell wall glycosidase involved in biofilm formation and cell separation; possibly secreted; hypoxia and hyphal induced; caspofungin repressed; Efg1p, Cph1p regulated; O-glycosylation, potential Kex2p substrate; 9 5' E-boxes; 5'-UTR intron;
orf19.6986Candida albicans SC5314Has domain(s) with predicted Rab GTPase activator activity, role in regulation of Rab GTPase activity and intracellular localization
orf19.3643Candida albicans SC5314Hap43p-repressed gene
orf19.6987DNM1Candida albicans SC5314Putative dynamin-related GTPase; transcription is upregulated in an RHE model of oral candidiasis; transcription is regulated by Nrg1p, Mig1p, and Tup1p
orf19.6989Candida albicans SC5314Has domain(s) with predicted nucleotide binding, nucleic acid binding activity
orf19.3646CTR1Candida albicans SC5314Copper transporter; transcribed in limited copper; induced by biofilm, Mac1p, Tye7p, macrophage interaction, alkaline pH via Rim101p; 17-beta-estradiol downregulated; complements S. cerevisiae ctr1 ctr3 copper transport mutant
orf19.3647SEC8Candida albicans SC5314Predicted subunit of the exocyst complex, involved in exocytosis; localizes to a crescent on the surface of the hyphal tip
orf19.3648Candida albicans SC5314Ortholog(s) have transcription coactivator activity, crossover junction endodeoxyribonuclease activity
orf19.3649Candida albicans SC5314Ortholog(s) have adenyl-nucleotide exchange factor activity, role in cytoplasmic translation and cytosolic ribosome localization
orf19.6991PRE3Candida albicans SC5314Putative beta-1 proteasome subunit; macrophage-induced protein; regulated by Gcn2p and Gcn4p
orf19.6992Candida albicans SC5314Predicted membrane transporter, member of the drug:proton antiporter (12 spanner) (DHA1) family, major facilitator superfamily (MFS)
orf19.6993GAP2Candida albicans SC5314General amino acid permease; ketoconazole, flucytosine repressed; Ssy1p-dependent histidine induction; regulated by Nrg1p, Tup1p; shows colony morphology-related gene regulation by Ssn6p; biofilm- and planktonic growth-induced
orf19.3651PGK1Candida albicans SC5314Phosphoglycerate kinase, enzyme of glycolysis; localizes to cell wall and cytoplasm; antigenic in murine/human infection; biofilm, planktonic culture-, Hog1p-, Hap43p-, GCN-induced; downregulated upon phagocytosis
orf19.6995ATO6Candida albicans SC5314Putative fungal-specific transmembrane protein
orf19.3653FAT1Candida albicans SC5314Predicted enzyme of sphingolipid biosynthesis; upregulated in biofilm
orf19.6997ATO5Candida albicans SC5314Putative fungal-specific transmembrane protein
orf19.3655Candida albicans SC5314
orf19.6999Candida albicans SC5314Has domain(s) with predicted oxidoreductase activity and role in oxidation-reduction process
Locus IdGene NameOrganismDescription
orf19.3658Candida albicans SC5314Ortholog(s) have role in protein folding in endoplasmic reticulum and mitochondrion localization
orf19.6200Candida albicans SC5314
orf19.6203PUT3Candida albicans SC5314Predicted zinc-finger protein; has similarity to S. cerevisiae Put3p, which is a transcription factor involved in the regulation of proline utilization genes
orf19.6205Candida albicans SC5314
orf19.3661Candida albicans SC5314Putative deubiquitinating enzyme; transcriptionally activated by Mnl1p under weak acid stress
orf19.3663PHO91Candida albicans SC5314Putative low-affinity phosphate transporter; fungal-specific (no human or murine homolog)
orf19.3665Candida albicans SC5314Hap43p-induced gene; ortholog of S. cerevisiae SET6, a SET domain protein of unknown function
orf19.3667Candida albicans SC5314Has domain(s) with predicted ATP binding, microtubule motor activity and role in microtubule-based movement
orf19.3668HGT2Candida albicans SC5314Putative glucose transporter of the major facilitator superfamily; the C. albicans glucose transporter family comprises 20 members; 12 probable membrane-spanning segments; expressed in rich medium with 2% glucose
orf19.6211Candida albicans SC5314
orf19.6214ATC1Candida albicans SC5314Cell wall acid trehalase; catalyzes hydrolysis of the disaccharide trehalose; similar to S. cerevisiae vacuolar acid trehalase (Ath1p); Hap43p-repressed gene
orf19.6217PGA63Candida albicans SC5314Ortholog(s) have structural molecule activity, role in COPII-coated vesicle budding and COPII vesicle coat, mating projection tip localization
orf19.3672GAL10Candida albicans SC5314UDP-glucose 4-epimerase, required for galactose utilization; mutant shows cell wall defects and increased filamentation; fluconazole- and ketoconazole-induced; stationary phase enriched protein; late-stage biofilm-induced gene
orf19.3673Candida albicans SC5314Ortholog(s) have Rab guanyl-nucleotide exchange factor activity, role in chromosome organization, ER to Golgi vesicle-mediated transport and TRAPP complex localization
orf19.3675GAL7Candida albicans SC5314Putative galactose-1-phoshphate uridyl transferase; downregulated by hypoxia, upregulated by ketoconazole; macrophage/pseudohyphal-repressed
orf19.3677Candida albicans SC5314Ortholog(s) have Atg8 ligase activity and role in CVT pathway, C-terminal protein lipidation, macroautophagy, piecemeal microautophagy of nucleus, mitochondrion degradation
orf19.3678Candida albicans SC5314Protein not essential for viability
orf19.6220Candida albicans SC5314Ortholog(s) have role in regulation of transcription from RNA polymerase II promoter and CCR4-NOT core complex localization
orf19.6224Candida albicans SC5314Has domain(s) with predicted role in response to stress and integral to membrane localization
orf19.6227Candida albicans SC5314Has domain(s) with predicted nucleic acid binding, zinc ion binding activity and intracellular localization
Locus IdGene NameOrganismDescription
orf19.3680SEP7Candida albicans SC5314Septin, required for wild-type invasive growth in vitro but not required for virulence in a mouse model of systemic infection; localizes to hyphal septum or bud neck; Asn-rich; aberrant gel mobility
orf19.3683AGE3Candida albicans SC5314Putative ADP-ribosylation factor GTPase activating protein, functional ortholog of S. cerevisiae GCS1; mutation affects endocytosis, hyphal growth, chemical and drug resistance, and sensitivity to cell wall inhibitors
orf19.3685PSY2Candida albicans SC5314Putative protein phosphatase PP4 complex subunit; macrophage-induced gene
orf19.3686Candida albicans SC5314Ortholog(s) have protein domain specific binding activity, role in mitochondrial proton-transporting ATP synthase complex assembly and mitochondrion localization
orf19.6230Candida albicans SC5314Ortholog(s) have m7G(5')pppN diphosphatase activity, enzyme regulator activity
orf19.6231MRPL19Candida albicans SC5314Putative ribosomal protein; induced upon adherence to polystyrene
orf19.6232NPR1Candida albicans SC5314Predicted serine/threonine protein kinase, involved in regulation of ammonium transport; induced in core stress response; Hap43p-repressed gene
orf19.6235Candida albicans SC5314
orf19.6236Candida albicans SC5314Ortholog(s) have rRNA binding activity, role in ribosomal small subunit biogenesis and 90S preribosome, nucleolus localization
orf19.6237RAC1Candida albicans SC5314G-protein of RAC subfamily; required for embedded filamentous growth, not for serum-induced hyphal growth; dynamic localization at plasma membrane and nucleus; similar to, but not interchangeable with, Cdc42p; lacks S. cerevisiae homolog
orf19.6238Candida albicans SC5314Has domain(s) with predicted oxidoreductase activity and role in oxidation-reduction process
orf19.6239Candida albicans SC5314Putative serine/threonine protein kinase; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.3693PGA5Candida albicans SC5314Putative GPI-anchored beta-1,3-glucanosyltransferase with similarity to the A. fumigatus GEL family; fungal-specific (no human or murine homolog)
orf19.3694Candida albicans SC5314
orf19.3695Candida albicans SC5314Ortholog(s) have ethanolaminephosphotransferase activity, diacylglycerol cholinephosphotransferase activity, role in phosphatidylethanolamine biosynthetic process, phosphatidylcholine biosynthetic process and Golgi apparatus localization
orf19.3697Candida albicans SC5314Ortholog(s) have role in re-entry into mitotic cell cycle after pheromone arrest
orf19.3698Candida albicans SC5314Predicted ORF in Assemblies 19, 20 and 21; filament induced
orf19.6240Candida albicans SC5314Ortholog(s) have role in barrier septum formation involved in cell cycle cytokinesis and cellular bud neck contractile ring localization
orf19.6243VPS34Candida albicans SC5314Autophosphorylated class III phosphatidylinositol 3-kinase, required for normal vesicle transport, hyphal growth, fibroblast adherence, virulence in mouse systemic infection; growth-regulated; caspofungin and hydrogen peroxide sensitivity
orf19.6245Candida albicans SC5314Predicted ORF in Assemblies 19, 20 and 21; regulated by osmotic stress (via Hog1p) and oxidative stress (Hog1p- and Cap1p-independent); transcription is induced in response to alpha pheromone in SpiderM medium
Locus IdGene NameOrganismDescription
orf19.6247Candida albicans SC5314Ortholog(s) have chromatin binding activity and role in replicative cell aging, double-strand break repair via break-induced replication, DNA-dependent DNA replication initiation, mitotic sister chromatid cohesion
orf19.6249HAK1Candida albicans SC5314Putative potassium transporter; similar to Schwanniomyces occidentalis Hak1p; amphotericin B induced; transcriptionally induced upon phagocytosis by macrophage; Hap43p-repressed gene
orf19.10ALK8Candida albicans SC5314Alkane-inducible cytochrome P450; catalyzes hydroxylation of lauric acid to hydroxylauric acid; overproduction causes fluconazole resistance in a wild-type background and causes multidrug resistance in a cdr1 cdr2 double mutant background
orf19.17SCP1Candida albicans SC5314Putative cortical actin cytoskeleton protein; constitutive expression independent of MTL or white-opaque status
orf19.6252Candida albicans SC5314Ortholog(s) have core RNA polymerase II binding transcription factor activity, RNA polymerase II transcription factor binding transcription factor activity
orf19.6253RPS23ACandida albicans SC5314Putative ribosomal protein; genes encoding cytoplasmic ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage
orf19.6255Candida albicans SC5314Putative protein of unknown function; Hap43p-repressed gene
orf19.6259Candida albicans SC5314Has domain(s) with predicted RNA binding, 3'-5'-exoribonuclease activity
orf19.24RTA2Candida albicans SC5314Putative flippase required for sphingolipid long chain base release; mediates calcineurin-dependent resistance to azoles; stress-associated protein; Ca2+, calcineurin-regulated; ketoconazole, caspofungin induced; Plc1p-regulated
orf19.25Candida albicans SC5314Ortholog(s) have tRNA (guanine) methyltransferase activity, role in tRNA methylation and nucleus, cytoplasm localization
orf19.29Candida albicans SC5314Late-stage biofilm-induced gene
orf19.5601Candida albicans SC5314
orf19.5602BMT6Candida albicans SC5314Putative beta-mannosyltransferase, member of a 9-gene family that includes characterized genes BMT1, BMT2, BMT3, and BMT4 with roles in beta-1,2-mannosylation of cell wall phosphopeptidomannan; biofilm- and planktonic growth-induced gene
orf19.5604MDR1Candida albicans SC5314Plasma membrane multidrug efflux pump; MDR major facilitator transporter superfamily; methotrexate is preferred substrate; overexpression in drug-resistant clinical isolates confers fluconazole resistance; repressed in young biofilms
orf19.5605Candida albicans SC5314
orf19.6263Candida albicans SC5314Predicted membrane transporter, member of the monocarboxylate porter (MCP) family, major facilitator superfamily (MFS)
orf19.5608Candida albicans SC5314Ortholog(s) have DNA-directed RNA polymerase activity, role in tRNA transcription from RNA polymerase III promoter and DNA-directed RNA polymerase III complex, mitochondrion localization
orf19.5609Candida albicans SC5314
orf19.6267Candida albicans SC5314Protein not essential for viability
orf19.6268Candida albicans SC5314Putative cohesin complex subunit; expression downregulated in an ssr1 null mutant
Locus IdGene NameOrganismDescription
orf19.30Candida albicans SC5314Putative calcium-transporting ATPase
orf19.35Candida albicans SC5314Biofilm-induced gene
orf19.36Candida albicans SC5314Predicted ORF in Assemblies 19, 20 and 21; clade-associated gene expression
orf19.5610ARG3Candida albicans SC5314Putative ornithine carbamoyltransferase; Gcn4p-regulated; Hap43p-induced gene; repressed in alkalinizing medium
orf19.5611Candida albicans SC5314Ortholog(s) have 3-methylbutanol:NAD(P) oxidoreductase activity, methylglyoxal reductase (NADPH-dependent) activity, role in filamentous growth, ergosterol metabolic process and nucleus, cytosol localization
orf19.5614Candida albicans SC5314Putative ribonuclease H1; biofilm-induced gene; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.6271Candida albicans SC5314
orf19.5615AYR2Candida albicans SC5314Putative NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase; shows colony morphology-related gene regulation by Ssn6p
orf19.5616Candida albicans SC5314
orf19.6273Candida albicans SC5314
orf19.5617Candida albicans SC5314Ortholog(s) have methylated histone residue binding, transcription factor binding activity
orf19.5618Candida albicans SC5314Has domain(s) with predicted role in vesicle docking involved in exocytosis
orf19.6277Candida albicans SC5314Has domain(s) with predicted phosphatidylinositol binding activity and role in cell communication
orf19.5621Candida albicans SC5314Putative protein of unknown function; mutation confers hypersensitivity to amphotericin B; overlaps orf19.5621
orf19.5623ARP4Candida albicans SC5314Subunit of the NuA4 histone acetyltransferase complex
orf19.6280Candida albicans SC5314
orf19.6282Candida albicans SC5314Has domain(s) with predicted nucleic acid binding, nucleotide binding activity
orf19.5626Candida albicans SC5314Biofilm-induced gene; Plc1p-regulated; transcriptionally activated by Mnl1p under weak acid stress
orf19.5627Candida albicans SC5314Hap43p-induced gene
orf19.5628Candida albicans SC5314Mitochondrial dicarboxylate transporter; possibly an essential gene, disruptants not obtained by UAU1 method
Locus IdGene NameOrganismDescription
orf19.5629QCR7Candida albicans SC5314Putative ubiquinol-cytochrome-c reductase, subunit 7; Hap43p-repressed gene
orf19.6286Candida albicans SC5314Ortholog(s) have role in vacuolar transport and endosome localization
orf19.6288Candida albicans SC5314
orf19.53Candida albicans SC5314Has domain(s) with predicted zinc ion binding, nucleotide binding, RNA binding activity and nucleus localization
orf19.54RHD1Candida albicans SC5314Putative beta-mannosyltransferase, required for the addition of beta-mannose to the acid-labile fraction of cell wall phosphopeptidomannan; member of a 9-gene family; transcriptionally regulated on yeast-hyphal and white-opaque switches
orf19.56ARG2Candida albicans SC5314Putative enzyme of arginine biosynthesis; transcription of genes of arginine biosynthesis pathway, except for ARG2, is induced upon phagocytosis by macrophage
orf19.58RRP6Candida albicans SC5314Putative nuclear exosome exonuclease component; Hap43p-induced gene; mutation confers hypersensitivity to 5-fluorocytosine (5-FC), 5-fluorouracil (5-FU), and tubercidin (7-deazaadenosine)
orf19.59REI1Candida albicans SC5314Putative cytoplasmic pre-60S factor; Hap43p-induced gene; decreased expression in response to prostaglandins
orf19.5633Candida albicans SC5314Late-stage biofilm-induced gene
orf19.5634FRP1Candida albicans SC5314Ferric reductase; alkaline-induced by Rim101p; iron-chelation-induced by CCAAT-binding factor; fluconazole-downregulated; ciclopirox-, biofilm-, hypoxia-, Hap43p-induced; colony morphology-related regulation by Ssn6p; 2 CCAAT box motifs
orf19.5635PGA7Candida albicans SC5314Hyphal surface antigen precursor; possible GPI-anchor; induced by ciclopirox olamine, ketoconazole, or by Rim101p at pH 8; regulated during biofilm and planktonic growth; cell wall regeneration-induced; Hap43p-, fluconazole, biofilm-induced
orf19.5636RBT5Candida albicans SC5314GPI-anchored cell wall protein involved in hemoglobin utilization; transcript regulated by Rfg1p, Rim101p, Tbf1p, iron; repressed by Sfu1p, Hog1p, Tup1p; induced by serum, alkaline pH, ketoconazole, ciclopirox olamine, Hap43p, biofilm
orf19.6293EMP24Candida albicans SC5314COPII-coated vesicle component
orf19.6295MAS2Candida albicans SC5314Putative processing peptidase, catalytic (alpha) subunit; protein level decreases in stationary phase cultures
orf19.6296VPS22Candida albicans SC5314Putative ESCRT-II complex protein with a role in multivesicular body (MVB) trafficking; Hap43p-repressed gene
orf19.6297Candida albicans SC5314Ortholog(s) have pseudouridine synthase activity, role in tRNA pseudouridine synthesis and nucleus, cytoplasm localization
orf19.5640PEX5Candida albicans SC5314Pex5p family protein; required for PTS1-mediated peroxisomal protein import, fatty acid beta-oxidation; similar to S. cerevisiae Pas10p peroxisomal targeting receptor; macrophage/pseudohyphal-repressed; Hap43p-repressed
orf19.5641CAR2Candida albicans SC5314Ornithine aminotransferase; role in arginine metabolism; alkaline upregulated; mutation confers hypersensitivity to toxic ergosterol analog and to amphotericin B; present in exponential and stationary phase yeast cultures; biofilm-induced
orf19.5643ECM7Candida albicans SC5314Ortholog(s) have role in cellular response to drug, fungal-type cell wall organization, calcium ion transport
orf19.5644Candida albicans SC5314
Locus IdGene NameOrganismDescription
orf19.2301Candida albicans SC5314Ortholog(s) have role in proteasome regulatory particle assembly and nucleus, cytosol localization
orf19.5645MET15Candida albicans SC5314O-acetylhomoserine O-acetylserine sulfhydrylase; involved in sulfur amino acid biosynthesis; immunogenic; Hog1p, biofilm, possibly adherence-induced; brown colony color of homozygous mutant in Pb(2+) medium is visual selection marker
orf19.2302Candida albicans SC5314Has domain(s) with predicted role in transmembrane transport
orf19.5646Candida albicans SC5314Ortholog of S. cerevisiae : YPL034W and C. glabrata CBS138 : CAGL0L06996g
orf19.2303FGR16Candida albicans SC5314Protein lacking an ortholog in S. cerevisiae; transposon mutation affects filamentous growth; fluconazole-downregulated
orf19.2304Candida albicans SC5314Protein similar to S. cerevisiae Gvp36p; transposon mutation affects filamentous growth
orf19.5648Candida albicans SC5314
orf19.2306Candida albicans SC5314Ortholog(s) have oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen activity and role in L-methionine salvage from methylthioadenosine
orf19.2308Candida albicans SC5314Hap43p-repressed gene; biofilm- and planktonic growth-induced gene
orf19.71Candida albicans SC5314Ortholog of C. glabrata CBS138 : CAGL0F00583g
orf19.73Candida albicans SC5314Ortholog(s) have role in ribosome biogenesis and ribosome, cytoplasm localization
orf19.75Candida albicans SC5314Predicted exocyst component; ortholog of S. cerevisiae Sec5p; merged with orf19.74 in Assembly 21
orf19.5650PRO3Candida albicans SC5314Delta 1-pyrroline-5-carboxylate reductase; protein induced during the mating process; alkaline upregulated; stationary phase enriched protein
orf19.5653ATP2Candida albicans SC5314F1 beta subunit of F1F0 ATPase complex; antigenic in human, mouse; induced by ciclopirox olamine; flucytosine; caspofungin repressed; macrophage/pseudohyphal-induced; detected during exponential and stationary growth phases
orf19.2310Candida albicans SC5314Putative single-stranded nucleic acid binding protein; biofilm-induced gene; ortholog of S. cerevisiae RRT5
orf19.2311RPL82Candida albicans SC5314Predicted ribosomal protein; genes encoding cytoplasmic ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage
orf19.2312Candida albicans SC5314Protein similar to ferric reductase Fre10p; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.5657SWI1Candida albicans SC5314Protein involved in transcription regulation; ortholog of S. cerevisiae Swi1p, which is a subunit of the SWI/SNF chromatin remodeling complex; interacts with Snf2p; SWI/SNF complex is essential for hyphal growth and virulence
orf19.5658MNN10Candida albicans SC5314Ortholog(s) have alpha-1,6-mannosyltransferase activity, role in barrier septum formation and alpha-1,6-mannosyltransferase complex localization
orf19.2315Candida albicans SC5314Putative transcription factor with bZIP DNA-binding motif
Locus IdGene NameOrganismDescription
orf19.2317Candida albicans SC5314Predicted ORF in Assemblies 19, 20 and 21; transcription is induced in response to alpha pheromone in SpiderM medium
orf19.81Candida albicans SC5314Has domain(s) with predicted RNA binding, 3'-5'-exoribonuclease activity
orf19.85GPX2Candida albicans SC5314Similar to glutathione peroxidase; expression greater in high iron; alkaline upregulated by Rim101p; transcriptionally induced by alpha factor or interaction with macrophage; regulated by Efg1p; caspofungin repressed
orf19.86Candida albicans SC5314Putative glutathione peroxidase; peroxide-induced; induced in response to peroxide, exposure to neutrophils and macrophage blood fractions; downregulated during infection of macrophages
orf19.88ILV5Candida albicans SC5314Putative ketol-acid reductoisomerase; antigenic during human/murine infection; regulated by Gcn4p; amino acid starvation (3-AT)-induced; biofilm induced; macrophage-downregulated protein; protein present in exponential and stationary phase
orf19.5660Candida albicans SC5314Ortholog(s) have ubiquitin-protein ligase activity, role in protein ubiquitination, protein import into peroxisome matrix and peroxisomal membrane localization
orf19.5661PTC7Candida albicans SC5314Protein phosphatase, type 2C; has S/T phosphatase activity, Mn2+/Mg2+ dependent; predicted membrane-spanning segment and mitochondrion-targeting signal
orf19.5663RCH1Candida albicans SC5314Putative transporter protein; null mutation confers resistance to azoles and terbinafine
orf19.5664HOF1Candida albicans SC5314Protein not essential for viability; similar to S. cerevisiae Hof1p, which is a protein localized to the bud neck and required for cytokinesis; periodic mRNA expression, peak at cell-cycle G2/M phase
orf19.5665Candida albicans SC5314Ortholog(s) have D-arabinose 1-dehydrogenase [NAD(P)+] activity and role in dehydro-D-arabinono-1,4-lactone biosynthetic process
orf19.2324UBA4Candida albicans SC5314Putative ubiquitin activating protein; Hap43p-repressed gene; increased expression in response to prostaglandins; clade-associated gene expression
orf19.2325Candida albicans SC5314Ortholog of S. cerevisiae : TFC6 and C. glabrata CBS138 : CAGL0A02695g
orf19.2326Candida albicans SC5314Ortholog(s) have role in chromatin silencing at silent mating-type cassette, intra-S DNA damage checkpoint, double-strand break repair via homologous recombination, mitotic sister chromatid cohesion and nucleus localization
orf19.95Candida albicans SC5314Ortholog of S. cerevisiae : PRM5
orf19.97CAN1Candida albicans SC5314Basic amino acid permease; complements lysine transport mutation; 10 predicted transmembrane regions, 3 predicted N-glycosylation sites; transcriptionally induced by phagocytosis by macrophages; late-stage biofilm-induced
orf19.5672MEP2Candida albicans SC5314Ammonium permease and regulator of nitrogen starvation-induced filamentation; 11 predicted transmembrane regions; in low nitrogen cytoplasmic C-terminus activates Ras/cAMP and MAPK signal transduction pathways to induce filamentation
orf19.5674PGA10Candida albicans SC5314Plasma membrane protein of heme-iron utilization; allows utilization of hemin and hemoglobin as iron sources in host tissues; predicted GPI anchor; biofilm, hypoxia, ketoconazole, ciclopirox, or hyphal-induced; upregulated by Rim101p at pH8
orf19.2331ADA2Candida albicans SC5314Putative transcriptional coactivator; cell wall integrity role; required for wild-type transcriptional response to caspofungin; mutant is caspofungin hypersensitive; role in regulation with Cas5p; zinc finger DNA-binding motif
orf19.5675Candida albicans SC5314Has domain(s) with predicted DNA binding, helicase activity, ATP binding, zinc ion binding activity
orf19.2332Candida albicans SC5314
Locus IdGene NameOrganismDescription
orf19.5676Candida albicans SC5314Ortholog(s) have cytoplasm localization
orf19.2333Candida albicans SC5314Ortholog(s) have role in retrograde transport, endosome to Golgi and late endosome localization
orf19.5677DUR4Candida albicans SC5314Putative urea permease; fungal-specific (no human or murine homolog); possibly an essential gene, disruptants not obtained by UAU1 method
orf19.2334BIG1Candida albicans SC5314Endoplasmic reticulum (ER) protein required for beta-1,6-glucan synthesis, filamentation, adhesion, and virulence; ortholog of S. cerevisiae Big1p
orf19.5678Candida albicans SC5314Ortholog(s) have role in peptidyl-diphthamide biosynthetic process from peptidyl-histidine and cytoplasm localization
orf19.2337ALP1Candida albicans SC5314Cystine transporter; fungal-specific (no human or murine homolog)
orf19.5680Candida albicans SC5314Predicted ORF in Assemblies 19, 20 and 21; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.5682Candida albicans SC5314Ortholog(s) have protein transporter activity, role in protein targeting to membrane, protein import into nucleus and nucleus, nuclear exosome (RNase complex), cytoplasm localization
orf19.5683Candida albicans SC5314Predicted ORF in Assemblies 19, 20 and 21; clade-associated gene expression
orf19.5684Candida albicans SC5314Ortholog(s) have structural constituent of ribosome activity and mitochondrial large ribosomal subunit localization
orf19.2341HNT1Candida albicans SC5314Protein with similarity to protein kinase C inhibitor-I; protein level decreases in stationary phase cultures
orf19.5685THS1Candida albicans SC5314Putative threonyl-tRNA synthetase; transcription regulated by Mig1p and Tup1p; downregulated upon phagocytosis by murine macrophages; stationary phase enriched protein
orf19.5686Candida albicans SC5314
orf19.2343VPS23Candida albicans SC5314Protein involved in proteolytic activation of Rim101p, which regulates pH response; similar to S. cerevisiae Stp22p/Vps23p, which is a member of the ESCRT I protein sorting complex
orf19.5689Candida albicans SC5314Ortholog(s) have role in late endosome to vacuole transport via multivesicular body sorting pathway, vesicle coating, ER to Golgi vesicle-mediated transport and endosome, COPI vesicle coat localization
orf19.2347MNN2Candida albicans SC5314Alpha-1,2-mannosyltransferase; likely involved in iron utilization in the endocytosis pathway under iron-limiting conditions; similar to S. cerevisiae Mnn2p and Mnn5p; transposon mutation affects filamentous growth; filament induced
orf19.5691CDC11Candida albicans SC5314Septin; required for wild-type cell and hyphal morphology, agar-invasive growth, full virulence and kidney tissue invasion in mouse, but not for kidney colonization, immunogenicity; phosphorylation is hyphal- and cell-cycle-regulated
orf19.5692Candida albicans SC5314
orf19.2350Candida albicans SC5314Protein similar to S. cerevisiae Yor378wp; transposon mutation affects filamentous growth; not essential for viability; member of MFS family of transporters; fungal-specific (no human or murine homolog)
orf19.2352Candida albicans SC5314Ortholog(s) have mitochondrion localization
Locus IdGene NameOrganismDescription
orf19.5698Candida albicans SC5314Putative mitochondrial ribosomal protein of the large subunit; transcription is upregulated in clinical isolates from HIV+ patients with oral candidiasis
orf19.1700RPS7ACandida albicans SC5314Ribosomal protein S7; genes encoding cytoplasmic ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage
orf19.1702ARF3Candida albicans SC5314Transcription is filament induced; Tup1p regulated (see Locus History Note for Assembly 19 correction)
orf19.1704FOX3Candida albicans SC5314Putative peroxisomal 3-oxoacyl CoA thiolase; expression is regulated upon white-opaque switching
orf19.2362Candida albicans SC5314Putative 90S preribosome component; Hap43p-induced gene; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.1706MET18Candida albicans SC5314Putative protein with a predicted role in nucleotide excision repair (NER) and RNA polymerase II (RNAP II) transcription; Plc1p-regulated
orf19.1708Candida albicans SC5314
orf19.2368Candida albicans SC5314Ortholog(s) have chromatin, U5 snRNP, U4/U6 x U5 tri-snRNP complex localization
orf19.2369Candida albicans SC5314Ortholog(s) have DNA replication origin binding, ATP binding activity
orf19.1711END3Candida albicans SC5314Regulated by Gcn4p; induced in response to amino acid starvation (3-aminotriazole treatment)
orf19.2370DSL1Candida albicans SC5314Protein similar to S. cerevisiae Dsl1p, which is a member of the t-SNARE complex of the endoplasmic reticulum
orf19.1716URA3Candida albicans SC5314Orotidine-5'-phosphate decarboxylase, enzyme of pyrimidine biosynthesis; gene used as a molecular genetic marker, but decreased expression when integrated at ectopic chromosomal locations can cause defects in hyphal growth and virulence
orf19.1719SGA1Candida albicans SC5314Putative glucoamylase; fungal-specific (no human or murine homolog)
orf19.2378Candida albicans SC5314Ortholog(s) have role in vacuolar proton-transporting V-type ATPase complex assembly and integral to endoplasmic reticulum membrane localization
orf19.2379NOT4Candida albicans SC5314Putative E3 ubiquitin-protein ligase; required for maintenance, but not induction, of hyphal development; homozygous null mutant is avirulent in mouse systemic infection despite persistence in host; repressed in rat oral candidiasis
orf19.7600FDH3Candida albicans SC5314Glutathione-dependent formaldehyde dehydrogenase involved in glycine catabolism; downregulated by Efg1p under yeast, not hyphal growth conditions; transcriptionally activated by Mnl1p under weak acid stress
orf19.7601Candida albicans SC5314Ortholog(s) have rRNA (uridine-2'-O-)-methyltransferase activity, role in rRNA methylation and mitochondrion localization
orf19.7605PUP1Candida albicans SC5314Putative beta 2 subunit of the 20S proteasome; macrophage/pseudohyphal-repressed
orf19.7606Candida albicans SC5314
orf19.7608Candida albicans SC5314Predicted ORF in Assemblies 19, 20 and 21; fluconazole-downregulated
Locus IdGene NameOrganismDescription
orf19.7609PGA11Candida albicans SC5314Putative GPI-anchored protein
orf19.1720Candida albicans SC5314Ortholog(s) have role in mitotic recombination
orf19.1721NCE103Candida albicans SC5314Carbonic anhydrase involved in the conversion of CO2 to bicarbonate; essential for virulence in host niches with limited CO2, wild-type white-opaque switching; biofilm induced; activated by Mnl1p under weak acid stress; Hap43p-induced gene
orf19.1722Candida albicans SC5314
orf19.1725Candida albicans SC5314Putative adhesin-like protein
orf19.1727PMC1Candida albicans SC5314Vacuolar calcium P-type ATPase; transcription is regulated by calcineurin and fluconazole; mutant shows increased resistance to fluconazole or lithium, and increased sensitivity to calcium
orf19.1728Candida albicans SC5314
orf19.1729Candida albicans SC5314Putative transcription factor with zinc finger DNA-binding motif
orf19.2386Candida albicans SC5314Ortholog of S. cerevisiae : UTP11 and C. glabrata CBS138 : CAGL0F07645g
orf19.7610PTP3Candida albicans SC5314Protein not essential for viability; similar to S. cerevisiae Ptp3p, which is a protein tyrosine phosphatase; hyphal induced; alkaline upregulated; regulated by Efg1p, Ras1p, cAMP pathways
orf19.7611TRX1Candida albicans SC5314Thioredoxin, involved in response to reactive oxygen species; biofilm, benomyl, flucytosine, peroxide, Hap43p induced; amphotericin B, caspofungin repressed; upregulated in the presence of human neutrophils; macrophage-downregulated gene
orf19.7612CTM1Candida albicans SC5314Putative cytochrome c lysine methyltransferase; early-stage biofilm-induced gene; regulated by Gcn2p and Gcn4p; transcriptionally activated by Mnl1p under weak acid stress
orf19.7613HCR1Candida albicans SC5314Putative translation initiation factor; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage
orf19.7615Candida albicans SC5314Protein involved in endoplasmic reticulum (ER) to Golgi vesicle-mediated transport; putative subunit of the transport protein particle (TRAPP) complex of the cis-Golgi
orf19.7617Candida albicans SC5314Ortholog(s) have peptide alpha-N-acetyltransferase activity, role in N-terminal protein amino acid acetylation, histone acetylation and NatA complex, cytosolic ribosome localization
orf19.1730Candida albicans SC5314Ortholog(s) have loop DNA binding, DNA end binding activity, role in double-strand break repair, nucleosome mobilization and Ino80 complex localization
orf19.1734Candida albicans SC5314Putative ATPase and nucleosome spacing factor; heterozygous null mutant displays sensitivity to virgineone
orf19.1735Candida albicans SC5314
orf19.2392Candida albicans SC5314Protein not essential for viability
orf19.2393Candida albicans SC5314Putative transcription factor with zinc finger DNA-binding motif
Locus IdGene NameOrganismDescription
orf19.1737Candida albicans SC5314
orf19.1738UGP1Candida albicans SC5314Protein similar to UTP-glucose-1-phosphaturidyl transferase; localizes to cell surface of yeast-form cells, but not hyphal cells; Hog1p-downregulated; stationary phase enriched protein
orf19.2396IFR2Candida albicans SC5314Zinc-binding dehydrogenase; upregulated by benomyl, ciclopirox olamine or alpha pheromone; regulated by oxidative stress (via Cap1p) and osmotic stress (via Hog1p); protein present in exponential and stationary phase; Hap43p-induced gene
orf19.2397Candida albicans SC5314Predicted membrane transporter, member of the anion:cation symporter (ACS) family, major facilitator superfamily (MFS); amphotericin B, caspofungin repressed; Hap43p-repressed
orf19.7620Candida albicans SC5314
orf19.7622SPT3Candida albicans SC5314Functional homolog of S. cerevisiae Spt3p; required for virulence in mouse systemic infection; homozygous null mutant is hyperfilamentous
orf19.7624Candida albicans SC5314Ortholog(s) have role in rRNA processing and 90S preribosome, nucleolus localization
orf19.7627Candida albicans SC5314Ortholog(s) have mitochondrion localization
orf19.7629Candida albicans SC5314Ortholog(s) have ribosome, extrinsic to fungal-type vacuolar membrane, Seh1-associated complex localization
orf19.1743ACS1Candida albicans SC5314Putative acetyl-CoA synthetase; upregulated by human neutrophils; fluconazole-downregulated; regulated by Nrg1p and Mig1p; shows colony morphology-related gene regulation by Ssn6p; only detected in stationary phase cultures; biofilm-induced
orf19.1745Candida albicans SC5314Hap43p-repressed gene
orf19.1747KIP2Candida albicans SC5314Protein similar to S. cerevisiae Kip2p; transcription is repressed in response to alpha pheromone in SpiderM medium; periodic mRNA expression, peak at cell-cycle G2/M phase
orf19.1748Candida albicans SC5314Predicted ORF in Assemblies 19, 20 and 21; shows colony morphology-related gene regulation by Ssn6p
orf19.7632Candida albicans SC5314
orf19.7634MCD1Candida albicans SC5314Protein similar to S. cerevisiae Mcd1p; transcription is repressed in response to alpha pheromone in SpiderM medium; cell-cycle regulated periodic mRNA expression; Hap43p-induced
orf19.7637YHB4Candida albicans SC5314Protein related to flavohemoglobins; not required for wild-type nitric oxide resistance; has predicted globin, FAD-binding, and NAD(P)-binding domains but lacks some conserved residues of flavohemoglobins; Hap43p-repressed gene
orf19.1751SPT23Candida albicans SC5314Protein involved in regulation of unsaturated fatty acid biosynthesis; controls the expression of the Ole1p delta-9-fatty acid desaturase
orf19.1753PUS7Candida albicans SC5314Protein similar to S. cerevisiae tRNA modification protein; induced upon biofilm formation
orf19.1755SET2Candida albicans SC5314Ortholog(s) have histone methyltransferase activity (H3-K36 specific) activity
orf19.1756GPD1Candida albicans SC5314Protein similar to S. cerevisiae glycerol-3-phosphate dehydrogenase (enzyme of glycerol biosynthesis); biofilm-induced expression; regulated by Efg1p; regulated by Tsa1p, Tsa1Bp under H2O2 stress conditions
Locus IdGene NameOrganismDescription
orf19.1757Candida albicans SC5314Putative transcription factor with zinc finger DNA-binding motif; transcription is upregulated in clinical isolates from HIV+ patients with oral candidiasis
orf19.1759PHO23Candida albicans SC5314Ortholog(s) have methylated histone residue binding activity
orf19.600TRK1Candida albicans SC5314Potassium transporter; mediates K+ and Cl- influx; role in sensitivity to cationic antimicrobial peptides, not by direct uptake, possibly related to membrane permeability; fungal-specific (no human or murine homolog); contains 5' UTR intron
orf19.603IMP4Candida albicans SC5314Putative SSU processome component; Hap43p-induced gene; decreased expression in response to prostaglandins
orf19.605Candida albicans SC5314
orf19.606Candida albicans SC5314Hap43p-induced gene; ortholog of S. cerevisiae YLR352W
orf19.7643Candida albicans SC5314Ortholog(s) have 4-hydroxybenzoate octaprenyltransferase activity, role in ubiquinone biosynthetic process and microsome, integral to mitochondrial membrane localization
orf19.7644Candida albicans SC5314Ortholog(s) have ubiquitin-protein ligase activity, role in anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process, protein ubiquitination and anaphase-promoting complex localization
orf19.609Candida albicans SC5314Predicted ORF in Assemblies 19, 20 and 21; transcription is specific to white cell type
orf19.7645Candida albicans SC5314Biotin protein ligase; catalyzes covalent attachment of biotin to biotin-dependent enzymes including acetyl CoA carboxylase and pyruvate carboxylase
orf19.7646Candida albicans SC5314Ortholog of C. glabrata CBS138 : CAGL0D03916g
orf19.7648Candida albicans SC5314Has domain(s) with predicted antiporter activity, drug transmembrane transporter activity, role in drug transmembrane transport and membrane localization
orf19.4305Candida albicans SC5314
orf19.4307Candida albicans SC5314Ortholog(s) have role in late endosome to vacuole transport via multivesicular body sorting pathway, protein targeting to vacuole and late endosome localization
orf19.4309GRP2Candida albicans SC5314Methylglyoxal reductase; regulation associated with azole resistance; induced in core stress response or by oxidative stress (via Cap1p), fluphenazine, benomyl, or with long term fluconazole treatment; Hap43p-induced; antigenic in humans
orf19.1760RAS1Candida albicans SC5314RAS signal transduction GTPase; regulates cAMP and MAP kinase pathways; role in hyphal induction, virulence, apoptosis, heat-shock sensitivity; nonessential; plasma membrane-localized; complements viability of S. cerevisiae ras1 ras2 mutant
orf19.1762OCA1Candida albicans SC5314Putative protein phosphatase of the PTP family (tyrosine-specific), similar to S. cerevisiae Oca1p; mutant shows virulence defect; not essential for viability
orf19.1764Candida albicans SC5314
orf19.1765Candida albicans SC5314Secreted protein; fluconazole-induced
orf19.1767Candida albicans SC5314Ortholog(s) have protein complex scaffold, ubiquitin-specific protease activity, role in histone deubiquitination, histone H3-K4 methylation, histone H3-K79 methylation and DUBm complex, SAGA complex, SLIK (SAGA-like) complex localization
Locus IdGene NameOrganismDescription
orf19.7650LTV1Candida albicans SC5314Putative GSE complex component; decreased expression in response to prostaglandins
orf19.4310Candida albicans SC5314
orf19.4311YNK1Candida albicans SC5314Nucleoside diphosphate kinase (NDP kinase); homo-hexameric; soluble protein in hyphae; flucytosine induced; biofilm induced; macrophage-induced protein; stationary phase enriched protein
orf19.4312Candida albicans SC5314Ortholog(s) have transcription cofactor activity, TBP-class protein binding activity
orf19.7657POP3Candida albicans SC5314Putative RNase MRP and nuclear RNase P component; decreased expression in response to prostaglandins
orf19.4315Candida albicans SC5314Has domain(s) with predicted Rab GTPase activator activity, role in regulation of Rab GTPase activity and intracellular localization
orf19.4317GRE3Candida albicans SC5314Putative D-xylose reductase; antigenic in murine systemic infection; soluble protein in hyphae; transcriptionally induced by macrophage interaction and by Mnl1p under weak acid stress; farnesol-induced; stationary-phase enriched protein
orf19.1770CYC1Candida albicans SC5314Cytochrome c; complements defects of S. cerevisiae cyc1 cyc7 double mutant; expression greater in high iron; alkaline downregulated; repressed by nitric oxide; Cap2-dependent downregulation in low iron; regulated by Sef1p, Sfu1p, and Hap43p
orf19.1773RAP1Candida albicans SC5314Transcriptional regulator that binds telomeres and regulatory sequences in DNA; involved in telomere maintenance; represses hyphal growth under yeast-favoring conditions; similar to (but shorter than) S. cerevisiae Rap1p
orf19.1774Candida albicans SC5314Predicted ORF in Assemblies 19, 20 and 21; transcription is upregulated in an RHE model of oral candidiasis; virulence-group-correlated expression
orf19.1776Candida albicans SC5314Ortholog(s) have role in coenzyme A biosynthetic process and nucleus, cytoplasm localization
orf19.1778Candida albicans SC5314
orf19.1779MP65Candida albicans SC5314Cell surface mannoprotein; cell-wall glucan metabolism, biofilm, adhesion; adhesin motif; O-glycosylation; induced by heat, germ tube formation, wall regeneration; mycelial antigen; diagnostic marker; fluconazole-repressed
orf19.7660VPS52Candida albicans SC5314Protein required for hyphal growth; has similarity to S. cerevisiae Vps52p
orf19.7661HMI1Candida albicans SC5314ATP-dependent 3' - 5' helicase involved in maintenance of mitochondrial DNA; ortholog of S. cerevisiae Hmi1p
orf19.7662Candida albicans SC5314
orf19.4320Candida albicans SC5314
orf19.7664Candida albicans SC5314
orf19.7665Candida albicans SC5314Ortholog(s) have role in mitochondrial respiratory chain complex IV assembly and mitochondrial inner membrane localization
orf19.4322DAP2Candida albicans SC5314Putative dipeptidyl aminopeptidase; transcriptionally regulated during macrophage response
Locus IdGene NameOrganismDescription
orf19.7666Candida albicans SC5314Predicted membrane transporter, member of the anion:cation symporter (ACS) family, major facilitator superfamily (MFS)
orf19.4323Candida albicans SC5314Ortholog(s) have phosphatidylinositol-3-phosphate binding activity and endosome localization
orf19.7667IAH1Candida albicans SC5314Protein similar to S. cerevisiae Iah1p, which is involved in acetate metabolism; mutation confers hypersensitivity to tunicamycin; transposon mutation affects filamentous growth
orf19.4324Candida albicans SC5314Has domain(s) with predicted electron carrier activity, NADH dehydrogenase (ubiquinone) activity and membrane localization
orf19.7668MAL2Candida albicans SC5314Alpha-glucosidase that hydrolyzes sucrose; required for sucrose utilization; transcriptionally regulated by Suc1p; expression induced by maltose, repressed by glucose; transposon mutation affects filamentous growth; upregulated in RHE model
orf19.4325Candida albicans SC5314
orf19.4326Candida albicans SC5314
orf19.4328CCC2Candida albicans SC5314Copper-transporting P-type ATPase of Golgi; required for wild-type iron assimilation (indirect effect via Fet3p); induced by iron starvation, ciclopirox olamine; caspofungin repressed; not required for virulence in mouse systemic infection
orf19.1780Candida albicans SC5314Has domain(s) with predicted catalytic activity
orf19.1789Candida albicans SC5314Ortholog of C. glabrata CBS138 : CAGL0J11110g
orf19.633Candida albicans SC5314Putative methyltransferase; decreased expression in hyphae compared to yeast-form cells; expression regulated during planktonic growth; late-stage biofilm-induced gene; Hap43p-repressed gene
orf19.7672Candida albicans SC5314Ortholog(s) have role in ER-associated protein catabolic process, endoplasmic reticulum unfolded protein response and endoplasmic reticulum, Doa10p ubiquitin ligase complex, Hrd1p ubiquitin ligase ERAD-L complex localization
orf19.637SDH2Candida albicans SC5314Succinate dehydrogenase, Fe-S subunit; localizes to surface of yeast cells, but not hyphae; transcriptionally regulated by iron; expression greater in high iron; repressed by nitric oxide, Hap43p; induced during log phase aerobic growth
orf19.7673Candida albicans SC5314Ortholog(s) have mRNA binding activity, role in nuclear mRNA splicing, via spliceosome and U1 snRNP, U2-type prespliceosome, U5 snRNP, U4/U6 x U5 tri-snRNP complex, commitment complex localization
orf19.638FDH1Candida albicans SC5314Formate dehydrogenase, oxidizes formate to produce CO2; Mig1p regulated; induced by macrophages; fluconazole-downregulated; downregulated by Efg1p under yeast, not hyphal, growth conditions; predicted cytosolic; stationary phase enriched
orf19.7676XYL2Candida albicans SC5314Putative D-xylulose reductase; immunogenic in mice; soluble protein in hyphae; induced by caspofungin, fluconazole, Hog1p and during cell wall regeneration; Mnl1p-induced in weak acid stress; stationary phase enriched; biofilm-induced
orf19.4335TNA1Candida albicans SC5314Putative nicotinic acid transporter; fungal-specific (no human or murine homolog); detected at germ tube plasma membrane by mass spectrometry; transcriptionally induced upon phagocytosis by macrophage
orf19.4337Candida albicans SC5314Predicted membrane transporter, member of the monocarboxylate porter (MCP) family, major facilitator superfamily (MFS)
orf19.4339VPS4Candida albicans SC5314Protein involved in transport from multivesicular body (MVB) to the vacuole; mutation causes decreased SAP secretion and decreased virulence in murine intravenous infection; regulated by Gcn2p and Gcn4p
orf19.1791Candida albicans SC5314Putative protein with a predicted role in 60S ribosomal subunit biogenesis; Hap43p-induced gene; ortholog of S. cerevisiae MAK11
Locus IdGene NameOrganismDescription
orf19.1792Candida albicans SC5314Ortholog(s) have role in mitotic cell cycle, anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process, negative regulation of DNA-dependent DNA replication initiation, protein ubiquitination
orf19.1794Candida albicans SC5314
orf19.1796Candida albicans SC5314Ortholog(s) have oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor activity and role in metabolic process
orf19.1797Candida albicans SC5314Predicted ORF in Assemblies 19, 20 and 21; induced upon biofilm formation; has GutQ domain, which is associated with phosphosugar binding
orf19.641Candida albicans SC5314Ortholog(s) have role in protein folding and endoplasmic reticulum localization
orf19.642Candida albicans SC5314Ortholog(s) have protein serine/threonine phosphatase activity, role in G1/S transition of mitotic cell cycle and cytoplasm localization
orf19.7680CTA26Candida albicans SC5314Putative transcriptional activator; downregulated by Efg1p; transcription is upregulated in an RHE model of oral candidiasis; member of a family of telomere-proximal genes; Hap43p-repressed
orf19.646GLN1Candida albicans SC5314Putative glutamate synthase; regulated by Tsa1p, Tsa1Bp under H2O2 stress conditions
orf19.4341Candida albicans SC5314Ortholog(s) have GPI-anchor transamidase complex localization
orf19.1002Candida albicans SC5314Hap43p-repressed gene
orf19.4348Candida albicans SC5314Ortholog(s) have RNA polymerase II repressing transcription factor binding activity and role in negative regulation of transcription from RNA polymerase II promoter, positive regulation of transcription from RNA polymerase II promoter
orf19.4349Candida albicans SC5314Protein of unknown function, transcription is repressed in the presence of elevated CO2
orf19.1008Candida albicans SC5314
orf19.1009Candida albicans SC5314
orf19.653Candida albicans SC5314
orf19.654Candida albicans SC5314
orf19.657SAM2Candida albicans SC5314S-adenosylmethionine synthetase, localizes to surface of hyphal cells, but not yeast-form cells; possible biofilm-induced expression (reports differ); alkaline upregulated; Hog1p-induced; farnesol-downregulated
orf19.658GIN1Candida albicans SC5314Protein involved in regulation of DNA-damage-induced filamentous growth; putative component of DNA replication checkpoint; ortholog of S. cerevisiae Mrc1p, an S-phase checkpoint protein; Hap43p-induced gene
orf19.1010MNT3Candida albicans SC5314Mannosyltransferase; transcription elevated in cyr1, chk1, nik1, and sln1 homozygous null mutants; fungal-specific (no human or murine homolog)
orf19.1011Candida albicans SC5314Ortholog(s) have alpha-1,2-mannosyltransferase activity, role in protein glycosylation and Golgi apparatus localization
Locus IdGene NameOrganismDescription
orf19.4355Candida albicans SC5314
orf19.4356HGT3Candida albicans SC5314Putative glucose transporter of the major facilitator superfamily; the C. albicans glucose transporter family comprises 20 members; 12 probable membrane-spanning segments, extended C terminus; expressed in rich medium with 2% glucose
orf19.4357Candida albicans SC5314Putative protein similar to S. cerevisiae Mgr3p, a subunit of the i-AAA protease supercomplex that degrades misfolded mitochondrial proteins
orf19.661KRR1Candida albicans SC5314Putative nucleolar protein; decreased transcription is observed upon benomyl treatment or in an azole-resistant strain that overexpresses MDR1; induced upon biofilm formation
orf19.3700TOM70Candida albicans SC5314Ortholog(s) have mitochondrion targeting sequence binding, protein channel activity and role in protein import into mitochondrial inner membrane, protein import into mitochondrial matrix
orf19.664Candida albicans SC5314
orf19.666Candida albicans SC5314
orf19.3705PTC6Candida albicans SC5314Mitochondrial protein phosphatase of the Type 2C-related family (serine/threonine-specific), functional homolog of S. cerevisiae Ptc6p; mutant shows virulence defect
orf19.668Candida albicans SC5314Ortholog of C. glabrata CBS138 : CAGL0B01188g
orf19.4363SGD1Candida albicans SC5314Putative protein with a predicted role in small ribosomal subunit biogenesis; downregulated during core stress response; transcription is increased in populations of cells exposed to fluconazole over multiple generations
orf19.3707YHB1Candida albicans SC5314Nitric oxide dioxygenase, acts in nitric oxide scavenging/detoxification; role in virulence in mouse; transcription activated by NO, macrophage interaction; hyphal downregulated; mRNA binds to She3p; Hap43p-repressed
orf19.4365Candida albicans SC5314Has domain(s) with predicted RNA methyltransferase activity and role in RNA processing
orf19.4366Candida albicans SC5314
orf19.4367SMC1Candida albicans SC5314Protein similar to chromosomal ATPases; RNA abundance regulated by tyrosol and cell density; cell-cycle regulated periodic mRNA expression
orf19.4369Candida albicans SC5314Protein not essential for viability
orf19.1027PDR16Candida albicans SC5314Phosphatidylinositol transfer protein; increased transcription correlates with CDR1 and CDR2 overexpression and azole resistance; induced by fluphenazine, 17-beta-estradiol, ethynyl estradiol, nitric oxide; farnesol-downregulated in biofilm
orf19.1029Candida albicans SC5314Ortholog(s) have ribonuclease MRP activity, ribonuclease P activity, role in intronic box C/D snoRNA processing, mRNA cleavage, rRNA processing, tRNA processing and ribonuclease MRP complex, nucleolar ribonuclease P complex localization
orf19.670SMT3Candida albicans SC5314SUMO, small ubiquitin-like protein; Smt3p-conjugated proteins localize to septation site and mother side of bud neck; C. albicans septins appear not to be Smt3p-modified, in contrast to S. cerevisiae septins
orf19.672Candida albicans SC5314Has domain(s) with predicted nucleic acid binding, ATP binding, ATP-dependent helicase activity
orf19.3710YHB5Candida albicans SC5314Protein related to flavohemoglobins; not required for wild-type nitric oxide resistance; has predicted globin, FAD-binding, and NAD(P)-binding domains but lacks some conserved residues of flavohemoglobins; mRNA detected; filament induced
Locus IdGene NameOrganismDescription
orf19.3711Candida albicans SC5314Biofilm-induced gene
orf19.3712Candida albicans SC5314Predicted ORF in Assemblies 19, 20 and 21; transcriptionally activated by Mnl1p under weak acid stress; late-stage biofilm-induced gene
orf19.3713Candida albicans SC5314Late-stage biofilm-induced gene; transcriptionally activated by Mnl1p under weak acid stress; transcription detected in high-resolution tiling array experiments
orf19.676Candida albicans SC5314Ortholog(s) have microtubule plus-end binding, structural constituent of cytoskeleton, protein homodimerization activity
orf19.4370Candida albicans SC5314Predicted ORF in Assemblies 19, 20 and 21; induced by nitric oxide; oxidative stress-induced via Cap1p; fungal-specific (no human or murine homolog)
orf19.677CHO1Candida albicans SC5314Putative phosphatidylserine synthase; similar to S. cerevisiae Cho1p, which is involved in phosphatidylserine biosynthesis; transposon mutation affects filamentous growth; regulated by Nrg1p, Tup1p; no human or murine homolog
orf19.3715ASF1Candida albicans SC5314Protein similar to S. cerevisiae Asf1p, a chromatin assembly complex component; likely to be essential for growth, based on an insertional mutagenesis strategy
orf19.4372Candida albicans SC5314Has domain(s) with predicted role in transmembrane transport and integral to membrane localization
orf19.679FGR39Candida albicans SC5314Protein lacking an ortholog in S. cerevisiae; transposon mutation affects filamentous growth
orf19.4373Candida albicans SC5314Protein similar to S. cerevisiae Fmn1p, which is riboflavin kinase; predicted Kex2p substrate; Hap43p-repressed gene
orf19.4374PRP42Candida albicans SC5314Putative component of the U1 snRNP, involved in splicing; ortholog of S. cerevisiae PRP42
orf19.1031HMG1Candida albicans SC5314HMG-CoA reductase; enzyme of sterol pathway; inhibited by lovastatin; gene not transcriptionally regulated in response to lovastatin and fluconazole
orf19.4375Candida albicans SC5314Ortholog(s) have S-adenosylmethionine-dependent methyltransferase activity, role in nicotinamide metabolic process, chromatin silencing at rDNA and cytoplasm localization
orf19.3719Candida albicans SC5314
orf19.1033STR2Candida albicans SC5314Ortholog(s) have cystathionine gamma-synthase activity, role in transsulfuration and nucleus, cytoplasm localization
orf19.1034Candida albicans SC5314Hap43p-repressed gene; caspofungin repressed; biofilm- and planktonic growth-induced gene
orf19.1035WAR1Candida albicans SC5314Predicted zinc cluster protein involved in resistance to weak organic acids; has similarity to S. cerevisiae War1p, which is a transcription factor involved in the regulation of weak acid stress response genes
orf19.1036MNS1Candida albicans SC5314Alpha-1,2-mannosidase; processes Man9GlcNAc2 to Man8GlcNAc2 isomer B; member of endoplasmic-reticulum localized glycosyl hydrolase family 47; ER form is converted by Kex2p to a cytosolic form
orf19.1037Candida albicans SC5314
orf19.1039Candida albicans SC5314Ortholog(s) have Rab geranylgeranyltransferase activity, role in protein targeting to membrane, protein geranylgeranylation, ER to Golgi vesicle-mediated transport and Rab-protein geranylgeranyltransferase complex localization
Locus IdGene NameOrganismDescription
orf19.681HAP43Candida albicans SC5314CCAAT-binding factor-dependent transcriptional repressor required for low iron response; similar to bZIP transcription factor AP-1; HAP4L-bZIP bipartite domain; gene negatively regulated by Sfu1p; ciclopirox olamine induced
orf19.683Candida albicans SC5314Predicted ORF from Assemblies 19 and 20; identical to orf19.3391; merged with orf19.3391 in Assembly 20 (see Locus History)
orf19.684Candida albicans SC5314Putative transcription factor with zinc finger DNA-binding motif; heterozygous null mutant exhibits hypersensitivity to parnafungin and cordycepin in the C. albicans fitness test
orf19.685YHM1Candida albicans SC5314Putative mitochondrial carrier protein; fungal-specific (no human or murine homolog); Hap43p-repressed gene
orf19.686Candida albicans SC5314Predicted ORF in Assemblies 19, 20 and 21; regulated by Nrg1p
orf19.687Candida albicans SC5314
orf19.688Candida albicans SC5314Ortholog(s) have structural constituent of ribosome activity and mitochondrial small ribosomal subunit localization
orf19.3727PHO112Candida albicans SC5314Putative constitutive acid phosphatase; transcription is negatively regulated by Rim101p; DTT-extractable; N-glycosylated; Hap43p-induced; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.4384HXT5Candida albicans SC5314Putative sugar transporter; transcription upregulated in response to treatment with ciclopirox olamine; Snf3p-induced; alkaline downregulated; shows colony morphology-related gene regulation by Ssn6p; possibly essential gene
orf19.3728Candida albicans SC5314Ortholog(s) have protein phosphatase type 1 regulator activity, protein phosphatase 1 binding activity, role in chromosome segregation, regulation of phosphoprotein phosphatase activity and cytoplasm localization
orf19.1042POR1Candida albicans SC5314Mitochondrial outer membrane porin; in detergent-resistant membrane fraction (possible lipid raft component); antigenic in human, mouse; Hap43p-induced; flucytosine-, macrophage-, farnesol- induced; fluconazole, caspofungin repressed
orf19.1043Candida albicans SC5314Ortholog(s) have role in protein targeting to vacuole and cytoplasm localization
orf19.1045Candida albicans SC5314Putative U2 snRNP protein; Hap43p-induced gene; mutation confers hypersensitivity to 5-fluorocytosine (5-FC), 5-fluorouracil (5-FU), and tubercidin (7-deazaadenosine)
orf19.1048IFD6Candida albicans SC5314Aldo-keto reductase family member; similar to aryl alcohol dehydrogenases; increased protein correlates with MDR1 overexpression (but not CDR1 or CDR2) in fluconazole-resistant clinical isolates; farnesol regulated; possibly essential gene
orf19.690PLB2Candida albicans SC5314Putative phospholipase B; conserved catalytic region; 6 putative N-glycosylation motifs; predicted secretion signal; no GPI anchor predicted; fungal-specific (no human or murine homolog)
orf19.691GPD2Candida albicans SC5314Similar to glycerol 3-P dehydrogenases; regulated by Ssn6p, Nrg1p, Efg1p; induced upon osmotic and oxidative stress (via Hog1p), cell wall regeneration, macrophage/pseudohyphal growth, core stress response; possibly essential (UAU1 method)
orf19.3730Candida albicans SC5314Protein similar to S. cerevisiae Kre27p, which has a role in resistance to killer toxin; predicted Kex2p substrate
orf19.693Candida albicans SC5314
orf19.695RGS2Candida albicans SC5314Protein of RGS superfamily; not essential for viability
orf19.696STE2Candida albicans SC5314Receptor for alpha factor mating pheromone, MFalpha; required for a-type cells to respond to alpha factor, for opaque a-form mating and white a-form response; possible Kex2p substrate; a-specific, alpha-factor induced, A1p-Alpha2p repressed
Locus IdGene NameOrganismDescription
orf19.4390Candida albicans SC5314Predicted ORF in Assemblies 19, 20 and 21; transcription is repressed in response to alpha pheromone in SpiderM medium; transcriptionally activated by Mnl1p under weak acid stress
orf19.697Candida albicans SC5314Ortholog(s) have mitochondrial outer membrane localization
orf19.3735Candida albicans SC5314Predicted ORF in Assemblies 19, 20 and 21; transcription is induced in response to alpha pheromone in SpiderM medium
orf19.698Candida albicans SC5314Ortholog(s) have role in endoplasmic reticulum inheritance and integral to endoplasmic reticulum membrane localization
orf19.3736KAR4Candida albicans SC5314Protein similar to S. cerevisiae Kar4p, which has a role in karyogamy; transcription is opaque-specific, a-specific, and induced by alpha factor
orf19.4393CIT1Candida albicans SC5314Citrate synthase; soluble in hyphae; expression greater in high iron; upregulated by phagocytosis, biofilm growth; Hog1p-downregulated; Efg1p-regulated under yeast, not hyphal growth conditions; present in exponential and stationary phase
orf19.1050Candida albicans SC5314Ortholog of C. glabrata CBS138 : CAGL0J01397g
orf19.4394Candida albicans SC5314Predicted ORF in Assemblies 19, 20 and 21; transcription is induced in response to alpha pheromone in SpiderM medium
orf19.1051HTA2Candida albicans SC5314Putative histone H2A; farnesol regulated; transcription is downregulated in both intermediate and mature biofilms; Hap43p-induced
orf19.1052Candida albicans SC5314Predicted histone H2B; Hap43p-induced gene
orf19.4396Candida albicans SC5314Ortholog(s) have role in cristae formation, protein import into mitochondrial intermembrane space and mitochondrial crista junction, mitochondrial crista, integral to mitochondrial inner membrane localization
orf19.4398Candida albicans SC5314Ortholog(s) have cytoplasm localization
orf19.1055CDC3Candida albicans SC5314Septin; essential for viability; functional homolog of S. cerevisiae Cdc3p; down-regulation associated with azole resistance; macrophage/pseudohyphal-repressed; virulence-group-correlated expression; gene has intron
orf19.4399Candida albicans SC5314Ortholog(s) have role in pseudohyphal growth, invasive growth in response to glucose limitation, protein urmylation, tRNA wobble position uridine thiolation and cytoplasm localization
orf19.1059HHF1Candida albicans SC5314Putative histone H4; reduced mRNA in homozygous fkh2 null mutant; regulated by Efg1p; fluconazole induced; amphotericin B repressed; farnesol regulated; shows colony morphology-related gene regulation by Ssn6p; Hap43p-induced gene
orf19.3740PGA23Candida albicans SC5314Putative GPI-anchored protein of unknown function; transcription is negatively regulated by Rim101p; regulated by Cyr1p; shows colony morphology-related gene regulation by Ssn6p
orf19.3743Candida albicans SC5314
orf19.3746IFC1Candida albicans SC5314Oligopeptide transporter; induced upon phagocytosis by macrophage; macrophage/pseudohyphal-repressed after 16h; fluconazole-induced; virulence-group-correlated expression; fungal-specific (no mammalian homolog); Hap43p-repressed
orf19.1061HHT21Candida albicans SC5314Putative histone H3; amphotericin B repressed; regulated by Efg1p; farnesol regulated; Hap43p-induced
orf19.1063Candida albicans SC5314Ortholog(s) have dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity, role in GPI anchor biosynthetic process and mannosyltransferase complex, integral to endoplasmic reticulum membrane, mitochondrion localization
Locus IdGene NameOrganismDescription
orf19.1064ACS2Candida albicans SC5314Acetyl-CoA synthetase; antigenic during human and murine infection; upregulated by Efg1p; macrophage-induced protein; soluble protein in hyphae; gene contains an intron
orf19.1066GIG1Candida albicans SC5314Protein induced by N-acetylglucosamine (GlcNAc); localized in cytoplasm; mutation causes increased resistance to nikkomycin Z
orf19.1069RPN4Candida albicans SC5314DNA binding protein with Cys2-His2 zinc-finger; putative regulator of proteasome genes; DNA recognition sequence (GAAGGCAAAA) enriched in regions upstream of proteasome genes; induced in core stress response; Hap43p-induced gene
orf19.3752RAD51Candida albicans SC5314Protein involved in homologous recombination and DNA repair; flucytosine induced; slow growth and increased white-to-opaque switching frequency in null mutant
orf19.3755Candida albicans SC5314Ortholog(s) have structural constituent of ribosome activity and mitochondrial large ribosomal subunit localization
orf19.3757ATP20Candida albicans SC5314Putative mitochondrial ATP synthase; shows colony morphology-related gene regulation by Ssn6p; flucytosine induced; caspofungin repressed; macrophage/pseudohyphal-induced
orf19.3758Candida albicans SC5314Ortholog(s) have fungal-type vacuole membrane localization
orf19.1077ATM1Candida albicans SC5314Member of MDR subfamily of ABC family; similar to S. cerevisiae ABC transporter, Atm1p; transcriptionally regulated by iron; expression greater in low iron; induced by nitric oxide independent of Yhb1p
orf19.6304LYS5Candida albicans SC5314Phosphopantetheinyl transferase; enzyme of lysine biosynthesis; modifies, and thereby activates, Lys2p alpha-aminoadipate reductase; functional homolog of S. cerevisiae Lys5p
orf19.6306Candida albicans SC5314Trimethylaminobutyraldehyde dehydrogenase, the third enzyme of the carnitine biosynthesis pathway
orf19.6307Candida albicans SC5314
orf19.6309MSS11Candida albicans SC5314Transcriptional activator, binds to Flo8p via a LisH motif to cooperatively activate transcription of hyphal-specific genes; required for hyphal growth
orf19.3761CDC54Candida albicans SC5314Putative pre-replication complex helicase subunit; transcription is regulated by Nrg1p and Mig1p; periodic mRNA expression, peak at cell-cycle M/G1 phase; Hap43p-induced gene
orf19.3762Candida albicans SC5314
orf19.3764GSG1Candida albicans SC5314Protein similar to S. cerevisiae Gsg1p, which is a subunit of the TRAPP complex involved in targeting of ER-to-Golgi transport vesicles; biofilm- and planktonic growth-induced gene
orf19.3767Candida albicans SC5314Ortholog(s) have signal sequence binding activity, role in protein targeting to vacuole, ER-associated protein catabolic process and Golgi apparatus localization
orf19.3769Candida albicans SC5314Ortholog(s) have zinc ion transmembrane transporter activity, role in zinc ion transport and endoplasmic reticulum localization
orf19.1083Candida albicans SC5314Putative protein of unknown function; macrophage-induced gene
orf19.1084CDC39Candida albicans SC5314Protein similar to S. cerevisiae Cdc39p, which is part of the CCR4-NOT transcription regulatory complex; transposon mutation affects filamentous growth
orf19.1086Candida albicans SC5314Ortholog(s) have role in ribophagy, protein deubiquitination, regulation of retrograde vesicle-mediated transport, Golgi to ER, regulation of ER to Golgi vesicle-mediated transport and cytoplasm localization
Locus IdGene NameOrganismDescription
orf19.1089PEX11Candida albicans SC5314Putative protein involved in fatty acid oxidation; expression is Tac1p-dependent
orf19.6312RPS3Candida albicans SC5314Ribosomal protein S3; Hog1p-, Hap43p-induced; genes encoding cytoplasmic ribosomal subunits, translation factors, tRNA synthetases are downregulated upon phagocytosis by murine macrophage; present in exponential and stationary phase cells
orf19.6314RPB8Candida albicans SC5314Putative subunit of RNA polymerases I, II, and III; regulated by Gcn4p; repressed in response to amino acid starvation (3-aminotriazole treatment); heterozygous null mutant exhibits resistance to parnafungin
orf19.6315Candida albicans SC5314
orf19.6317ADE6Candida albicans SC53145-Phosphoribosylformyl glycinamidine synthetase, enzyme of adenine biosynthesis; not induced in GCN response, in contrast to the S. cerevisiae ortholog; protein only detected in stationary phase yeast-form cultures
orf19.6318Candida albicans SC5314Ortholog(s) have mitochondrion localization
orf19.3770ARG8Candida albicans SC5314Putative acetylornithine aminotransferase; Gcn2p-, Gcn4p-regulated; transcription is upregulated in both intermediate and mature biofilms
orf19.3773CDL1Candida albicans SC5314Putative RNAse III, ortholog of S. cerevisiae RNT1; merged with orf19.3772 in Assembly 21
orf19.3774PPG1Candida albicans SC5314Putative protein phosphatase of the Type 2A-related family (serine/threonine-specific), similar to S. cerevisiae Ppg1p; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.3775SSK2Candida albicans SC5314MAP kinase kinase kinase (MAPKKK) that regulates Hog1p activation and signaling; transcription is downregulated in response to treatment with ciclopirox olamine
orf19.3777Candida albicans SC5314Ortholog(s) have structural constituent of ribosome activity and mitochondrial large ribosomal subunit localization
orf19.3778Candida albicans SC5314Hap43p-induced gene; mutation confers hypersensitivity to 5-fluorocytosine (5-FC), 5-fluorouracil (5-FU); downregulated in core stress response; decreased expression in response to prostaglandins
orf19.1092Candida albicans SC5314Ortholog(s) have alpha-1,3-mannosyltransferase activity, role in oligosaccharide-lipid intermediate biosynthetic process and endoplasmic reticulum localization
orf19.1093FLO8Candida albicans SC5314Transcription factor; required for wild-type hyphal formation; regulates hyphal gene expression; required for virulence in mouse systemic infection; binds Efg1p; binds Mss11p via LisH motif; has LUFS domain; ortholog of S. cerevisiae Flo8p
orf19.1097ALS2Candida albicans SC5314ALS family protein; role in adhesion, biofilm formation, germ tube induction; expressed at infection of human buccal epithelial cells; putative GPI-anchor; induced by ketoconazole, low iron and at cell wall regeneration; regulated by Sfu1p
orf19.6321PGA48Candida albicans SC5314Putative GPI-anchored; adhesin-like protein; similar to S. cerevisiae Spi1p, which is induced at stationary phase; transcriptionally regulated by iron; expression greater in high iron; late-stage biofilm-induced
orf19.6322ARDCandida albicans SC5314D-arabitol dehydrogenase, NAD-dependent (ArDH); enzyme of D-arabitol and D-arabinose catabolism; D-arabitol is a marker for active infection in humans; has conserved YXXXK motif of short-chain alcohol-polyol-sugar dehydrogenases
orf19.6324VID27Candida albicans SC5314Protein similar to S. cerevisiae Vid27p; transposon mutation affects filamentous growth; mutation confers hypersensitivity to toxic ergosterol analog; fungal-specific (no human or murine homolog)
orf19.6326Candida albicans SC5314
orf19.6327HET1Candida albicans SC5314Putative sphingolipid transfer protein involved in localization of glucosylceramide, which is important for virulence
Locus IdGene NameOrganismDescription
orf19.3780Candida albicans SC5314Protein likely to be essential for growth, based on an insertional mutagenesis strategy
orf19.3782Candida albicans SC5314Predicted membrane transporter, member of the peptide-acetyl-coA transporter (PAT) family, major facilitator superfamily (MFS); transcription is induced in response to alpha pheromone in Spider medium
orf19.3785Candida albicans SC5314Has domain(s) with predicted nucleotide binding, unfolded protein binding, heat shock protein binding activity and role in protein folding
orf19.3788SPC34Candida albicans SC5314Subunit of the Dam1 (DASH) complex, which acts in chromosome segregation by coupling kinetochores to spindle microtubules
orf19.6336PGA25Candida albicans SC5314Putative GPI-anchored adhesin-like protein; fluconazole-downregulated
orf19.6338Candida albicans SC5314
orf19.6339NRG2Candida albicans SC5314Protein similar to S. cerevisiae Nrg2p transcription factor, which regulates invasive growth in S. cerevisiae; transposon mutation affects filamentous growth
orf19.3792Candida albicans SC5314Ortholog of S. cerevisiae : PAT1 and C. glabrata CBS138 : CAGL0M07029g
orf19.3794CSR1Candida albicans SC5314Putative zinc-finger transcription factor involved in zinc homeostasis; involved in regulation of biofilm matrix; mutation affects filamentous growth; suppresses S. cerevisiae rok1 mutant inviability
orf19.3795AGP3Candida albicans SC5314Putative serine transporter with possible role in assimilation of sulfur; induced upon early biofilm formation; fungal-specific (no human or murine homolog)
orf19.3797Candida albicans SC5314Ortholog(s) have structural constituent of ribosome activity and mitochondrial large ribosomal subunit localization
orf19.3799Candida albicans SC5314Ortholog(s) have role in protein import into nucleus, endoplasmic reticulum organization and Golgi apparatus, cortical endoplasmic reticulum, integral to endoplasmic reticulum membrane, mitochondrion localization
orf19.6341Candida albicans SC5314Ortholog(s) have 5-amino-6-(5-phosphoribosylamino)uracil reductase activity and role in riboflavin biosynthetic process
orf19.6342Candida albicans SC5314Has domain(s) with predicted extracellular region localization
orf19.3000ORC1Candida albicans SC5314Putative origin recognition complex large subunit; essential for viability; similar to S. cerevisiae Orc1p origin recognition complex subunit
orf19.6344RBK1Candida albicans SC5314Ortholog(s) have nucleus, cytoplasm localization
orf19.6345RPG1ACandida albicans SC5314Putative translation initiation factor; mutation confers hypersensitivity to roridin A and verrucarin A; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage
orf19.6347Candida albicans SC5314Ortholog(s) have second spliceosomal transesterification activity
orf19.3004Candida albicans SC5314
orf19.6349RVS162Candida albicans SC5314Protein containing a BAR domain, which is found in proteins involved in membrane curvature; null mutant does not display the endocytic, hyphal growth, virulence, or cell wall defects exhibited by mutants in related genes RVS161 and RVS167
Locus IdGene NameOrganismDescription
orf19.3008COQ4Candida albicans SC5314Protein with a putative role in coenzyme Q biosynthesis; transcriptionally induced by interaction with macrophage; Hap43p-repressed gene
orf19.6350Candida albicans SC5314
orf19.6353Candida albicans SC5314
orf19.3010Candida albicans SC5314Ortholog(s) have ligase activity, role in protein lipoylation and mitochondrion localization
orf19.3012ARO80Candida albicans SC5314Regulator of aromatic alcohol biosynthesis via the Ehrlich pathway; not essential for viability; similar to S. cerevisiae Aro80p, which is a transcriptional activator required for aromatic amino acid catabolism
orf19.3013CDC12Candida albicans SC5314Septin; essential for viability; gene has predicted splice sites; forms ring at sites of cell division and also forms filaments in mature chlamydospore; filamentous growth induced; regulated by Nrg1p, Tup1p, tyrosol and cell density
orf19.6357Candida albicans SC5314Ortholog(s) have role in mitotic cell cycle G2/M transition decatenation checkpoint, nucleocytoplasmic transport, mitotic cell cycle spindle assembly checkpoint and nuclear pore, kinetochore localization
orf19.3014BMH1Candida albicans SC5314Sole 14-3-3 protein in C. albicans; role in hyphal growth; possibly regulated by host interaction; localizes to yeast-form cell surface,not hyphae; alternatively spliced intron in 5' UTR; present in exponential and stationary phase cultures
orf19.6358Candida albicans SC5314Ortholog(s) have ubiquitin-protein ligase activity, role in free ubiquitin chain polymerization, protein polyubiquitination, postreplication repair and ubiquitin conjugating enzyme complex, nucleus, cytoplasm localization
orf19.3015ARX1Candida albicans SC5314Putative ribosomal large subunit biogenesis protein; downregulated during core stress response; decreased expression in response to prostaglandins
orf19.6359Candida albicans SC5314Has domain(s) with predicted mitochondrial inner membrane peptidase complex localization
orf19.3016Candida albicans SC5314
orf19.3018SPP1Candida albicans SC5314Putative histone methyltransferase; induced by nitric oxide independent of Yhb1p; cell-cycle regulated periodic mRNA expression
orf19.5700TLO11Candida albicans SC5314Member of a family of telomere-proximal genes of unknown function; may be spliced in vivo
orf19.6360Candida albicans SC5314Ortholog(s) have role in nuclear mRNA splicing, via spliceosome and U2-type spliceosomal complex localization
orf19.5704Candida albicans SC5314Ortholog(s) have rRNA binding activity, role in mitochondrial RNA processing, rRNA metabolic process, mitochondrial genome maintenance and mitochondrion localization
orf19.6362SPA2Candida albicans SC5314Protein involved in cell polarity, Spitzenkorper formation; required for mouse virulence; localizes to hyphal tip; cell-cycle regulated localization in yeast-form cells; functional domains conserved with S. cerevisiae ; Hap43p-induced gene
orf19.6365PTP1Candida albicans SC5314Ortholog(s) have protein tyrosine phosphatase activity, role in invasive growth in response to glucose limitation, pseudohyphal growth, protein dephosphorylation and mitochondrion localization
orf19.3022Candida albicans SC5314Ortholog(s) have structural constituent of ribosome activity and mitochondrial small ribosomal subunit localization
orf19.3023NGG1Candida albicans SC5314Ortholog(s) have histone acetyltransferase activity, role in histone acetylation and SAGA complex, Ada2/Gcn5/Ada3 transcription activator complex, SLIK (SAGA-like) complex localization
Locus IdGene NameOrganismDescription
orf19.6367SSB1Candida albicans SC5314HSP70 family heat shock protein; mRNA in yeast cells and germ tubes; at surface of yeast cells, not hyphae; antigenic in human, mouse systemic infection; macrophage, GCN-induced; possibly essential gene; sumoylation target; Hap43p-induced
orf19.3026MAS1Candida albicans SC5314Putative mitochondrial processing protease; Hap43p-repressed gene; transcription is regulated by Nrg1p; oxidative stress-induced via Cap1p
orf19.3029Candida albicans SC5314Ortholog(s) have 3-hydroxyisobutyryl-CoA hydrolase activity and mitochondrion localization
orf19.5711Candida albicans SC5314Putative phosphatidylinositol transfer protein; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.5713YMX6Candida albicans SC5314Putative NADH dehydrogenase; macrophage-downregulated gene; induced by nitric oxide
orf19.6371Candida albicans SC5314
orf19.6373DCP2Candida albicans SC5314Has domain(s) with predicted manganese ion binding, RNA binding, hydrolase activity
orf19.5717Candida albicans SC5314
orf19.6374Candida albicans SC5314Ortholog(s) have unfolded protein binding activity, role in mitochondrial proton-transporting ATP synthase complex assembly and mitochondrial inner membrane, integral to mitochondrial membrane localization
orf19.3031SEC62Candida albicans SC5314Putative endoplasmic reticulum (ER) protein-translocation complex subunit
orf19.6375RPS20Candida albicans SC5314Putative ribosomal protein; genes encoding cytoplasmic ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage; transcription is positively regulated by Tbf1p
orf19.6376PTC5Candida albicans SC5314Putative protein phosphatase of the Type 2C-related family (serine/threonine-specific), similar to S. cerevisiae Ptc5p; mutant shows virulence defect
orf19.3034RLI1Candida albicans SC5314Member of RNase L inhibitor (RLI) subfamily of ABC family; predicted not to be a transporter; regulated by Sef1p, Sfu1p, and Hap43p
orf19.6379Candida albicans SC5314
orf19.3038TPS2Candida albicans SC5314Trehalose-6-phosphate (Tre6P) phosphatase; mutant heat sensitive, has Tre6P accumulation, decreased mouse virulence; possible drug target; two conserved phospohydrolase motifs; no mammalian homolog; Hap43p-repressed gene; biofilm-induced
orf19.5725Candida albicans SC5314
orf19.3040EHT1Candida albicans SC5314Protein similar to S. cerevisiae Eht1p; transcription is induced in response to alpha pheromone in SpiderM medium; regulated by Sef1p-, Sfu1p-, and Hap43p
orf19.3041Candida albicans SC5314
orf19.6385ACO1Candida albicans SC5314Aconitase; expression greater in high iron; 2 upstream CCAAT motifs; amino acid starvation (3-AT), amphotericin B, phagocytosis, farnesol induced; fluconazole-downregulated; Gcn4p-regulated; Hap43p-repressed; antigenic in infection
orf19.6387HSP104Candida albicans SC5314Heat-shock protein; functional homolog of S. cerevisiae Hsp104p; chaperone and prion propagation activity in S. cerevisiae; guanidine-insensitive; heat shock/stress induced; downregulated in farnesol-treated biofilm; sumoylation target
Locus IdGene NameOrganismDescription
orf19.3048Candida albicans SC5314Predicted ORF in Assemblies 19, 20 and 21; transcription is repressed in response to alpha pheromone in SpiderM medium
orf19.5730Candida albicans SC5314Predicted ORF in Assemblies 19, 20 and 21; clade-associated gene expression
orf19.5731PAD1Candida albicans SC5314Putative phenylacrylic acid decarboxylase; repressed by Rgt1p
orf19.5734POP2Candida albicans SC5314Component of the Ccr4-Pop2 mRNA deadenylase; heterozygous null mutant exhibits resistance to parnafungin and cordycepin in the C. albicans fitness test
orf19.5735CDC50Candida albicans SC5314Putative endosomal protein; transcriptionally activated by Mnl1p under weak acid stress
orf19.6392Candida albicans SC5314
orf19.5736ALS5Candida albicans SC5314ALS family adhesin; highly variable; expression in S. cerevisiae causes adhesion to human epithelium, endothelium or ECM, endothelial invasiveness by endocytosis and, at high abundance, ECM-induced aggregation; can form amyloid fibrils
orf19.6393Candida albicans SC5314Putative Arf3p GTPase activating protein; Hap43p-repressed gene; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.3050AGE1Candida albicans SC5314Putative GTPase activator; transcriptionally regulated by iron; expression greater in low iron
orf19.3052YPT1Candida albicans SC5314Functional homolog of S. cerevisiae Ypt1p, which is an essential small Ras-type GTPase involved in protein secretion at ER-to-Golgi; dominant-negative mutation causes SAP secretion defect and accumulation of intracellular secretory vesicles
orf19.6396Candida albicans SC5314Putative patatin-like phospholipase; similar to S. cerevisiae Nte1p, which is predicted to be a membrane protein; antigenic during human oral infection; Hap43p-repressed gene
orf19.3053Candida albicans SC5314Protein present in exponential and stationary growth phase yeast cultures; identified in extracts from biofilm and planktonic cells; biofilm-induced gene
orf19.3054RPN3Candida albicans SC5314Putative non-ATPase regulatory subunit of the 26S proteasome lid; amphotericin B repressed; oxidative stress-induced via Cap1p
orf19.3055Candida albicans SC5314Putative RNA polymerase II mediator complex subunit; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.3057Candida albicans SC5314Ortholog(s) have role in mitochondrial genome maintenance and endoplasmic reticulum localization
orf19.3059SUA71Candida albicans SC5314Predicted transcriptional regulator; downregulated during planktonic growth, whereas related SUA72 is induced; transcription is positively regulated by Tbf1p
orf19.5741ALS1Candida albicans SC5314Adhesin; ALS family of cell-surface glycoproteins; adhesion, virulence roles; immunoprotective; band at hyphal base; amyloid domain; biofilm-induced; Rfg1p, Ssk1p; strain background affects expression; N-term binds fucose-containing glycans
orf19.2400Candida albicans SC5314Ortholog(s) have role in positive regulation of ATPase activity, nuclear mRNA splicing, via spliceosome, maturation of SSU-rRNA, positive regulation of helicase activity
orf19.2401Candida albicans SC5314Ortholog(s) have cysteine-type endopeptidase activity
orf19.5746ALA1Candida albicans SC5314Alanyl-tRNA synthetase; translational regulation generates cytoplasmic and mitochondrial forms; Gcn4p-regulated; repressed by amino acid starvation (3-AT); translation-related genes downregulated upon phagocytosis by murine macrophages
Locus IdGene NameOrganismDescription
orf19.3060Candida albicans SC5314Ortholog(s) have dolichyl-diphosphooligosaccharide-protein glycotransferase activity, role in protein N-linked glycosylation and oligosaccharyltransferase complex localization
orf19.2404Candida albicans SC5314Ortholog(s) have ribonuclease MRP activity, ribonuclease P activity, role in intronic box C/D snoRNA processing, mRNA cleavage, rRNA processing, tRNA processing and nucleolar ribonuclease P complex localization
orf19.3062Candida albicans SC5314Ortholog(s) have ASTRA complex, mitochondrion localization
orf19.3063HFL1Candida albicans SC5314HAP5-like protein; phosphorylated protein
orf19.2407DPS1-1Candida albicans SC5314Putative tRNA-Asp synthetase; genes encoding ribosomal subunits, translation factors, tRNA synthetases are downregulated upon phagocytosis by murine macrophage; protein enriched in stationary phase yeast cultures
orf19.2408Candida albicans SC5314Ortholog(s) have tRNA methyltransferase activity and role in tRNA methylation, wybutosine biosynthetic process
orf19.3066ENG1Candida albicans SC5314Endo-1,3-beta-glucanase required for cell separation after division, orthologous to S. cerevisiae Dse4p; caspofungin-, fluconazole-repressed; fungal-specific; repressed in response to alpha pheromone in SpiderM medium; biofilm-induced gene
orf19.5751ORM1Candida albicans SC5314Putative endoplasmic reticulum membrane protein; Hap43p-repressed gene; mutation confers hypersensitivity to aureobasidin A
orf19.5753HGT10Candida albicans SC5314Glycerol permease involved in glycerol uptake; member of the major facilitator superfamily; induced by osmotic stress, at low glucose in rich media, during cell wall regeneration; 12 membrane spans; Hap43p-induced gene
orf19.2410SYS3Candida albicans SC5314Protein similar to S. cerevisiae Sys3p; putative role in endosome-Golgi vesicle docking; upregulated in biofilm; induced upon adherence to polystyrene
orf19.2412Candida albicans SC5314Ortholog(s) have role in late endosome to vacuole transport via multivesicular body sorting pathway and late endosome, Vps55/Vps68 complex localization
orf19.2414Candida albicans SC5314Hap43p-repressed gene
orf19.3071MIH1Candida albicans SC5314Putative protein phosphatase of the PTP family (tyrosine-specific), similar to S. cerevisiae Mih1p; mRNA binds to She3p
orf19.2415Candida albicans SC5314Ortholog(s) have role in mitochondrial translation and mitochondrion localization
orf19.3073Candida albicans SC5314
orf19.2418Candida albicans SC5314
orf19.3076Candida albicans SC5314Ortholog(s) have role in vesicle-mediated transport and integral to Golgi membrane, COPI-coated vesicle localization
orf19.3077VID21Candida albicans SC5314Subunit of the NuA4 histone acetyltransferase complex; soluble protein in hyphae
orf19.5760IHD1Candida albicans SC5314Putative GPI-anchored protein; alkaline upregulated; greater transcription in hyphal form than yeast form; regulated by Nrg1p, Rfg1p, Tup1p; regulated by Tsa1p, Tsa1Bp in minimal media at 37; not essential for viability
orf19.5763Candida albicans SC5314Has domain(s) with predicted oxidoreductase activity, nucleotide binding activity and role in oxidation-reduction process
Locus IdGene NameOrganismDescription
orf19.5764SKI8Candida albicans SC5314Ortholog of S. cerevisiae : SKI8 and C. glabrata CBS138 : CAGL0I07073g
orf19.5767Candida albicans SC5314Ortholog(s) have RNA binding activity and role in nuclear mRNA splicing, via spliceosome
orf19.3080Candida albicans SC5314Has domain(s) with predicted binding activity
orf19.2425HGT18Candida albicans SC5314Putative glucose transporter of the major facilitator superfamily; the C. albicans glucose transporter family comprises 20 members; 12 probable membrane-spanning segments; expressed in rich medium with 2% glucose
orf19.3083Candida albicans SC5314Ortholog(s) have role in DNA repair, actin cytoskeleton organization, cellular manganese ion homeostasis, dephosphorylation and endoplasmic reticulum localization
orf19.3084Candida albicans SC5314
orf19.2429Candida albicans SC5314Predicted ORF in Assemblies 19, 20 and 21; transcription is induced in response to alpha pheromone in SpiderM medium
orf19.3086Candida albicans SC5314Ortholog(s) have exocyst, mating projection tip localization
orf19.3087UBI3Candida albicans SC5314Fusion of ubiquitin with the S34 protein of the small ribosomal subunit; mRNA decreases upon heat shock, appears to be degraded; functional homolog of S. cerevisiae RPS31; Hap43p-induced gene
orf19.3089Candida albicans SC5314Ortholog(s) have role in cristae formation, phosphatidylethanolamine metabolic process, cardiolipin metabolic process and extrinsic to mitochondrial inner membrane, mitochondrial intermembrane space localization
orf19.5770OPT8Candida albicans SC5314Possible oligopeptide transporter; similar to Opt1p and to S. cerevisiae Ygl114wp, but not other OPTs; induced by nitric oxide, amphotericin B; expression of OPT6, -7, or -8 does not complement mutants lacking Opt1p, Opt2p, and Opt3p
orf19.5771PBP2Candida albicans SC5314Putative RNA binding protein; transcription is regulated by Nrg1p, Mig1p, and Tup1p
orf19.5772Candida albicans SC5314Ortholog(s) have role in histone exchange and Swr1 complex localization
orf19.2430Candida albicans SC5314
orf19.5775Candida albicans SC5314Predicted ORF in Assemblies 19, 20 and 21; member of a family encoded by FGR6-related genes in the RB2 repeat sequence
orf19.5776TOM1Candida albicans SC5314Putative E3 ubiquitin ligase; transcription is regulated by Nrg1p and Mig1p
orf19.2433Candida albicans SC5314
orf19.2434NPL4Candida albicans SC5314Putative ubiquitin-binding protein; regulated by Gcn2p and Gcn4p
orf19.2435MSI3Candida albicans SC5314Antigenic HSP70 family protein; functional homolog of S. cerevisiae Msi3p; interacts by 2-hybrid with Cgr1p; transcriptionally regulated by iron; expression greater in high iron; farnesol downregulated in biofilm; sumoylation target
orf19.2436Candida albicans SC5314Has domain(s) with predicted protein serine/threonine kinase activity, ATP binding, protein tyrosine kinase activity and role in protein phosphorylation
Locus IdGene NameOrganismDescription
orf19.2437ARC35Candida albicans SC5314Putative ARP2/3 complex subunit; shows colony morphology-related gene regulation by Ssn6p; mutation confers hypersensitivity to cytochalasin D
orf19.3098Candida albicans SC5314Hap43p-induced gene
orf19.5780Candida albicans SC5314Putative protein of unknown function; Hap43p-repressed gene
orf19.5782Candida albicans SC5314Ortholog(s) have mitochondrion localization
orf19.2443RGD1Candida albicans SC5314GTPase activator protein; transcriptionally regulated by iron; expression greater in low iron; alkaline upregulated; localized to the bud emergence area in G1 phase and in the bud tip during S and G2 phases
orf19.5788EFT2Candida albicans SC5314Elongation Factor 2 (eEF2); GTPase; essential; highly expressed; target of sordarin antifungals; antigenic in human/mouse; lacks site for regulatory phosphorylation by eEF2 kinase; GCN-regulated; higher protein amount in stationary phase
orf19.5789ADE8Candida albicans SC5314Putative phosphoribosylglycinamide formyl-transferase, enzyme of amino acid biosynthesis pathway; upregulated in biofilm; S. cerevisiae ortholog is Gcn4p regulated; protein enriched in stationary phase yeast-form cultures
orf19.2446Candida albicans SC5314Ortholog(s) have nucleus, cytoplasm localization
orf19.2449Candida albicans SC5314Putative adhesin-like protein; macrophage-induced gene
orf19.5792SMP3Candida albicans SC5314Mannosyltransferase of glycosylphosphatidylinositol (GPI) biosynthesis; catalyzes mannosylation of Man3-GPI precursor; essential for viability; 8-9 transmembrane regions predicted; has HQEXRF motif; functional homolog of S. cerevisiae Smp3p
orf19.5793PR26Candida albicans SC5314Protein with similarity to proteasomal 26S regulatory subunit of S. cerevisiae, H. sapiens, Methanobacterium thermoautotrophicum (Archaebacterium)
orf19.2452Candida albicans SC5314Transcriptionally regulated by iron; expression greater in high iron; downregulated in core caspofungin response; ketoconazole-repressed; shows colony morphology-related gene regulation by Ssn6p; possibly subject to Kex2p processing
orf19.5797PLC2Candida albicans SC5314Phosphatidylinositol (PtdIns)-specific phospholipase C (PI-PLC); predicted type 2 membrane protein; role in, and regulated by, filamentation, Nrg1p and Tup1p; no mouse systemic virulence role; orf19.5797 and orf19.1586 are almost identical
orf19.2454PHO87Candida albicans SC5314Putative phosphate permease; transcription negatively regulated by Rim101p at pH 8; expression regulated upon white-opaque switching; caspofungin repressed; biofilm-regulated; biofilm-induced; virulence-group-correlated expression
orf19.2455Candida albicans SC5314Ortholog(s) have omega peptidase activity, role in glutathione catabolic process and nucleus, cytoplasm localization
orf19.2457Candida albicans SC5314
orf19.5001CUP2Candida albicans SC5314Protein required for normal resistance to copper; similar to S. cerevisiae Cup2p, a copper-binding transcription factor that activates transcription of metallothionein genes; Hap43p-repressed gene
orf19.5003Candida albicans SC5314Ortholog(s) have GTPase regulator activity and nucleus, cytoplasm localization
orf19.5005OSM2Candida albicans SC5314Putative mitochondrial fumarate reductase; regulated by Ssn6p, Gcn2p, and Gcn4p; Hog1p-downregulated; stationary phase enriched protein; Hap43p-repressed gene
orf19.5007ACT1Candida albicans SC5314Actin; gene has intron; transcriptionally regulated by growth phase and by starvation; localizes to polarized growth site in budding and hyphal cells; required for wild-type Cdc42p localization; unprocessed N terminus; Hap43p-induced
Locus IdGene NameOrganismDescription
orf19.5009Candida albicans SC5314Ortholog(s) have cytoplasm localization
orf19.1802Candida albicans SC5314Putative termination and polyadenylation protein; decreased expression in response to prostaglandins
orf19.1803CDC43Candida albicans SC5314Beta subunit of heterodimeric protein geranylgeranyltransferase type I; GGTase I enzyme binds zinc, is Mg-dependent; Cdc42p is GGTase I substrate
orf19.1804Candida albicans SC5314Ortholog(s) have mitochondrion localization
orf19.1805PEX14Candida albicans SC5314Ortholog(s) have protein binding, bridging activity, role in protein import into peroxisome matrix, docking and peroxisomal membrane localization
orf19.2462PRN3Candida albicans SC5314Protein similar to pirin; transcriptionally activated by Mnl1p under weak acid stress; Hap43p-repressed gene
orf19.2463PRN2Candida albicans SC5314Protein similar to pirin; Hap43p-repressed gene
orf19.2465POL32Candida albicans SC5314Predicted ORF in Assemblies 19, 20 and 21; cell-cycle regulated periodic mRNA expression
orf19.2467PRN1Candida albicans SC5314Protein with similarity to pirins; increased transcription is observed upon benomyl treatment and in response to alpha pheromone in SpiderM medium; transcriptionally activated by Mnl1p under weak acid stress
orf19.2468Candida albicans SC5314Ortholog(s) have trans-aconitate 3-methyltransferase activity and cytosol localization
orf19.2469RAD10Candida albicans SC5314Ortholog of S. cerevisiae RAD10, an endonuclease involved in nucleotide excision repair; null mutant is extremely sensitive to UV irradiation; transcription is downregulated in alkaline conditions
orf19.5010DIM1Candida albicans SC5314Putative 18S rRNA dimethylase with a predicted role in rRNA modification and processing; induced upon biofilm formation; Hap43p-induced; likely to be essential for growth based on insertional mutagenesis strategy
orf19.5012Candida albicans SC5314
orf19.5013AGM1Candida albicans SC5314Phosphoacetylglucosamine mutase (N-acetylglucosamine-phosphate mutase); enzyme of UDP-N-acetylglucosamine (UDP-GlcNAc) biosynthesis
orf19.5014Candida albicans SC5314Ortholog(s) have mitochondrion localization
orf19.5019Candida albicans SC5314
orf19.1814Candida albicans SC5314Putative phosphatidylinositol-4-kinase; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.2471GIM5Candida albicans SC5314Putative heterohexameric cochaperone prefoldin complex subunit; macrophage/pseudohyphal-repressed gene and macrophage-induced protein
orf19.2472Candida albicans SC5314
orf19.2473Candida albicans SC5314Putative RSC chromatin remodeling complex component; decreased transcription is observed upon fluphenazine treatment or in an azole-resistant strain that overexpresses CDR1 and CDR2
Locus IdGene NameOrganismDescription
orf19.2478Candida albicans SC5314
orf19.5020Candida albicans SC5314Hap43p-induced gene
orf19.5022Candida albicans SC5314Ortholog(s) have inorganic cation transmembrane transporter activity and role in cellular cobalt ion homeostasis, cobalt ion transport, cellular manganese ion homeostasis, manganese ion transport
orf19.5023DAL7Candida albicans SC5314Putative allantoate permease; fungal-specific (no human or murine homolog); not essential for viability
orf19.5025MET3Candida albicans SC5314ATP sulfurlyase of sulfate assimilation; repressed by Met or Cys, Sfu1p, or in fluconazole-resistant isolate; strongly induced on biofilm formation, even in presence of Met and Cys; Hog1p-, caspofungin-, white phase-induced
orf19.5027LCB2Candida albicans SC5314Putative serine palmitoyltransferase component; mutation confers hypersensitivity to aureobasidin A
orf19.1824PGA50Candida albicans SC5314Putative GPI-anchored protein; adhesin-like protein
orf19.2483RIM1Candida albicans SC5314Putative single-stranded DNA-binding protein; protein level decreases in stationary phase cultures
orf19.1827Candida albicans SC5314Biofilm-induced gene; transcription is induced in response to alpha pheromone in SpiderM medium
orf19.1828BUD16Candida albicans SC5314Protein similar to S. cerevisiae Bud16p; induced in response to alpha pheromone in SpiderM medium
orf19.2487Candida albicans SC5314Ortholog(s) have nucleus, cytoplasm localization
orf19.2489Candida albicans SC5314Putative karyopherin beta; repressed by nitric oxide
orf19.5031SSK1Candida albicans SC5314Response regulator of two-component system; role in oxidative stress response, cell wall biosynthesis, virulence, hyphal growth on solid media; expressed in hyphae and yeast-form cells; putative peroxisomal targeting sequence (PTS1)
orf19.5033Candida albicans SC5314Ortholog(s) have protein tag, Atg8 ligase activity and role in C-terminal protein lipidation, CVT pathway, autophagic vacuole assembly, mitochondrion degradation, piecemeal microautophagy of nucleus
orf19.5038Candida albicans SC5314Ortholog(s) have tRNA (guanine) methyltransferase activity, role in tRNA methylation and cytoplasm localization
orf19.1830Candida albicans SC5314Hap43p-induced gene
orf19.1831Candida albicans SC5314
orf19.1832FCY23Candida albicans SC5314Putative transporter; Gcn4p-regulated; more similar to S. cerevisiae Tpn1p, which is a vitamin B6 transporter, than to purine-cytosine permeases
orf19.1834Candida albicans SC5314Has domain(s) with predicted binding activity
orf19.1835Candida albicans SC5314
Locus IdGene NameOrganismDescription
orf19.1836APN2Candida albicans SC5314Putative class II abasic (AP) endonuclease; flucytosine induced
orf19.2494Candida albicans SC5314Ortholog(s) have glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity, role in mitochondrial translation, glutaminyl-tRNAGln biosynthesis via transamidation and mitochondrion, glutamyl-tRNA(Gln) amidotransferase complex localization
orf19.2495GSL1Candida albicans SC5314Beta-1,3-glucan synthase subunit; 10 predicted transmembrane regions; caspofungin induced; repressed upon yeast-to-hyphal transition; similar to S. cerevisiae Fks3p; fungal-specific; young biofilm repressed, induced by biofilm drug exposure
orf19.1839RPA190Candida albicans SC5314Putative RNA polymerase I subunit A190; Hap43p-induced gene; flucytosine induced
orf19.5040Candida albicans SC5314
orf19.5041Candida albicans SC5314
orf19.5043Candida albicans SC5314
orf19.5046RAM1Candida albicans SC5314Protein that acts in prenylation; transcription is alpha-factor induced; regulated in response to lovastatin and fluconazole; Hap43p-repressed gene
orf19.5049Candida albicans SC5314Putative U3-containing 90S preribosome processome complex subunit; Hap43p-induced gene; induced upon biofilm formation
orf19.1841Candida albicans SC5314Hap43p-induced gene
orf19.1843ALG6Candida albicans SC5314Putative glucosyltransferase involved in cell wall mannan biosynthesis; transcription is elevated in chk1, nik1, and sln1 homozygous null mutants; repressed by nitric oxide; possibly essential gene, disruptants not obtained by UAU1 method
orf19.1847ARO10Candida albicans SC5314Aromatic decarboxylase of the Ehrlich fusel oil pathway of aromatic alcohol biosynthesis; pH-regulated (alkaline downregulated); protein abundance is affected by URA3 expression in the CAI-4 strain background
orf19.5050MTO1Candida albicans SC5314Putative mitochondrial protein; transcription is upregulated in both intermediate and mature biofilms
orf19.5051Candida albicans SC5314Has domain(s) with predicted DNA binding activity
orf19.5053Candida albicans SC5314Ortholog(s) have chromatin binding, acetyltransferase activity
orf19.5057Candida albicans SC5314
orf19.1850SIW14Candida albicans SC5314Putative protein phosphatase of the PTP family (tyrosine-specific), similar to S. cerevisiae Siw14p; mutant shows virulence defect; Hap43p-repressed gene
orf19.1852Candida albicans SC5314
orf19.1853HHT2Candida albicans SC5314Putative histone H3; farnesol regulated; Hap43p-induced gene
orf19.1855Candida albicans SC5314Predicted membrane transporter, member of the anion:cation symporter (ACS) family, major facilitator superfamily (MFS); Gcn4p-regulated; flucytosine induced; ketoconazole-repressed; oxidative stress-induced via Cap1p
Locus IdGene NameOrganismDescription
orf19.1857Candida albicans SC5314Protein not essential for viability
orf19.702Candida albicans SC5314Ortholog(s) have DNA helicase activity, role in regulation of translational termination and polysome localization
orf19.704SOL3Candida albicans SC5314Putative 6-phosphogluconolactonase; present in exponential and stationary growth phase yeast cultures; macrophage-downregulated protein abundance
orf19.706NMD3Candida albicans SC5314Putative nonsense-mediated mRNA decay protein; downregulated in core stress response; decreased expression in response to prostaglandins
orf19.707APG7Candida albicans SC5314Ortholog(s) have APG8 activating enzyme activity, APG12 activating enzyme activity
orf19.708Candida albicans SC5314Ortholog(s) have structural constituent of cytoskeleton activity and outer plaque of spindle pole body, inner plaque of spindle pole body, gamma-tubulin small complex, spindle pole body localization
orf19.709PUP2Candida albicans SC5314Alpha5 subunit of the 20S proteasome; macrophage/pseudohyphal-repressed; regulated by Gcn2p and Gcn4p; protein present in exponential and stationary growth phase yeast cultures
orf19.5061ADE5,7Candida albicans SC5314Phosphoribosylamine-glycine ligase and phosphoribosylformylglycinamidine cyclo-ligase; interacts with Vps34p; required for hyphal growth and virulence; flucytosine induced; not induced in GCN response, in contrast to S. cerevisiae ortholog
orf19.4406Candida albicans SC5314Ortholog(s) have mitochondrion localization
orf19.5064MRPL3Candida albicans SC5314Ribosomal protein of the large subunit, mitochondrial; downregulated in core stress response; protein present in exponential and stationary growth phase yeast cultures
orf19.4409Candida albicans SC5314Has domain(s) with predicted catalytic activity and role in metabolic process
orf19.5068IRE1Candida albicans SC5314Putative protein kinase with a role in cell wall regulation; mutant is hypersensitive to caspofungin
orf19.5069Candida albicans SC5314
orf19.1862Candida albicans SC5314Possible stress protein; increased transcription associated with CDR1 and CDR2 overexpression or fluphenazine treatment; transcription regulated by Sfu1p, Nrg1p, Tup1p; stationary phase enriched protein
orf19.1863Candida albicans SC5314Has domain(s) with predicted Rho guanyl-nucleotide exchange factor activity, role in regulation of Rho protein signal transduction and intracellular localization
orf19.1865Candida albicans SC5314Ortholog(s) have role in reciprocal meiotic recombination and endoplasmic reticulum localization
orf19.1867Candida albicans SC5314Putative malate permease; induced during macrophage infection; regulated by Gcn2p and Gcn4p; has putative peroxisome targeting signal; Hap43p-repressed gene
orf19.1868RNR22Candida albicans SC5314Putative ribonucleoside diphosphate reductase; shows colony morphology-related gene regulation by Ssn6p; RNA abundance regulated by tyrosol and cell density; Hap43p-repressed gene; biofilm- and planktonic growth-induced
orf19.712KIP1Candida albicans SC5314Non-essential kinesin from the bipolar (Kinesis-5) family; involved in formation of the mitotic spindle
orf19.713Candida albicans SC5314Ortholog(s) have role in apoptosis and nucleus, cytoplasm localization
Locus IdGene NameOrganismDescription
orf19.714Candida albicans SC5314Ortholog(s) have GTPase activity and role in intracellular protein transport, retrograde transport, endosome to Golgi
orf19.715Candida albicans SC5314Hap43p-induced gene
orf19.717HSP60Candida albicans SC5314Heat shock protein; soluble in hyphae; regulated by Nrg1p and by iron; expression greater in high iron; heavy metal (cadmium) stress-induced; sumoylation target; protein present in exponential and stationary phase cells; Hap43p-repressed
orf19.4410ALG1Candida albicans SC5314Protein similar to S. cerevisiae Alg1p, a mannosyltransferase involved in N-linked protein glycosylation; likely to be essential for growth, based on an insertional mutagenesis strategy
orf19.718RRN11Candida albicans SC5314Putative RNA polymerase I subunit; transcription is upregulated in both intermediate and mature biofilms
orf19.4411HOS1Candida albicans SC5314Histone deacetylase; similar to S. cerevisiae Hos1p; has conserved deacetylation motif; slightly greater expression in white cells than in opaque cells
orf19.4412Candida albicans SC5314Ortholog(s) have deoxycytidyl transferase activity, DNA-directed DNA polymerase activity, role in error-free translesion synthesis, error-prone translesion synthesis and mitochondrion, nuclear chromatin, replication fork localization
orf19.719Candida albicans SC5314Ortholog(s) have ubiquitin-protein ligase activity, role in ER-associated protein catabolic process, fungal-type cell wall organization and Hrd1p ubiquitin ligase ERAD-M complex, Hrd1p ubiquitin ligase ERAD-L complex localization
orf19.4413CMD1Candida albicans SC5314Calmodulin; calmodulin inhibitors cause a defect in hyphal growth; not transcriptionally regulated by yeast-hyphal transition; mutation confers hypersensitivity to cytochalasin D and high concentrations of tunicamycin; gene has intron
orf19.4414Candida albicans SC5314
orf19.5071NRP1Candida albicans SC5314Ortholog(s) have cytoplasmic stress granule localization
orf19.4416VPS13Candida albicans SC5314Putative vacuolar protein sorting-associated protein; gene used for multilocus sequence typing
orf19.5076PFY1Candida albicans SC5314Profilin, functional homolog of S. cerevisiae Pfy1p; hyphal-induced; macrophage/pseudohyphal-induced; regulated by Nrg1p, Tup1p; gene lacks intron (unlike S. cerevisiae PFY1); complements growth of S. cerevisiae srv2 mutant; nonessential
orf19.5077Candida albicans SC5314Hap43p-repressed gene; repressed by nitric oxide
orf19.5079CDR4Candida albicans SC5314Putative transporter of ATP-binding cassette (ABC) superfamily; biofilm, fluconazole, Sfu1p, Hog1p, core stress response induced; caspofungin repressed; fluconazole resistance is not affected by mutation or correlated with expression
orf19.1872Candida albicans SC5314Plasma membrane protein; repressed by nitric oxide
orf19.1873Candida albicans SC5314Hap43p-repressed gene; repressed by nitric oxide
orf19.1877Candida albicans SC5314Ortholog(s) have nucleus, cytoplasm localization
orf19.1878Candida albicans SC5314Ortholog(s) have role in transcription from RNA polymerase II promoter and core mediator complex localization
orf19.721Candida albicans SC5314Ortholog(s) have polynucleotide 5'-hydroxyl-kinase activity, role in termination of RNA polymerase I transcription, rRNA processing and nucleolar chromatin localization
Locus IdGene NameOrganismDescription
orf19.725Candida albicans SC5314
orf19.726PPZ1Candida albicans SC5314Putative protein phosphatase of the Type 1 family (serine/threonine-specific), similar to S. cerevisiae Ppz1p
orf19.4420Candida albicans SC5314Predicted ORF in Assemblies 19, 20 and 21; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.4423Candida albicans SC5314Putative glucosyltransferase; localized to the mitochondrial membrane
orf19.4426PEX3Candida albicans SC5314Putative peroxisomal protein involved in targeting proteins into peroxisomes; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.5083DRG1Candida albicans SC5314Member of the DRG family of GTP-binding proteins; involved in regulation of invasive filamentous growth
orf19.4428Candida albicans SC5314Protein not essential for viability
orf19.5087BUD6Candida albicans SC5314Protein required for Spitzenkorper formation in hyphal cells (wild-type localization of Mlc1p to the Spitzenkorper); localizes to polarisome
orf19.5089TERTCandida albicans SC5314Telomerase reverse transcriptase; catalytic protein subunit of telomere synthesis; essential for telomerase activity; has telomerase-specific motif T and other conserved reverse transcriptase motifs
orf19.1883YCS4Candida albicans SC5314Putative condensin complex subunit; cell-cycle regulated periodic mRNA expression
orf19.1885TAF4Candida albicans SC5314Putative TFIID subunit; mutation confers hypersensitivity to toxic ergosterol analog
orf19.1887Candida albicans SC5314Ortholog(s) have sterol esterase activity, role in sterol metabolic process and lipid particle, integral to membrane localization
orf19.729.1RGD3Candida albicans SC5314Putative Rho GTPase activating protein; fungal-specific (no human or murine homolog)
orf19.732Candida albicans SC5314Transcription upregulated in both intermediate and mature biofilms
orf19.734GLK1Candida albicans SC5314Putative glucokinase; transcription is regulated upon yeast-hyphal switch; transcriptionally regulated by Efg1p; fluconazole-induced; induced in core stress response; shows colony morphology-related gene regulation by Ssn6p
orf19.4430Candida albicans SC5314Ortholog(s) have nucleus, cytoplasm localization
orf19.738MYO5Candida albicans SC5314Class I myosin; nonessential; role in cortical actin patch polarity and polar budding; required for hyphal growth; regulatory phosphorylation on S366; downregulated on adherence to polystyrene; sole class I myosin in C. albicans
orf19.4432KSP1Candida albicans SC5314Putative serine/threonine protein kinase; mRNA binds to She3p and is localized to hyphal tips; mutation confers hypersensitivity to amphotericin B
orf19.5090Candida albicans SC5314Ortholog(s) have tRNA-specific adenosine deaminase activity, role in tRNA modification and nucleus, cytoplasm localization
orf19.5092Candida albicans SC5314
Locus IdGene NameOrganismDescription
orf19.4437Candida albicans SC5314Ortholog(s) have nucleosome binding, rDNA binding, DNA binding, ATPase activity
orf19.4438RME1Candida albicans SC5314Protein similar to S. cerevisiae meiotic regulator Rme1p; white-specific transcription; upregulation correlates with clinical development of fluconazole resistance; biofilm and planktonic growth-induced gene; Upc2p-regulated in hypoxia
orf19.5095Candida albicans SC5314Putative oxysterol-binding protein; caspofungin induced; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.4439Candida albicans SC5314
orf19.5097CAT8Candida albicans SC5314Predicted zinc-cluster protein; null mutant shows a defect in transcription of JEN1 lactate permease gene; flucytosine repressed; similar to S. cerevisiae Cat8p but mutant phenotype suggests that it has a different set of target genes
orf19.5098NTG1Candida albicans SC5314Protein with strong similarity to both S. cerevisiae Ntg1p and Ntg2p DNA repair glycosylases; transcriptionally regulated by iron; expression greater in high iron; Hap43p-repressed gene
orf19.1890Candida albicans SC5314Ortholog(s) have role in medium-chain fatty acid biosynthetic process
orf19.1891APR1Candida albicans SC5314Vacuolar aspartic proteinase; mRNA abundance equivalent in yeast-form and mycelial cells but is elevated at lower growth temperatures; upregulated in the presence of human neutrophils; protein enriched in stationary phase cultures
orf19.1893Candida albicans SC5314
orf19.1896SSC1Candida albicans SC5314Heat shock protein; at yeast-form cell surface, not hyphae; antigenic; Gcn4p-regulated; induced by amino acid starvation (3-aminotriazole) or upon adherence to polystyrene; macrophage-downregulated; sumoylation target; possibly essential
orf19.1897Candida albicans SC5314
orf19.741Candida albicans SC5314
orf19.744GDB1Candida albicans SC5314Putative glycogen debranching enzyme; expression is regulated upon white-opaque switching; regulated by Nrg1p, Tup1p
orf19.745VAC8Candida albicans SC5314Protein involved in vacuolar inheritance; required for hyphal growth; contains armadillo repeats
orf19.4440SEC34Candida albicans SC5314Ortholog(s) have role in CVT pathway, peroxisome degradation, ER to Golgi vesicle-mediated transport, macroautophagy, retrograde transport, vesicle recycling within Golgi
orf19.4441Candida albicans SC5314Ortholog(s) have DNA replication origin binding, single-stranded DNA binding, double-stranded DNA binding activity
orf19.748Candida albicans SC5314Ortholog(s) have RNA binding activity
orf19.4444PHO15Candida albicans SC5314Putative 4-nitrophenyl phosphatase, possible histone H2A phosphatase; involved in regulation of white-opaque switching; hyphal downregulated; induced in core stress response; induced by heavy metal (cadmium) stress via Hog1p
orf19.4447YMC1Candida albicans SC5314Putative inner mitochondrial membrane transporter; flucytosine induced
orf19.1105Candida albicans SC5314
Locus IdGene NameOrganismDescription
orf19.1106Candida albicans SC5314Protein with Mob2p-dependent hyphal regulation; fluconazole-induced
orf19.1107Candida albicans SC5314
orf19.1109Candida albicans SC5314
orf19.750Candida albicans SC5314Predicted ORF in Assemblies 19, 20 and 21; exogenously expressed protein is a substrate for Kex2p processing in vitro
orf19.752Candida albicans SC5314Has domain(s) with predicted methyltransferase activity and role in metabolic process
orf19.754YBN5Candida albicans SC5314Ortholog(s) have ATPase activity and cytoplasm localization
orf19.756SAP7Candida albicans SC5314Member of the secreted aspartyl proteinase family; expression detected during human oral infection; regulated by Ssn6p; role in murine intravenous infection; induced during, but not required for, murine vaginal infection; N-glycosylated
orf19.4451RIA1Candida albicans SC5314Putative translation elongation factor; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage
orf19.759Candida albicans SC5314Ortholog(s) have role in ER to Golgi vesicle-mediated transport, retrograde vesicle-mediated transport, Golgi to ER and endosome, COPI vesicle coat localization
orf19.1110Candida albicans SC5314Thiamine pyrophosphokinase, phosphorylates thiamine to produce the coenzyme thiamine pyrophosphate (thiamine diphosphate); active as a homodimer
orf19.4455Candida albicans SC5314
orf19.1113Candida albicans SC5314
orf19.1114Candida albicans SC5314Membrane-localized protein
orf19.4459Candida albicans SC5314Protein similar to S. cerevisiae Ynl234wp, which is a putative heme-binding stress-related protein; transposon mutation affects filamentous growth
orf19.1117Candida albicans SC5314Protein similar to Candida boidinii formate dehydrogenase; virulence-group-correlated expression; Hap43p-repressed gene
orf19.7002Candida albicans SC5314
orf19.761TCO89Candida albicans SC5314Putative homolog of S. cerevisiae Tco89p, which is a component of the TOR C1 complex that is involved in the regulation of growth and cell wall integrity; heterozygous null mutant displays sensitivity to rapamycin
orf19.762Candida albicans SC5314Has domain(s) with predicted hydrolase activity
orf19.7009Candida albicans SC5314Has domain(s) with predicted nucleotide binding, catalytic activity, coenzyme binding activity and role in cellular metabolic process
orf19.3801FAV1Candida albicans SC5314Protein with weak similarity to S. cerevisiae Fus2p; induced by alpha pheromone mating factor in MTLa/MTLa opaque cells
Locus IdGene NameOrganismDescription
orf19.764Candida albicans SC5314Ortholog(s) have clathrin-coated vesicle localization
orf19.3802PMT6Candida albicans SC5314Protein mannosyltransferase, required for virulence in mice and for adhesion to endothelium; role in hyphal growth signaling and hygromycin B sensitivity; not a major contributor to overall cellular PMT activity; Hap43p-repressed gene
orf19.767ERG3Candida albicans SC5314C-5 sterol desaturase; introduces C-5(6) double bond into episterol in ergosterol biosynthesis; clinically-isolated homozygous null mutants show azole resistance, defects in hyphal growth and virulence; Efg1p-repressed; fluconazole-induced
orf19.4461Candida albicans SC5314
orf19.768SYG1Candida albicans SC5314Ortholog(s) have role in signal transduction and mitochondrion, plasma membrane localization
orf19.769IFE1Candida albicans SC5314Ortholog(s) have nucleus, cytoplasm localization
orf19.1120FAV2Candida albicans SC5314Putative adhesin-like protein; induced by mating factor in MTLa/MTLa opaque cells; greater mRNA abundance observed in a cyr1 homozygous null mutant than in wild type; filament induced; regulated by Nrg1p, Rfg1p, Tup1p
orf19.1121Candida albicans SC5314
orf19.1122Candida albicans SC5314Predicted ORF in Assemblies 19, 20 and 21; transcription is induced in response to alpha pheromone in SpiderM medium
orf19.1123Candida albicans SC5314
orf19.4468Candida albicans SC5314Putative succinate dehydrogenase; localized to the mitochondrial membrane; Hap43p-repressed gene
orf19.7010Candida albicans SC5314Ortholog(s) have cytoplasm localization
orf19.7011Candida albicans SC5314Ortholog(s) have 90S preribosome, nucleus localization
orf19.7013Candida albicans SC5314
orf19.7015RPP0Candida albicans SC5314Putative ribosomal protein; antigenic in mouse; biofilm induced; cytoplasmic ribosomal subunit, translation factor, tRNA synthetase genes are downregulated upon phagocytosis by murine macrophage; induced by Tbf1p; overlaps orf19.7014
orf19.7016PHM5Candida albicans SC5314Ortholog(s) have endopolyphosphatase activity, exopolyphosphatase activity, role in polyphosphate catabolic process and fungal-type vacuole membrane, nucleus localization
orf19.772LYS21Candida albicans SC5314Putative homocitrate synthase of lysine biosynthesis; expression increased in a fluconazole-resistant isolate; colony morphology-related gene regulation by Ssn6p; ketoconazole-repressed; regulated by Gcn2p, Gcn4p, Hap43p
orf19.7017YOX1Candida albicans SC5314Putative homeodomain-containing transcriptional repressor; periodic mRNA expression, peak at cell-cycle G1/S phase
orf19.3810Candida albicans SC5314Ortholog(s) have methylenetetrahydrofolate dehydrogenase (NAD+) activity, role in purine base biosynthetic process, one-carbon metabolic process, folic acid-containing compound biosynthetic process and cytosol localization
orf19.7019YML6Candida albicans SC5314Putative mitochondrial ribosomal protein; induced upon adherence to polystyrene
Locus IdGene NameOrganismDescription
orf19.3811GYP1Candida albicans SC5314Putative Cis-golgi GTPase-activating protein; transcription is regulated by Nrg1p, Mig1p, and Tup1p
orf19.3812SSZ1Candida albicans SC5314Putative HSP70 chaperone; protein level decreases in stationary phase cultures
orf19.775Candida albicans SC5314
orf19.4471Candida albicans SC5314
orf19.3815Candida albicans SC5314Has domain(s) with predicted ubiquitin thiolesterase activity and role in ubiquitin-dependent protein catabolic process
orf19.4472Candida albicans SC5314
orf19.779HAT1Candida albicans SC5314Ortholog(s) have histone binding, histone acetyltransferase activity, role in histone acetylation, chromatin silencing at telomere and histone acetyltransferase complex, cytoplasm localization
orf19.3818GOA1Candida albicans SC5314Protein required for respiratory growth, resistance to oxidants, chlamydospore formation, hyphal growth under some conditions, and virulence; relocalizes from the cytoplasm to the mitochondrion during oxidative or osmotic stress
orf19.3819Candida albicans SC5314Predicted ORF in Assemblies 19, 20 and 21; transcription detected in high-resolution tiling array experiments
orf19.4476Candida albicans SC5314Predicted ORF in Assemblies 19, 20 and 21; transcript induced by ketoconazole
orf19.4477CSH1Candida albicans SC5314Aldo-keto reductase family member, similar to aryl alcohol dehydrogenases; role in fibronectin adhesion, cell surface hydrophobicity; regulated by temperature, growth phase, benomyl, macrophage interaction; azole resistance associated
orf19.4478Candida albicans SC5314Ortholog(s) have aspartate-tRNA ligase activity, role in mitochondrial aspartyl-tRNA aminoacylation and mitochondrion localization
orf19.4479Candida albicans SC5314Putative U3-containing 90S preribosome subunit; Hap43p-induced gene; downregulated during core stress response
orf19.1137Candida albicans SC5314Ortholog(s) have thymidylate kinase activity, uridylate kinase activity, role in dTDP biosynthetic process, dTTP biosynthetic process, dUDP biosynthetic process and nucleus, cytoplasm localization
orf19.1139Candida albicans SC5314Has domain(s) with predicted NADP binding, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor activity and role in oxidation-reduction process
orf19.7021GPH1Candida albicans SC5314Putative glycogen phosphorylase with a role in glycogen metabolism; regulated by Ssk1p, Mig1p, Tup1p, Hap43p; fluconazole-induced; localizes to cell surface of hyphae, not yeast cells; stationary phase enriched protein
orf19.7022Candida albicans SC5314
orf19.7023Candida albicans SC5314Predicted ORF in Assemblies 19, 20 and 21; oxidative stress-induced via Cap1p
orf19.7024Candida albicans SC5314
orf19.780DUR1,2Candida albicans SC5314Urea amidolyase; urea carboxylase and allophanate hydrolase activities; hydrolyzes urea to CO2; needed for utilization of urea as nitrogen source and for hyphal switch in macrophage; transcription regulated by Nrg1p, Hap43p; biofilm-induced
Locus IdGene NameOrganismDescription
orf19.7027Candida albicans SC5314
orf19.782Candida albicans SC5314Has domain(s) with predicted protein tyrosine/serine/threonine phosphatase activity, protein tyrosine phosphatase activity and role in protein dephosphorylation
orf19.7028Candida albicans SC5314Predicted ORF in Assemblies 19, 20 and 21; merged with orf19.7027 in Assembly 21
orf19.3820Candida albicans SC5314Predicted ORF in Assemblies 19, 20 and 21; clade-associated gene expression
orf19.783Candida albicans SC5314Ortholog(s) have role in vacuole organization, endocytosis, retrograde vesicle-mediated transport, Golgi to ER and endosome, COPI-coated vesicle, Golgi membrane localization
orf19.7029Candida albicans SC5314Putative guanine deaminase; mutation confers hypersensitivity to toxic ergosterol analog
orf19.3822SCS7Candida albicans SC5314Putative ceramide hydroxylase; transcription is regulated by Nrg1p; transcriptionally regulated by iron; expression greater in high iron; fluconazole-induced; Hap43p-repressed
orf19.3823ZDS1Candida albicans SC5314Nonessential protein; similar to S. cerevisiae Zds1p
orf19.787Candida albicans SC5314
orf19.4481MFALPHACandida albicans SC5314Alpha factor mating pheromone precursor; three copies of pheromone that are proteolytically processed by Kex2p and possibly by Orf19.5851p; required for alpha cells to mate; expressed specifically in opaque phase MTLalpha/MTLalpha cells
orf19.3825RCE1Candida albicans SC5314Putative Type II CAAX prenyl protease; induced during the mating process
orf19.3826Candida albicans SC5314Predicted ORF in Assemblies 19, 20 and 21; Plc1p-regulated
orf19.1140Candida albicans SC5314
orf19.3829PHR1Candida albicans SC5314Glycosidase of cell surface; may act on cell-wall beta-1,3-glucan prior to beta-1,6-glucan linkage; E169 and E270 at active site; role in systemic but not vaginal virulence (neutral, not low pH); high pH or filamentation induced
orf19.1143Candida albicans SC5314
orf19.4488Candida albicans SC5314Predicted ORF in Assemblies 19, 20 and 21; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.1146Candida albicans SC5314
orf19.1149MRF1Candida albicans SC5314Putative mitochondrial respiratory protein; induced by farnesol, benomyl treatment, nitric oxide, core stress response; oxidative stress-induced via Cap1p; stationary-phase enriched protein
orf19.7030SSR1Candida albicans SC5314Beta-glucan associated ser/thr rich cell-wall protein with a role in cell wall structure; GPI anchor; similar mRNA abundance in yeast-form and germ tubes; detected at germ tube plasma membrane; repressed in cells treated with Congo Red
orf19.7032Candida albicans SC5314
Locus IdGene NameOrganismDescription
orf19.7034Candida albicans SC5314
orf19.7035RFC2Candida albicans SC5314Putative heteropentameric replication factor C subunit; periodic mRNA expression, peak at cell-cycle G1/S phase
orf19.7036Candida albicans SC5314Ortholog(s) have phosphatase activator activity and role in actin filament organization, regulation of growth, response to salt stress, endocytosis, response to heat, mitochondrion degradation
orf19.7037YAE1Candida albicans SC5314Ortholog(s) have nucleus, cytoplasm localization
orf19.792Candida albicans SC5314Has domain(s) with predicted protein tyrosine kinase activity, protein serine/threonine kinase activity, ATP binding activity and role in protein phosphorylation
orf19.793CAK1Candida albicans SC5314Monomeric CDK-activating kinase; functional homolog of S. cerevisiae Cak1p; phosphorylates cyclin-free human CDK2; lacks glycine loop motif; conserved lysine (K36) not required for activity; possibly essential gene (by UAU1 method)
orf19.794SSN3Candida albicans SC5314Putative cyclin-dependent protein kinase; mutants are sensitive to growth on H2O2 medium
orf19.797BAT21Candida albicans SC5314Putative branched chain amino acid aminotransferase; regulated by Gcn4p, Gcn2p; induced in response to amino acid starvation (3-aminotriazole treatment); early-stage biofilm-induced
orf19.4492Candida albicans SC5314Ortholog(s) have role in nuclear division, rRNA processing and nuclear periphery, nucleolus, preribosome, large subunit precursor localization
orf19.3838EFB1Candida albicans SC5314Translation elongation factor EF-1 beta; downregulated in the presence of human whole blood or PMNs; macrophage/pseudohyphal-induced; antigenic in mouse; farnesol-downregulated; the snoRNA snR18 is encoded within the EFB1 intron
orf19.4495NDH51Candida albicans SC5314Subunit of nicotinamide adenine dinucleotide dehydrogenase complex I, of the mitochondrial electron transport chain; required for wild-type filamentous growth; alkaline downregulated; Hap43p-repressed
orf19.3839SAP10Candida albicans SC5314Secreted aspartyl protease; roles in adhesion, virulence (RHE model), cell surface integrity; distinct specificity from Sap9p; at cell membrane and wall; GPI-anchored; N-glycosylated; expression greater in low iron; Tbf1p-activated
orf19.4496Candida albicans SC5314Ortholog(s) have fungal-type vacuole localization
orf19.4497MED8Candida albicans SC5314Ortholog(s) have RNA polymerase II transcription corepressor activity, RNA polymerase II core promoter proximal region sequence-specific DNA binding, TBP-class protein binding, structural molecule activity
orf19.1155DPP2Candida albicans SC5314Protein similar to S. cerevisiae pyrophosphate phosphatase Lpp1p; possible role in farnesol biosynthesis
orf19.1156FUS1Candida albicans SC5314Probable ortholog of S. cerevisiae Fus1p, a membrane protein required for mating; transcription is activated by Cph1p in mating type a cells, homozygous for the MTLa locus; alpha factor induced
orf19.1159Candida albicans SC5314Protein similar to A. nidulans CYSA serine O-trans-acetylase, suggesting that C. albicans uses an O-acetyl-serine (OAS) pathway of sulfur assimilation; induced upon biofilm formation
orf19.7041Candida albicans SC5314Putative pre-tRNA processing protein; heterozygous null mutant exhibits hypersensitivity to parnafungin and cordycepin in the C. albicans fitness test
orf19.7043Candida albicans SC5314Ortholog(s) have endoplasmic reticulum localization
orf19.7044RIM15Candida albicans SC5314Ortholog(s) have protein kinase activity, role in age-dependent response to oxidative stress involved in chronological cell aging, protein phosphorylation, regulation of meiosis and nucleus, cytoplasm localization
Locus IdGene NameOrganismDescription
orf19.7047RTF1Candida albicans SC5314Putative RNA polymerase II-associated Paf1 complex subunit; induced during the mating process
orf19.3840Candida albicans SC5314Predicted ORF in Assemblies 19, 20 and 21; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.7049CYB5Candida albicans SC5314Cytochrome b(5); not essential for viability; similar to S. cerevisiae Cyb5p; transcriptionally regulated by iron; expression greater in high iron; fluconazole-induced; shows colony morphology-related gene regulation by Ssn6p
orf19.3843Candida albicans SC5314Ortholog(s) have role in filamentous growth, posttranslational protein targeting to membrane, translocation and Sec62/Sec63 complex localization
orf19.3844MRP8Candida albicans SC5314Protein not essential for viability; similar to S. cerevisiae Mrp8p, which is a mitochondrial ribosomal protein; greater transcription in hyphal form than yeast form
orf19.3845FGR3Candida albicans SC5314Protein lacking an ortholog in S. cerevisiae; transposon mutation affects filamentous growth
orf19.3846LYS4Candida albicans SC5314Homoaconitase; regulated by Gcn4p, Gcn2p; induced in response to amino acid starvation (3-AT treatment); upregulated in the presence of human whole blood or polymorphonuclear (PMN) cells; Hap43p-repressed gene
orf19.1160Candida albicans SC5314Ortholog(s) have COPII adaptor activity and role in protein glycosylation, protein retention in Golgi apparatus, fungal-type cell wall organization, ER to Golgi vesicle-mediated transport
orf19.3848Candida albicans SC5314
orf19.1166CTA3Candida albicans SC5314Protein similar to S. cerevisiae Ede1p, which is involved in endocytosis; activates transcription in 1-hybrid assay in S. cerevisiae
orf19.1168ZCF3Candida albicans SC5314Predicted zinc-finger protein; required for wild-type filamentous growth and resistance to rapamycin and flucytosine; possibly an essential gene, disruptants not obtained by UAU1 method; Hap43p-repressed gene; biofilm-induced
orf19.1169Candida albicans SC5314Ortholog(s) have mitochondrion localization
orf19.7051Candida albicans SC5314Has domain(s) with predicted cytoplasm localization
orf19.7052Candida albicans SC5314Putative polyphosphatidylinositol phosphatase; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.7054Candida albicans SC5314
orf19.7055Candida albicans SC5314
orf19.7056Candida albicans SC5314Putative protein of unknown function, transcription is upregulated in clinical isolates from HIV+ patients with oral candidiasis; regulated by Sef1p-, Sfu1p-, and Hap43p
orf19.7058Candida albicans SC5314Ortholog(s) have cytoplasm localization
orf19.7059Candida albicans SC5314Ortholog(s) have endoribonuclease activity, role in transcription, DNA-dependent, nuclear mRNA surveillance of mRNP export and nucleus, cytoplasm localization
orf19.3852Candida albicans SC5314Has domain(s) with predicted catalytic activity
Locus IdGene NameOrganismDescription
orf19.3856CDC28Candida albicans SC5314Cyclin-dependent protein kinase, interacts with regulatory subunit Cyb1p; involved in determination of cell morphology during the cell cycle; phosphorylated primarily by Swe1p and phosphorylation is regulated by Hsl1p; intron in 5'-UTR
orf19.1170ARO7Candida albicans SC5314Putative chorismate mutase; fungal-specific (no human or murine homolog); alkaline upregulated
orf19.1171Candida albicans SC5314
orf19.1177Candida albicans SC5314Ortholog of S. cerevisiae RTT106; Hap43p-repressed gene
orf19.1178Candida albicans SC5314Putative transcription factor with bZIP DNA-binding motif; Hap43p-repressed gene
orf19.6400Candida albicans SC5314Ortholog(s) have role in inositol metabolic process and nucleus, cytoplasm localization
orf19.7060Candida albicans SC5314
orf19.6404GSH2Candida albicans SC5314Putative glutathione synthase; transcriptionally regulated by iron; expression greater in high iron; heavy metal (cadmium) stress-induced
orf19.7061Candida albicans SC5314Has domain(s) with predicted ATP binding, kinase activity and role in metabolic process
orf19.7062RPA135Candida albicans SC5314Putative RNA polymerase I subunit A135; decreased expression in response to prostaglandins
orf19.6406Candida albicans SC5314Ortholog(s) have role in regulation of sporulation resulting in formation of a cellular spore and cytoplasm localization
orf19.6407Candida albicans SC5314Ortholog(s) have role in ribosomal large subunit biogenesis and cytosolic large ribosomal subunit, preribosome, large subunit precursor, cytoplasm localization
orf19.7064GLN4Candida albicans SC5314Putative tRNA-Gln synthetase; genes encoding ribosomal subunits, translation factors, tRNA synthetases are downregulated upon phagocytosis by murine macrophage; protein present in exponential and stationary growth phase yeast cultures
orf19.7065PSF3Candida albicans SC5314Putative GINS complex subunit; cell-cycle regulated periodic mRNA expression
orf19.7067Candida albicans SC5314Ortholog(s) have RNA polymerase II transcription factor binding transcription factor activity, triplex DNA binding, RNA polymerase II core binding activity
orf19.7069Candida albicans SC5314Putative AdoMet-dependent proline methyltransferase; Hap43p-induced gene; required for normal biofilm growth
orf19.3861SIS1Candida albicans SC5314Putative Type II HSP40 co-chaperone; macrophage/pseudohyphal-repressed; heavy metal (cadmium) stress-induced; heterozygous null mutant displays sensitivity to virgineone
orf19.3863Candida albicans SC5314
orf19.3867RPL7Candida albicans SC5314Ribosomal protein L7; genes encoding cytoplasmic ribosomal subunits, translation factors, tRNA synthetases are downregulated upon phagocytosis by murine macrophages; Hap43p-induced gene
orf19.1181Candida albicans SC5314Has domain(s) with predicted catalytic activity and membrane localization
Locus IdGene NameOrganismDescription
orf19.1183Candida albicans SC5314Ortholog of C. glabrata CBS138 : CAGL0L03938g
orf19.1189Candida albicans SC5314Late-stage biofilm-induced gene; transcription regulated upon yeast-hyphal switch; transcriptionally activated by Mnl1p under weak acid stress; contains a 5' UTR intron
orf19.6411Candida albicans SC5314Protein similar to S. cerevisiae Vac14p; a protein involved in regulated synthesis of PtdIns(3,5)P(2); transposon mutation affects filamentous growth
orf19.6413Candida albicans SC5314
orf19.6414Candida albicans SC5314
orf19.6416Candida albicans SC5314
orf19.7073Candida albicans SC5314Ortholog of S. cerevisiae : YCL002C and C. glabrata CBS138 : CAGL0B04719g
orf19.6417TSR1Candida albicans SC5314Component of 20S pre-rRNA processing unit; decreased expression in response to prostaglandins
orf19.7074Candida albicans SC5314Ortholog(s) have methylated histone residue binding, RNA polymerase II transcription factor recruiting transcription factor activity
orf19.6418Candida albicans SC5314Ortholog(s) have role in ribosomal large subunit biogenesis and nucleus, cytoplasm localization
orf19.7077Candida albicans SC5314Putative ferric reductase; transcription is activated by Mac1p under copper starvation; Plc1p-regulated; transcription is negatively regulated by Rim101p
orf19.7078Candida albicans SC5314Ortholog of S. cerevisiae : YCL012C and C. glabrata CBS138 : CAGL0B04829g
orf19.3870ADE13Candida albicans SC5314Adenylosuccinate lyase; enzyme of adenine biosynthesis; soluble protein in hyphae; not induced during GCN response, in contrast to the S. cerevisiae ortholog; repressed by nitric oxide
orf19.7079Candida albicans SC5314
orf19.3871DAD3Candida albicans SC5314Subunit of the Dam1 (DASH) complex, which acts in chromosome segregation by coupling kinetochores to spindle microtubules
orf19.3873ARC40Candida albicans SC5314Protein similar to S. cerevisiae Arc40p, which is involved in actin filament organization in S. cerevisiae; transposon mutation affects filamentous growth
orf19.3876ZCF19Candida albicans SC5314Predicted zinc-finger protein
orf19.3877Candida albicans SC5314Predicted ORF in Assemblies 19, 20 and 21; previously merged with orf19.3878; unmerged from orf19.3878 in a revision of Assembly 21
orf19.1193GNP1Candida albicans SC5314Protein similar to asparagine and glutamine permease; fluconazole or caspofungin induced; transcription is regulated by Nrg1p, Mig1p, Tup1p, Gcn2p, Gcn4p, and alkaline regulated by Rim101p; biofilm-induced; fungal-specific
orf19.1195Candida albicans SC5314Ortholog(s) have metalloendopeptidase activity, role in protein processing involved in protein targeting to mitochondrion, cellular iron ion homeostasis and mitochondrion localization
Locus IdGene NameOrganismDescription
orf19.1198Candida albicans SC5314Predicted ORF in Assemblies 19, 20 and 21; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.6420PGA13Candida albicans SC5314Putative adhesin-like GPI-anchored protein; similar to mucins; induced during cell wall regeneration and during core caspofungin response; regulated by Tsa1p, Tsa1Bp in minimal media at 37 deg and by Cyr1p, Nrg1p, Tup1p, Rlm1p, Hap43p
orf19.6422SSY5Candida albicans SC5314Ortholog(s) have serine-type endopeptidase activity, role in response to amino acid stimulus, protein processing and extrinsic to plasma membrane localization
orf19.7080LEU2Candida albicans SC5314Isopropyl malate dehydrogenase; enzyme of leucine biosynthesis; upregulated in the presence of human whole blood or polymorphonuclear (PMN) cells; protein level decreases in stationary phase cultures
orf19.6424Candida albicans SC5314Ortholog(s) have SUMO ligase activity, role in protein sumoylation, mitotic spindle elongation and condensed nuclear chromosome localization
orf19.6425Candida albicans SC5314Ortholog(s) have role in nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay, nuclear-transcribed mRNA catabolic process, non-stop decay and Ski complex localization
orf19.7084DFI1Candida albicans SC5314Cell-surface associated glycoprotein; promotes activation of Cek1p in a matrix-dependent manner; N-glycosylated
orf19.7089PMR1Candida albicans SC5314Putative secretory pathway P-type Ca2+/Mn2+-ATPase; required for protein glycosylation and cell wall maintenance; required for hyphal tip oscillation in semisolid substrate; putative ortholog of S. cerevisiae PMR1
orf19.3884FGR50Candida albicans SC5314Protein lacking an ortholog in S. cerevisiae; transposon mutation affects filamentous growth
orf19.3885Candida albicans SC5314Has domain(s) with predicted N-acetyltransferase activity and role in metabolic process
orf19.3887Candida albicans SC5314Ortholog of C. glabrata CBS138 : CAGL0J06666g
orf19.6431Candida albicans SC5314
orf19.6434PEX19Candida albicans SC5314Ortholog(s) have peroxisome membrane targeting sequence binding activity and role in ER-dependent peroxisome organization, protein exit from endoplasmic reticulum, protein import into peroxisome membrane, protein stabilization
orf19.7092Candida albicans SC5314Ortholog(s) have mitochondrion localization
orf19.7093HGT13Candida albicans SC5314Predicted sugar transporter, involved in glycerol utilization; member of the major facilitator superfamily; 12 transmembrane; gene has intron; oxidative stress-induced via Cap1p; expressed in rich medium, 2% glucose
orf19.6437CDC23Candida albicans SC5314Similar to anaphase-promoting complex component; possibly transcriptionally regulated by Tac1p
orf19.6438Candida albicans SC5314Ortholog(s) have serine C-palmitoyltransferase activity, role in sphingolipid biosynthetic process and microsome, SPOTS complex localization
orf19.7096Candida albicans SC5314Ortholog(s) have fungal-type vacuole membrane, mitochondrion localization
orf19.7098Candida albicans SC5314Putative protein of unknown function; Hap43p-repressed gene; repressed by nitric oxide
orf19.3893SCW11Candida albicans SC5314Cell wall protein; transcription decreased in mutant lacking ACE2; downregulated in core caspofungin response; expression greater in high iron; possibly an essential gene, disruptants not obtained by UAU1 method; planktonic growth-induced
Locus IdGene NameOrganismDescription
orf19.3894Candida albicans SC5314Putative inositol oxygenase; mutation confers hypersensitivity to toxic ergosterol analog
orf19.3899SDC1Candida albicans SC5314Putative COMPASS/SET1C histone methyltransferase complex subunit
orf19.6440Candida albicans SC5314Ortholog(s) have ubiquitin-protein ligase activity, role in ubiquitin-dependent protein catabolic process and nuclear inner membrane, endoplasmic reticulum membrane localization
orf19.6443Candida albicans SC5314Has domain(s) with predicted catalytic activity and role in metabolic process
orf19.6444Candida albicans SC5314Ortholog(s) have role in cellular response to amino acid starvation, regulation of TOR signaling cascade, meiosis and extrinsic to fungal-type vacuolar membrane, Seh1-associated complex localization
orf19.6445ECI1Candida albicans SC5314Protein similar to S. cerevisiae Eci1p, which is involved in fatty acid oxidation; transposon mutation affects filamentous growth; expression is regulated upon white-opaque switching
orf19.3102CTA6Candida albicans SC5314Protein that activates transcription in 1-hybrid assay in S. cerevisiae
orf19.3103Candida albicans SC5314Ortholog(s) have DNA-directed RNA polymerase activity, role in tRNA transcription from RNA polymerase III promoter and DNA-directed RNA polymerase III complex localization
orf19.6447ARF1Candida albicans SC5314ADP-ribosylation factor, probable GTPase involved in intracellular transport; one of several C. albicans ADP-ribosylation factors; N-myristoylprotein; substrate of Nmt1p
orf19.3104YDC1Candida albicans SC5314Protein with Mob2p-dependent hyphal regulation; transcription is regulated by Nrg1p and Mig1p; Hap43p-repressed gene
orf19.6448Candida albicans SC5314
orf19.3105Candida albicans SC5314Putative cytochrome P450 protein; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.6449Candida albicans SC5314
orf19.3106MET16Candida albicans SC5314Putative 3'-phosphoadenylsulfate reductase; sulfur amino acid metabolism; reports differ on regulation during biofilm formation; fungal-specific; possibly an essential gene, disruptants not obtained by UAU1 method; Hap43p-repressed gene
orf19.3107Candida albicans SC5314
orf19.3108Candida albicans SC5314Putative DNA repair methyltransferase; induced by nitric oxide independent of Yhb1p
orf19.3109Candida albicans SC5314
orf19.6453Candida albicans SC5314
orf19.3111PRA1Candida albicans SC5314Cell surface protein enriched at hyphal tips; also released extracellularly; binds to host complement regulators, integrin alphaMbeta2; mediates leukocyte adhesion and migration; immunogenic in mouse; produced at ambient pH; Rim101p induced
orf19.3112ZRT1Candida albicans SC5314Putative zinc transporter; hyphal- and macrophage-induced; alkaline upregulated by Rim101p; induced upon adherence to polystyrene
Locus IdGene NameOrganismDescription
orf19.3113Candida albicans SC5314
orf19.6457Candida albicans SC5314Ortholog of S. cerevisiae : YBL086C and C. glabrata CBS138 : CAGL0C01815g
orf19.6458Candida albicans SC5314
orf19.6459DPP3Candida albicans SC5314Protein similar to S. cerevisiae pyrophosphate phosphatase Dpp1p; required for farnesol biosynthesis; downregulated in response to 17-beta-estradiol, ethynyl estradiol
orf19.3116EXM2Candida albicans SC5314Putative U1 snRNP complex compotent; decreased transcription is observed upon fluphenazine treatment
orf19.5801RNR21Candida albicans SC5314Ribonucleoside-diphosphate reductase; regulated by tyrosol and cell density; transcription upregulated in response to ciclopirox olamine; fluconazole or flucytosine induced; regulated by Sef1p, Sfu1p, and Hap43p; planktonic growth-induced
orf19.5802Candida albicans SC5314Ortholog(s) have role in maturation of SSU-rRNA and nucleus, cytoplasm localization
orf19.5804HYU1Candida albicans SC5314Putative hydantoin utilization protein A; induced upon adherence to polystyrene; regulated by Gcn2p and Gcn4p
orf19.5805DLD1Candida albicans SC5314Putative D-lactate dehydrogenase; transcription is specific to white cell type; shows colony morphology-related gene regulation by Ssn6p; transcription is upregulated in both intermediate and mature biofilms; Hap43p-repressed gene
orf19.5806ALD5Candida albicans SC5314NAD-aldehyde dehydrogenase; decreased expression in fluconazole-resistant isolate, or in hyphae; biofilm induced; fluconazole-downregulated; protein abundance is affected by URA3 expression in the CAI-4 strain; stationary phase enriched
orf19.6465Candida albicans SC5314
orf19.3122ARR3Candida albicans SC5314Protein not essential for viability; similar to S. cerevisiae Arr3p, an arsenite transporter of the plasma membrane required for resistance to arsenic compounds; benomyl-induced; Gcn4p-regulated; Hap43p-repressed
orf19.3123RPT5Candida albicans SC531426S proteasome regulatory subunit; transcription is regulated by Nrg1p and Mig1p; regulated by Gcn2p and Gcn4p; protein level decreases in stationary phase cultures
orf19.3124Candida albicans SC5314Ortholog(s) have mRNA binding, metalloaminopeptidase activity, role in negative regulation of gene expression, protein initiator methionine removal involved in protein maturation and cytosolic ribosome localization
orf19.6469Candida albicans SC5314Predicted ORF in retrotransposon Tca11 with similarity to the Gag-Pol region of retrotransposons, which encodes nucleocapsid-like protein, reverse transcriptase, protease, and integrase
orf19.3126CCT6Candida albicans SC5314Putative cytosolic chaperonin Cct ring complex subunit; mutation confers hypersensitivity to cytochalasin D
orf19.5811MET1Candida albicans SC5314Putative uroporphyrin-3 C-methyltransferase, methionine biosynthesis enzyme; upregulated by human whole blood or polymorphonuclear (PMN) cells; Hog1p-induced; fungal-specific (no human or murine homolog); Hap43p-repressed
orf19.5813Candida albicans SC5314Putative adhesin-like protein; expression upregulated during growth in the mouse cecum; late-stage biofilm-induced
orf19.6470AHP2Candida albicans SC5314Putative thiol-specific peroxiredoxin; macrophage-downregulated gene
orf19.5815SCT2Candida albicans SC5314Putative glycerol-3-phosphate acyltransferase; fungal-specific (no human or murine homolog)
Locus IdGene NameOrganismDescription
orf19.5816EBP7Candida albicans SC5314Putative NADPH oxidoreductase; mutation confers hypersensitivity to toxic ergosterol analog; oxidative stress-induced via Cap1p
orf19.5817Candida albicans SC5314Ortholog(s) have Rab guanyl-nucleotide exchange factor activity, role in ER to Golgi vesicle-mediated transport, intra-Golgi vesicle-mediated transport and cis-Golgi network membrane, TRAPP complex localization
orf19.6474Candida albicans SC5314Membrane-localized protein
orf19.3132Candida albicans SC5314Predicted ORF in Assemblies 19, 20 and 21; induced by nitric oxide
orf19.3133GUT2Candida albicans SC5314Glycerol-3-phosphate dehydrogenase; Plc1p-regulated; transcription is upregulated in both intermediate and mature biofilms
orf19.3134Candida albicans SC5314Late-stage biofilm-induced gene
orf19.6478YCF1Candida albicans SC5314Putative glutathione S-conjugate transporter; MRP/CFTR-subfamily, ABC transporter family; human neutrophil-induced; oxidative stress-induced via Cap1p; possible association with multidrug resistance; possibly an essential gene (UAU1 method)
orf19.3135Candida albicans SC5314Ortholog(s) have protein binding, bridging activity and role in protein secretion, ER-associated protein catabolic process
orf19.6479SEC1Candida albicans SC5314Ortholog(s) have SNARE binding activity, role in positive regulation of vesicle fusion, vesicle docking involved in exocytosis and cellular bud tip, plasma membrane, cellular bud neck localization
orf19.3136Candida albicans SC5314Has domain(s) with predicted role in response to stress
orf19.3138NOP1Candida albicans SC5314Nucleolar protein; flucytosine induced; Hap43p-induced gene
orf19.5820UGA6Candida albicans SC5314Putative GABA-specific permease; decreased transcription is observed upon benomyl treatment or in an azole-resistant strain that overexpresses MDR1
orf19.5821Candida albicans SC5314Ortholog of S. cerevisiae : YML002W and C. glabrata CBS138 : CAGL0L07634g
orf19.5823SGT2Candida albicans SC5314Putative small tetratricopeptide repeat (TPR)-containing protein; protein abundance is affected by URA3 expression in the CAI-4 strain background; transcription is regulated by Mig1p
orf19.6480Candida albicans SC5314Ortholog(s) have role in UDP-glucose transport and COPI-coated vesicle localization
orf19.5824Candida albicans SC5314Has domain(s) with predicted catalytic activity
orf19.6481YPS7Candida albicans SC5314Putative aspartic-type endopeptidase with limited ability to degrade alpha pheromone; mutants show increased sensitivity to alpha pheromone
orf19.5827BUB2Candida albicans SC5314Ortholog(s) have role in mitotic cell cycle spindle orientation checkpoint and spindle pole body localization
orf19.3140Candida albicans SC5314
orf19.3141Candida albicans SC5314Ortholog of C. glabrata CBS138 : CAGL0M06149g
Locus IdGene NameOrganismDescription
orf19.6486LDG3Candida albicans SC5314Putative LDG family protein; induced upon biofilm formation
orf19.6487Candida albicans SC5314
orf19.6489FMP45Candida albicans SC5314Protein induced during the mating process; mutation confers hypersensitivity to toxic ergosterol analog and to amphotericin B; alkaline downregulated; repressed by alpha pheromone in SpiderM medium
orf19.3148Candida albicans SC5314Predicted ORF in Assemblies 19, 20 and 21; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.5830Candida albicans SC5314Protein similar to S. cerevisiae Hsp70p; predicted Kex2p substrate; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.5831Candida albicans SC5314
orf19.5833Candida albicans SC5314Ortholog(s) have polyubiquitin binding activity, role in cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process, ER-associated protein catabolic process and Cdc48p-Npl4p-Ufd1p AAA ATPase complex localization
orf19.6491Candida albicans SC5314
orf19.6492Candida albicans SC5314Ortholog(s) have mitochondrion localization
orf19.6493Candida albicans SC5314
orf19.3150GRE2Candida albicans SC5314Putative reductase; Nrg1p- and Tup1p-regulated; benomyl- and hyphal-induced; macrophage/pseudohyphal-repressed; expression greater in low iron; reported to be involved in osmotic stress response; stationary phase enriched protein
orf19.5838Candida albicans SC5314Ortholog(s) have phosphoserine phosphatase activity, role in L-serine biosynthetic process and nucleus, cytoplasm localization
orf19.3151Candida albicans SC5314Has domain(s) with predicted catalytic activity, coenzyme binding, nucleotide binding activity and role in cellular metabolic process
orf19.3152AMO2Candida albicans SC5314Protein similar to A. niger predicted peroxisomal copper amino oxidase; mutation confers hypersensitivity to toxic ergosterol analog; induced upon biofilm formation
orf19.3153MSS4Candida albicans SC5314Phosphatidylinositol-4-phosphate 5-kinase; activity induced by phosphatidic acid (Pld1p product); macrophage/pseudohyphal-repressed; mRNA binds to She3p and is localized to yeast cell buds and hyphal tips; Hap43p-induced gene
orf19.3154Candida albicans SC5314Ortholog(s) have mitochondrion localization
orf19.6499Candida albicans SC5314Has domain(s) with predicted DNA binding, DNA-directed RNA polymerase activity and role in transcription, DNA-dependent
orf19.3158Candida albicans SC5314Ortholog(s) have cytoplasm localization
orf19.3159UTP20Candida albicans SC5314Protein likely to be essential for growth; similar to S. cerevisiae Utp20p, which is a putative snoRNA-binding protein; downregulated in core stress response; mutation confers resistance to 5-fluorocytosine (5-FC) and parnafungin
orf19.2500Candida albicans SC5314Has domain(s) with predicted transferase activity and role in biosynthetic process
Locus IdGene NameOrganismDescription
orf19.5846Candida albicans SC5314Putative TFIIH and nucleotide excision repair factor 3 complex subunit; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.2503Candida albicans SC5314
orf19.5847Candida albicans SC5314Ortholog(s) have DNA-directed RNA polymerase activity, role in tRNA transcription from RNA polymerase III promoter and DNA-directed RNA polymerase III complex localization
orf19.2504BMS1Candida albicans SC5314Putative GTPase; Hap43p-induced gene; mutation confers resistance to 5-fluorocytosine (5-FC); flucytosine induced; decreased expression in response to prostaglandins
orf19.5848Candida albicans SC5314Late-stage biofilm-induced gene
orf19.2505Candida albicans SC5314
orf19.2506Candida albicans SC5314Predicted ORF in Assemblies 19, 20 and 21; opaque-specific transcription; Hog1p-downregulated
orf19.2507ARP9Candida albicans SC5314Protein similar to S. cerevisiae Arp3p, a component of the Arp2/3 complex involved in actin-dependent processes; likely to be essential for growth, based on an insertional mutagenesis strategy
orf19.2508PRM9Candida albicans SC5314Protein not essential for viability; similar to S. cerevisiae Prm9p, which may bind to COPII coated vesicles
orf19.3166Candida albicans SC5314Ortholog(s) have role in cell morphogenesis, Golgi to endosome transport, endoplasmic reticulum organization and endosome, mitochondrion, trans-Golgi network localization
orf19.3168RPN8Candida albicans SC5314Putative regulatory subunit of the 26S proteasome; mutation confers hypersensitivity to amphotericin B; transcription is regulated by Mig1p; regulated by Gcn2p and Gcn4p
orf19.3169Candida albicans SC5314Ortholog(s) have role in establishment of mitotic sister chromatid cohesion and cytoplasm localization
orf19.5850NOC2Candida albicans SC5314Putative nucleolar complex protein; Hap43p-induced gene; transposon mutation affects filamentous growth; mutation confers hypersensitivity to 5-fluorouracil (5-FU), tubercidin (7-deazaadenosine); downregulated during core stress response
orf19.5851STE13Candida albicans SC5314Protein similar to S. cerevisiae Ste13p, which is a pheromone-processing dipeptidyl aminopeptidase; possible Kex2p substrate; transposon mutation affects filamentous growth; induced by low nitrogen, germ tube formation
orf19.5852Candida albicans SC5314
orf19.5854SBP1Candida albicans SC5314Similar to RNA binding proteins; downregulated upon adherence to polystyrene; stationary-phase enriched protein
orf19.5855MBP1Candida albicans SC5314Putative component of the MBF transcription complex involved in G1/S cell-cycle progression; non-periodic mRNA expression; predicted, conserved MBF binding sites upstream of G1/S-regulated genes
orf19.5856Candida albicans SC5314Membrane-localized protein
orf19.2513Candida albicans SC5314
orf19.3170Candida albicans SC5314Ortholog(s) have role in formation of translation preinitiation complex and cytoplasm, cytosolic ribosome localization
Locus IdGene NameOrganismDescription
orf19.2514Candida albicans SC5314Has domain(s) with predicted methyltransferase activity and role in metabolic process
orf19.3171ACH1Candida albicans SC5314Acetyl-coA hydrolase; acetate utilization; nonessential; soluble protein in hyphae; antigenic in human; induced on polystyrene adherence; farnesol-, ketoconazole-induced; no human or murine homolog; stationary phase-enriched protein
orf19.5859DAL8Candida albicans SC5314Putative allantoate permease; fungal-specific (no human or murine homolog)
orf19.3173Candida albicans SC5314Ortholog(s) have cytoplasm localization
orf19.3174CDC24Candida albicans SC5314GDP-GTP exchange factor for Cdc42p; phosphorylated; required for maintenance of hyphal growth; misexpression blocks hyphal growth and causes avirulence in a mouse model of systemic infection; antigenic during human oral infection
orf19.2518Candida albicans SC5314Ortholog(s) have ATPase activator activity, soluble NSF attachment protein activity and role in vesicle fusion with Golgi apparatus, SNARE complex disassembly, autophagy, vacuole fusion, non-autophagic
orf19.2519Candida albicans SC5314Ortholog(s) have role in chromosome segregation and spindle pole, nuclear MIS12/MIND type complex localization
orf19.3177Candida albicans SC5314Ortholog(s) have pseudouridine synthase activity, 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate deaminase activity, role in tRNA pseudouridine synthesis, riboflavin biosynthetic process and cytoplasm localization
orf19.3178Candida albicans SC5314Ortholog(s) have RNA binding activity, role in nuclear mRNA splicing, via spliceosome and U2-type prespliceosome localization
orf19.5861KRE9Candida albicans SC5314Protein of beta-1,6-glucan biosynthesis; required for serum-induced hyphal growth; required for efficient utilization of galactose and for growth on glucose; similar to S. cerevisiae Kre9p and Knh1p; O-glycosylated by Pmt1p
orf19.5863Candida albicans SC5314
orf19.2520Candida albicans SC5314Ortholog(s) have structural constituent of ribosome activity and mitochondrial small ribosomal subunit localization
orf19.5866Candida albicans SC5314Protein not essential for viability
orf19.3180Candida albicans SC5314Ortholog(s) have phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity, role in phosphatidylinositol dephosphorylation and endoplasmic reticulum localization
orf19.2525LYS12Candida albicans SC5314Putative mitochondrial homoisocitrate dehydrogenase; clade-associated gene expression; protein level decreases in stationary phase cultures
orf19.5869Candida albicans SC5314Ortholog(s) have role in ubiquitin-dependent protein catabolic process, protein targeting to vacuole, metal ion transport and fungal-type vacuole membrane, endoplasmic reticulum localization
orf19.3184Candida albicans SC5314Has domain(s) with predicted role in vesicle-mediated transport and integral to membrane localization
orf19.2529Candida albicans SC5314Predicted ORF in Assemblies 19, 20 and 21; shares similarity with human Pig-H, which is involved in glycosylphosphatidylinositol assembly
orf19.3187ZNC1Candida albicans SC5314Putative transcription factor; has Zn(2)-Cys(6) binuclear cluster; predicted to bind DNA; regulated by Gcn2p and Gcn4p; gene is located in zinc cluster region of Chromosome 5, near the MTL locus
orf19.2530Candida albicans SC5314
Locus IdGene NameOrganismDescription
orf19.5875VAM3Candida albicans SC5314Predicted target membrane receptor (t-SNARE) involved in vacuolar transport, endocytosis, and secretion; required for biofilm formation and virulence
orf19.5876Candida albicans SC5314Predicted ORF in Assemblies 19, 20 and 21; greater mRNA abundance observed in a cyr1 homozygous null mutant than in wild type; transcription is induced in response to alpha pheromone in SpiderM medium
orf19.3190HAL9Candida albicans SC5314Protein with Zn(2)-Cys(6) binuclear cluster; gene in zinc cluster region of Chr. 5; transcriptionally activated by Mnl1p in weak acid; similar to S. cerevisiae Hal9p, which is a putative transcription factor involved in salt tolerance
orf19.5879Candida albicans SC5314Has domain(s) with predicted nucleotide binding, oxidoreductase activity and role in oxidation-reduction process
orf19.3193FCR3Candida albicans SC5314Transcriptional regulator of the bZIP family; partially functionally complements the fluconazole sensitivity of an S. cerevisiae pdr1 pdr3 double mutant; probable ortholog of S. cerevisiae Yap3p; Hap43p-induced
orf19.2537Candida albicans SC5314Predicted ORF in Assemblies 19, 20 and 21; transcription detected in high-resolution tiling array experiments
orf19.3195HIP1Candida albicans SC5314Similar to amino acid permeases; alkaline upregulated; flucytosine induced; regulated by Plc1p, Gcn2p and Gcn4p; fungal-specific (no human or murine homolog)
orf19.3196Candida albicans SC5314
orf19.3197PAP1Candida albicans SC5314Poly(A) polymerase, likely involved in mRNA polyadenylation; PAP is inhibited by parnafungin antifungals; gene is located within the MTLa mating-type-like locus
orf19.3198OBPACandida albicans SC5314Similar to oxysterol binding protein; gene is located within the MTLa mating-type-like locus; Plc1p-regulated
orf19.3199PIKACandida albicans SC5314Putative phosphatidylinositol kinase; gene is located within the MTLa mating-type-like locus; planktonic growth-induced gene
orf19.5880Candida albicans SC5314Ortholog(s) have voltage-gated chloride channel activity, role in cellular iron ion homeostasis, cellular copper ion homeostasis and endosome, endoplasmic reticulum, fungal-type vacuole, plasma membrane, Golgi medial cisterna localization
orf19.2540SAS3Candida albicans SC5314Similar to silencing proteins; increased transcription is observed upon fluphenazine treatment
orf19.2541Candida albicans SC5314Ortholog(s) have 3'-5'-exodeoxyribonuclease activity, endonuclease activity, role in cellular response to oxidative stress, DNA fragmentation involved in apoptotic nuclear change and cytoplasm localization
orf19.2542Candida albicans SC5314Has domain(s) with predicted heat shock protein binding activity
orf19.5886CUP5Candida albicans SC5314Putative proteolipid subunit of the vacuolar H(+)-ATPase V0 sector; caspofungin repressed
orf19.5887NUP85Candida albicans SC5314Ortholog(s) have role in mRNA export from nucleus, ribosomal large subunit export from nucleus, nuclear envelope organization and Nup107-160 complex localization
orf19.2544Candida albicans SC5314Ortholog(s) have aminoacyl-tRNA hydrolase activity, role in negative regulation of proteasomal ubiquitin-dependent protein catabolic process and mitochondrial outer membrane localization
orf19.2547Candida albicans SC5314Has domain(s) with predicted ribonuclease activity, RNA binding activity
orf19.5890Candida albicans SC5314
Locus IdGene NameOrganismDescription
orf19.5893RIP1Candida albicans SC5314Putative ubiquinol cytochrome c-reductase; transcriptionally regulated by iron; expression greater in high iron; alkaline downregulated; repressed by nitric oxide; Hap43p-repressed
orf19.2551MET6Candida albicans SC5314Essential 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase (cobalamin-independent methionine synthase); antigenic during murine or human systemic infection; heat shock, estrogen, possibly biofilm, and GCN-induced
orf19.2552Candida albicans SC5314Protein similar to S. cerevisiae Pmr1p; amphotericin B induced; previously merged with orf19.2553; unmerged from orf19.2553 in a revision of Assembly 21
orf19.5896Candida albicans SC5314Predicted ORF in Assemblies 19, 20 and 21; transcription is induced in response to alpha pheromone in SpiderM medium
orf19.5897Candida albicans SC5314Ortholog(s) have extrinsic to fungal-type vacuolar membrane, Seh1-associated complex localization
orf19.2559CDC4Candida albicans SC5314F-box subunit of SCF(CDC4) ubiquitin ligase; functional homolog of S. cerevisiae Cdc4p; mutation or depletion causes hyperfilamentation; nonessential; Sol1p is a substrate of SCF-Cdc4p
orf19.5100MLT1Candida albicans SC5314Vacuolar membrane transporter: MRP subfamily of ABC family; similar to S. cerevisiae Bpt1p and Ycf1p; may transport organic anions conjugated to glutathione, glucuronate, or sulfate; required for virulence in mouse peritonitis model
orf19.5102PLB5Candida albicans SC5314Putative GPI-linked phospholipase B, fungal-specific (no mammalian homolog); null mutation eliminates cell-associated phospholipase A2 activity and attenuates virulence; fluconazole-repressed
orf19.5104LTP1Candida albicans SC5314Putative protein phosphatase of the PTP family (tyrosine-specific), similar to S. cerevisiae Ltp1p
orf19.5106DIP2Candida albicans SC5314Putative small ribonucleoprotein complex; transposon mutation affects filamentous growth; physically interacts with TAP-tagged Nop1p; heterozygous null mutant exhibits resistance to parnafungin; Hap43p-induced gene
orf19.5107NOT5Candida albicans SC5314Protein with similarity to S. cerevisiae Not5p, a member of the transcription regulatory CCR4-NOT complex; required for hyphal growth; antigenic during human oral infection; greater expression in yeast-form cells than hyphae
orf19.1906Candida albicans SC5314Late-stage biofilm-induced gene
orf19.1907EMC9Candida albicans SC5314Protein not essential for viability, induced during the mating process
orf19.2564Candida albicans SC5314
orf19.2568IFU5Candida albicans SC5314Predicted membrane protein; estradiol-induced; increased transcription associated with CDR1 and CDR2 overexpression or fluphenazine treatment; putative drug-responsive regulatory site; similar to S. cerevisiae Wwm1p; Hap43p-repressed gene
orf19.5112TKL1Candida albicans SC5314Putative transketolase; localizes to surface of yeast-form cells, but not hyphae; soluble protein in hyphae; transcription regulated by Nrg1p, Mig1p, and Tup1p; antigenic in human or murine infection; possibly essential (by UAU1 method)
orf19.5113ADH2Candida albicans SC5314Alcohol dehydrogenase; soluble in hyphae; fungal-specific; expression regulated by white-opaque switching; regulated by Ssn6p; transcriptionally indued by Mnl1p by weak acid stress; protein enriched in stationary phase yeast cultures
orf19.5117OLE1Candida albicans SC5314Fatty acid desaturase, essential protein involved in oleic acid synthesis; required for aerobic hyphal growth and chlamydospore formation; subject to hypoxic regulation; fluconazole-induced; caspofungin repressed; Hap43p-induced
orf19.1910Candida albicans SC5314Hap43p-repressed gene
orf19.1913Candida albicans SC5314Late-stage biofilm-induced gene
Locus IdGene NameOrganismDescription
orf19.1914FAV3Candida albicans SC5314Putative alpha-1,6-mannanase; induced by mating factor in MTLa/MTLa opaque cells
orf19.2571SEC4Candida albicans SC5314Small GTPase of Rab family; role in post-Golgi secretion; possible C-terminal palmitoylation; downregulated on adherence to polystyrene; localizes to the Spitzenkorper during hyphal growth; functional homolog of S. cerevisiae Sec4p
orf19.2573FRS1Candida albicans SC5314Phenylalanyl-tRNA synthetase; possible role in early cell wall biosynthesis; downregulated by phagocytosis by macrophages; possibly essential gene, disruptants not obtained by UAU1 method; protein present in exponential and stationary phase
orf19.2574Candida albicans SC5314Ortholog of S. cerevisiae : YFL034W and C. glabrata CBS138 : CAGL0K12584g
orf19.2575Candida albicans SC5314Putative S-adenosylmethionine-dependent methyltransferase; Hap43p-induced gene
orf19.5121OPT5Candida albicans SC5314Oligopeptide transporter; fungal-specific (no human or murine homolog); induced by BSA, but not by tetrapeptide or pentapeptide
orf19.5124RBR3Candida albicans SC5314Cell wall adhesin-like protein; expression is repressed by Rim101p; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.5126Candida albicans SC5314Putative adhesin-like protein
orf19.1920Candida albicans SC5314
orf19.5129Candida albicans SC5314
orf19.1923RRN3Candida albicans SC5314Protein with a predicted role in recruitment of RNA polymerase I to rDNA; caspofungin induced, flucytosine repressed; downregulated in core stress response; decreased expression in response to prostaglandins
orf19.2580HST2Candida albicans SC5314Putative histone deacetylase, involved in regulation of white-opaque switching
orf19.2581Candida albicans SC5314Hap43p-repressed gene
orf19.2583Candida albicans SC5314Putative oligopeptide transporter
orf19.1927SNM1Candida albicans SC5314Protein similar to RNase MRP RNA binding protein; ciclopirox olamine induced; regulated by Sef1p-, Sfu1p-, and Hap43p
orf19.2587HNM3Candida albicans SC5314Putative transporter; Hap43p-repressed gene; flucytosine repressed; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.5131Candida albicans SC5314Hap43p-repressed gene
orf19.5133ZCF29Candida albicans SC5314Predicted zinc-finger protein; null mutant displays sensitivity to caffeine and menadione, and resistance to fenpropimorph; Hap43p-repressed gene; mutants display decreased colonization of mouse kidneys
orf19.5134Candida albicans SC5314
orf19.5136Candida albicans SC5314Putative pyridoxamine 5'-phosphate oxidase; early-stage biofilm- and planktonic growth-induced gene
Locus IdGene NameOrganismDescription
orf19.5138IFA21Candida albicans SC5314Protein not essential for viability
orf19.1930CFL5Candida albicans SC5314Ferric reductase; expression greater in low iron; negatively regulated by Sfu1p; ciclopirox olamine, flucytosine induced; amphotericin B repressed; transcription is positively regulated by Tbf1p, Hap43p; Sfu1p-regulated
orf19.1932CFL4Candida albicans SC5314C-terminus similar to ferric reductases; expression high in low iron; transcription negatively regulated by Sfu1p; ciclopirox olamine induced; shows colony morphology-related gene regulation by Ssn6p; Hap43p-repressed; Sef1p-regulated
orf19.2590Candida albicans SC5314Putative dethiobiotin synthetase; transcription is upregulated in clinical isolates from HIV+ patients with oral candidiasis; Hap43p-repressed gene
orf19.1934HST3Candida albicans SC5314Histone H3K56 deacetylase; reduced copy number increases opaque cell formation; repressed by MMS, hydroxyurea and high-levels of hydrogen peroxide; Hap43p-induced; ectopic expression blocks genotoxin-induced switching; nicotinamide target
orf19.1935Candida albicans SC5314
orf19.2594Candida albicans SC5314Ortholog(s) have DNA-directed RNA polymerase activity, role in transcription of nuclear large rRNA transcript from RNA polymerase I promoter and DNA-directed RNA polymerase I complex localization
orf19.2597MRS2Candida albicans SC5314Putative magnesium ion transporter, mitochondrial; fungal-specific (no human or murine homolog)
orf19.2599CRC1Candida albicans SC5314Mitochondrial carnitine carrier protein
orf19.5140Candida albicans SC5314
orf19.5142DFR1Candida albicans SC5314Trimethoprim resistant dihydrofolate reductase (DHFR), reduces 7,8-dihydrofolate to 5,4,7,8-tetrahydrofolate; binds NADPH; target of drugs that selectively inhibit the fungal enzyme rather than the human enzyme
orf19.5145SSP96Candida albicans SC5314Putative flavin-containing monooxygenase; induced upon biofilm formation
orf19.5148CYR1Candida albicans SC5314Class III adenylyl cyclase; mutant lacks cAMP; mutant hyphal growth defect rescued by exogenous cAMP; required for mouse mucosal or systemic infection; role in macrophage sensitivity, apoptosis; downstream of Ras1p and CO2 signaling
orf19.1941NUF2Candida albicans SC5314Kinetochore component; amount of Nuf2p and Mtw1p protein detected at each centromere is consistent with a single kinetochore microtubule attachment site
orf19.1943Candida albicans SC5314
orf19.1944GPR1Candida albicans SC5314Plasma membrane G-protein-coupled receptor of the cAMP-PKA pathway; required for wild-type hyphal growth; reports differ on role in cAMP-mediated glucose signaling; Gpr1p C terminus binds Gpa2p; regulates HWP1 and ECE1; biofilm-induced
orf19.1946Candida albicans SC5314Similar to an aldose 1-epimerase-related protein; antigenic during murine systemic infection; protein present in exponential and stationary growth phase yeast cultures; Hap43p-induced gene
orf19.1949VPS1Candida albicans SC5314Dynamin-family GTPase-related protein; induced upon adherence to polystyrene; regulated by Gcn2p and Gcn4p
orf19.5155CHS6Candida albicans SC5314Protein with tetratricopeptide repeats (TPRs); similar to S. cerevisiae Chs6p, which has role in localizing chitin synthase; decreased mRNA abundance in cyr1 mutant hyphae; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.5158Candida albicans SC5314Protein with similarity to a human gene associated with colon cancer and to orf19.5158; regulated by Gcn4p, Cyr1p; induced in response to amino acid starvation; macrophage-induced protein, macrophage-downregulated gene
Locus IdGene NameOrganismDescription
orf19.1953Candida albicans SC5314Predicted ORF in Assemblies 19, 20 and 21; not essential for viability; merged with orf19.1952 in Assembly 21
orf19.1954PUS4Candida albicans SC5314Putative pseudouridine synthase; transcription is regulated by Nrg1p, Mig1p, and Tup1p
orf19.1956Candida albicans SC5314
orf19.1957CYC3Candida albicans SC5314Cytochrome c heme lyase, mitochondrial; gene also encodes antigenic cell-wall protein; mRNA more abundant in filaments than yeast-form; induced on polystyrene adherence, interaction with macrophage; N-glycosylation, 2 heme-binding motifs
orf19.1959Candida albicans SC5314Ortholog(s) have ribosome, cytoplasm localization
orf19.802UGA1Candida albicans SC5314Putative GABA transaminase; transcription regulated by Mig1p and Tup1p; stationary phase enriched protein
orf19.804Candida albicans SC5314Ortholog(s) have mitochondrion localization
orf19.805Candida albicans SC5314Putative protein of unknown function; Hap43p-repressed gene; S. cerevisiae ortholog YGR021W localizes to mitochondria
orf19.806VMA7Candida albicans SC5314Putative subunit of the V-ATPase complex, which is involved in control of vacuolar pH; highly similar to S. cerevisiae Vma7p; interacts with phosphatidylinositol 3-kinase Vps34p
orf19.807CHS5Candida albicans SC5314Putative chitin biosynthesis protein; fungal-specific (no human or murine homolog); transcription decreases upon yeast-to-hyphal switch
orf19.808Candida albicans SC5314
orf19.4502Candida albicans SC5314Ortholog(s) have rDNA binding, TBP-class protein binding, ATPase activity
orf19.809Candida albicans SC5314Ortholog(s) have role in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and nucleolus, preribosome localization
orf19.4503Candida albicans SC5314
orf19.5160Candida albicans SC5314Ortholog(s) have protein serine/threonine phosphatase activity, role in tRNA wobble uridine modification, G1/S transition of mitotic cell cycle and mitochondrion localization
orf19.4504Candida albicans SC5314Has domain(s) with predicted zinc ion binding, oxidoreductase activity, nucleotide binding activity and role in oxidation-reduction process
orf19.5161Candida albicans SC5314Ortholog(s) have structural constituent of ribosome activity and mitochondrial large ribosomal subunit localization
orf19.4505ADH3Candida albicans SC5314Putative NAD-dependent (R,R)-butanediol dehydrogenase; expression is regulated upon white-opaque switching; induced by nitric oxide independent of Yhb1p
orf19.5162BCK1Candida albicans SC5314Protein similar to S. cerevisiae Bck1p MAP kinase kinase kinase of cell integrity pathway; mutant is hypersensitive to caspofungin
orf19.5163SFI1Candida albicans SC5314Putative centrin-binding protein with a predicted role in spindle pole body duplication; transcription is induced in response to alpha pheromone in SpiderM medium; essential for growth
Locus IdGene NameOrganismDescription
orf19.5164ECM39Candida albicans SC5314Putative mannosyltransferase similar to S. cerevisiae Ecm39p, which has a role in Calcofluor white resistance; predicted Kex2p substrate; has HKEXRF motif
orf19.4508Candida albicans SC5314
orf19.4509Candida albicans SC5314
orf19.5168Candida albicans SC5314Ortholog(s) have role in maturation of SSU-rRNA and cytoplasm localization
orf19.5169Candida albicans SC5314Has domain(s) with predicted carbon-nitrogen ligase activity, with glutamine as amido-N-donor, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides activity
orf19.1963GDS1Candida albicans SC5314Putative mitochondrial protein; Hap43p-repressed gene
orf19.1967Candida albicans SC5314Ortholog(s) have structural constituent of ribosome activity and mitochondrial large ribosomal subunit localization
orf19.1969CCW14Candida albicans SC5314Putative mannoprotein of cell wall with role in response to stress; increased mRNA abundance observed in cyr1 homozygous mutant (hyphal or yeast-form cells) and in ras1 homozygous mutant (yeast-form cells)
orf19.810Candida albicans SC5314Ortholog(s) have DNA helicase activity, role in synapsis, reciprocal meiotic recombination, DNA unwinding involved in replication and nucleus localization
orf19.812Candida albicans SC5314
orf19.814SSY1Candida albicans SC5314Amino acid sensor, required for wild-type hyphal growth on solid serum or Lees media, not for hyphal growth under all conditions; 12 predicted membrane spanning regions; Hap43p-repressed gene
orf19.4510IFA4Candida albicans SC5314Predicted ORF in Assemblies 19, 20 and 21; oxidative stress-induced via Cap1p
orf19.819Candida albicans SC5314Ortholog(s) have role in lipoate biosynthetic process and mitochondrion localization
orf19.5170ENA21Candida albicans SC5314Predicted ORF similar to S. cerevisiae sodium transporters Ena1p and Ena5p; Gcn4p-regulated; flucytosine, amphotericin B, or ketoconazole-induced; osmotic stress-induced; overlaps orf19.5170.1, which is annotated as a blocked reading frame
orf19.5171PMT1Candida albicans SC5314Protein mannosyltransferase (PMT), required for virulence in mouse systemic infection and for adhesion to epithelial cells; role in hyphal growth and drug sensitivity; Als1p, Sec20p, Kre9p, Pir1p are substrates; one of 5 PMT family members
orf19.5172LIP9Candida albicans SC5314Secreted lipase, member of a lipase gene family whose members are expressed differentially in response to carbon source and during infection; may have a role in nutrition and/or in creating an acidic microenvironment
orf19.5174TAF19Candida albicans SC5314Putative TFIID subunit; mutation confers hypersensitivity to amphotericin B
orf19.4518Candida albicans SC5314Protein not essential for viability
orf19.4519SUV3Candida albicans SC5314Protein required for chlamydospore formation, for embedded hyphal growth, and for wild-type respiratory growth; similar to S. cerevisiae Suv3p, which is an RNA helicase involved in mitochondrial RNA catabolism
orf19.5178ERG5Candida albicans SC5314Putative C-22 sterol desaturase; fungal C-22 sterol desaturases are cytochrome P450 enzymes of ergosterol biosynthesis, catalyze formation of the C-22(23) double bond in the sterol side chain; transposon mutation affects filamentous growth
Locus IdGene NameOrganismDescription
orf19.1970Candida albicans SC5314Putative vacuole biogenesis protein
orf19.1975Candida albicans SC5314Ortholog(s) have role in nuclear mRNA splicing, via spliceosome and U5 snRNP, U4/U6 x U5 tri-snRNP complex localization
orf19.1976TRX2Candida albicans SC5314Similar to thioredoxins; not expected to be enzymatically active because it lacks a canonical thioredoxin active site (Trp-Cys-Gly-Pro-Cys); TRX1 encodes all of the cytoplasmic/nuclear thioredoxin function in C. albicans; Hap43p-induced
orf19.1978GIT2Candida albicans SC5314Putative glycerophosphoinositol permease; fungal-specific (no human or murine homolog); transcription is repressed in response to alpha pheromone in SpiderM medium; Hap43p-repressed gene
orf19.820SDS22Candida albicans SC5314Putative protein serine-threonine phosphatase; macrophage/pseudohyphal-repressed
orf19.825GCD7Candida albicans SC5314Putative translation initiator; downregulated in the presence of human whole blood or polymorphonuclear (PMN) cells
orf19.4520Candida albicans SC5314Ortholog(s) have cytoplasm localization
orf19.4521Candida albicans SC5314Predicted ORF in Assemblies 19, 20 and 21; hyphal-induced expression
orf19.828Candida albicans SC5314Putative ribosomal protein, large subunit, mitochondrial precursor; decreased expression in response to prostaglandins
orf19.829SCH9Candida albicans SC5314Protein kinase involved in growth control, normal cell size, resistance to rapamycin and cations, chlamydospore formation, filamentous growth under some conditions, and virulence; prevents hypha formation under hypoxia at high CO2 levels
orf19.4523Candida albicans SC5314Ortholog(s) have 5-formyltetrahydrofolate cyclo-ligase activity, role in folic acid-containing compound biosynthetic process and mitochondrion localization
orf19.5180PRX1Candida albicans SC5314Putative cysteine peroxidase; transcriptionally induced by interaction with macrophage; fluconazole induced; Fkh2p-downregulated; caspofungin repressed; protein present in exponential and stationary growth phase yeast cultures
orf19.4524ZCF24Candida albicans SC5314Predicted zinc-finger protein; caspofungin induced; Hap43p-repressed
orf19.5181NIK1Candida albicans SC5314Histidine kinase involved in a two-component signaling pathway that regulates cell wall biosynthesis; required for wild-type virulence in mouse systemic infection but not for wild-type growth or drug sensitivity/resistance; 9 HAMP domains
orf19.4525Candida albicans SC5314Ortholog(s) have endoplasmic reticulum, nuclear pore localization
orf19.5182POL3Candida albicans SC5314Large subunit of DNA polymerase III; partially complements defects of an S. cerevisiae cdc2 mutant; differing reports about periodic (G1/S) or non-periodic mRNA expression through cell cycle; Hap43p-repressed
orf19.4526HSP30Candida albicans SC5314Putative heat shock protein; fluconazole-downregulated; amphotericin B induced
orf19.4527HGT1Candida albicans SC5314High-affinity glucose transporter, member of major facilitator superfamily; transcription induced by progesterone and by drugs including chloramphenicol and benomyl; likely essential for growth, based on an insertional mutagenesis strategy
orf19.5184Candida albicans SC5314Ortholog(s) have signal transducer activity, role in ribosomal subunit export from nucleus, rRNA export from nucleus and nuclear chromatin localization
orf19.4528Candida albicans SC5314Ortholog(s) have role in vacuolar protein processing
Locus IdGene NameOrganismDescription
orf19.4529Candida albicans SC5314Putative adhesin-like protein; not essential for viability
orf19.5188CHS1Candida albicans SC5314Chitin synthase; essential; required for primary septum synthesis in yeast-form cells and hyphae; one of multiple chitin synthases; enzymatically activated by proteolytic processing; complements defects of S. cerevisiae chs1 or chs2 mutant
orf19.1981Candida albicans SC5314Ortholog(s) have endopeptidase activity, role in protein processing involved in protein targeting to mitochondrion and mitochondrial inner membrane peptidase complex localization
orf19.1985Candida albicans SC5314Biofilm-induced gene
orf19.1988CDC45Candida albicans SC5314Putative DNA replication initiation factor; transcriptionally regulated by interaction with macrophage
orf19.1989DCW1Candida albicans SC5314Protein with predicted GPI modification; dfg5 dcw1 double mutant is inviable; not required for wild-type hyphal growth; increased mRNA abundance observed in cyr1 null mutant (yeast-form or hyphal); fungal-specific; Hap43p-induced
orf19.832GPI13Candida albicans SC5314Major facilitator superfamily protein; has phosphodiesterase/nucleotide pyrophosphatase domain; similar to S. cerevisiae Gpi13p, which acts in GPI anchor biosynthesis; Hap43p-induced gene
orf19.834Candida albicans SC5314Ortholog(s) have carbohydrate binding, mannosyl-oligosaccharide 1,2-alpha-mannosidase activity, role in ER-associated protein catabolic process and endoplasmic reticulum lumen localization
orf19.835Candida albicans SC5314
orf19.837GNA1Candida albicans SC5314Glucosamine-6-phosphate acetyltransferase; enzyme of UDP-GlcNAc biosynthesis; required for viability in absence of GlcNAc supplementation; required for persistent infection and wild-type virulence in mouse systemic infection
orf19.4531Candida albicans SC5314Putative PDR-subfamily ABC transporter
orf19.5190Candida albicans SC5314
orf19.4534Candida albicans SC5314Putative UBX-domain (ubiquitin-regulatory domain) protein; macrophage-downregulated gene
orf19.4535PTR3Candida albicans SC5314Protein similar to S. cerevisiae Ptr3p, which is a sensor of external amino acids; expression upregulated in an ssr1 null mutant
orf19.4536CYS4Candida albicans SC5314Cystathionine beta-synthase; sulfur amino acid biosynthesis; antigenic in mouse; biofilm and alkaline upregulated; macrophage/pseudohyphal-induced; present in exponential and stationary growth phase yeast cultures
orf19.5197APE2Candida albicans SC5314Neutral arginine-, alanine-, leucine-specific metallo-aminopeptidase; expected to be secreted, purified from cell wall and intracellular fractions; protein repressed during the mating process; Hog1p-, farnesol-induced; possibly essential
orf19.1990SNX4Candida albicans SC5314Putative sorting nexin; induced during the mating process
orf19.1993Candida albicans SC5314Ortholog(s) have structural molecule activity, role in proteasome assembly, ubiquitin-dependent protein catabolic process and proteasome regulatory particle, lid subcomplex, proteasome storage granule localization
orf19.1994Candida albicans SC5314Has domain(s) with predicted phosphatidylinositol binding activity and role in cell communication
orf19.1996CHA1Candida albicans SC5314Similar to catabolic serine/threonine dehydratases; negatively regulated by Rim101p; expression greater in low iron; regulated on white-opaque switching; filament induced; transposon mutation affects filamentous growth; biofilm-induced
Locus IdGene NameOrganismDescription
orf19.1998Candida albicans SC5314
orf19.840RPL21ACandida albicans SC5314Putative ribosomal protein; genes encoding cytoplasmic ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage
orf19.842ASR3Candida albicans SC5314Gene regulated by cAMP and by osmotic stress; greater mRNA abundance observed in a cyr1 or ras1 homozygous null mutant than in wild type
orf19.843Candida albicans SC5314Putative DNA repair exonuclease; fungal-specific (no human or murine homolog)
orf19.846Candida albicans SC5314Predicted ORF in Assemblies 19, 20 and 21; transcriptionally activated by Mnl1p under weak acid stress
orf19.847YIM1Candida albicans SC5314Protein similar to protease of mitochondrial inner membrane; increased transcription is observed upon benomyl treatment; macrophage-downregulated gene
orf19.4542Candida albicans SC5314Ortholog(s) have role in phosphorylation of RNA polymerase II C-terminal domain, transcription from RNA polymerase II promoter and TFIIK complex, mitochondrion localization
orf19.849Candida albicans SC5314Ortholog(s) have role in protein O-linked glycosylation, protein N-linked glycosylation, response to stress
orf19.1201Candida albicans SC5314Ortholog(s) have serine-tRNA ligase activity, role in invasive growth in response to glucose limitation, pseudohyphal growth, mitochondrial seryl-tRNA aminoacylation and mitochondrion localization
orf19.4545SWI4Candida albicans SC5314Putative component of the SBF transcription complex involved in G1/S cell-cycle progression; periodic mRNA expression, peak at cell-cycle G1/S phase; predicted, conserved MBF binding sites upstream of G1/S-regulated genes
orf19.1204Candida albicans SC5314Phosphorylated protein of unknown function, transcription is upregulated clinical isolates from HIV positive patients with oral candidiasis
orf19.4548MAK32Candida albicans SC5314Putative protein involved in the structural stability of L-A double-stranded RNA-containing particles; downregulated upon adherence to polystyrene
orf19.4549FGR38Candida albicans SC5314Protein lacking an ortholog in S. cerevisiae; member of a family of related proteins; transposon mutation affects filamentous growth; macrophage-induced gene; Hap43p-repressed gene
orf19.1207Candida albicans SC5314
orf19.1208Candida albicans SC5314Predicted ORF in Assemblies 19, 20 and 21; member of a family encoded by FGR6-related genes in the RB2 repeat sequence
orf19.850Candida albicans SC5314Ortholog(s) have protein N-terminal asparagine amidohydrolase activity, role in protein modification process, protein catabolic process and mitochondrion localization
orf19.851Candida albicans SC5314Protein of unknown function; transcription is negatively regulated by Rim101p; negatively modulates intracellular ATP levels during the development of azole resistance; induced by Ca(2+) in a calcineurin-dependent manner
orf19.854UGA11Candida albicans SC5314Putative gamma-aminobutyrate (GABA) transaminase; macrophage-induced gene; overlaps orf19.854.1, which is a region annotated as a blocked reading frame
orf19.4550Candida albicans SC5314Predicted membrane transporter, member of the drug:proton antiporter (12 spanner) (DHA1) family, major facilitator superfamily (MFS); biofilm-induced
orf19.4551CTN1Candida albicans SC5314Predicted carnitine acetyl transferase; required for growth on nonfermentable carbon sources but not for hyphal growth or virulence in mouse systemic model; transcription induced in macrophage; macrophage/pseudohyphal-repressed after 16 hr
Locus IdGene NameOrganismDescription
orf19.4553Candida albicans SC5314
orf19.1210Candida albicans SC5314Ortholog(s) have L-glutamate transmembrane transporter activity, L-aspartate transmembrane transporter activity, role in amino acid export from vacuole and fungal-type vacuole membrane localization
orf19.4555ALS4Candida albicans SC5314ALS family protein; role in adhesion and wild-type germ tube induction; growth and temperature regulated; expressed during infection of human buccal epithelial cells; down-regulated upon vaginal contact; putative GPI-anchored
orf19.1212Candida albicans SC5314Has domain(s) with predicted structural molecule activity
orf19.4557Candida albicans SC5314Ortholog(s) have structural constituent of cytoskeleton, microtubule binding activity and role in protein localization to kinetochore, mitotic cell cycle spindle assembly checkpoint, sister chromatid biorientation, microtubule nucleation
orf19.1214Candida albicans SC5314Ortholog(s) have metalloaminopeptidase activity and role in protein initiator methionine removal involved in protein maturation
orf19.1215Candida albicans SC5314
orf19.1217Candida albicans SC5314Has domain(s) with predicted zinc ion binding activity
orf19.1219Candida albicans SC5314
orf19.7100Candida albicans SC5314Putative vacuolar transporter of large neutral amino acids; possibly transcriptionally regulated upon hyphal formation
orf19.7104Candida albicans SC5314Adhesin-like cell wall protein; similar to mucins and to a Litomosoides microfilarial sheath protein; N-terminal secretion signal
orf19.7105FAR1Candida albicans SC5314Protein involved in regulation of pheromone-mediated mating; repressed by A1p and Alpha2p in white-phase cells; null mutant shows no pheromone response in opaque cells; overexpression causes enhanced pheromone response and cell cycle arrest
orf19.861CAP4Candida albicans SC5314Predicted transcriptional regulator with bZip domain; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.862Candida albicans SC5314
orf19.7107Candida albicans SC5314Ortholog(s) have role in ribosomal large subunit biogenesis and ribosome, nucleus, cytoplasm localization
orf19.3900Candida albicans SC5314Ortholog(s) have role in mitochondrial fusion and integral to mitochondrial outer membrane localization
orf19.7109Candida albicans SC5314Ortholog of S. cerevisiae : YGL242C and C. glabrata CBS138 : CAGL0H07755g
orf19.3901Candida albicans SC5314Putative benzene desulfurase; induced by nitric oxide independent of Yhb1p
orf19.866RAD32Candida albicans SC5314Protein similar to S. cerevisiae protein with role in nucleotide excision repair; down-regulation associated with azole resistance; Hap43p-repressed gene
orf19.4560BFR1Candida albicans SC5314Protein involved in the maintenance of normal ploidy; S. cerevisiae ortholog cofers Brefeldin A resistance; stationary phase enriched protein
Locus IdGene NameOrganismDescription
orf19.867Candida albicans SC5314Ortholog(s) have ribosome localization
orf19.868ADAECCandida albicans SC5314Protein of unknown function; transcription is specific to white cell type
orf19.4563Candida albicans SC5314Putative protein of unknown function; Hap43p-induced gene; decreased expression in response to prostaglandins
orf19.3908Candida albicans SC5314
orf19.1221ALG2Candida albicans SC5314Putative mannosyltransferase involved in cell wall mannan biosynthesis; transcription is elevated in chk1, nik1, and sln1 homozygous null mutants
orf19.4566Candida albicans SC5314Protein similar to S. cerevisiae Rot1p, which has roles in cytoskeletal dynamics and cell wall biosynthesis; predicted Kex2p substrate
orf19.4567Candida albicans SC5314Catechol 1,2-dioxygenase (1,2-CTD), involved in degradation of aromatic compounds
orf19.4568ZCF25Candida albicans SC5314Putative transcription factor with zinc cluster DNA-binding motif
orf19.1228HAP2Candida albicans SC5314CCAAT-binding factor regulates low-iron induction of FRP1, in these conditions CBF comprises Hap43p and probably Hap2p and Hap3p; possibly an essential gene, disruptants not obtained by UAU1 method; Cap1p-dependent induction in low iron
orf19.1229Candida albicans SC5314Ortholog(s) have importin-alpha export receptor activity, role in protein export from nucleus and nuclear envelope localization
orf19.7111Candida albicans SC5314Putative mitochondrial outer membrane protein membrane fission effector; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.7112FRP2Candida albicans SC5314Putative ferric reductase; alkaline upregulated by Rim101p; fluconazole-downregulated; upregulated in the presence of human neutrophils; possibly adherence-induced; regulated by Sef1p, Sfu1p, and Hap43p
orf19.7114CSA1Candida albicans SC5314Surface antigen on elongating hyphae and buds; no obvious hyphal defects in mutant; strain variation in repeat domain number; upregulated in filaments; alkaline upregulated by Rim101p; ciclopirox induced; Efg1p-, Cph1p, Hap43p-regulated
orf19.7115SAC7Candida albicans SC5314Putative GTPase activating protein (GAP) for RHO1; downregulated upon adherence to polystyrene; macrophage/pseudohyphal-repressed; transcription is upregulated in RHE model of oral candidiasis and in clinical oral candidiasis
orf19.7116Candida albicans SC5314Putative protein of unknown function, transcription is upregulated in an RHE model of oral candidiasis
orf19.872Candida albicans SC5314
orf19.7118Candida albicans SC5314Ortholog(s) have adenylate kinase activity, nucleoside triphosphate adenylate kinase activity, role in nucleotide metabolic process and mitochondrial inner membrane localization
orf19.3910Candida albicans SC5314Has domain(s) with predicted RNA binding, ribonuclease T2 activity
orf19.7119RAD3Candida albicans SC5314Ortholog of S. cerevisiae RAD3; has helicase activity on a duplex DNA substrate
orf19.874Candida albicans SC5314Hap43p-repressed gene
Locus IdGene NameOrganismDescription
orf19.3912GLN3Candida albicans SC5314GATA transcription factor involved in regulation of filamentous growth induced by nitrogen starvation; regulates transcription of Mep2p ammonium permease; regulated by Gcn2p and Gcn4p; mRNA binds to She3p
orf19.875Candida albicans SC5314Protein required for respiratory growth
orf19.876PGA33Candida albicans SC5314Putative GPI-anchored protein
orf19.4570Candida albicans SC5314
orf19.878NBN1Candida albicans SC5314Subunit of the NuA4 histone acetyltransferase complex; Plc1p-regulated
orf19.879Candida albicans SC5314Ortholog(s) have myosin binding activity, role in intracellular mRNA localization, mating type switching and cytoplasm localization
orf19.4575Candida albicans SC5314Ortholog(s) have mitochondrion localization
orf19.1232VRG4Candida albicans SC5314GDP-mannose transporter; essential; required for glycosylation, hyphal growth; functional homolog of S. cerevisiae Vrg4p, which imports GDP-mannose from cytoplasm to Golgi for protein and lipid mannosylation; no mammalian homolog
orf19.4577Candida albicans SC5314
orf19.1234FGR6-10Candida albicans SC5314Protein lacking an ortholog in S. cerevisiae; member of a family encoded by FGR6-related genes in the RB2 repeat sequence; transposon mutation affects filamentous growth
orf19.1235HOM3Candida albicans SC5314Putative L-aspartate 4-P-transferase; fungal-specific (no human or murine homolog); regulated by Gcn2p and Gcn4p; early-stage biofilm-induced gene
orf19.1236Candida albicans SC5314Ortholog(s) have role in vacuole organization, endocytosis, establishment or maintenance of actin cytoskeleton polarity and integral to Golgi membrane localization
orf19.1237ARO9Candida albicans SC5314Aromatic transaminase of the Ehrlich fusel oil pathway of aromatic alcohol biosynthesis; Rim101p-dependent pH-regulation (alkaline induced); Hap43p-induced gene
orf19.7121Candida albicans SC5314
orf19.7124RVS161Candida albicans SC5314Protein required for endocytosis; contains a BAR domain, which is found in proteins involved in membrane curvature; null mutant exhibits defects in hyphal growth, virulence, cell wall integrity, and actin patch localization
orf19.7125Candida albicans SC5314
orf19.881DFG16Candida albicans SC5314Rim101p pathway protein that regulates filamentation in response to alkaline pH; required for host tissue invasion during infection; similar to S. cerevisiae Dfg16p that acts in Rim101p processing; late-stage biofilm-induced
orf19.7127TLO16Candida albicans SC5314Member of a family of telomere-proximal genes of unknown function; may be spliced in vivo
orf19.7128SYS1Candida albicans SC5314Putative Golgi integral membrane protein; transcription is regulated by Mig1p
orf19.3920Candida albicans SC5314Ortholog(s) have protein disulfide oxidoreductase activity, protein disulfide isomerase activity, role in protein folding and fungal-type vacuole localization
Locus IdGene NameOrganismDescription
orf19.3923PGA37Candida albicans SC5314Putative GPI-anchored protein; Hap43p-repressed gene
orf19.886PAN1Candida albicans SC5314Essential protein involved in endocytosis and polarized growth; similar to S. cerevisiae Pan1p, which is a part of a complex that regulates actin cytoskeleton
orf19.3924Candida albicans SC5314
orf19.3926RNY11Candida albicans SC5314Ortholog(s) have endoribonuclease activity, role in cell morphogenesis, RNA catabolic process, apoptosis and cytosol, extracellular region, vacuole localization
orf19.889THI20Candida albicans SC5314Putative phosphomethylpyrimidine kinase; also described as a putative transcription factor with TENA DNA-binding motif; fungal-specific (no human or murine homolog)
orf19.1240Candida albicans SC5314Ortholog of S. cerevisiae : YPR117W and C. glabrata CBS138 : CAGL0D04510g
orf19.4585TFG1Candida albicans SC5314Protein similar to S. cerevisiae Tfg1p, which is part of transcription factor TFIIF; transposon mutation affects filamentous growth; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.4587HGH1Candida albicans SC5314Putative HMG1/2-related protein; transcription is regulated by Mig1p
orf19.4589Candida albicans SC5314Ortholog(s) have polyamine oxidase activity, role in polyamine catabolic process, pantothenate biosynthetic process and cytoplasm localization
orf19.1248Candida albicans SC5314Putative RNA polymerase II subunit B44; heterozygous null mutant exhibits resistance to parnafungin in the C. albicans fitness test
orf19.7130Candida albicans SC5314Hap43p-repressed gene
orf19.7131Candida albicans SC5314Butyrobetaine dioxygenase, the fourth enzyme of the carnitine biosynthesis pathway
orf19.7136SPT6Candida albicans SC5314Protein similar to S. cerevisiae Spt6p transcription elongation factor; transposon mutation affects filamentous growth; transcription is upregulated in an RHE model of oral candidiasis and in clinical isolates from oral candidiasis
orf19.891Candida albicans SC5314Putative AMP deaminase; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.3930YUH2Candida albicans SC5314Putative ubiquitin C-terminal hydrolase; sumoylation target
orf19.893PGA17Candida albicans SC5314Putative GPI-anchored protein; exogenously expressed protein is a substrate for Kex2p processing in vitro; transcription is repressed in response to alpha pheromone in SpiderM medium; macrophage-induced gene
orf19.7139Candida albicans SC5314
orf19.3931SFC1Candida albicans SC5314Putative succinate-fumarate transporter; gene is involved in repression of growth on sorbose; alkaline upregulated; transcription is upregulated in both intermediate and mature biofilms
orf19.894Candida albicans SC5314
orf19.895HOG1Candida albicans SC5314MAP kinase of osmotic-, heavy metal-, and core stress response; role in regulation of glycerol, D-arabitol in response to stress; phosphorylated in response to H2O2 (Ssk1p-dependent) or NaCl; mutant induces protective mouse immune response
Locus IdGene NameOrganismDescription
orf19.896CHK1Candida albicans SC5314Histidine kinase involved in two-component signaling pathway, regulates cell wall biosynthesis; disruption impairs hyphal growth, decreases virulence in mouse intravenous (but not rat vaginal) infection and increases rate of phagocytosis
orf19.3934CAR1Candida albicans SC5314Arginase involved in arginine catabolism; transcription regulated by Nrg1p, Mig1p, and Tup1p; colony morphology-related regulation by Ssn6p; alkaline upregulated; protein decreased in stationary phase; biofilm-induced; sumoylation target
orf19.897VPS20Candida albicans SC5314Putative ESCRT III complex protein with a role in multivesicular body (MVB) trafficking
orf19.4591CAT2Candida albicans SC5314Major carnitine acetyl transferase localized in peroxisomes and mitochondria; involved in intracellular acetyl-CoA transport; farnesol-upregulated in biofilm; induced in macrophages; Hog1p-downregulated; stationary phase enriched protein
orf19.898HEM2Candida albicans SC5314Putative porphobilinogen synthase; transcriptionally regulated by iron; expression greater in high iron; protein level decrease in stationary phase cultures
orf19.4592HSX11Candida albicans SC5314UDP-glucose:ceramide glucosyltransferase (glucosylceramide synthase [GCS], EC 2.4.1.80); involved in glucosylceramide biosynthesis, which is important for virulence
orf19.1250Candida albicans SC5314Ortholog(s) have role in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and nucleolus, cytoplasm localization
orf19.4594Candida albicans SC5314Ortholog(s) have role in endocytosis
orf19.1251BRN1Candida albicans SC5314Putative condensin complex subunit; cell-cycle regulated periodic mRNA expression
orf19.3939Candida albicans SC5314Ortholog(s) have role in protein folding in endoplasmic reticulum and ER membrane protein complex localization
orf19.4596Candida albicans SC5314
orf19.1253Candida albicans SC5314Protein required for growth in medium lacking phosphate and for resistance to copper and Phloxine B; transcriptionally activated by Mnl1p under weak acid stress
orf19.1254SEC23Candida albicans SC5314Putative GTPase-activating protein; transcription is regulated upon yeast-hyphal switch
orf19.1258Candida albicans SC5314Putative adhesin-like protein; regulated by Tsa1p, Tsa1Bp in minimal media at 37 deg; transcription is induced in response to alpha pheromone in SpiderM medium; clade-associated gene expression; Hap43p-induced gene
orf19.100Candida albicans SC5314Hap43p-repressed gene; late-stage biofilm-induced
orf19.101RIM9Candida albicans SC5314Protein required for alkaline pH response via the RIM101 signaling pathway; ortholog of S. cerevisiae RIM9 and A. nidulans palI
orf19.103KAR5Candida albicans SC5314Protein similar to S. cerevisiae Kar5p, involved in nuclear membrane fusion during karyogamy; induced by alpha factor
orf19.104Candida albicans SC5314Predicted ORF in Assemblies 19, 20 and 21; transcription is induced in response to alpha pheromone in SpiderM medium
orf19.105HAL22Candida albicans SC5314Putative phosphoadenosine-5'-phosphate (PAP) or 3'-phosphoadenosine 5'-phosphosulfate (PAPS) phosphatase; possible role in sulfur recycling; induced upon biofilm formation; Hap43p-repressed gene
orf19.7141UFE1Candida albicans SC5314Protein interacting with Sec20p, possibly involved in retrograde transport between the Golgi and the endoplasmic reticulum; functional homolog of S. cerevisiae Ufe1p, which is an ER t-SNARE that mediates the retrograde traffic
Locus IdGene NameOrganismDescription
orf19.7144Candida albicans SC5314Ortholog(s) have ribosome binding, GTPase activity, role in nuclear-transcribed mRNA catabolic process, no-go decay, nonfunctional rRNA decay, ribosome disassembly and cytoplasm localization
orf19.7148TPO2Candida albicans SC5314Putative polyamine transport protein; fungal-specific (no human or murine homolog)
orf19.7149Candida albicans SC5314Has domain(s) with predicted phospholipase C activity and role in lipid metabolic process, intracellular signal transduction
orf19.3941URA7Candida albicans SC5314CTP synthase 1; flucytosine induced; protein present in exponential and stationary growth phase yeast cultures
orf19.3944GRR1Candida albicans SC5314Protein involved in the negative control of pseudohyphal growth; ortholog of S. cerevisiae Grr1p, which is an F-box protein component of the SCF ubiquitin-ligase complex required for cell cycle progression
orf19.3945Candida albicans SC5314Ortholog(s) have role in adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion, nuclear mRNA splicing, via spliceosome and transcriptionally active chromatin localization
orf19.1261CGT1Candida albicans SC5314mRNA 5' guanylyltransferase; small subunit of mRNA capping enzyme; binds an RNA Pol II C-terminal domain peptide; Cet1p and Cgt1p form a 2:1 complex; functional homolog of S. cerevisiae Ceg1p
orf19.1264CFL2Candida albicans SC5314Putative oxidoreductase, iron utilization; regulated by Sfu1p, Sef1p, Hap43p, Nrg1p, Tup1p, Rim101p; alkaline, low iron, fluphenazine, ciclopirox olamine, flucytosine, fluconazole, biofilm induced; caspofungin, amphotericin B repressed
orf19.1266Candida albicans SC5314Predicted ORF in Assemblies 19, 20 and 21; transcription detected in high-resolution tiling array experiments
orf19.1268Candida albicans SC5314Predicted ORF in Assemblies 19, 20 and 21; transcription detected in high-resolution tiling array experiments
orf19.111CAN2Candida albicans SC5314Basic amino acid permease; arginine metabolism; transcription regulated by Nrg1p, Tup1p; caspofungin and flucytosine induced; shows colony morphology-related regulation by Ssn6p; fungal-specific (no human/murine homolog); Hap43p-repressed
orf19.114Candida albicans SC5314
orf19.7150NRG1Candida albicans SC5314Transcriptional repressor; regulates chlamydospore development, hyphal gene induction, virulence genes, and genes involved in rescue/stress responses; effects both Tup1p-dependent (major) and -independent (minor) regulation; biofilm-induced
orf19.7151Candida albicans SC5314
orf19.7153Candida albicans SC5314Putative exportin, member of the Exportin-T family
orf19.118FAD2Candida albicans SC5314Delta-12 fatty acid desaturase, involved in production of linoleic acid, which is a major component of membranes
orf19.7154UTP18Candida albicans SC5314Putative U3 snoRNA-associated protein; Hap43p-induced gene; downregulated during core stress response; physically interacts with TAP-tagged Nop1p
orf19.119Candida albicans SC5314Has domain(s) with predicted protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity, role in C-terminal protein methylation and integral to membrane localization
orf19.7156FAA2-3Candida albicans SC5314Predicted acyl CoA synthetase
orf19.7157Candida albicans SC5314Biofilm-induced gene
Locus IdGene NameOrganismDescription
orf19.7158Candida albicans SC5314Protein of allantoate permease family; fungal-specific (no human or murine homolog); Hap43p-repressed gene
orf19.3950MSM1Candida albicans SC5314Mitochondrial methionyl-tRNA synthetase (MetRS); functionally complements methionine auxotrophy of an E. coli MetRS mutant; transcription regulated by Nrg1p; biofilm- and planktonic growth-induced
orf19.7159Candida albicans SC5314Putative protein of unknown function; Hap43p-repressed gene; ortholog of S. cerevisiae YMR185W
orf19.3951TIP1Candida albicans SC5314Protein with a predicted role in biogenesis of ER-derived COPII transport vesicles; mutation confers hypersensitivity to toxic ergosterol analog
orf19.3952Candida albicans SC5314Ortholog(s) have GTP binding, signal recognition particle binding activity, role in protein targeting to ER and endoplasmic reticulum membrane localization
orf19.3954Candida albicans SC5314Ortholog(s) have phosphatidylserine decarboxylase activity, role in phosphatidylcholine biosynthetic process and endosome localization
orf19.3956Candida albicans SC5314Ortholog(s) have glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity and role in glutaminyl-tRNAGln biosynthesis via transamidation, endoplasmic reticulum organization
orf19.3957Candida albicans SC5314Ortholog(s) have GTP cyclohydrolase I activity, role in folic acid-containing compound biosynthetic process and nucleus, cytoplasm localization
orf19.1270FRE3Candida albicans SC5314Protein with similarity to ferric reductase Fre10p; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.3959SSD1Candida albicans SC5314Protein with role in resistance to host antimicrobial peptides; virulence role in murine infection; functional homolog of S. cerevisiae Ssd1p, which suppresses various mutant phenotypes; constitutively expressed and not cell-cycle regulated
orf19.1272Candida albicans SC5314Ortholog(s) have role in regulation of cell size and nucleus, cytoplasm localization
orf19.1274Candida albicans SC5314Has domain(s) with predicted DNA binding, zinc ion binding activity, role in transcription, DNA-dependent and nucleus localization
orf19.1279CDS1Candida albicans SC5314Protein similar to S. cerevisiae Cds1p; transposon mutation affects filamentous growth
orf19.6500ECM42Candida albicans SC5314Putative ornithine acetyltransferase; fungal-specific (no human or murine homolog); Gcn2p-, Gcn4p-regulated; clade-specific gene expression; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.121ARC18Candida albicans SC5314Putative ARP2/3 complex subunit; mutation confers hypersensitivity to cytochalasin D
orf19.122CDC20Candida albicans SC5314Protein similar to S. cerevisiae Cdc20p; induced under Cdc5p depletion; member of conserved Mcm1p regulon; mRNA expression peaks at cell-cycle G2/M phase; mRNA binds to She3p and is localized to buds of yeast-form cells and hyphal tips
orf19.6503Candida albicans SC5314Ortholog of C. glabrata CBS138 : CAGL0M08382g
orf19.7160Candida albicans SC5314Ortholog(s) have role in cellular response to oxidative stress, response to osmotic stress, ribosomal small subunit biogenesis and cytoplasm localization
orf19.125EBP1Candida albicans SC5314NADPH oxidoreductase; interacts with phenolic substrates, such as 17beta-estradiol; possible role in response to estrogen; induced by oxidative and weak acid stress, nitric oxide, benomyl; activated by Cap1p, Mnl1p; Sko1p-, Hap43p-repressed
orf19.7163Candida albicans SC5314
Locus IdGene NameOrganismDescription
orf19.6507Candida albicans SC5314Stationary phase enriched protein
orf19.6508Candida albicans SC5314Ortholog(s) have protein transporter activity, role in intracellular protein transport, Golgi to plasma membrane transport and vesicle coat localization
orf19.6509Candida albicans SC5314Has domain(s) with predicted protein disulfide oxidoreductase activity, electron carrier activity and role in cell redox homeostasis
orf19.3960HYS2Candida albicans SC5314Putative DNA polymerase III (delta) subunit with a predicted role in DNA replication and DNA repair; cell-cycle regulated periodic mRNA expression
orf19.3963Candida albicans SC5314Ortholog(s) have mitochondrion localization
orf19.3965Candida albicans SC5314
orf19.3966CRH12Candida albicans SC5314Putative cell wall protein, member of the CRH family; transcription is regulated by Nrg1p and Tup1p; alkaline upregulated by Rim101p; repressed during cell wall regeneration; biofilm-induced gene
orf19.1280SUI1Candida albicans SC5314Putative translation initiation factor; flucytosine induced; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage
orf19.3969SFL2Candida albicans SC5314Probable transcription factor required for filamentous growth; required for virulence in an RHE model but not in mouse systemic infection; upregulated upon RHE infection but C. dubliniensis ortholog is not upregulated
orf19.1283MEC1Candida albicans SC5314Cell cycle checkpoint protein with a role in genome integrity; RNA abundance regulated by tyrosol and cell density
orf19.1286Candida albicans SC5314
orf19.1288FOX2Candida albicans SC53143-hydroxyacyl-CoA epimerase, required for fatty acid beta-oxidation; upregulated upon phagocytosis; transcription regulated by Mig1p, by white-opaque switching and by DNA methylation; transcriptional activation by oleate requires Ctf1p
orf19.1289SCT1Candida albicans SC5314Putative glycerol-3-phosphate O-acyltransferase; fungal-specific (no human or murine homolog)
orf19.6510GRX1Candida albicans SC5314Putative glutaredoxin; transcriptionally regulated by iron; expression greater in low iron
orf19.131Candida albicans SC5314
orf19.6511LIG1Candida albicans SC5314tRNA ligase; functional homolog of S. cerevisiae Trl1p; fungal-specific (no human or murine homolog)
orf19.6512EXO70Candida albicans SC5314Predicted subunit of the exocyst complex, involved in exocytosis; localizes to a crescent on the surface of the hyphal tip; induced during planktonic growth
orf19.134Candida albicans SC5314Predicted ORF in Assemblies 19, 20 and 21; ciclopirox olamine induced
orf19.6514CUP9Candida albicans SC5314Genecupregulated in clinical isolates from HIV+ patients with oral candidiasis; transcription reduced upon yeast-hyphal switch; ketoconazole-induced; Plc1p-regulated; shows colony morphology-related Ssn6p regulation; biofilm-induced gene
orf19.6515HSP90Candida albicans SC5314Essential chaperone of Hsp90 family, activated by heat shock, stress; regulates several signal transduction pathways; localizes to surface of hyphae, not yeast cells; mediates echinocandin resistance
Locus IdGene NameOrganismDescription
orf19.136Candida albicans SC5314Predicted membrane transporter, member of the drug:proton antiporter (12 spanner) (DHA1) family, major facilitator superfamily (MFS); Hap43p-repressed gene
orf19.7173Candida albicans SC5314
orf19.6518Candida albicans SC5314Has domain(s) with predicted aldehyde dehydrogenase [NAD(P)+] activity and role in cellular aldehyde metabolic process, oxidation-reduction process
orf19.139TRA1Candida albicans SC5314Subunit of the NuA4 histone acetyltransferase complex
orf19.7175HLJ1Candida albicans SC5314Putative HSP40 co-chaperone; repressed during the mating process
orf19.7176NPT1Candida albicans SC5314Putative nicotinate phosphoribosyltransferase, involved in NAD salvage pathway; fungal-specific (no human or murine homolog)
orf19.7177KAP120Candida albicans SC5314Putative karyopherin; mutation confers hypersensitivity to cytochalasin D
orf19.7178PRE5Candida albicans SC5314Alpha6 subunit of the 20S proteasome; regulated by Gcn4p; induced in response to amino acid starvation (3-aminotriazole treatment)
orf19.7179Candida albicans SC5314Has domain(s) with predicted ATP binding activity
orf19.3971Candida albicans SC5314Early-stage biofilm-induced gene
orf19.3972Candida albicans SC5314Ortholog(s) have role in Golgi to endosome transport, ER to Golgi vesicle-mediated transport and endoplasmic reticulum, Golgi membrane, ER to Golgi transport vesicle localization
orf19.3973Candida albicans SC5314Late-stage biofilm-induced gene
orf19.3974PUT2Candida albicans SC5314Putative delta-1-pyrroline-5-carboxylate dehydrogenase; alkaline upregulated; protein present in exponential and stationary growth phase yeast cultures; late-stage biofilm-induced gene
orf19.3976Candida albicans SC5314Has domain(s) with predicted role in microtubule-based process and dynactin complex localization
orf19.3977Candida albicans SC5314Ortholog(s) have role in cytoplasmic translation and cytoplasm localization
orf19.3978Candida albicans SC5314Ortholog(s) have role in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), G1 phase of mitotic cell cycle and nucleolus localization
orf19.1291ABZ1Candida albicans SC5314Ortholog(s) have 4-amino-4-deoxychorismate synthase activity, role in para-aminobenzoic acid biosynthetic process and cytoplasm localization
orf19.1295VAS1Candida albicans SC5314Putative tRNA-Val synthetase; genes encoding ribosomal subunits, translation factors, and tRNA synthetases are downregulated upon phagocytosis by murine macrophage
orf19.1297Candida albicans SC5314Ortholog(s) have phosphatidylinositol-3-phosphate binding activity and role in CVT pathway, early endosome to Golgi transport, macroautophagy, mitochondrion degradation
orf19.1299RPN6Candida albicans SC5314Putative 26S proteasome subunit; Hap43p-induced gene; regulated by Gcn2p and Gcn4p
Locus IdGene NameOrganismDescription
orf19.144SNU114Candida albicans SC5314Protein similar to S. cerevisiae Snu114p, which is an RNA helicase involved in pre-mRNA splicing; likely to be essential for growth, based on an insertional mutagenesis strategy
orf19.6524TOM40Candida albicans SC5314Protein involved in mitochondrial protein import
orf19.7181Candida albicans SC5314
orf19.7182Candida albicans SC5314Ortholog(s) have RNA binding activity, role in tRNA modification and nucleus, cytoplasm localization
orf19.6526Candida albicans SC5314Ortholog(s) have Golgi apparatus, COPI-coated vesicle localization
orf19.7183Candida albicans SC5314Ortholog(s) have role in protein folding in endoplasmic reticulum and ER membrane protein complex localization
orf19.6527Candida albicans SC5314Predicted ORF in Assemblies 19, 20 and 21; shows colony morphology-related gene regulation by Ssn6p; transcriptionally activated by Mnl1p under weak acid stress; possibly an essential gene, disruptants not obtained by UAU1 method
orf19.7184Candida albicans SC5314
orf19.149Candida albicans SC5314Predicted ORF in Assemblies 19, 20 and 21; transcription detected in high-resolution tiling array experiments
orf19.6529CDC34Candida albicans SC5314Putative ubiquitin-protein ligase; transcription is regulated by Nrg1p and Tup1p, and by Gcn2p and Gcn4p; planktonic growth-induced gene
orf19.7187MAM33Candida albicans SC5314Putative mitochondrial acidic matrix protein; regulated by Ssn6p; protein present in exponential and stationary growth phase yeast cultures
orf19.3980Candida albicans SC5314Ortholog(s) have role in cytoplasmic translation, regulation of translation and polysomal ribosome, cytoplasm localization
orf19.3981MAL31Candida albicans SC5314Putative high-affinity maltose transporter; transcription is upregulated in clinical isolates from HIV+ patients with oral candidiasis; alkaline upregulated
orf19.3983Candida albicans SC5314Biofilm-induced gene; S. cerevisiae ortholog YGR266W localizes to plasma membrane, mitochondrial outer membrane
orf19.3986PPR1Candida albicans SC5314Putative transcription factor with zinc cluster DNA-binding motif; has similarity to S. cerevisiae Ppr1p, which is a transcription factor involved in the regulation of uracil biosynthesis genes
orf19.6530Candida albicans SC5314Similar to bacterial DnaJ; transcriptionally regulated by iron; expression greater in low iron; late-stage biofilm-induced
orf19.6533MSK1Candida albicans SC5314Putative mitochondrial lysine-tRNA synthetase; flucytosine repressed
orf19.7190OGG1Candida albicans SC5314Ortholog(s) have oxidized purine base lesion DNA N-glycosylase activity, role in b